Details of Drug

Drug General Information (ID: D1190)
Drug Name	Osimertinib
Drug Type	Small molecule
Drug Synonymous	Tagrisso Click to Show/Hide
Disease Class	2C25: Lung cancer; 2C30: Melanoma
Therapeutic Class	Egfr Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C28H33N7O2
InChI	1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)
InChIKey	DUYJMQONPNNFPI-UHFFFAOYSA-N
Canonical SMILES	CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC
External Link
	Pubchem ID	71496458
	CAS Number	1421373-65-0
	CHEBI ID	90943
	TTD ID	D0O8GK
	INTEDE ID	DR1207
	VARIDT ID	DR00655

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Osimertinib
Affected cellular transport
	Transporter inhibition					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[141]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[230], [19], [9], [231], [232], [233], [234], [235], [236]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[264]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[19], [266]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[269]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[29]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[281]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[19], [282]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[287]
D1539		Tedizolid	C17H15FN6O3	11234049	Moderate		Inter Info	[9], [288]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 56
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[1]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[147]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[1]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[1]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[1]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[1]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[227], [1]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[1]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[1]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[1]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[1]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[1]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[1]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[1]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[1]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[1]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[1]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[1]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[18], [19], [9]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[254]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[1]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[267]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[1]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[227], [1]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[1]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[227], [270]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[280]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[1]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[1]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[1]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[1]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[1]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[1]
	CYP450 enzyme induction					Drug Num: 103
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[19], [9], [1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[19], [9], [1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[19], [9], [1]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[19], [9], [1]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[19], [9], [1]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[19], [9], [1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[19], [9], [1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[19], [9], [1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[19], [9], [1]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[19], [9], [1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[19], [9], [1]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[19], [9], [1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[19], [9], [1]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[9], [1]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[1]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[1]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[1]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[1]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[9], [1]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[222]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[1]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[1]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[1]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[1]
D0231		Caffeine	C8H10N4O2	2519	Moderate		Inter Info	[1]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[1]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[9], [1]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[9], [1]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[9], [226]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[1]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[1]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[9], [1]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[1]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[9], [1]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[9], [1]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[1]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[9], [1]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[1]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[9], [1]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[1]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[9], [1]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[9], [1]
D0994		Melatonin	C13H16N2O2	896	Moderate		Inter Info	[1]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[9], [1]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[250], [1], [251]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[9], [1]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[1]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[9], [1]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[1]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[1]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[1]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[1]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[9], [1]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[19], [9], [260], [29]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[9], [1]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[9], [1]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[19], [265]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[1]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[1]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[268]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[1]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[1]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[1]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[250], [1], [251]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[1]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[9], [289]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[1]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[9], [1]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[1]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[1]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[1]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[304]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[1]
D1405		Riluzole	C8H5F3N2OS	5070	Moderate		Inter Info	[1]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[1]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[1]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[1]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[1]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[9], [1]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[9], [1]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[250], [1], [251]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[1]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[9], [1]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[1]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[1]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[9], [1]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[305]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[9], [1]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[9], [1]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[1]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[1]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[9], [1]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[1]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[9], [1]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[9], [1]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[9], [1]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[9], [1]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[1]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[1]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[9], [310], [311], [312], [313]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[314]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[315], [316], [317], [318]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[2], [3], [4], [5], [6], [7]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[2], [6], [7]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[9], [59]
D0614		Etanercept	NA	NA	Major		Inter Info	[2], [3], [4], [5], [6], [7]
D0736		Golimumab	NA	NA	Major		Inter Info	[2], [3], [4], [5], [6], [7]
D0802		Infliximab	NA	NA	Major		Inter Info	[2], [3], [4], [5], [6], [7]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[120], [121]
D1111		Natalizumab	NA	NA	Major		Inter Info	[136]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[19], [9], [140]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[153]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[120], [121]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[202]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[150], [207], [208]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[209]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[210], [211], [212]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[19], [9]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[210], [211], [212]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[228]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[229]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[240]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[9], [252]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[253]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[229]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[229]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[271]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[272]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[283]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[19], [9], [286]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[290]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[303]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[210], [211], [212]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[307]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[308]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[19], [9], [309]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[60], [61]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[19], [63], [64]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[191]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[19], [9], [245], [246]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[19], [9], [245], [246]
	Increased risk of prolong QT interval					Drug Num: 166
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0003		Abarelix	C72H95ClN14O14	16131215	Major		Inter Info	[1]
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[1]
D0036		Alfuzosin	C19H27N5O4	2092	Major		Inter Info	[1]
D0037		Alimemazine	C18H22N2S	5574	Major		Inter Info	[16], [1], [17]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[18], [19], [9], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[18], [19], [9], [31]
D0097		Apomorphine	C17H17NO2	6005	Major		Inter Info	[1]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[1]
D0119		Atomoxetine	C17H21NO	54841	Major		Inter Info	[1]
D0139		Azithromycin	C38H72N2O12	447043	Major		Inter Info	[1]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[34]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[18], [19], [9], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Major		Inter Info	[1]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[1]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[1]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[35], [9], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[1]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[18], [19], [9], [13], [54], [55]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[18], [19], [9], [56], [57], [29], [58]
D0358		Clofazimine	C27H22Cl2N4	2794	Major		Inter Info	[1]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[62]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[1]
D0429		Daunorubicin	C27H29NO10	30323	Major		Inter Info	[1]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Major		Inter Info	[16], [1], [17]
D0437		Degarelix	C82H103ClN18O16	16136245	Major		Inter Info	[1]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[16], [1], [17]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[18], [19], [9], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[18], [19], [9], [65]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[18], [19], [9], [66]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[1]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[16], [1], [17]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[1]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Major		Inter Info	[16], [1], [17]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[18], [19], [9], [67]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[18], [19], [9], [68], [69], [29]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[70]
D0584		Epirubicin	C27H29NO11	41867	Major		Inter Info	[1]
