Details of Drug

Drug General Information (ID: D1200)
Drug Name	Oxitriptan
Drug Type	Small molecule
Drug Synonymous	5-hydroxytryptophan Click to Show/Hide
Therapeutic Class	Antidepressants
Structure
Structure	3D Structure		2D Structure
Formula	C11H12N2O3
InChI	1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1
InChIKey	LDCYZAJDBXYCGN-VIFPVBQESA-N
Canonical SMILES	C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N
External Link
	Pubchem ID	439280
	CAS Number	895096
	CHEBI ID	17780
	TTD ID	D09BNS
	VARIDT ID	DR01071

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM038 Additive CNS depression effects BM040 Additive dopaminergic effects BM046 Additive serotonergic effects BM083 Potentiated the pharmacological effects (Unspecific) BM098 Antagonize the effect of serotonergic agents
Relation Graph

Full list of drugs interacting with Oxitriptan
Affected intra/extra-hepatic metabolism
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[7], [8], [9]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[30], [31], [32]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[30], [31], [32]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[30], [31], [32]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[30], [31], [32]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[30], [31], [32]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[30], [31], [32]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[39], [21], [40]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[30], [31], [32]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[30], [31], [32]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[30], [31], [32]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[30], [31], [32]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[30], [31], [32]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[22], [41], [19]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[30], [31], [32]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[30], [31], [32]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[30], [31], [32]
	Additive dopaminergic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0258		Carbidopa	C10H14N2O4	34359	Moderate		Inter Info	[33], [34], [35]
	Additive serotonergic effects					Drug Num: 57
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0041		Almotriptan	C17H25N3O2S	123606	Major		Inter Info	[1], [2], [3]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1], [2], [3]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1], [2], [3]
D0222		Buspirone	C21H31N5O2	2477	Major		Inter Info	[1], [2], [3]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[4], [5], [6]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1], [2], [3]
D0398		Cyclobenzaprine	C20H21N	2895	Major		Inter Info	[1], [2], [3]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1], [2], [3]
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[1], [2], [3]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[10], [11], [12]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[1], [2], [3]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[1], [2], [3]
D0539		Duloxetine	C18H19NOS	60835	Major		Inter Info	[4], [5], [6]
D0557		Eletriptan	C22H26N2O2S	77993	Major		Inter Info	[1], [2], [3]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[4], [5], [6]
D0641		Fenfluramine	C12H16F3N	3337	Major		Inter Info	[4], [5], [6]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[1], [2], [3]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[4], [5], [6]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[4], [5], [6]
D0702		Frovatriptan	C14H17N3O	77992	Major		Inter Info	[1], [2], [3]
D0738		Granisetron	C18H24N4O	5284566	Major		Inter Info	[10], [11], [12]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1], [2], [3]
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[13], [14], [15]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[16], [17], [18]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[1], [2], [3]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[1], [2], [3]
D1110		Naratriptan	C17H25N3O2S	4440	Major		Inter Info	[1], [2], [3]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2], [3]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1], [2], [3]
D1181		Ondansetron	C18H19N3O	4595	Major		Inter Info	[10], [11], [12]
D0451		Desvenlafaxine	C16H25NO2	125017	Major		Inter Info	[4], [5], [6]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Major		Inter Info	[19], [20], [21]
D0920		Levomilnacipran	C15H22N2O	6917779	Major		Inter Info	[4], [5], [6]
D0952		Lorcaserin	C11H14ClN	11658860	Major		Inter Info	[22], [23], [19]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[13], [14], [15]
D1066		Milnacipran	C15H22N2O	65833	Major		Inter Info	[24], [25], [26]
D1437		Safinamide	C17H19FN2O2	131682	Major		Inter Info	[13], [14], [15]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[4], [5], [6]
D1696		Vilazodone	C26H27N5O2	6918314	Major		Inter Info	[4], [5], [6]
D1708		Vortioxetine	C18H22N2S	9966051	Major		Inter Info	[4], [5], [6]
D1216		Palonosetron	C19H24N2O	6337614	Major		Inter Info	[10], [11], [12]
D1229		Paroxetine	C19H20FNO3	43815	Major		Inter Info	[4], [5], [6]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[13], [14], [15]
D1385		Rasagiline	C12H13N	3052776	Major		Inter Info	[13], [14], [15]
D1419		Rizatriptan	C15H19N5	5078	Major		Inter Info	[1], [2], [3]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[13], [14], [15]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[4], [5], [6]
D1464		Sibutramine	C17H26ClN	5210	Major		Inter Info	[27], [28], [29]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1], [2], [3]
D1521		Sumatriptan	C14H21N3O2S	5358	Major		Inter Info	[1], [2], [3]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1], [2], [3]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[13], [14], [15]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[1], [2], [3]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[1], [2], [3]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[4], [5], [6]
D1728		Zolmitriptan	C16H21N3O2	60857	Major		Inter Info	[1], [2], [3]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[42], [43], [44]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[28], [17], [29]
Pharmacodynamic antagonistic effects
	Antagonize the effect of serotonergic agents					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[36], [37], [38]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[36], [37], [38]

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