Details of Drug

Details of Drug

 Drug General Information (ID: D1297)
  Drug Name
Piperazine
  Drug Type Small molecule
  Drug Synonymous
Anthalazine; Antiren; Diethylenediamine; Diethyleneimine; Dispermine; Eraverm; Hexahydropyrazine; Lumbrical; PZE; Piperazidine; Piperazin; Pipersol; Upixon; Uvilon; Vermex; Vermizine; Wurmirazin; Piperazin [German]; Piperazin [Germany]; Piperazine Dihydrochloride Dihydrochloride Hydrate; Piperazine [USAN]; Piperazine anhydrous; Piperazinium oleate; Pyrazine hexahydride; LTBB000432; Piperazine [UN2579] [Corrosive]; Eraverm (VAN); PIPERAZINE (HEXAHYDRATE); Piperazine (USP); Piperazine Hexa-Hydrate; Piperazine, anhydrous; Pyrazine, hexahy; Vermizine (TN); Worm-away; Asca-Trol No. 3; Worm-A-Ton; Hexahydro-1,4-diazine; 1,4-Diazacyclohexane; 1,4-Diethylenediamine; 1,4-Piperazine
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  Disease Class 1F65: Enterobiasis; 1F62: Ascariasis
  Therapeutic Class Antinematodal Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C4H10N2
  InChI 1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2
  InChIKey GLUUGHFHXGJENI-UHFFFAOYSA-N
  Canonical SMILES C1CNCCN1
  External Link
Pubchem ID 4837
CAS Number 110-85-0
CHEBI ID 28568
TTD ID D01XLM
INTEDE ID DR1297

Drug-Drug Interaction Network
  Sunburst Graph
AM003  Affected organization distribution
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
BM014  Interference of cell/tissue uptake
BM017  CYP450 enzyme inhibition
BM069  Increased risk of lowers seizure threshold
  Relation Graph
 Full list of drugs interacting with Piperazine
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1822
 
Iodide I-123
 
I-
 
135300 
Moderate    Inter Info   
[42], [43], [44]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0220
 
Bupropion
 
C13H18ClNO
 
444 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
      Pharmacodynamic additive effects
   Increased risk of lowers seizure threshold Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0833
 
Iohexol
 
C19H26I3N3O9
 
3730 
Major    Inter Info   
[20], [21], [22], [23], [24]
D0834
 
Iopamidol
 
C17H22I3N3O8
 
65492 
Major    Inter Info   
[20], [21], [22], [23], [24]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Major    Inter Info   
[25], [9], [15], [26]
D0932
 
Lindane
 
C6H6Cl6
 
727 
Moderate    Inter Info   
[27], [28], [29]
D0054
 
Amifampridine
 
C5H7N3
 
5918 
Moderate    Inter Info   
[30], [31]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[32], [33]
D0722
 
Ginkgo biloba
 
NA
 
NA
Moderate    Inter Info   
[34], [35], [36], [37], [38], [39], [40], [41]
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Moderate    Inter Info   
[45], [46], [33]
D1308
 
Polyethylene glycol (3350 with electrolytes)
 
C2H6O2
 
174 
Moderate    Inter Info   
[45], [46], [33]
D1488
 
Sodium sulfate
 
Na2O4S
 
24436 
Moderate    Inter Info   
[45], [46], [33]
References
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10 Product Information. Aplenzin (buPROPion). sanofi-aventis , Bridgewater, NJ.
11 Product Information. Wellbutrin (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
12 Product Information. Wellbutrin SR (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
13 Product Information. Wellbutrin XL (buPROPion). GlaxoSmithKline, Philadelphia, PA.
14 Product Information. Zyban (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
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20 Product Information. Isovue-M-200 (iopamidol). Bracco Diagnostics Inc, Princeton, NJ.
21 Product Information. Amipaque (metrizamide) Nycomed Inc, Princeton, NJ.
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23 Product Information. Omnipaque 180 (iohexol). Amersham Health, Princeton, NJ.
24 Product Information. Osmovist 240 (iotrolan). Berlex Canada Inc, Lachine, QC.
25 Product Information. Ultram (tramadol). McNeil Pharmaceutical, Raritan, NJ.
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29 Product Information. Kwell (lindane). Reed and Carnrick, Jersey City, NJ.
30 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
31 Product Information. Firdapse (amifampridine). Catalyst Pharmaceuticals, Inc., Coral Gables, FL.
32 Cerner Multum, Inc. "Australian Product Information.".
33 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
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40 Miwa H, Iijima M, Tanaka S, Mizuno Y "Generalized convulsions after consuming a large amount of Gingko nuts." Epilepsia 42 (2001): 280-1. [PMID: 11240603]
41 Kupiec T, Raj V "Fatal seizures due to potential herb-drug interactions with Ginkgo biloba." J Anal Toxicol 29 (2005): 755-8. [PMID: 16419414]
42 Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
43 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
44 Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
45 Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
46 Salik JM, Kurtin P "Severe hyponatremia after colonoscopy preparation in a patient with the acquired immune deficiency syndrome." Am J Gastroenterol 80 (1985): 177-9. [PMID: 2983533]