Details of Drug

Drug General Information (ID: D1194)
Drug Name	Oxamniquine
Drug Type	Small molecule
Drug Synonymous	Mansil; Oxaminiquine; Oxamniquina; Oxamniquinum; Vansil; UK 4261; UK 4271; Mansil (TN); Oxamniquina [INN-Spanish]; Oxamniquinum [INN-Latin]; UK-4271; Vansil (TN); Oxamniquine (USAN/INN); Oxamniquine [USAN:BAN:INN]; {2-[(Isopropylamino)methyl]-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl}methanol; [7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,4-tetrahydroquinolin-6-yl]methanol; (2-{[(1-methylethyl)amino]methyl}-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl)methanol; 1,2,3,4-Tetrahydro-2-(((1-methylethyl)amino)methyl)-7-nitro-6-quinolinemethanol; 1,2,3,4-Tetrahydro-2-((isopropylamino)methyl)-7-nitro-6-quinolinemethanol; 1,2,3,4-Tetrahydro-2-[(isopropylamino)methyl]-7-nitro-6-quinolinemethanol; 2-((Isopropylamino)methyl)-7-nitro-1,2,3,4-tetrahydro-6-quinolinemethanol; 2-(Isopropylaminomethyl)-7-nitro-1,2,3,4-tetrahydroquinoline-6-methanol; 6-Hydroxymethyl-2-isopropylaminomethyl-7-nitro-1,2,3,4-tetrahydroquinoline Click to Show/Hide
Disease Class	1F86: Schistosomiasis
Therapeutic Class	Schistosomicides
Structure
Structure	3D Structure		2D Structure
Formula	C14H21N3O3
InChI	1S/C14H21N3O3/c1-9(2)15-7-12-4-3-10-5-11(8-18)14(17(19)20)6-13(10)16-12/h5-6,9,12,15-16,18H,3-4,7-8H2,1-2H3
InChIKey	XCGYUJZMCCFSRP-UHFFFAOYSA-N
Canonical SMILES	CC(C)NCC1CCC2=CC(=C(C=C2N1)[N+](=O)[O-])CO
External Link
	Pubchem ID	4612
	CAS Number	21738-42-1
	CHEBI ID	78416
	TTD ID	D0P4MT
	INTEDE ID	DR1211

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM069 Increased risk of lowers seizure threshold
Relation Graph

Full list of drugs interacting with Oxamniquine
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[69], [70], [71]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[21], [22], [23]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[26], [27], [28]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[29]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[30]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[44], [27]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[45], [46], [47], [48], [27], [49]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[50], [51]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[52]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[53]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[49]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[59]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[60]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[46], [37], [74]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[75]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[76]
D1553		Terbinafine	C21H25N	1549008	Moderate		Inter Info	[77], [78], [79], [80]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[81], [82], [83]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[84], [37], [85], [86]
D1607		Tolterodine	C22H31NO	443879	Minor		Inter Info	[87], [88], [37]
Pharmacodynamic additive effects
	Increased risk of lowers seizure threshold					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[16], [17], [18], [19], [20]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[16], [17], [18], [19], [20]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[24], [14], [13], [25]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[45], [46]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[54], [55], [56]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[57], [58]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[72], [73], [46]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[72], [73], [46]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[72], [73], [46]

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