D0594		Eribulin	C40H59NO11	11354606	Major		Inter Info	[1]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[1]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[18], [71], [19], [9], [72], [73], [29]
D0632		Ezogabine	C16H18FN3O2	121892	Major		Inter Info	[1]
D0664		Flecainide	C17H20F6N2O3	3356	Major		Inter Info	[1]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[1]
D0682		Flutamide	C11H11F3N2O3	3397	Major		Inter Info	[1]
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[1]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[75], [76], [77], [18], [19], [9], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Major		Inter Info	[1]
D0737		Goserelin	C59H84N18O14	5311128	Major		Inter Info	[1]
D0738		Granisetron	C18H24N4O	5284566	Major		Inter Info	[1]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[76], [18], [19], [9], [98], [99], [100]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[101], [18], [19], [9], [102], [103], [104], [105], [106]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[18], [19], [9], [107], [108], [109], [110], [111], [112], [29]
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[1]
D0758		Histrelin	C66H86N18O12	25077993	Major		Inter Info	[1]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[35], [9], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Major		Inter Info	[1]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[18], [19], [9], [113]
D0788		Idarubicin	C26H27NO9	42890	Major		Inter Info	[1]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[18], [19], [9], [114], [29]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[1]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Major		Inter Info	[1]
D0908		Leuprolide	C59H84N16O12	657181	Major		Inter Info	[1]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[9], [122], [29]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[1]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Major		Inter Info	[1]
D0942		Lofexidine	C11H12Cl2N2O	30668	Major		Inter Info	[1]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Major		Inter Info	[1]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[19], [9], [123]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[1]
D0992		Mefloquine	C17H16F6N2O	4046	Major		Inter Info	[1]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[18], [19], [9], [124], [29]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[18], [19], [9], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [29]
D1026		Methotrimeprazine	C19H24N2OS	72287	Major		Inter Info	[1]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[1]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[18], [19], [9], [135]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[1]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[75], [76], [77], [18], [19], [9], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[18], [19], [9], [61]
D1137		Nilutamide	C12H10F3N3O4	4493	Major		Inter Info	[1]
D1155		Norfloxacin	C16H18FN3O3	4539	Major		Inter Info	[1]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1]
D1165		Ofloxacin	C18H20FN3O4	4583	Major		Inter Info	[1]
D1181		Ondansetron	C18H19N3O	4595	Major		Inter Info	[1]
D0452		Deutetrabenazine	C19H27NO3	73437646	Major		Inter Info	[1]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[1]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[1]
D0700		Fostemsavir	C25H26N7O8P	11319217	Major		Inter Info	[1]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[1]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[1]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[142]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[143]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[16], [1], [17]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[144]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[145]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[1]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[1]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[1]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[9], [148]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Major		Inter Info	[1]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[1]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[1]
D1210		Oxytocin	C43H66N12O12S2	439302	Major		Inter Info	[1]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[1]
D1216		Palonosetron	C19H24N2O	6337614	Major		Inter Info	[1]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[154]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[155], [156], [157], [158], [159], [160], [161], [162]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[18], [19], [9], [163]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[1]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[1]
D1254		Perflutren	C3F8	6432	Major		Inter Info	[164], [165]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[1]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[1]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[9], [68], [166], [29]
D1339		Primaquine	C15H21N3O	4908	Major		Inter Info	[1]
D1342		Probucol	C31H48O2S2	4912	Major		Inter Info	[1]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[18], [19], [9], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1346		Prochlorperazine	C20H24ClN3S	4917	Major		Inter Info	[1]
D1351		Promazine	C17H20N2S	4926	Major		Inter Info	[1]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[1]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[1]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[1]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[18], [19], [9], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1372		Quinine	C20H24N2O2	3034034	Major		Inter Info	[1]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[1]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[1]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[1]
D1424		Romidepsin	C24H36N4O6S2	5352062	Major		Inter Info	[1]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[192], [193], [18], [19], [9], [194], [195]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1]
D1463		Sevoflurane	C4H3F7O	5206	Major		Inter Info	[1]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[1]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Major		Inter Info	[1]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[18], [19], [9], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[76], [18], [19], [9], [196], [197], [80], [82], [84], [198], [85], [86], [199], [88], [89], [90], [91], [200], [95], [100], [201]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[1]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[1]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[1]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[1]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[18], [19], [9], [203]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[1]
D1637		Trifluoperazine	C21H24F3N3S	5566	Major		Inter Info	[1]
D1638		Triflupromazine	C18H19F3N2S	5568	Major		Inter Info	[1]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[1]
D1651		Triptorelin	C64H82N18O13	25074470	Major		Inter Info	[1]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[18], [19], [9], [204]
D1682		Vardenafil	C23H32N6O4S	135400189	Major		Inter Info	[1]
D1683		Vasopressin	C46H65N15O12S2	644077	Major		Inter Info	[1]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[18], [19], [9], [205]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[1]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[18], [19], [9], [68], [206], [29]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[19], [9], [216], [217], [218], [219], [220], [221]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[19], [9], [241]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[247], [248]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[293], [294], [295], [296], [297], [298], [299], [300], [301], [302]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[19], [319], [320], [321]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[18], [19], [9], [322], [323], [324], [325]
	Increased risk of ventricular arrhythmias					Drug Num: 39
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0025		Adenosine	C10H13N5O4	60961	Major		Inter Info	[8], [9], [10], [11], [12], [13], [14], [15]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[30]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[32], [33]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[74], [58]
D0859		Isoprenaline	C11H17NO3	3779	Major		Inter Info	[115], [116], [117]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[9], [118], [119]
D1185		Orciprenaline	C11H17NO3	4086	Major		Inter Info	[115], [116], [117]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[9], [146]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[19], [149]
D1414		Ritodrine	C17H21NO3	33572	Major		Inter Info	[115], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [116], [185], [186], [187], [188], [117], [189], [190]
D1554		Terbutaline	C12H19NO3	5403	Major		Inter Info	[115], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [116], [185], [186], [187], [188], [117], [189], [190]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[115], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [213], [214], [179], [180], [181], [182], [183], [215], [184], [116], [185], [186], [187], [188], [117], [189], [190]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[18], [19], [9], [223], [224], [225]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[18], [19], [9], [237], [238], [239]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[115], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [213], [214], [179], [180], [181], [182], [183], [215], [184], [116], [185], [186], [187], [188], [117], [189], [190]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[18], [19], [9], [237], [238], [239]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[115], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [213], [214], [179], [180], [181], [182], [183], [215], [184], [116], [185], [186], [187], [188], [117], [189], [190]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[115], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [213], [214], [179], [180], [181], [182], [183], [215], [184], [116], [185], [186], [187], [188], [117], [189], [190]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[18], [19], [9], [223], [224], [225]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[18], [19], [9], [223], [224], [225]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[115], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [213], [214], [179], [180], [181], [182], [183], [215], [184], [116], [185], [186], [187], [188], [117], [189], [190]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[18], [19], [9], [223], [224], [225]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[19], [9], [225]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[18], [19], [9], [223], [224], [225]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[18], [19], [9], [223], [224], [225]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[213], [185], [188]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[18], [19], [9], [223], [224], [225]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[18], [19], [9], [223], [224], [225]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[9], [284], [285]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[18], [19], [9], [223], [224], [225]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[9], [284], [285]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[115], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [213], [214], [179], [180], [181], [182], [183], [215], [184], [116], [185], [186], [187], [188], [117], [189], [190]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[9], [284], [285]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[19], [9], [225]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[18], [19], [9], [237], [238], [239]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[171], [177], [182]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[115], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [213], [214], [179], [180], [181], [182], [183], [215], [184], [116], [185], [186], [187], [188], [117], [189], [190]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[19], [9], [306]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[213], [185], [188]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[137], [138], [139]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[137], [138], [139]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[137], [138], [139]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[137], [138], [139]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[137], [138], [139]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[150], [19], [151]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[152]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[137], [138], [139]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[137], [138], [139]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[137], [138], [139]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[249]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[150], [255], [256]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[150], [255], [256]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[150], [255], [256]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[150], [255], [256]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[150], [255], [256]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[150], [255], [256]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[150], [255], [256]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[273], [150], [19], [274], [275], [276], [255], [277], [278], [279], [256]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[150], [255], [256]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[150], [255], [256]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[150], [255], [256]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[257], [258], [259]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[257], [258], [259]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[261], [262], [263]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[261], [262], [263]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[261], [262], [263]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[261], [262], [263]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[242], [243], [244]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[291], [292]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[242], [243], [244]

