Drug General Information (ID: D1262)
  Drug Name
Phendimetrazine
  Drug Type Small molecule
  Drug Synonymous
Adphen; Antapentan; Dyrexan; Fendimetrazina; Hyrex; Mephenmetrazine; Phendimetrazinum; Sedafamen; Wehless; Adipost (TN); Adphen (base); Appecon (TN); Bontril PDM (TN); Fendimetrazina [INN-Spanish]; Melfiat (TN); Obezine (TN); Phendiet (TN); Phendimetrazine (INN); Phendimetrazine [INN:BAN]; Phendimetrazinum [INN-Latin]; Plegine (TN); Statobex (TN); X-Trozine; Anorex-SR (TN); Prelu-2 (TN); Phendimetrazine, (2S-trans)-isomer; D-2-Phenyl-3,4-dimethylmorpholine; Morpholine, 3,4-dimethyl-2-phenyl; (+)-3,4-Dimethyl-2-phenylmorpholine; (+)-Phendimetrazine; (2R-trans)-3,4-Dimethyl-2-phenylmorpholine; (2S,3S)-3,4-Dimethyl-2-phenylmorpholine; 3,4-Dimethyl-2-phenylmorpholine; 3,4-Dimethyl-2-phenyltetrahydro-1,4-oxazine; 3-Phenyl-2-methylmorpholine
    Click to Show/Hide
  Disease Class 5B80-5B81: Obesity
  Therapeutic Class Anorexiants
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C12H17NO
  InChI 1S/C12H17NO/c1-10-12(14-9-8-13(10)2)11-6-4-3-5-7-11/h3-7,10,12H,8-9H2,1-2H3/t10-,12+/m0/s1
  InChIKey MFOCDFTXLCYLKU-CMPLNLGQSA-N
  Canonical SMILES CC1C(OCCN1C)C2=CC=CC=C2
  External Link
Pubchem ID 30487
CAS Number 634-03-7
CHEBI ID 8059
TTD ID D0T6SU

Drug-Drug Interaction Network
  Sunburst Graph
AM003  Affected organization distribution
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM014  Interference of cell/tissue uptake
BM038  Additive CNS depression effects
BM041  Additive hypertensive effects
BM061  Increased risk of hyperpyrexia
BM064  Increased risk of hypoglycemia
BM069  Increased risk of lowers seizure threshold
BM078  Increased risk of rapid heart rate
BM081  Increased risk of ventricular arrhythmias
BM083  Potentiated the pharmacological effects (Unspecific)
BM089  Antagonize the effect of antihypertensive agents
BM093  Antagonize the effect of dopaminergic agents
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Phendimetrazine
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  2
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0829
 
Iobenguane (I-131)
 
C8H10IN3
 
60860 
Major    Inter Info   
[54]
D1821
 
Iobenguane (I-123)
 
C8H10IN3
 
60860 
Moderate    Inter Info   
[115], [116], [117]
      Pharmacodynamic additive effects
   Additive CNS depression effects Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0617
 
Ethanol
 
C2H6O
 
702 
Moderate    Inter Info   
[59], [94], [57]
   Additive hypertensive effects Drug Num:  55
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0345
 
Citalopram
 
C20H21FN2O
 
2771 
Major    Inter Info   
[19], [20], [21]
D0377
 
Cocaine (nasal)
 
C17H21NO4
 
446220 
Major    Inter Info   
[22], [23], [24]
D0378
 
Cocaine (topical)
 
C17H21NO4
 
446220 
Major    Inter Info   
[22], [23], [24]
D0539
 
Duloxetine
 
C18H19NOS
 
60835 
Major    Inter Info   
[19], [20], [21]
D0599
 
Escitalopram
 
C20H21FN2O
 
146570 
Major    Inter Info   
[19], [20], [21]
D0676
 
Fluoxetine
 
C17H18F3NO
 
3386 
Major    Inter Info   
[19], [20], [21]
D0687
 
Fluvoxamine
 
C15H21F3N2O2
 
5324346 
Major    Inter Info   
[19], [20], [21]
D1229
 
Paroxetine
 
C19H20FNO3
 
43815 
Major    Inter Info   
[19], [20], [21]
D0451
 
Desvenlafaxine
 
C16H25NO2
 
125017 
Major    Inter Info   
[19], [20], [21]
D0600
 
Esketamine
 
C13H16ClNO
 
182137 
Major    Inter Info   
[52], [53]
D0920
 
Levomilnacipran
 
C15H22N2O
 
6917779 
Major    Inter Info   
[19], [20], [21]
D1066
 
Milnacipran
 
C15H22N2O
 
65833 
Major    Inter Info   
[19], [20], [21]
D1535
 
Tapentadol
 
C14H23NO
 
9838022 
Major    Inter Info   
[19], [20], [21]
D1696
 
Vilazodone
 
C26H27N5O2
 
6918314 
Major    Inter Info   
[19], [20], [21]
D1708
 
Vortioxetine
 
C18H22N2S
 
9966051 
Major    Inter Info   
[19], [20], [21]
D1461
 
Sertraline
 
C17H17Cl2N
 
68617 
Major    Inter Info   
[19], [20], [21]
D1464
 
Sibutramine
 
C17H26ClN
 
5210 
Major    Inter Info   
[19], [20], [21]
D1689
 
Venlafaxine
 
C17H27NO2
 
5656 
Major    Inter Info   
[19], [20], [21]
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Moderate    Inter Info   
[62], [63], [64]
D0072
 
Amoxapine
 
C17H16ClN3O
 
2170 
Moderate    Inter Info   
[62], [63], [64]
D0103
 
Arformoterol
 
C19H24N2O4
 
3083544 
Moderate    Inter Info   
[43], [45], [65]
D0361
 
Clomipramine
 
C19H23ClN2
 
2801 
Moderate    Inter Info   
[62], [63], [64]
D0446
 
Desipramine
 
C18H22N2
 
2995 
Moderate    Inter Info   
[62], [63], [64]
D0510
 
Dobutamine
 
C18H23NO3
 
36811 
Moderate    Inter Info   
[43], [45], [65]
D0517
 
Dopamine
 
C8H11NO2
 
681 
Moderate    Inter Info   
[43], [45], [65]
D0526
 
Doxepin (topical)
 
