Details of Drug

Drug General Information (ID: D1214)
Drug Name	Palbociclib
Drug Type	Small molecule
Drug Synonymous	571190-30-2; PD0332991; PD-0332991; Ibrance; PD 0332991; UNII-G9ZF61LE7G; Palbociclib(PD0332991); 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one; 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one; G9ZF61LE7G; PD 332991; 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE; LQQ; PD 332991, PD 0332991, PD0332991; 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one; 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one; HMR-2934 Click to Show/Hide
Disease Class	2A00-2F9Z: Solid tumour/cancer; 6A20: Schizophrenia; 2C60-2C6Y: Breast cancer
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C24H29N7O2
InChI	1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29)
InChIKey	AHJRHEGDXFFMBM-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C
External Link
	Pubchem ID	5330286
	CAS Number	571190-30-2
	CHEBI ID	85993
	TTD ID	D00UZR
	INTEDE ID	DR1229
	VARIDT ID	DR01288

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Palbociclib
Affected cellular transport
	Transporter inhibition					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[23]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[8], [25]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[8], [9], [216]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[8], [9], [227]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[230]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[237]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[243]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 149
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[7]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[7]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[7]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[7]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[7]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[7]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[7]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[7]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[7]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[7]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[7]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[7]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[7]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[7]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[7]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[8], [24]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[7]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[7]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[7]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[7]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[7]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[7]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[7]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[7]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[36], [37], [9], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[9], [7]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[7]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [47], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[9], [117]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [47], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[9], [7]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[9], [7]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[9], [7]
D0342		Cisapride	C23H29ClFN3O4	6917698	Moderate		Inter Info	[127], [128], [129], [68], [130], [131], [132], [133], [134], [135], [136]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[9], [7]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[137]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[7]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[9], [7]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[7]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[9], [7]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[9], [7]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[9], [7]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[9], [7]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[139], [140], [141], [142], [143], [68], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[9], [7]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[164], [8], [9], [165], [166], [167], [168], [169], [170]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[171]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[172]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[173]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[175]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[145], [147], [158]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[139], [140], [141], [142], [143], [68], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[9], [7]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[176], [47]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[177], [178], [179], [180], [50]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[184]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[9], [7]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[9], [7]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[9], [7]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[9], [187]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[188], [8], [9], [189], [190], [191], [192]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[8], [9], [189]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[193]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[9], [7]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[194], [195]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[9], [7]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[7]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[9], [7]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [47], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[196]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[8], [9], [197], [47]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[199]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[200]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[145], [147], [158]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[9], [7]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[7]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[201], [202]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[9], [7]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[9], [7]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[203]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[188], [8], [9]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[9], [7]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[8], [9], [205]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[206]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[207]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[208], [47]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[9], [211]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[8], [9], [212]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[8], [9], [217]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[221]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[9], [7]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[9], [7]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[9], [222]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[223]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[9], [7]
D0739		Grazoprevir	C38H50N6O9S	44603531	Moderate		Inter Info	[224], [225]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[9], [226]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[228]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[9], [7]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[229]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[7]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[9], [232]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[233]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[9], [234]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[235]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[236]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[9], [7]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[9], [7]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[9], [238]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[239]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[241]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[246]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[8], [9], [247]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[9], [7]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[248], [249]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[252]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[8], [253], [68], [254], [255], [256], [257], [258], [259]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[9], [7]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[8], [261], [9], [262]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[9], [263]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[264], [265], [266], [267]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[268]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [47], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[8], [9], [269], [270], [271], [47], [272]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[273]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[7]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[8], [274]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[8], [9], [269], [270], [271], [47], [272]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[275]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[276]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[7]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[9], [7]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[9], [278], [279]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[7]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[281], [47]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[8], [9], [282]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[9], [7]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[7]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[7]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[7]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[7]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[283], [284]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[285], [286], [287], [288]
D0599		Escitalopram	C20H21FN2O	146570	Minor		Inter Info	[283], [284]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[289]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[290]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[291]
D1434		Ruxolitinib	C17H18N6	25126798	Minor		Inter Info	[9], [292]
	CYP450 enzyme induction					Drug Num: 47
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[8], [9], [7]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[8], [9], [7]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[8], [9], [7]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[8], [9], [7]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[8], [9], [7]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[8], [9], [7]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[8], [9], [7]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[8], [9], [7]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[31], [7]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[8], [9], [7]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[7]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[8], [9], [7]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[8], [9], [7]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[8], [9], [7]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[8], [9], [7]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[8], [9], [7]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[8], [9], [7]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[8], [9], [7]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[8], [9], [7]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[8], [9], [7]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[8], [9], [7]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[8], [9], [7]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[8], [9], [7]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[8], [9], [7]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[8], [9], [7]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[8], [9], [7]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[8], [9], [7]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[8], [9], [7]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[8], [9], [7]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[8], [9], [7]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[8], [9], [7]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[8], [9], [7]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[8], [9], [7]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[8], [9], [7]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[8], [9], [7]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[8], [9], [7]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[8], [9], [7]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[8], [9], [7]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[244]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[9], [245]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[8], [9], [7]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[8], [9], [7]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[8], [9], [7]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[8], [9], [7]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[8], [9], [7]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[8], [9], [7]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[8], [9], [7]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 27
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[15]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[16], [17]
D1111		Natalizumab	NA	NA	Major		Inter Info	[18]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[8], [9], [22]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[8], [26]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[30]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[27], [33], [34]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[52], [53], [54]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[52], [53], [54]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[138]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[163]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[174]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[204]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[163]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[163]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[231]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[240]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[8], [9], [242]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[260]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[52], [53], [54]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[277]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[280]
	Additive myelosuppressive effects					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[9], [10]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[9], [11], [12]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[8], [13], [14]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[32]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[35]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[8], [9]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[8], [9], [185], [186]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[8], [9], [185], [186]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[19], [20], [21]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[19], [20], [21]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[19], [20], [21]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[19], [20], [21]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[19], [20], [21]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[27], [8], [28]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[29]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[19], [20], [21]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[19], [20], [21]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[19], [20], [21]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[198]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[27], [209], [210]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[27], [209], [210]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[27], [209], [210]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[27], [209], [210]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[27], [209], [210]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[27], [209], [210]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[27], [209], [210]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[27], [209], [210]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[27], [209], [210]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[27], [209], [210]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[27], [209], [210]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[213], [214], [215]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[213], [214], [215]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[218], [219], [220]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[218], [219], [220]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[218], [219], [220]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[218], [219], [220]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[181], [182], [183]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[250], [251]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[181], [182], [183]