References
1	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
2	Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
3	Product Information. Enbrel (etanercept). Wyeth-Ayerst Laboratories, Philadelphia, PA.
4	Product Information. Humira (adalimumab). Abbott Pharmaceutical, Abbott Park, IL.
5	Product Information. Remicade (infliximab). Centocor Inc, Malvern, PA.
6	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.
7	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Drug labels for the Tumor Necrosis Factor-alpha (TNFa) blockers now include warnings about infection with Legionella and Listeria bacteria. ".
8	Celiker A, Tokel K, Cil E, Ozkutlu S, Ozme S "Adenosine induced torsades de pointes in a child with congenital long QT syndrome." Pacing Clin Electrophysiol 17 (1994): 1814-7. [PMID: 7838793]
9	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
10	Teodorovich N, Margolin E, Kogan Y, Paz O, Swissa M. Torsades de pointes after adenosine administration. J Electrocardiol. 2016;49(2):171-173. [PMID: 26850499]
11	Harrington GR, Froelich EG "Adenosine-induced torsades de pointes." Chest 103 (1993): 1299-1301. [PMID: 8131497]
12	Mallet ML "Proarrhythmic effects of adenosine: a review of the literature." Emerg Med J 21 (2004): 408-10. [PMID: 15208219]
13	Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75. [PMID: 10926350]
14	Tachakra SS, Robinson S "Adenosine and cardiac arrhythmias." BMJ 305 (1992): 422. [PMID: 1392935]
15	Wesley RC Jr, Turnquest P "Torsades de pointe after intravenous adenosine in the presence of prolonged QT syndrome." Am Heart J 123 (1992): 794-6. [PMID: 1539535]
16	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
17	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
18	Canadian Pharmacists Association.
19	Cerner Multum, Inc. "Australian Product Information.".
20	Maxa JL, Hebeler RF, Adeeko MA "Torsades de pointes following concurrent amiodarone and levofloxacin therapy." Proc (Bayl Univ Med Cent) 19 (2006): 345-6. [PMID: 17106497]
21	Product Information. Betapace (sotalol). Berlex, Richmond, CA.
22	Product Information. Cordarone (amiodarone). Wyeth-Ayerst Laboratories, Philadelphia, PA.
23	Product Information. Norpace (disopyramide). Searle, Skokie, IL.
24	Product Information. Procan SR (procainamide). Parke-Davis, Morris Plains, NJ.
25	Product Information. Quiniglute (quinidine). Berlex, Richmond, CA.
26	Product Information. Vascor (bepridil). McNeil Pharmaceutical, Raritan, NJ.
27	Trujillo TC, Nolan PE "Antiarrhythmic agents - Drug interactions of clinical significance." Drug Safety 23 (2000): 509-32. [PMID: 11144659]
28	Yamreudeewong W, DeBisschop M, Martin L, Lower D "Potentially Significant Drug Interactions of Class III Antiarrhythmic Drugs." Drug Saf 26 (2003): 421-38. [PMID: 12688833]
29	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
30	Product Information. Barhemsys (amisulpride). Acacia Pharma, Inc, Indianapolis, IN.
31	Product Information. Agrylin (anagrelide). Roberts Pharmaceutical Corporation, Eatontown, NJ.
32	Ohnishi K, Yoshida H, Shigeno K, et al. "Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia." Ann Intern Med 133 (2000): 881-5. [PMID: 11103058]
33	Product Information. Trisenox (arsenic trioxide) Cephalon Inc, West Chester, PA.
34	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
35	Harper KM, Knapp DJ, Criswell HE, Breese GR "Vasopressin and alcohol: A multifaceted relationship." Psychopharmacology (Berl) 235 (2018): 3363-79. [PMID: 32936259]
36	Javelot H, El-Hage W, Meyer G, Becker G, Michel B, Hingray C "COVID-19 and (hydroxy)chloroquine-azithromycin combination: should we take the risk for our patients?" Br J Clin Pharmacol Apr 29 (2020): epub ahead of print. [PMID: 32350872]