C19H21NO
 
667477 
Moderate    Inter Info   
[62], [63], [64]
D0579
 
Ephedrine
 
C10H15NO
 
9294 
Moderate    Inter Info   
[43], [45], [65]
D0581
 
Epinephrine
 
C9H13NO3
 
5816 
Moderate    Inter Info   
[43], [45], [65]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Moderate    Inter Info   
[62], [63], [64]
D0854
 
Isoetharine
 
C13H21NO3
 
3762 
Moderate    Inter Info   
[43], [45], [65]
D0859
 
Isoprenaline
 
C11H17NO3
 
3779 
Moderate    Inter Info   
[43], [45], [65]
D0879
 
Ketamine
 
C13H16ClNO
 
3821 
Moderate    Inter Info   
[52], [22], [104]
D1002
 
Mephentermine
 
C11H17N
 
3677 
Moderate    Inter Info   
[43], [45], [65]
D1013
 
Metaraminol
 
C9H13NO2
 
5906 
Moderate    Inter Info   
[43], [45], [65]
D1027
 
Methoxamine
 
C11H17NO3
 
6082 
Moderate    Inter Info   
[43], [45], [65]
D1061
 
Midodrine
 
C12H18N2O4
 
4195 
Moderate    Inter Info   
[22], [111]
D1153
 
Norepinephrine
 
C8H11NO3
 
439260 
Moderate    Inter Info   
[43], [45], [65]
D1185
 
Orciprenaline
 
C11H17NO3
 
4086 
Moderate    Inter Info   
[43], [45], [65]
D0538
 
Droxidopa
 
C9H11NO5
 
92974 
Moderate    Inter Info   
[114]
D0797
 
Indacaterol
 
C24H28N2O3
 
6918554 
Moderate    Inter Info   
[43], [45], [65]
D0857
 
Isometheptene
 
C9H19N
 
22297 
Moderate    Inter Info   
[43], [45], [65]
D0921
 
Levonordefrin
 
C9H13NO3
 
164739 
Moderate    Inter Info   
[43], [45], [65]
D0924
 
Levosalbutamol
 
C13H21NO3
 
123600 
Moderate    Inter Info   
[43], [45], [65]
D1171
 
Olodaterol
 
C21H26N2O5
 
11504295 
Moderate    Inter Info   
[43], [45], [65]
D1374
 
Racepinephrine
 
C9H13NO3
 
838 
Moderate    Inter Info   
[43], [45], [65]
D1695
 
Vilanterol
 
C24H33Cl2NO5
 
10184665 
Moderate    Inter Info   
[43], [45], [65]
D1298
 
Pirbuterol
 
C12H20N2O3
 
4845 
Moderate    Inter Info   
[43], [45], [65]
D1361
 
Protriptyline
 
C19H21N
 
4976 
Moderate    Inter Info   
[62], [63], [64]
D1363
 
Pseudoephedrine
 
C10H15NO
 
7028 
Moderate    Inter Info   
[43], [45], [65]
D1385
 
Rasagiline
 
C12H13N
 
3052776 
Moderate    Inter Info   
[30], [118], [31], [22], [120], [32], [33], [121], [35], [36], [122], [37], [123], [124], [38], [129], [39], [130], [150], [46], [47], [49], [151], [50], [51]
D1414
 
Ritodrine
 
C17H21NO3
 
33572 
Moderate    Inter Info   
[43], [45], [65]
D1438
 
Salbutamol
 
C13H21NO3
 
2083 
Moderate    Inter Info   
[43], [45], [65]
D1440
 
Salmeterol
 
C25H37NO4
 
5152 
Moderate    Inter Info   
[43], [45], [65]
D1554
 
Terbutaline
 
C12H19NO3
 
5403 
Moderate    Inter Info   
[43], [45], [65]
D1647
 
Trimipramine
 
C20H26N2
 
5584 
Moderate    Inter Info   
[62], [63], [64]
   Increased risk of hyperpyrexia Drug Num:  8
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0853
 
Isocarboxazid
 
C12H13N3O2
 
3759 
Major    Inter Info   
[30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D0933
 
Linezolid
 
C16H20FN3O4
 
441401 
Major    Inter Info   
[30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D1036
 
Methylene blue
 
C16H18ClN3S
 
6099 
Major    Inter Info   
[30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D1263
 
Phenelzine
 
C8H12N2
 
3675 
Major    Inter Info   
[30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D1345
 
Procarbazine
 
C12H19N3O
 
4915 
Major    Inter Info   
[30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D1455
 
Selegiline
 
C13H17N
 
26757 
Major    Inter Info   
[30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D1620
 
Tranylcypromine
 
C9H11N
 
19493 
Major    Inter Info   
[30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Moderate    Inter Info   
[30], [118], [31], [52], [22], [119], [120], [32], [33], [121], [34], [35], [36], [122], [37], [123], [124], [125], [126], [127], [38], [128], [129], [39], [130], [131], [132], [133], [40], [41], [134], [135], [42], [43], [136], [137], [138], [44], [139], [140], [45], [141], [46], [142], [47], [48], [143], [144], [49], [50], [145], [146], [147], [51]
   Increased risk of hypoglycemia Drug Num:  39
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0009
 
Acarbose
 
C25H43NO18
 
41774 
Moderate    Inter Info   
[57], [58], [59]
D0013
 
Acetohexamide
 
C15H20N2O4S
 
1989 
Moderate    Inter Info   
[57], [58], [59]
D0325
 
Chlorpropamide
 
C10H13ClN2O3S
 
2727 
Moderate    Inter Info   
[57], [58], [59]
D0728
 
Glipizide
 
C21H27N5O4S
 
3478 
Moderate    Inter Info   
[57], [58], [59]
D0730
 
Glyburide
 
C23H28ClN3O5S
 
3488 
Moderate    Inter Info   
[57], [58], [59]
D0807
 
Insulin aspart (aspart protamine)
 