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101	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
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103	Product Information. Zocor (simvastatin). Merck & Co, Inc, West Point, PA.
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155	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
156	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
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172	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
173	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
174	Product Information. Raptiva (efalizumab). Genentech, South San Francisco, CA.
175	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
176	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
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179	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
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182	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
183	Product Information. Stemgen (ancestim) Amgen, Thousand Oaks, CA.
184	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
185	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
186	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
187	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
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192	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
193	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
194	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
195	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
196	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
197	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
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199	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
200	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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202	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
203	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
204	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
205	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
206	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
207	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
208	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
209	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
210	Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations.".
211	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
212	Product Information. Biktarvy (bictegravir/emtricitabine/tenofovir). Gilead Sciences, Foster City, CA.
213	Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
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216	Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
217	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
218	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
219	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
220	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
221	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
222	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
223	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
224	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
225	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
226	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
227	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
228	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
229	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
230	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
231	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
232	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
233	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
234	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
235	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
236	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
237	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
238	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
239	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
240	AnazaoHealth Corporation "P32 Sodium Phosphate."
241	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
242	Multum Information Services, Inc. Expert Review Panel.
243	Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
244	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
245	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
246	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
247	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
248	Hamberg P, Woo MM, Chen LC, et al. "Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor." Cancer Chemother Pharmacol 68 (2011): 805-13. [PMID: 21706316]
249	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
250	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
251	Product Information. Neulasta (pegfilgrastim). Amgen, Thousand Oaks, CA.
252	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
253	Desta Z, Kerbusch T, Flockhart DA "Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6)." Clin Pharmacol Ther 65 (1999): 10-20. [PMID: 9951426]
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257	Mangum EM, Graham KK "Lopinavir-Ritonavir: a new protease inhibitor." Pharmacotherapy 21 (2001): 1352-63. [PMID: 11714208]
258	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
259	Product Information. Sporanox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
260	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
261	Cerner Multum, Inc. "Canadian Product Information.".
262	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
263	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
264	Hyland R, Roe GH, Jones BC, Smith DA "Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil." Br J Clin Pharmaacol 51 (2001): 239-48. [PMID: 11298070]
265	Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
266	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
267	Warrington JS, Shader RI, vonMoltke LL, Greenblatt DJ "In vitro biotransformation of sildenafil (Viagra): Identification of human cytochromes and potential drug interactions." Drug Metab Disposition 28 (2000): 392-7. [PMID: 10725306]
268	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
269	Christians U, Schmidt G, Bader A, et al "Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes." Br J Clin Pharmacol 41 (1996): 187-90. [PMID: 8866917]
270	Product Information. Parlodel (bromocriptine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
271	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
272	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
273	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
274	Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
275	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
276	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
277	Product Information. Hycamtin (topotecan). SmithKline Beecham, Philadelphia, PA.
278	Machiels JP, Staddon A, Herremans C, et al. "Impact of cytochrome P450 3A4 inducer and inhibitor on the pharmacokinetics of trabectedin in patients with advanced malignancies: open-label, multicenter studies." Cancer Chemother Pharmacol 74 (2014): 729-37. [PMID: 25100135]
279	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
280	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
281	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
282	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
283	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
284	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
285	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
286	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
287	Rojas-Fernandez C, Fisher C "Drug interactions and donepezil." J Am Geriat Soc 40 (2000): 597-8. [PMID: 10811561]
288	Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses." Br J Clin Pharmacol 46 (1998): 30-4. [PMID: 9839763]
289	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
290	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
291	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
292	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.

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