37	National Institutes of Health (NIH) "Coronavirus Disease 2019 (COVID-19) Treatment Guidelines.".
38	Product Information. Chloroquine Phosphate (chloroquine). West-Ward Pharmaceutical Corporation, Eatontown, NJ.
39	Product Information. Hydroxychloroquine Sulfate (hydroxychloroquine). Prasco Laboratories, Cincinnati, OH.
40	Product Information. Plaquenil (R). (hydroxychloroquine). Sanofi Winthrop Pharmaceuticals, New York, NY.
41	Roden DM, Harrington RA, Poppas A, Russo AM "Considerations for drug interactions on QTc in exploratory COVID-19 (Coroanvirus disease 2019) treatment." Heart Rhythm Apr 14 (2020): epub ahead of print. [PMID: 32302703]
42	Sacher F, Fauchier L, Boveda S, et.al "Use of drugs with potential cardiac effect in the setting of SARS-CoV-2 infection." Arch Cardiovasc Dis Apr 24 (2020): epub ahead of print. [PMID: 32354666]
43	Saleh M, Gabriels J, ChangD, et.al "The effect of chloroquine, hydroxychloroquine and azithromycin on the corrected QT interval in patients with SARS-CoV-2 infection." Circ Arrhythm Electrophysiol Apr 29 (2020): epub ahead of print. [PMID: 32347743]
44	Sapp JL, Alqarawi W, MacIntyre CJ, et.al "Guidance on minimizing risk of drug-induced ventricular arrhythmia during treatment of COVID-19: A statement from the Canadian Heart Rhythm Society." Can J Cardiol Apr 8 (2020): epub ahead of print. [PMID: 32299753]
45	Smit C, Peeters MYM, van den Anker JN, Knibbe CAJ "Chloroquine for SARS-CoV-2: Implications of its unique pharmacokinetic and safety properties." Clin Pharmacokinet Ar 18 (2020): epub ahead of print. [PMID: 32306288]
46	Bessiere F, Roccia H, Deliniere A, et.al "Assessment of QT intervals in a case series of patients with coronavirus disease 2019 (COVID-19) infection treated with hydroxychloroquine alone or in combination with azithromycin in an intensive care unit." JAMA Cardiol May 1 (2020): epub ahead of print. [PMID: 32936266]
47	Borba MGS, Val FFA, Sampaio VS, et.al "Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 1 (SARS-CoV-2) infection: A randomized clinical trial." JAMA Netw Open Apr 1 (2020): epub ahead of print. [PMID: 32330277]
48	Giudicessi JR, Noseworthy PA, Friedman PA, Ackerman MJ "Urgent guidance for navigating and circumventing the QTc-prolonging and torsadogenic potential of possible pharmacotherapies for coronavirus disease 19 (COVID-19)" Mayo Clin Proc Apr 7 (2020): epub ahead of print. [PMID: 32359771]
49	Kapoor A, Pandurangi U, Arora V, et.al "Cardiovascular risks of hydroxychloroquine in treatment and prophylaxis of COVID-19 patients: A scientific statement from the Indian Heart Rhythm Society." Indian Pacing Electorphysiol J Apr 8 (2020): epub ahead of print. [PMID: 32278018]
50	Mercuro NJ, Yen CF, Shim DJ, et.al "Risk of QT interval prolongation associated with the use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19)" JAMA Cardiol May 1:e201834 (2020): epub ahead of print. [PMID: 32936252]
51	mitra RL, Greenstein SA, Epstein lm "An algorithm for managing QT prolongation in coronavirus disease 2019 (COVID-19) patients treated with either chloroquine or hydroxychloroquine in conjunction with azithromycin Possible benefits of intravenous lidocaine." HeartRythm Case Rep Apr 1 (2020): epub ahead of print. [PMID: 32363145]
52	US Food and Drug Administration "FACT SHEET FOR HEALTH CARE PROVIDERS EMERGENCY USE AUTHORIZATION (EUA) OF CHLOROQUINE PHOSPHATE SUPPLIED FROM THE STRATEGIC NATIONAL STOCKPILE FOR TREATMENT OF COVID-19 IN CERTAIN HOSPITALIZED PATIENTS. Available from: URL: https://www.fda.gov/media/13653" ([2020, Apr 27]):.
53	US Food and Drug Administration "Hydroxychloroquine or Chloroquine for COVID-19: Drug Safety Communication - FDA Cautions Against Use Outside of the Hospital Setting or a Clinical Trial Due to Risk of Heart Rhythm Problems.".
54	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.
55	Trinkle R "Comment: syncopal episodes associated with cisapride." Ann Pharmacother 33 (1999): 251. [PMID: 10084425]
56	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Abnormal heart rhythms associated with high doses of Celexa (citalopram hydrobromide).".
57	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
58	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod).".
59	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
60	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
61	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
62	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
63	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
64	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
65	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
66	Product Information. Anzemet (dolasetron). Hoechst Marion-Roussel Inc, Kansas City, MO.
67	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
68	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
69	Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
70	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
71	Castro VM, Clements CC, Murphy SN, et al. "QT interval and antidepressant use: a cross sectional study of electronic health records." BMJ 346 (2013): f288. [PMID: 23360890]
72	Do A, Noohi S, Elie D, et al. Health Canada Warning on Citalopram and Escitalopram--Its Effects on Prescribing in Consultation-Liaison Psychiatry.?Psychosomatics. 2016;57(1):57-63. [PMID: 26633294]
73	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
74	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
75	Ansari SR, Chopra N "Gatifloxacin and Prolonged QT Interval." Am J Med Sci 327 (2004): 55-6. [PMID: 14722399]
76	Ball P "Quinolone-induced QT interval prolongation: a not-so-unexpected class effect." J Antimicrob Chemother 45 (2000): 557-9. [PMID: 10797074]
77	Bertino JS Jr, Owens RC Jr, Carnes TD, Iannini PB "Gatifloxacin-associated corrected QT interval prolongation, torsades de pointes, and ventricular fibrillation in patients with known risk factors." Clin Infect Dis 34 (2002): 861-3. [PMID: 11830802]
78	Dale KM, Lertsburapa K, Kluger J, White CM "Moxifloxacin and torsade de pointes." Ann Pharmacother 41 (2007): 336-40. [PMID: 17284508]
79	Demolis JL, Kubitza D, Tenneze L, Funck-Bretano C "Effect of a single oral dose of moxifloxacin (400 mg and 800 mg) on ventricular repolarization in healthy subjects." Clin Pharmacol Ther 68 (2000): 658-66. [PMID: 11180026]
80	Falagas ME, Rafailidis PI, Rosmarakis ES "Arrhythmias associated with fluoroquinolone therapy." Int J Antimicrob Agents 29 (2007): 374-9. [PMID: 17241772]
81	Frothingham R "Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin." Pharmacotherapy 21 (2001): 1468-72. [PMID: 11765299]
82	Iannini PB "Cardiotoxicity of macrolides, ketolides and fluoroquinolones that prolong the QTc interval." Expert Opin Drug Saf 1 (2002): 121-8. [PMID: 12904146]
83	Iannini PB, Circiumaru I "Gatifloxacin-induced QTc prolongation and ventricular tachycardia." Pharmacotherapy 21 (2001): 361-2. [PMID: 11253862]
84	Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H "Risk of torsades de pointes with non-cardiac drugs." BMJ 322 (2001): 46-7. [PMID: 11141163]
85	Kang J, Wang L, Chen XL, Triggle DJ, Rampe D "Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG." Mol Pharmacol 59 (2001): 122-6. [PMID: 11125032]
86	Katritsis D, Camm AJ "Quinolones: cardioprotective or cardiotoxic." Pacing Clin Electrophysiol 26 (2003): 2317-20. [PMID: 14675020]
87	Noel GJ, Natarajan J, Chien S, Hunt TL, Goodman DB, Abels R "Effects of three fluoroquinolones on QT interval in healthy adults after single doses." Clin Pharmacol Ther 73 (2003): 292-303. [PMID: 12709719]
88	Oliphant CM, Green GM "Quinolones: a comprehensive review." Am Fam Physician 65 (2002): 455-64. [PMID: 11858629]
89	Owens RC "QT Prolongation with Antimicrobial Agents : Understanding the Significance." Drugs 64 (2004): 1091-124. [PMID: 15139788]
90	Owens RC "Risk assessment for antimicrobial agent-induced QTc interval prolongation and torsades de pointes." Pharmacotherapy 21 (2001): 301-19. [PMID: 11253855]
91	Owens RC Jr, Ambrose PG "Torsades de pointes associated with fluoroquinolones." Pharmacotherapy 22 (2002): 663-8 discussion 668-72. [PMID: 12013370]
