Details of Drug

Drug General Information (ID: D1242)
Drug Name	Pemigatinib
Drug Type	Small molecule
Drug Synonymous	Unii-Y6BX7BL23K; UNII-Y6BX7BL23K; Y6BX7BL23K; GTPL9767; SCHEMBL15556271; HCDMJFOHIXMBOV-UHFFFAOYSA-N; example 126 [WO2014007951]; 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-4,7-dihydropyrrolo[4,5]pyrido[1,2-d]pyrimidin-2-one; 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one; INCB54828 Click to Show/Hide
Disease Class	2C94: Bladder cancer; 2A20: Myeloproliferative neoplasm; 2C12: Liver cancer
Therapeutic Class	Multikinase Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C24H27F2N5O4
InChI	1S/C24H27F2N5O4/c1-4-30-21-14(11-27-23-16(21)9-15(28-23)13-29-5-7-35-8-6-29)12-31(24(30)32)22-19(25)17(33-2)10-18(34-3)20(22)26/h9-11H,4-8,12-13H2,1-3H3,(H,27,28)
InChIKey	HCDMJFOHIXMBOV-UHFFFAOYSA-N
Canonical SMILES	CCN1C2=C3C=C(NC3=NC=C2CN(C1=O)C4=C(C(=CC(=C4F)OC)OC)F)CN5CCOCC5
External Link
	Pubchem ID	86705695
	CAS Number	1513857-77-6
	TTD ID	D0O6UY

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction
Relation Graph

Full list of drugs interacting with Pemigatinib
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 72
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[2], [1]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[2], [1]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Major		Inter Info	[2], [1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[2], [1]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[2], [1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[2], [1]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[2], [1]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[2], [1]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[1]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[2], [1]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[2], [1]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[2], [1]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[1]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[2], [1]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[2], [1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[2], [1]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[2], [1]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[1]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[2], [1]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[2], [1]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[2], [1]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[2], [1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[2], [1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[2], [1]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[2], [1]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[2], [1]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[2], [1]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[1]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[1]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[2], [1]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[2], [1]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[2], [1]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[2], [1]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[2], [1]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[4]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[2], [1]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[2], [1]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[2], [1]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[2], [1]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[2], [1]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[2], [1]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[2], [1]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[2], [1]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[2], [1]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[5], [1]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[2], [1]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[2], [1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[2], [1]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[5], [1]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[5], [1]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[2], [1]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[2], [1]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[2], [1]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[2], [1]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[5], [1]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[2], [1]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[2], [1]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[5], [1]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[5], [1]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[2], [1]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[2], [1]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[2], [1]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[5], [1]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[2], [1]
	CYP450 enzyme induction					Drug Num: 54
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[2], [1]
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[2], [1]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[2], [1]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[2], [1]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[2], [1]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[2], [1]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[2], [1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[2], [1]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[2], [1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[2], [1]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[2], [1]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[3], [1]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[2], [1]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[2], [1]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[2], [1]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[2], [1]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[3], [1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[2], [1]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[2], [1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[3], [1]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[2], [1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[2], [1]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[1]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[1]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[2], [1]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[2], [1]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[2], [1]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[2], [1]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[1]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[2], [1]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[1]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[2], [1]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[2], [1]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[2], [1]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[2], [1]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[2], [1]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[2], [1]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[1]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[1]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[2], [1]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[2], [1]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[2], [1]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[2], [1]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[1]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[2], [1]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[2], [1]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[1]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[1]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[1]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[1]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[1]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[1]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[1]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[2], [1]

References
1	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
4	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
5	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.

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