C256H381N65O79S6
 
118984445 
Moderate    Inter Info   
[57], [58], [59]
D0808
 
Insulin aspart (aspart)
 
C256H381N65O79S6
 
118984445 
Moderate    Inter Info   
[57], [58], [59]
D0810
 
Insulin detemir
 
C267H402N64O76S6
 
16137271 
Moderate    Inter Info   
[57], [58], [59]
D0811
 
Insulin glargine
 
C267H404N72O78S6
 
118984454 
Moderate    Inter Info   
[57], [58], [59]
D0812
 
Insulin glulisine
 
C258H384N64O78S6
 
16136701 
Moderate    Inter Info   
[57], [58], [59]
D0813
 
Insulin human
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[57], [58], [59]
D0814
 
Insulin human (inhalation, rapid acting)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[57], [58], [59]
D0815
 
Insulin human (isophane)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[57], [58], [59]
D0816
 
Insulin human (regular)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[57], [58], [59]
D0817
 
Insulin human (zinc extended)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[57], [58], [59]
D0818
 
Insulin human (zinc)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[57], [58], [59]
D0819
 
Insulin lispro
 
C257H389N65O77S6
 
16132438 
Moderate    Inter Info   
[57], [58], [59]
D0820
 
Insulin lispro (protamine)
 
C257H389N65O77S6
 
16132438 
Moderate    Inter Info   
[57], [58], [59]
D1015
 
Metformin
 
C4H11N5
 
4091 
Moderate    Inter Info   
[57], [58], [59]
D1064
 
Miglitol
 
C8H17NO5
 
441314 
Moderate    Inter Info   
[57], [58], [59]
D1112
 
Nateglinide
 
C19H27NO3
 
5311309 
Moderate    Inter Info   
[57], [58], [59]
D0029
 
Albiglutide
 
C148H224N40O45
 
145994868 
Moderate    Inter Info   
[57], [58], [59]
D0042
 
Alogliptin
 
C18H21N5O2
 
11450633 
Moderate    Inter Info   
[57], [58], [59]
D0245
 
Canagliflozin
 
C24H25FO5S
 
24812758 
Moderate    Inter Info   
[57], [58], [59]
D0418
 
Dapagliflozin
 
C21H25ClO6
 
9887712 
Moderate    Inter Info   
[57], [58], [59]
D0565
 
Empagliflozin
 
C23H27ClO7
 
11949646 
Moderate    Inter Info   
[57], [58], [59]
D0809
 
Insulin degludec
 
C274H411N65O81S6
 
118984462 
Moderate    Inter Info   
[57], [58], [59]
D0930
 
Linagliptin
 
C25H28N8O2
 
10096344 
Moderate    Inter Info   
[57], [58], [59]
D0936
 
Liraglutide
 
C172H265N43O51
 
16134956 
Moderate    Inter Info   
[57], [58], [59]
D0941
 
Lixisenatide
 
C215H347N61O65S
 
90472060 
Moderate    Inter Info   
[57], [58], [59]
D1449
 
Saxagliptin
 
C18H25N3O2
 
11243969 
Moderate    Inter Info   
[57], [58], [59]
D1294
 
Pioglitazone
 
C19H20N2O3S
 
4829 
Moderate    Inter Info   
[57], [58], [59]
D1326
 
Pramlintide
 
C171H267N51O53S2
 
70691388 
Moderate    Inter Info   
[57], [58], [59]
D1392
 
Repaglinide
 
C27H36N2O4
 
65981 
Moderate    Inter Info   
[57], [58], [59]
D1429
 
Rosiglitazone
 
C18H19N3O3S
 
77999 
Moderate    Inter Info   
[57], [58], [59]
D1477
 
Sitagliptin
 
C16H15F6N5O
 
4369359 
Moderate    Inter Info   
[57], [58], [59]
D1601
 
Tolazamide
 
C14H21N3O3S
 
5503 
Moderate    Inter Info   
[57], [58], [59]
D1603
 
Tolbutamide
 
C12H18N2O3S
 
5505 
Moderate    Inter Info   
[57], [58], [59]
D1652
 
Troglitazone
 
C24H27NO5S
 
5591 
Moderate    Inter Info   
[57], [58], [59]
   Increased risk of lowers seizure threshold Drug Num:  10
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0220
 
Bupropion
 
C13H18ClNO
 
444 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18]
D0833
 
Iohexol
 
C19H26I3N3O9
 
3730 
Major    Inter Info   
[25], [26], [27], [28], [29]
D0834
 
Iopamidol
 
C17H22I3N3O8
 
65492 
Major    Inter Info   
[25], [26], [27], [28], [29]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Major    Inter Info   
[55], [17], [16], [56]
D0722
 
Ginkgo biloba
 
NA
 
NA
Moderate    Inter Info   
[95], [96], [97], [98], [99], [100], [101], [102]
D0932
 
Lindane
 
C6H6Cl6
 
727 
Moderate    Inter Info   
[108], [109], [110]
D0054
 
Amifampridine
 
C5H7N3
 
5918 
Moderate    Inter Info   
[112], [113]
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Moderate    Inter Info   
[148], [149], [22]
D1308
 
Polyethylene glycol (3350 with electrolytes)
 
C2H6O2
 
174 
Moderate    Inter Info   
[148], [149], [22]
D1488
 
Sodium sulfate
 
Na2O4S
 
24436 
Moderate    Inter Info   
[148], [22], [149]
   Potentiated the pharmacological effects (Unspecific) Drug Num:  3
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0925
 
Levothyroxine
 
C15H11I4NO4
 
5819 
Moderate    Inter Info   
[105], [106], [107]
D0934
 
Liothyronine
 
C15H12I3NO4
 
5920 
Moderate    Inter Info   
[105], [106], [107]
D1577
 
Thyroid, porcine
 
NA
 
NA
Moderate    Inter Info   
[105], [106], [107]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  9
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0165
 