92	Product Information. Avelox (moxifloxacin) Bayer, West Haven, CT.
93	Product Information. Tequin (gatifloxacin) Bristol-Myers Squibb, Princeton, NJ.
94	Siepmann M, Kirch W "Drug points - Tachycardia associated with moxifloxacin." Br Med J 322 (2001): 23. [PMID: 11141146]
95	Stahlmann R "Clinical toxicological aspects of fluoroquinolones." Toxicol Lett 127 (2002): 269-77. [PMID: 12052667]
96	Tsikouris JP, Peeters MJ, Cox CD, Meyerrose GE, Seifert CF "Effects of three fluoroquinolones on QT analysis after standard treatment courses." Ann Noninvasive Electrocardiol 11 (2006): 52-6. [PMID: 16472283]
97	White CM, Grant EM, Quintiliani R "Moxifloxacin does increase the corrected QT interval." Clin Infect Dis 33 (2001): 1441-2. [PMID: 11565091]
98	Lode H, Vogel F, Elies W "Grepafloxacin: A review of its safety profile based on clinical trials and postmarketing surveillance." Clin Ther 21 (1999): 61-74. [PMID: 10090425]
99	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
100	Thomas M, Maconochie JG, Fletcher E "The dilemma of the prolonged QT interval in early drug studies." Br J Clin Pharmacol 41 (1996): 77-81. [PMID: 8838432]
101	Abernethy DR, Wesche DL, Barbey JT, et al. "Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation." Br J Clin Pharmacol 51 (2001): 231-7. [PMID: 11298069]
102	Giao PT, de Vries PJ "Pharmacokinetic interactions of antimalarial agents." Clin Pharmacokinet 40 (2001): 343-73. [PMID: 11432537]
103	Nosten F, ter Kuile FO, Luxemburger C, et al "Cardiac effects of antimalarial treatment with halofantrine." Lancet 341 (1993): 1054-6. [PMID: 8096959]
104	Product Information. Halfan (halofantrine). GlaxoSmithKline, Philadelphia, PA.
105	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
106	Sudden death in a traveler following halofantrine administration--Togo, 2000. MMWR Morb Mortal Wkly Rep 50 (2001): 169-70, 179. [PMID: 11393488]
107	Hatta K, Takahashi T, Nakamura H, Yamashiro H, Asukai N, Matsuzaki I, Yonezawa Y "The association between intravenous haloperidol and prolonged QT interval." J Clin Psychopharmacol 21 (2001): 257-61. [PMID: 11386487]
108	Huyse F, van Schijndel RS "Haloperidol and cardiac arrest." Lancet 2 (1988): 568-9. [PMID: 2900948]
109	Metzger E, Friedman R "Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill." J Clin Psychopharmacol 13 (1993): 128-32. [PMID: 8463445]
110	O'Brien JM, Rockwood RP, Suh KI "Haloperidol-induced torsade de pointes." Ann Pharmacother 33 (1999): 1046-9. [PMID: 10534216]
111	Product Information. Haldol (haloperidol). McNeil Pharmaceutical, Raritan, NJ.
112	Wilt JL, Minnema AM, Johnson RF, Rosenblum AM "Torsade de pointes associated with the use of intravenous haloperidol." Ann Intern Med 119 (1993): 391-4. [PMID: 8338292]
113	Product Information. Corvert (ibutilide). Pharmacia and Upjohn, Kalamazoo, MI.
114	Product Information. Exforge HCT (amlodipine/hydrochlorothiazide/valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
115	Bengtsson B, Fagerstrom PO "Extrapulmonary effects of terbutaline during prolonged administration." Clin Pharmacol Ther 31 (1982): 726-32. [PMID: 7042176]
116	Rakhmanina NY, Kearns GL, Farrar HC "Hypokalemia in an asthmatic child from abuse of albuterol metered dose inhaler." Pediatr Emerg Care 14 (1998): 145-7. [PMID: 9583400]
117	Windom H, Grainger J, Burgess C, Crane J, Pearce N, Beasley R "A comparison of the haemodynamic and hypokalaemic effects of inhaled pirbuterol and salbutamol." N Z Med J 103 (1990): 259-61. [PMID: 1972557]
118	Mittal SR "Slow junctional rhythm, QTc prolongation and transient torsades de-pointes following combined use of Ivabradine, Diltiazem and Ranolazine." J Assoc Physicians India 62 (2014): 426-7. [PMID: 25438492]
