Details of Drug

Drug General Information (ID: D1291)
Drug Name	Pimecrolimus (topical)
Drug Type	Small molecule
Drug Synonymous	Elidel; ASM 981; SDZ ASM 981; ASM-981; ASM-998; Elidel (TN); SDZ-ASM 981; Pimecrolimus [USAN:INN:BAN]; SDZ-ASM-981; Pimecrolimus (JAN/USAN/INN); 33-epi-Chloro-33-desoxyascomycin Click to Show/Hide
Disease Class	EA80: Atopic eczema
Therapeutic Class	Dermatologic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C43H68ClNO11
InChI	1S/C43H68ClNO11/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)45-16-12-11-13-32(45)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-31(44)35(22-29)52-7/h18,20,25,27-33,35-39,46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31-,32-,33-,35+,36-,37-,38+,39+,43+/m0/s1
InChIKey	KASDHRXLYQOAKZ-XDSKOBMDSA-N
Canonical SMILES	CCC1C=C(CC(CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC1=O)O)C)C(=CC4CCC(C(C4)OC)Cl)C)O)C)OC)OC)C)C
External Link
	Pubchem ID	6509979
	CAS Number	137071-32-0
	CHEBI ID	135888
	TTD ID	D0Z4UN
	INTEDE ID	DR1289

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme
Relation Graph

Full list of drugs interacting with Pimecrolimus (topical)
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 70
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[1]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[4]
D0367		Clotrimazole	C22H17ClN2	2812	Minor		Inter Info	[10]
D0402		Cyclosporine	C62H111N11O12	5284373	Minor		Inter Info	[10]
D0597		Erythromycin	C37H67NO13	12560	Minor		Inter Info	[10]
D0667		Fluconazole	C13H12F2N6O	3365	Minor		Inter Info	[10]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Minor		Inter Info	[10]
D0799		Indinavir	C36H47N5O4	5362440	Minor		Inter Info	[10]
D1119		Nelfinavir	C32H45N3O4S	64143	Minor		Inter Info	[10]
D0080		Amprenavir	C25H35N3O6S	65016	Minor		Inter Info	[10]
D0100		Aprepitant	C23H21F7N4O3	135413536	Minor		Inter Info	[10]
D0116		Atazanavir	C38H52N6O7	148192	Minor		Inter Info	[10]
D0171		Berotralstat	C30H26F4N6O	137528262	Minor		Inter Info	[10]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Minor		Inter Info	[10]
D0192		Boceprevir	C27H45N5O5	10324367	Minor		Inter Info	[10]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Minor		Inter Info	[10]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[10]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[10]
D0349		Clarithromycin	C38H69NO13	84029	Minor		Inter Info	[10]
D0375		Cobicistat	C40H53N7O5S2	25151504	Minor		Inter Info	[10]
D0386		Conivaptan	C32H26N4O2	151171	Minor		Inter Info	[10]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Minor		Inter Info	[10]
D0413		Dalfopristin	C34H50N4O9S	6323289	Minor		Inter Info	[10]
D0416		Danazol	C22H27NO2	28417	Minor		Inter Info	[10]
D0426		Darunavir	C27H37N3O7S	213039	Minor		Inter Info	[10]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Minor		Inter Info	[10]
D0439		Delavirdine	C22H28N6O3S	5625	Minor		Inter Info	[10]
D0497		Diltiazem	C22H26N2O4S	39186	Minor		Inter Info	[10]
D0534		Dronedarone	C31H44N2O5S	208898	Minor		Inter Info	[10]
D0543		Duvelisib	C22H17ClN6O	50905713	Minor		Inter Info	[10]
D0577		Entrectinib	C31H34F2N6O2	25141092	Minor		Inter Info	[10]
D0638		Fedratinib	C27H36N6O3S	16722836	Minor		Inter Info	[10]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Minor		Inter Info	[10]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Minor		Inter Info	[10]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Minor		Inter Info	[10]
D0740		Grepafloxacin	C19H22FN3O3	72474	Minor		Inter Info	[10]
D0789		Idelalisib	C22H18FN7O	11625818	Minor		Inter Info	[10]
D0793		Imatinib	C29H31N7O	5291	Minor		Inter Info	[10]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Minor		Inter Info	[10]
D0858		Isoniazid	C6H7N3O	3767	Minor		Inter Info	[10]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Minor		Inter Info	[10]
D0869		Ivacaftor	C24H28N2O3	16220172	Minor		Inter Info	[10]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Minor		Inter Info	[10]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Minor		Inter Info	[10]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Minor		Inter Info	[10]
D0906		Letermovir	C29H28F4N4O4	45138674	Minor		Inter Info	[10]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Minor		Inter Info	[10]
D1057		Miconazole	C18H14Cl4N2O	4189	Minor		Inter Info	[10]
D1063		Mifepristone	C29H35NO2	55245	Minor		Inter Info	[10]
D1117		Nefazodone	C25H32ClN5O2	4449	Minor		Inter Info	[10]
D1127		Netupitant	C30H32F6N4O	6451149	Minor		Inter Info	[10]
D1134		Nifedipine	C17H18N2O6	4485	Minor		Inter Info	[10]
D1136		Nilotinib	C28H22F3N7O	644241	Minor		Inter Info	[10]
D1315		Posaconazole	C37H42F2N8O4	468595	Minor		Inter Info	[10]
D1398		Ribociclib	C23H30N8O	44631912	Minor		Inter Info	[10]
D1415		Ritonavir	C37H48N6O5S2	392622	Minor		Inter Info	[10]
D1432		Rucaparib	C19H18FN3O	9931954	Minor		Inter Info	[10]
D1444		Saquinavir	C38H50N6O5	441243	Minor		Inter Info	[10]
D1459		Selpercatinib	C29H31N7O3	134436906	Minor		Inter Info	[10]
D1505		Stiripentol	C14H18O3	5311454	Minor		Inter Info	[10]
D1541		Telaprevir	C36H53N7O6	3010818	Minor		Inter Info	[10]
D1544		Telithromycin	C43H65N5O10	3002190	Minor		Inter Info	[10]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Minor		Inter Info	[10]
D1653		Troleandomycin	C41H67NO15	202225	Minor		Inter Info	[10]
D1660		Tucatinib	C26H24N8O2	51039094	Minor		Inter Info	[10]
D1690		Verapamil	C27H38N2O4	2520	Minor		Inter Info	[10]
D1706		Voriconazole	C16H14F3N5O	71616	Minor		Inter Info	[10]
D1709		Voxelotor	C19H19N3O3	71602803	Minor		Inter Info	[10]
D1714		Zafirlukast	C31H33N3O6S	5717	Minor		Inter Info	[10]
D1383		Ranolazine	C24H33N3O4	56959	Minor		Inter Info	[10]
	CYP450 enzyme induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0545		Echinacea	NA	NA	Moderate		Inter Info	[2], [3]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[5], [6]
	Competitive inhibition of metabolic enzyme					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[7], [8], [9]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[7], [8], [9]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[7], [8], [9]

References
1	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
2	Cerner Multum, Inc. "Australian Product Information.".
3	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
4	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
5	Product Information. Sonata (zaleplon) Wyeth-Ayerst Laboratories, Philadelphia, PA.
6	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
7	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
8	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
9	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
10	Product Information. Elidel (pimecrolimus topical). Novartis Pharmaceuticals, East Hanover, NJ.

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