Benzphetamine
 
C17H21N
 
5311017 
Major    Inter Info   
[1], [2], [3]
D0457
 
Dexfenfluramine
 
C12H16F3N
 
66265 
Major    Inter Info   
[1], [2], [3]
D0486
 
Diethylpropion
 
C13H19NO
 
7029 
Major    Inter Info   
[1], [2], [3]
D0641
 
Fenfluramine
 
C12H16F3N
 
3337 
Major    Inter Info   
[1], [2], [3]
D0981
 
Mazindol
 
C16H13ClN2O
 
4020 
Major    Inter Info   
[1], [2], [3]
D1012
 
Metamfetamine
 
C10H15N
 
10836 
Major    Inter Info   
[1], [2], [3]
D0952
 
Lorcaserin
 
C11H14ClN
 
11658860 
Major    Inter Info   
[1], [2], [3]
D1270
 
Phentermine
 
C10H15N
 
4771 
Major    Inter Info   
[1], [2], [3]
D1281
 
Phenylpropanolamine
 
C9H13NO
 
26934 
Major    Inter Info   
[1], [2], [3]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antihypertensive agents Drug Num:  4
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0444
 
Deserpidine
 
C32H38N2O8
 
8550 
Moderate    Inter Info   
[91], [92], [93]
D0743
 
Guanadrel
 
C10H19N3O2
 
38521 
Moderate    Inter Info   
[91], [92], [93]
D0744
 
Guanethidine
 
C10H22N4
 
3518 
Moderate    Inter Info   
[91], [92], [93]
D1393
 
Reserpine
 
C33H40N2O9
 
5770 
Moderate    Inter Info   
[91], [92], [93]
   Antagonize the effect of dopaminergic agents Drug Num:  16
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0037
 
Alimemazine
 
C18H22N2S
 
5574 
Moderate    Inter Info   
[60], [39], [61]
D0324
 
Chlorpromazine
 
C17H19ClN2S
 
2726 
Moderate    Inter Info   
[66], [67], [68], [69], [70], [71], [72], [73], [74], [60], [75], [76], [39], [77], [78], [79], [80], [41], [81], [82], [42], [57], [83], [43], [84], [44], [85], [86], [46], [61], [87], [88], [89], [90]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[66], [67], [68], [69], [70], [71], [72], [73], [74], [60], [75], [76], [39], [77], [78], [79], [80], [41], [81], [82], [42], [57], [83], [43], [84], [44], [85], [86], [46], [61], [87], [88], [89], [90]
D0750
 
Haloperidol
 
C21H23ClFNO2
 
3559 
Moderate    Inter Info   
[66], [67], [103], [68], [70], [71], [72], [73], [74], [60], [75], [76], [77], [78], [79], [80], [41], [46], [61], [87], [88], [89], [90]
D1010
 
Mesoridazine
 
C21H26N2OS2
 
4078 
Moderate    Inter Info   
[66], [67], [68], [69], [70], [71], [72], [73], [74], [60], [75], [76], [39], [77], [78], [79], [80], [41], [81], [82], [42], [57], [83], [43], [84], [44], [85], [86], [46], [61], [87], [88], [89], [90]
D1019
 
Methdilazine
 
C18H20N2S
 
14677 
Moderate    Inter Info   
[66], [67], [68], [69], [70], [71], [72], [73], [74], [60], [75], [76], [39], [77], [78], [79], [80], [41], [81], [82], [42], [57], [83], [43], [84], [44], [85], [86], [46], [61], [87], [88], [89], [90]
D1026
 
Methotrimeprazine
 
C19H24N2OS
 
72287 
Moderate    Inter Info   
[66], [67], [68], [69], [70], [71], [72], [73], [74], [60], [75], [76], [39], [77], [78], [79], [80], [41], [81], [82], [42], [57], [83], [43], [84], [44], [85], [86], [46], [61], [87], [88], [89], [90]
D1257
 
Perphenazine
 
C21H26ClN3OS
 
4748 
Moderate    Inter Info   
[66], [67], [68], [69], [70], [71], [72], [73], [74], [60], [75], [76], [39], [77], [78], [79], [80], [41], [81], [82], [42], [57], [83], [43], [84], [44], [85], [86], [46], [61], [87], [88], [89], [90]
D1346
 
Prochlorperazine
 
C20H24ClN3S
 
4917 
Moderate    Inter Info   
[66], [67], [68], [69], [70], [71], [72], [73], [74], [60], [75], [76], [39], [77], [78], [79], [80], [41], [81], [82], [42], [57], [83], [43], [84], [44], [85], [86], [46], [61], [87], [88], [89], [90]
D1351
 
Promazine
 
C17H20N2S
 
4926 
Moderate    Inter Info   
[66], [67], [68], [69], [70], [71], [72], [73], [74], [60], [75], [76], [39], [77], [78], [79], [80], [41], [81], [82], [42], [57], [83], [43], [84], [44], [85], [86], [46], [61], [87], [88], [89], [90]
D1352
 
Promethazine
 
C17H20N2S
 
4927 
Moderate    Inter Info   
[66], [67], [68], [69], [70], [71], [72], [73], [74], [60], [75], [76], [39], [77], [78], [79], [80], [41], [81], [82], [42], [57], [83], [43], [84], [44], [85], [86], [46], [61], [87], [88], [89], [90]
D1355
 
Propiomazine
 
C20H24N2OS
 
4940 
Moderate    Inter Info   
[66], [67], [68], [69], [70], [71], [72], [73], [74], [60], [75], [76], [39], [77], [78], [79], [80], [41], [81], [82], [42], [57], [83], [43], [84], [44], [85], [86], [46], [61], [87], [88], [89], [90]
D1572
 
Thiethylperazine
 
C22H29N3S2
 
5440 
Moderate    Inter Info   
[66], [67], [68], [69], [70], [71], [72], [73], [74], [60], [75], [76], [39], [77], [78], [79], [80], [41], [81], [82], [42], [57], [83], [43], [84], [44], [85], [86], [46], [61], [87], [88], [89], [90]
D1574
 