119	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
120	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
121	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
122	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
123	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
124	Product Information. Serentil (mesoridazine) Boehringer-Ingelheim, Ridgefield, CT.
125	De Bels D, Staroukine M, Devriendt J "Torsades de pointes due to methadone." Ann Intern Med 139 (2003): E156. [PMID: 12859181]
126	Ehret GB, Desmeules JA, Broers B "Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology." Expert Opin Drug Saf 6 (2007): 289-303. [PMID: 17480178]
127	Gil M, Sala M, Anguera I, et al. "QT prolongation and Torsades de Pointes in patients infected with human immunodeficiency virus and treated with methadone." Am J Cardiol 92 (2003): 995-7. [PMID: 14556883]
128	Krantz MJ, Kutinsky IB, Robertson AD, Mehler PS "Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes." Pharmacotherapy 23 (2003): 802-5. [PMID: 12820821]
129	Krantz MJ, Lewkowiez L, Hays H, et al "Torsade de pointes associated with very-high-dose methadone." Ann Intern Med 137 (2002): 501-4. [PMID: 12230351]
130	Krantz MJ, Mehler PS "Synthetic opioids and QT prolongation." Arch Intern Med 163 (2003): 1615 author reply 1615. [PMID: 12860589]
131	Martell BA, Arnsten JH, Krantz MJ, Gourevitch MN "Impact of methadone treatment on cardiac repolarization and conduction in opioid users." Am J Cardiol 95 (2005): 915-8. [PMID: 15781034]
132	Mokwe EO, Ositadinma O "Torsade de pointes due to methadone." Ann Intern Med 139 (2003): W64. [PMID: 12966000]
133	Sala M, Anguera I, Cervantes M "Torsade de pointes due to methadone." Ann Intern Med 139 (2003): W64. [PMID: 12966001]
134	Walker PW, Klein D, Kasza L "High dose methadone and ventricular arrhythmias: a report of three cases." Pain 103 (2003): 321-4. [PMID: 12791438]
135	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
136	Product Information. Tysabri (natalizumab). Elan Pharmaceutical/Athena Neurosciences Inc, South San Francisco, CA.
137	Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998).
138	Product Information. Attenuvax (measles virus vaccine, live, attenuated). Merck &amp Co, Inc, West Point, PA.
139	Product Information. YF-Vax (yellow fever vaccine). sanofi pasteur, Swiftwater, PA.
140	Product Information. Olumiant (baricitinib). Lilly, Eli and Company, Indianapolis, IN.
141	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
142	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
143	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
144	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
145	Product Information. Olinvyk (oliceridine). Trevena Inc, Chesterbrook, PA.
146	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
147	Product Information. Orgovyx (relugolix). Myovant Sciences, Inc., Brisbane, CA.
148	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
149	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
150	CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
151	Product Information. Dryvax (smallpox vaccine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
152	Product Information. Imlygic (talimogene laherparepvec). Amgen USA, Thousand Oaks, CA.
153	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
154	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
155	Goto M, Sato M, Kitzazawa H, et.al "Papaverine-induced QT interval prolongation and ventricular fibrillation in a patient with a history of drug-induced QT prolongation." Intern Med 53 (2014): 1629-31. [PMID: 25088875]
156	Inoue T, Asahi S, Takayanagi K, Morooka S, Takabatake Y "QT prolongation and possibility of ventricular arrhythmias after intracoronary papaverine." Cardiology 84 (1994): 9-13. [PMID: 7511988]
157	Jain A, Jenkins MG "Intracoronary electrocardiogram during torsade des pointes secondary to intracoronary papaverine." Cathet Cardiovasc Diagn 18 (1989): 255-7. [PMID: 2605630]
158	Kern MJ, Deligonul U, Serota H, Gudipati C, Buckingham T "Ventricular arrhythmia due to intracoronary papaverine: analysis of QT intervals and coronary vasodilatory reserve." Cathet Cardiovasc Diagn 19 (1990): 229-36. [PMID: 2334953]
159	Nakayama M, Saito A, Kitazawa H, et.al "Papaverine-induced polymorphic ventricular tachycardia in relation to QTU and giant T-U waves in four cases." Intern Med 51 (2012): 351-6. [PMID: 22333368]
160	Nakayama M, Tanaka N, Sakoda K, et.al "Papaverine-induced polymorphic ventricular tachycardia during coronary flow reserve study of patients with moderate coronary artery disease." Circ J 79 (2015): 530-6. [PMID: 25746536]
161	Talman CL, Winniford MD, Rossen JD, Simonetti I, Kienzle MG, Marcus ML "Polymorphous ventricular tachycardia: a side effect of intracoronary papaverine." J Am Coll Cardiol 15 (1990): 275-8. [PMID: 2299067]
162	Vrolix M, Piessens J, De Geest H "Torsades de pointes after intracoronary papaverine." Eur Heart J 12 (1991): 273-6. [PMID: 2044564]