Thioridazine
 
C21H26N2S2
 
5452 
Moderate    Inter Info   
[66], [67], [68], [69], [70], [71], [72], [73], [74], [60], [75], [76], [39], [77], [78], [79], [80], [41], [81], [82], [42], [57], [83], [43], [84], [44], [85], [86], [46], [61], [87], [88], [89], [90]
D1637
 
Trifluoperazine
 
C21H24F3N3S
 
5566 
Moderate    Inter Info   
[66], [67], [68], [69], [70], [71], [72], [73], [74], [60], [75], [76], [39], [77], [78], [79], [80], [41], [81], [82], [42], [57], [83], [43], [84], [44], [85], [86], [46], [61], [87], [88], [89], [90]
D1638
 
Triflupromazine
 
C18H19F3N2S
 
5568 
Moderate    Inter Info   
[66], [67], [68], [69], [70], [71], [72], [73], [74], [60], [75], [76], [39], [77], [78], [79], [80], [41], [81], [82], [42], [57], [83], [43], [84], [44], [85], [86], [46], [61], [87], [88], [89], [90]
References
1 Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
2 Product Information. Diethylpropion Hydrochloride SR (diethylpropion). Watson Pharmaceuticals, Parsippany, NJ.
3 Product Information. Phendimetrazine Tartrate SR (phendimetrazine). Sandoz Inc, Broomfield, CO.
4 Product Information. Wellbutrin XL (buPROPion). GlaxoSmithKline, Philadelphia, PA.
5 Sheehan DV, Welch JB, Fishman SM "A case of bupropion-induced seizure." J Nerv Ment Dis 174 (1986): 496-8. [PMID: 3090199]
6 Canadian Pharmacists Association.
7 Product Information. Wellbutrin (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
8 Gittelman DK, Kirby MG "A seizure following bupropion overdose." J Clin Psychiatry 54 (1993): 162. [PMID: 8486598]
9 Product Information. Wellbutrin SR (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
10 James WA, Lippmann S "Bupropion: overview and prescribing guidelines in depression." South Med J 84 (1991): 222-4. [PMID: 1899294]
11 Masco HL, Kiev A, Holloman LC, Batey SR, Johnston JA, Lineberry CG "Safety and efficacy of bupropion and nortriptyline in outpatients with depression." Curr Ther Res Clin Exp 55 (1994): 851-63.
12 Dufresne RL, Weber SS, Becker RE "Bupropion hydrochloride." Drug Intell Clin Pharm 18 (1984): 957-64. [PMID: 6439541]
13 Product Information. Zyban (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
14 Storrow AB "Bupropion overdose and seizure." Am J Emerg Med 12 (1994): 183-4. [PMID: 8161393]
15 Johnston JA, Lineberry CG, Ascher JA, et al. "A 102-center prospective study of seizure in association with bupropion." J Clin Psychiatry 52 (1991): 450-6. [PMID: 1744061]
16 Rosenstein DL, Nelson JC, Jacobs SC "Seizures associated with antidepressants: a review." J Clin Psychiatry 54 (1993): 289-99. [PMID: 8253696]
17 Pisani F, Spina E, Oteri G "Antidepressant drugs and seizure susceptibility: from in vitro data to clinical practice." Epilepsia 40(Suppl 10) (1999): S48-56. [PMID: 10609604]
18 Product Information. Aplenzin (buPROPion). sanofi-aventis , Bridgewater, NJ.
19 Barrett J, Meehan O, Fahy T "SSRI and sympathomimetic interaction." Br J Psychiatry 168 (1996): 253.[PMID: 8837926]
20 Prior FH, Isbister GK, Dawson AH, Whyte IM "Serotonin toxicity with therapeutic doses of dexamphetamine and venlafaxine." Med J Aust 176 (2002): 240-1.[PMID: 11999244]
21 Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998):
22 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
23 Thevasagyam M, Jindal M, Allsop P, Oates J "Does epinephrine infiltration in septoplasty make any difference?" Eur Arch Otorhinolaryngol 264 (2007): 1175-8.[PMID: 17530270]
24 Product Information. Cocaine Hydrochloride (cocaine topical). Mallinckrodt Medical Inc, St. Louis, MO.
25 Product Information. Isovue-M-200 (iopamidol). Bracco Diagnostics Inc, Princeton, NJ.
26 Product Information. Amipaque (metrizamide) Nycomed Inc, Princeton, NJ.
27 Hindmarsh T, Grepe A, Widen L "Metrizamide-phenothiazine interaction: report of a case with seizures following myelography." Acta Radiol Diagn (Stockh) 16 (1975): 129-35. [PMID: 810000]
28 Product Information. Omnipaque 180 (iohexol). Amersham Health, Princeton, NJ.
29 Product Information. Osmovist 240 (iotrolan). Berlex Canada Inc, Lachine, QC.
30 Ban TA "Drug interactions with psychoactive drugs." Dis Nerv Syst 36 (1975): 164-6. [PMID: 1116424]
31 Boakes AJ, Laurence DR, Teoh PC, Barar FS, Benedikter LT, Pritchard BN "Interactions between sympathomimetic amines and antidepressant agents in man." Br Med J 1 (1973): 311-5. [PMID: 4685619]
32 FISCHER E, ORLANDO J, LUDMER RL. INFLUENCIA DE METILANFETAMINA, IPRONIACIDA Y TRANILCIPROMINA SOBRE LA DEPRESI'ON PSICOMOTORA ADRENAL'INICA [EFFECT OF METHYLAMPHETAMINE, IPRONIAZID AND TRANYLCYPROMINE ON ADRENALINE PSYCHOMOTOR DEPRESSION]. Prensa Med Argent. 1964;51:1538-1540. [PMID: 14272082]
33 Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31. [PMID: 8845455]
34 De Vita VT, Hahn MA, Oliverio VT "Monoamine oxidase inhibition by a new carcinostatic agent, n-isopropyl-a-(2-methylhydrazino)-p-toluamide (MIH). (30590)." Proc Soc Exp Biol Med 120 (1965): 561-5. [PMID: 4379192]
35 Elis J, Laurence DR, Mattie H, Prichard BN "Modification by monoamine oxidase inhibitors of the effect of some sympathomimetics on blood pressure." Br Med J 2 (1967): 75-8. [PMID: 6020852]
36 Goldberg LI "Monoamine oxidase inhibitors: adverse reactions and possible mechanisms." JAMA 190 (1964): 456-62. [PMID: 14197995]
37 Harrison WM, McGrath PJ, Stewart JW, Quitkin F "MAOIs and hypertensive crises: the role of OTC drugs." J Clin Psychiatry 50 (1989): 64-5. [PMID: 2464583]
38 Krisko I, Lewis E, Johnson JE "Severe hyperpyrexia due to tranylcypromine-amphetamine toxicity." Ann Intern Med 70 (1969): 559-64. [PMID: 5775035]
39 Markowitz JS, Patrick KS "Pharmacokinetic and pharmacodynamic drug interactions in the treatment of attention-deficit hyperactivity disorder." Clin Pharmacokinet 40 (2001): 753-72. [PMID: 11707061]
40 Pettinger WA, Soyangco FG, Oates JA "Inhibition of monoamine oxidase in man by furazolidone." Clin Pharmacol Ther 9 (1968): 442-7. [PMID: 5655478]
41 Product Information. Adderall (amphetamine-dextroamphetamine) Shire Richwood Pharmaceutical Company, Florence, KY.
42 Product Information. Dexedrine (dextroamphetamine) SmithKline Beecham, Philadelphia, PA.
43 Product Information. Focalin (dexmethylphenidate). Mikart Inc, Atlanta, GA.
44 Product Information. Ritalin (methylphenidate). Novartis Pharmaceuticals, East Hanover, NJ.
45 Product Information. Strattera (atomoxetine). Lilly, Eli and Company, Indianapolis, IN.
46 Product Information. Vyvanse (lisdexamfetamine). Shire US Inc, Florence, KY.
47 Schildkraut JJ, Klerman GL, Friend DG, Greenblatt M "Biochemical and pressor effects of oral d,l-dihydroxyphenylalanine in patients pretreated with antidepressant drugs." Ann N Y Acad Sci 107 (1963): 1005-15. [PMID: 13991689]
48 Schulz R, Antonin KH, Hoffmann E, et al "Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline." Clin Pharmacol Ther 46 (1989): 528-36. [PMID: 2510962]
49 Sjoqvist F "Psychotropic drugs (2) interaction between monoamine oxidase (MAO) inhibitors and other substances." Proc R Soc Med 58 (1965): 967-78. [PMID: 4952963]
50 Smookler S, Bermudez AJ "Hypertensive crisis resulting from an MAO inhibitor and an over-the-counter appetite suppressant." Ann Intern Med 11 (1982): 482-4. [PMID: 7114595]
51 Wright SP "Hazards with monoamine-oxidase inhibitors: a persistent problem." Lancet 1 (1978): 284-5. [PMID: 74715]
52 Cerner Multum, Inc. "Australian Product Information.".
53 Product Information. Spravato (esketamine). Janssen Pharmaceuticals, Titusville, NJ.
54 Product Information. Azedra (iobenguane I-131). Progenics Pharmaceuticals, Inc., New York, NY.
55 Product Information. Ultram (tramadol). McNeil Pharmaceutical, Raritan, NJ.
56 Gardiner JS, Blough D, Drinkard CR, et al. "Tramadol and seizures: a surveillance study in a managed care population." Pharmacotherapy 20 (2000): 1423-31. [PMID: 11130214]
57 Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
58 Product Information. Xenical (orlistat). Roche Laboratories, Nutley, NJ.
59 Product Information. Suprenza (phentermine). Akrimax Pharmaceuticals, Cranford, NJ.
60 Lake CR "Manic psychosis after coffee and phenylpropanolamine." Biol Psychiatry 30 (1991): 401-4. [PMID: 1912131]
61 Reid AA "Pharmacological antagonism between chlorpromazine and phenmetrazine in mental hospital patients." Med J Aust 1 (1964): 187-8. [PMID: 14126355]
62 Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):.
63 Haritos VS, Ghabrial H, Ahokas JT, Ching MS "Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin." Pharmacogenetics 10 (2000): 591-603. [PMID: 11037801]
64 Raisfeld IH "Cardiovascular complications of antidepressant therapy: interactions at the adrenergic neuron." Am Heart J 83 (1972): 129-33
65 Cavanaugh JH, Griffith JD, Oates JA "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther 11 (1970): 656
66 Achor MB, Extein I "Diet aids, mania, and affective illness" Am J Psychiatry 138 (1981): 392. [PMID: 7468847]
67 Angrist B, Lee HK, Gershon S "The antagonism of amphetamine-induced symptomatology by a neuroleptic." Am J Psychiatry 131 (1974): 817-9. [PMID: 4600629]
68 Casey JF, Hollister LE, Klett CJ, Lasky JJ, Caffey EM "Combined drug therapy of chronic schizophrenics." Am J Psychiatry 177 (1961): 997. [PMID: 13691268]
69 Chouinard G, Ghadirian AM, Jones BD "Death attributed to ventricular arrhythmia induced by thioridazine in combination with a single Contac*C capsule." Can Med Assoc J 119 (1978): 729-31. [PMID: 709472]
70 Cornelius JR, Soloff PH, Reynolds CF, 3d "Paranoia, homicidal behavior, and seizures associated with phenylpropanolamine." Am J Psychiatry 141 (1984): 120-1. [PMID: 6691429]
71 Dewsnap P, Libby G "A case of affective psychosis after routine use of proprietary cold remedy containing phenylpropanolamine" Hum Exp Toxicol 11 (1992): 295-6. [PMID: 1354981]
72 Dietz AJ, Jr "Amphetamine-like reactions to phenylpropanolamine." JAMA 245 (1981): 601-2. [PMID: 7452888]
73 Finton CK, Barton M, Chernow B "Possible adverse effects of phenylpropanolamine (diet pills) on sympathetic nervous system function--caveat emptor!" Mil Med 147 (1982): 1072. [PMID: 6817204]