163	Product Information. Signifor (pasireotide). Novartis Pharmaceuticals, East Hanover, NJ.
164	Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
165	Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
166	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
167	Braden GL, vonOeyen PT, Germain MJ, Watson DJ, Haag BL "Ritodrine- and terbutaline-induced hypokalemia in preterm labor: Mechanisms and consequences." Kidney Int 51 (1997): 1867-75. [PMID: 9186877]
168	Clifton GD, Hunt BA, Patel RC, Burki NK "Effects of sequential doses of parenteral terbutaline on plasma levels of potassium and related cardiopulmonary responses." Am Rev Respir Dis 141 (1990): 575-9. [PMID: 2178522]
169	Dickens GR, Mccoy RA, West R, Stapczynski JS, Clifton GD "Effect of nebulized albuterol on serum potassium and cardiac rhythm in patients with asthma or chronic obstructive pulmonary disease." Pharmacotherapy 14 (1994): 729-33. [PMID: 7885977]
170	Ferguson GT, Funck-Brentano C, Fischer T, Darken P, Reisner C "Cardiovascular Safety of Salmeterol in COPD." Chest 123 (2003): 1817-24. [PMID: 12796155]
171	Gelmont DM, Balmes JR, Yee A "Hypokalemia induced by inhaled bronchodilators." Chest 94 (1988): 763-6. [PMID: 3168573]
172	Gross TL, Sokol RJ "Severe hypokalemia and acidosis: a potential complication of beta- adrenergic treatment." Am J Obstet Gynecol 138 (1980): 1225-6. [PMID: 7446635]
173	Hastwell G, Lambert BE "The effect of oral salbutamol on serum potassium and blood sugar." Br J Obstet Gynaecol 85 (1978): 767-9. [PMID: 708661]
174	Hurlbert BJ, Edelman JD, David K "Serum potassium levels during and after terbutaline." Anesth Analg 60 (1981): 723-5. [PMID: 7197475]
175	Hypokalaemia due to salbutamol overdosage. Br Med J (Clin Res Ed) 283 (1981): 500-1. [PMID: 6114774]
176	Kantola I, Tarssanen L "Hypokalemia from usual salbutamol dosage ." Chest 89 (1986): 619-20. [PMID: 3956296]
177	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
178	Milic M, Bao X, Rizos D, Liu F, Ziegler MG "Literature review and pilot studies of the effect of qt correction formulas on reported beta(2)-agonist-induced QTc prolongation." Clin Ther 28 (2006): 582-90. [PMID: 16750469]
179	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
180	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
181	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
182	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
183	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
184	Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
185	Sanders JP, Potter DE, Ellis S, Bee DE, Grant JA "Metabolic and cardiovascular effects of carbuterol and metaproterenol." J Allergy Clin Immunol 60 (1977): 174-9. [PMID: 19514]
186	Sun ZH, Swan H, Vitasalo M, Toivonen L "Effects of epinephrine and phenylephrine on QT interval dispersion in congenital long QT syndrome." J Am Coll Cardiol 31 (1998): 1400-5. [PMID: 9581741]
187	Tveskov C, Djurhuus MS, Klitgaard NAH, Egstrup K "Potassium and magnesium distribution, ECG changes, and ventricular ectopic beats during beta(2)-adrenergic stimulation with terbutaline in healthy subjects." Chest 106 (1994): 1654-9. [PMID: 7988180]
188	Whyte KF, Addis GJ, Whitesmith R, Reid JL "The mechanism of salbutamol-induced hypokalaemia." Br J Clin Pharmacol 23 (1987): 65-71. [PMID: 3545273]
189	Wong CS, Pavord ID, Williams J, Britton JR, Tattersfield AE "Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma." Lancet 336 (1990): 1396-9. [PMID: 1978872]
190	Larsson S, Svedmyr N "Bronchodilating effect and side effects of beta2- adrenoceptor stimulants by different modes of administration (tablets, metered aerosol, and combinations thereof). A study with salbutamol inasthmatics." Am Rev Respir Dis 116 (1977): 861-9. [PMID: 921062]
191	Product Information. Quadramet (samarium sm 153 lexidronam) Berlex Laboratories, Richmond, CA.
192	Anson BD, Weaver JG, Ackerman MJ, et al. "Blockade of HERG channels by HIV protease inhibitors." Lancet 365 (2005): 682-686. [PMID: 15721475]
193	Biondi L "Health Canada endorsed important safety information on Invirase (saquinavir mesylate)." .
194	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
195	FDA. U.S. Food and Drug Administration "FDA drug safety communication: Ongoing safety review of Invirase (saquinavir) and possible association with abnormal heart rhythms.".
196	Demolis JL, Charransol A, Funck-Brentano C, Jaillon P "Effects of a single oral dose of sparfloxacin on ventricular repolarization in healthy volunteers." Br J Clin Pharmacol 41 (1996): 499-503. [PMID: 8799513]
197	Dupont H, Timsit JF, Souweine B, Gachot B, Wolff M, Regnier B "Torsades de pointe probably related to sparfloxacin." Eur J Clin Microbiol Infect Dis 15 (1996): 350-1. [PMID: 8781892]
198	Jaillon P, Morganroth J, Brumpt I, Talbot G "Overview of electrocardiographic and cardiovascular safety data for sparfloxacin. Sparfloxacin Safety Group." J Antimicrob Chemother 37(suppl a) (1996): 161-7. [PMID: 8737135]
199	Lipsky BA, Dorr MB, Magner DJ, Talbot GH "Safety profile of sparfloxacin, a new fluoroquinolone antibiotic." Clin Ther 21 (1999): 148-59. [PMID: 10090432]
200	Product Information. Zagam (sparfloxacin). Rhone-Poulenc Rorer, Collegeville, PA.
201	Zix JA, GeerdesFenge HF, Rau M, Vockler J, Borner K, Koeppe P, Lode H "Pharmacokinetics of sparfloxacin and interaction with cisapride and sucralfate." Antimicrob Agents Chemother 41 (1997): 1668-72. [PMID: 9257738]
202	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
203	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
204	Product Information. Vandetanib (vandetanib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
205	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
206	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
207	Product Information. Amevive (alefacept). Biogen, Cambridge, MA.
208	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
209	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
210	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
211	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
212	Product Information. Kineret (anakinra). Amgen, Thousand Oaks, CA.
213	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
214	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
215	Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
216	Goodnick PJ, Jerry J, Parra F "Psychotropic drugs and the ECG: focus on the QTc interval." Expert Opin Pharmacother 3 (2002): 479-98. [PMID: 11996627]
217	Kane JM, Carson WH, Saha AR, et al. "Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder." J Clin Psychiatry 63 (2002): 763-71. [PMID: 12363115]
218	Keck PE Jr, Marcus R, Tourkodimitris S, et al. "A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania." Am J Psychiatry 160 (2003): 1651-8. [PMID: 12944341]
219	Nelson S, Leung JG "Torsades de Pointes After Administration of Low-Dose Aripiprazole (February)." Ann Pharmacother (2013):. [PMID: 23362038]
220	Pigott TA, Carson WH, Saha AR, Torbeyns AF, Stock EG, Ingenito GG "Aripiprazole for the prevention of relapse in stabilized patients with chronic schizophrenia: a placebo-controlled 26-week study." J Clin Psychiatry 64 (2003): 1048-56. [PMID: 14628980]
221	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
222	Product Information. Treanda (bendamustine). Cephalon Inc, West Chester, PA.
223	Chin RL "Laxative-induced hypokalemia." Ann Emerg Med 32 (1998): 517-8. [PMID: 9774942]
224	Muller-Lissner SA "Adverse effects of laxatives: fact and fiction." Pharmacology 47 (1993): 138-45. [PMID: 8234421]
225	Schaefer DC, Cheskin LJ "Constipation in the elderly." Am Fam Physician 58 (1998): 907-14. [PMID: 9767726]
226	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
227	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
228	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
229	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
230	Aronson JK, Grahame-Smith DG "Clinical pharmacology: adverse drug interactions." Br Med J 282 (1981): 288-91. [PMID: 6779990]
231	Engels FK, Mathot RA, Loos WJ, van Schaik RH, Verweij J "Influence of high-dose ketoconazole on the pharmacokinetics of docetaxel." Cancer Biol Ther 5 (2006): 833-9. [PMID: 16775418]
232	McInnes GT, Brodie MJ "Drug interactions that matter: a critical reappraisal." Drugs 36 (1988): 83-110. [PMID: 3063497]