74 Grieger TA, Clayton AH, Goyer PF "Affective disorder following use of phenylpropanolamine" Am J Psychiatry 147 (1990): 367-8. [PMID: 2309957]
75 Lake CR, Tenglin R, Chernow B, Holloway HC "Psychomotor stimulant-induced mania in a genetically predisposed patient: a review of the literature and report of a case." J Clin Psychopharmacol 3 (1983): 97-100. [PMID: 6341419]
76 Lambert MT "Paranoid psychoses after abuse of proprietary cold remedies." Br J Psychiatry 151: (1987): 548-50. [PMID: 3447673]
77 Marshall RD, Douglas CJ "Phenylpropanolamine-induced psychosis: potential predisposing factors." Gen Hosp Psychiatry 16 (1994): 358-60. [PMID: 7995508]
78 Modell W, Hussar AE "Failure of dextroamphetamine sulfate to incluence eating and sleeping patterns in obese schizophrenic patients." JAMA 193 (1965): 275-8. [PMID: 14310348]
79 Mueller SM "Neurologic complications of phenylpropanolamine use." Neurology 33 (1983): 650-2. [PMID: 6682504]
80 Norvenius G, Widerlov E, Lonnerholm G "Phenylpropanolamine and mental disturbances" Lancet 2 (1979): 1367-8. [PMID: 92706]
81 Product Information. Cylert (pemoline). Abbott Pharmaceutical, Abbott Park, IL.
82 Product Information. Desoxyn (methamphetamine) Abbott Pharmaceutical, Abbott Park, IL.
83 Product Information. Fastin (phentermine). SmithKline Beecham, Philadelphia, PA.
84 Product Information. Prelu-2 (phendimetrazine) Boehringer-Ingelheim, Ridgefield, CT.
85 Product Information. Sanorex (mazindol) Novartis Pharmaceuticals, East Hanover, NJ.
86 Product Information. Tenuate (diethylpropion) Aventis Pharmaceuticals, Swiftwater, PA.
87 Schaffer CB, Pauli MW "Psychotic reaction caused by proprietary oral diet agents." Am J Psychiatry 137 (1980): 1256-7. [PMID: 7416278]
88 Sletten IW, Ognjanov V, Menendez S, Sundland D, El-Toumi A "Weight reduction with chlorphentermine and phenmetrazine in obese psychiatric patients during chlorpromazine therapy." Curr Ther Res Clin Exp 9 (1967): 570-5. [PMID: 4965506]
89 Stroe AE, Hall J, Amin F "Psychotic episode related to phenylpropanolamine and amantadine in a healthy female." Gen Hosp Psychiatry 17 (1995): 457-8. [PMID: 8714809]
90 Wharton BK "Nasal decongestants and paranoid psychosis." Br J Psychiatry 117 (1970): 439-40. [PMID: 4098187]
91 Gulati OD, Dave BT, Gokhale SD, Shah KM "Antagonism of adrenergic neuron blockade in hypertensive subjects." Clin Pharmacol Ther 7 (1966): 510-4. [PMID: 5939974]
92 Gerkens JF, McCulloch MW, Wilson J "Mechanism of the antagonism between guanethidine and dexamphetamine." Br J Pharmacol 35 (1969): 563-72
93 Flegin OT, Morgan DH, Oates JA, Shand DG, Turner P "The mechanism of the reversal of the effect of guanethidine by amphetamines in cat and man." Br J Pharmacol 39 (1970): p253
94 Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
95 Kajiyama Y, Fujii K, Takeuchi H, Manabe Y "Ginkgo seed poisoning." Pediatrics 109 (2002): 325-7. [PMID: 11826216]
96 Granger AS "Ginkgo biloba precipitating epileptic seizures." Age Ageing 30 (2001): 523-5. [PMID: 11742783]
97 Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
98 Spinella M "Herbal medicines and epilepsy: the potential for benefit and adverse effects." Epilepsy Behav 2 (2001): 524-32. [PMID: 12609386]
99 Gregory PJ "Seizure associated with Ginkgo biloba?." Ann Intern Med 134 (2001): 344. [PMID: 11182853]
100 Harms SL, Garrard J, Schwinghammer P, Eberly LE, Chang Y, Leppik IE "Ginkgo biloba use in nursing home elderly with epilepsy or seizure disorder." Epilepsia 47 (2006): 323-9. [PMID: 16499756]
101 Miwa H, Iijima M, Tanaka S, Mizuno Y "Generalized convulsions after consuming a large amount of Gingko nuts." Epilepsia 42 (2001): 280-1. [PMID: 11240603]
102 Kupiec T, Raj V "Fatal seizures due to potential herb-drug interactions with Ginkgo biloba." J Anal Toxicol 29 (2005): 755-8. [PMID: 16419414]
103 Capstick C, Checkley S, Gray J, Dawe S "Dystonia induced by amphetamine and haloperidol." Br J Psychiatry 165 (1994): 276. [PMID: 7953053]
104 Product Information. Ketalar (ketamine). JHP Pharmaceuticals, Saddle River, NJ.
105 Product Information. Armour thyroid (thyroid desiccated). Forest Pharmaceuticals, St. Louis, MO.
106 Product Information. Synthroid (levothyroxine). Abbott Pharmaceutical, Abbott Park, IL.
107 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
108 Matsuoka LY "Convulsions following application of gamma benzene hexachloride." J Am Acad Dermatol 5 (1981): 98-9. [PMID: 6168673]
109 Cox R, Krupnick J, Bush N, Houpt A "Seizures caused by concomitant use of lindane and dextroamphetamine in a child with attention deficit hyperactivity disorder." J Miss State Med Assoc 41 (2000): 690-2. [PMID: 10974795]
110 Product Information. Kwell (lindane). Reed and Carnrick, Jersey City, NJ.
111 Product Information. ProAmatine (midodrine). Roberts Pharmaceutical Corporation, Eatontown, NJ.
112 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
113 Product Information. Firdapse (amifampridine). Catalyst Pharmaceuticals, Inc., Coral Gables, FL.
114 Product Information. Northera (droxidopa). Chelsea Therapeutics Inc, Charlotte, NC.
115 Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
116 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
117 Product Information. AdreView (iobenguane I-123). GE Healthcare, Princeton, NJ.
118 Boakes AJ, Laurence DR, Teoh PC, Barar FS, Benedikter LT, Prichard BN "Interactions between sympathomimetic amines and antidepressant agents in man." Br Med J 1 (1973): 311-5. [PMID: 4685619]
119 Coleman AL, Robin AL, Pollack IP, Rudikoff MT, Enger C, Mayer PR "Cardiovascular and intraocular pressure effects and plasma concentrations of apraclonidine." Arch Ophthalmol 108 (1990): 1264-7. [PMID: 2205182]
120 Cuthbert MF, Greenberg MP, Morley SW "Cough and cold remedies: a potential danger to patients on monoamine oxidase inhibitors." Br Med J 1 (1969): 404-6. [PMID: 5763957]
121 Davies B, Bannister R, Sever P "Pressor amines and monoamine-oxidase inhibitors for treatment of postural hypotension in autonomic failure: limitations and hazards." Lancet 1 (1978): 172-5. [PMID: 74603]
122 Goulet JP, Perusse R, Turcotte JY "Contraindications to vasoconstrictors in dentistry: Part III. Pharmacologic interactions." Oral Surg Oral Med Oral Pathol 74 (1992): 692-7. [PMID: 1359489]
123 Horler AR, Wynne NA "Hypertensive crisis due to pargyline and metaraminol." Br Med J 5459 (1965): 460-1. [PMID: 14314914]
124 Humberstone PM "Hypertension from cold remedies." Br Med J 1 (1969): 846. [PMID: 5813090]
125 Hunter KR, Boakes AJ, Laurence DR, Stern GM "Monoamine oxidase inhibitors and L-dopa." Br Med J 3 (1970): 388. [PMID: 5451592]
126 King MH, Richards DW "Near syncope and chest tightness after administration of apraclonidine before argon laser iridotomy." Am J Ophthalmol 110 (1990): 308-9. [PMID: 2204271]
127 Kraft KE, Dore FH "Computerized drug interaction programs: how reliable?." JAMA 275 (1996): 1087. [PMID: 8601924]
128 Kronig MH, Roose SP, Walsh BT, Woodring S, Glassman AH "Blood pressure effects of phenelzine." J Clin Psychopharmacol 3 (1983): 307-10. [PMID: 6630590]
129 Lefebvre H, Noblet C, Morre N, Wolf LM "Pseudo-phaeochromocytoma after multiple drug interactions involving the selective monoamine oxidase inhibitor selegiline." Clin Endocrinol (Oxf) 42 (1995): 95-8. [PMID: 7889639]
130 Mason AM, Buckle RM ""Cold" cures and monoamine-oxidase inhibitors." Br Med J 1 (1969): 845-6. [PMID: 5813089]
131 Nordlund JR, Pasquale LR, Robin AL, Rudikoff MT, Ordman J, Chen KS, Walt J "The cardiovascular, pulmonary, and ocular hypotensive effects of 0.2% brimonidine." Arch Ophthalmol 113 (1995): 77-83. [PMID: 7826297]
132 Paykel ES "Hallucinosis on combined methyldopa and pargyline." Br Med J 1 (1966): 803. [PMID: 5910115]
133 Pekdemir M, Yanturali S, Karakus G "More than just an ocular solution." Emerg Med J 22 (2005): 753-4. [PMID: 16189050]
134 Product Information. Aldomet (methyldopa). Merck & Co, Inc, West Point, PA.
135 Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
136 Product Information. Iopidine (apraclonidine). Alcon Laboratories Inc, Fort Worth, TX.
137 Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
138 Product Information. Parcopa (carbidopa-levodopa). Schwarz Pharma, Mequon, WI.
139 Product Information. Sinemet (carbidopa-levodopa). DuPont Pharmaceuticals, Wilmington, DE.
140 Product Information. Stalevo 50 (carbidopa/entacapone/levodopa). Novartis Pharmaceuticals, East Hanover, NJ.
141 Product Information. Tyzine (tetrahydrozoline). Kenwood Laboratories, Fairfield, NJ.
142 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
143 Sharpe J, Marquez-Julio A, Ashby P "Idiopathic orthostatic hypotension treated with levodopa and MAO inhibitor: a preliminary report." Can Med Assoc J 107 (1972): 296-300. [PMID: 5056115]
144 Sjoerdsma A "Catecholamine-drug interactions in man." Pharmacol Rev 18 (1966): 673-83. [PMID: 5904180]
145 Teychenne PF, Calne DB, Lewis PJ, Findley LJ "Interactions of levodopa with inhibitors of monoamine oxidase and L-aromatic amino acid decarboxylase." Clin Pharmacol Ther 18 (1975): 273-7. [PMID: 1164817]
146 van Rossum JM "Potential danger of monoamineoxidase inhibitors and a-methyldopa." Lancet 1 (1963): 950-1. [PMID: 13975251]
147 van Rossum JM, Hurkmans JA "Reversal of the effect of a-Methyldopa by monamine oxidase inhibitors." J Pharm Pharmacol 15 (1963): 493-9. [PMID: 14059015]
148 Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
149 Salik JM, Kurtin P "Severe hyponatremia after colonoscopy preparation in a patient with the acquired immune deficiency syndrome." Am J Gastroenterol 80 (1985): 177-9. [PMID: 2983533]
150 Product Information. Azilect (rasagiline). Teva Pharmaceuticals USA, North Wales, PA.
151 Smookler S, Barmudez AJ "Hypertensive crisis resulting from an MAO inhibitor and an over-the counter appetite suppressant." Ann Emerg Med 11 (1982): 482-4. [PMID: 7114595]