233	Product Information. Taxotere (docetaxel). Rhone-Poulenc Rorer, Collegeville, PA.
234	Starr SP, Hammann F, Gotta V, et al. "Pharmacokinetic interaction between taxanes and amiodarone leading to severe toxicity." Br J Clin Pharmacol 450 (2016): 22-27. [PMID: 27868228]
235	Vodovar D, Arnaout M, Mongardon N, et al. "Severe docetaxel overdose induced by pharmacokinetic interaction with dronedarone." J Clin Oncol 29 (2011): e694-5. [PMID: 21730272]
236	Yong WP, Wang LZ, Tham LS, et al. "A phase I study of docetaxel with ketoconazole modulation in patients with advanced cancers." Cancer Chemother Pharmacol 62 (2008): 243-51. [PMID: 17909805]
237	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
238	Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
239	Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
240	Product Information. Raptiva (efalizumab). Genentech, South San Francisco, CA.
241	Product Information. Pepcid (famotidine). Merck & Co, Inc, West Point, PA.
242	Product Information. Granix (tbo-filgrastim). Teva Pharmaceuticals USA, North Wales, PA.
243	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
244	Product Information. Stemgen (ancestim) Amgen, Thousand Oaks, CA.
245	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
246	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
247	Eggleston W, Clark KH, Marraffa JM "Loperamide abuse associated with cardiac dysrhythmia and death." Ann Emerg Med 69 (2017): 83-6. [PMID: 27140747]
248	US Food and Drug Administration "FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse.".
249	Shen AK, Mead PS, Beard CB. The Lyme disease vaccine--a public health perspective. Clin Infect Dis. 2011;52 Suppl 3:s247-s252. [PMID: 21217171]
250	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
251	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
252	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
253	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
254	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
255	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
256	Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations.".
257	Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
258	Schlegel L, Lemerle S, Geslin P "Lactobacillus species as opportunistic pathogens in immunocompromised patients." Eur J Clin Microbiol Infect Dis 17 (1998): 887-8. [PMID: 10052559]
259	Salminen MK, Tynkkynen S, Rautelin H, et al. "Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland." Clin Infect Dis 35 (2002): 1155-60. [PMID: 12410474]
260	Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
261	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
262	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
263	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
264	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
265	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
266	Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
267	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
268	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
269	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
270	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
271	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
272	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
273	CDC Centers for Disease Control and Prevention "General Best Practice Guidelines for Immunization: Altered Immunocompetence." .
274	Product Information. Biothrax (anthrax vaccine adsorbed). Emergent BioSolutions Inc., Lansing, MI.
275	Product Information. Fluzone Influenza Vaccine (influenza virus vaccine). Connaught, Swiftwater, PA.
276	Product Information. Havrix (hepatitis A vaccine). SmithKline Beecham, Philadelphia, PA.
277	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
278	Product Information. Omnihib (haemophilus b conjugate vaccine). SmithKline Beecham, Philadelphia, PA.
279	CDC Centers for Disease Control and Prevention "Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States.".
280	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
281	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
282	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
283	AnazaoHealth Corporation "P32 Sodium Phosphate."
284	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
285	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
286	Multum Information Services, Inc. Expert Review Panel.
287	Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
288	Product Information. Sivextro (tedizolid). Cubist Pharmaceuticals Inc, Lexington, MA.
289	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
290	Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.
291	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
292	Product Information. Neulasta (pegfilgrastim). Amgen, Thousand Oaks, CA.
293	Hanci V, Aydin M, Yurtlu BS, et.al "Anesthesia induction with sevoflurane and propofol: evaluation of P-wave dispersion, QT and corrected QT intervals." Kaohsiung J Med Sci 26 (2010): 470-7. [PMID: 20837343]
294	Kim DH, Kweon TD, Nam SB, Han DW, Cho WY, Lee JS "Effects of target concentration infusion of propofol and tracheal intubation on QTc interval." Anaesthesia 63 (2008): 1061-4. [PMID: 18717665]
295	Kleinsasser A, Kuenszberg E, Loeckinger A, et.al "Sevoflurane, but not propofol, significantly prolongs the Q-T interval." Anesth Analg 90 (2000): 25-7. [PMID: 10624970]
296	Kleinsasser A, Loeckinger A, Lindner KH, Keller C, Boehler M, Puehringer F "Reversing sevoflurane-associated Q-Tc prolongation by changing to propofol." Anaesthesia 56 (2001): 248-50. [PMID: 11251432]
297	Paventi S, Santevecchi A, Ranieri R "Effects of sevoflurane versus propofol on QT interval." Minerva Anestesiol 67 (2001): 637-40. [PMID: 11731753]
298	Scalese MJ, Herring HR, Rathburn RC, Skrepnek GH, Ripley TL "Propofol-associated QTc prolongation." Ther Adv Drug Saf 7 (2016): 68-78. [PMID: 27298717]
299	Staikou C, Stamelos M, Stavroulakis E "Impact of anaesthetic drugs and adjuvants on ECG markers of torsadogenicity." Br J Anaesth 112 (2014): 217-30. [PMID: 24305646]
300	Toyoda T, Terao Y, Oji M, Okada M, Fukusaki M, Sumikawa K "The interaction of antiemetic dose of droperidol with propofol on QT interval during anesthetic induction." J Anesth 27 (2013): 885-9. [PMID: 23660990]
301	Whyte SD, Booker PD, Buckley DG "The Effects of Propofol and Sevoflurane on the QT Interval and Transmural Dispersion of Repolarization in Children." Anesth Analg 100 (2005): 71-77. [PMID: 15616054]
302	Wutzler A, De Asmundis C, Matsuda H, et.al "Effects of propofol on ventricular repolarization and incidence of malignant arrhythmias in adults." J Electrocardiol 51 (2018): 170-4. [PMID: 29174097]
303	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
304	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
305	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
306	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
307	Product Information. Hycamtin (topotecan). SmithKline Beecham, Philadelphia, PA.
308	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
309	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
310	Hellmann A, Rule S, Walewski J, et al. "Effect of cytochrome P450 3A4 inducers on the pharmacokinetic, pharmacodynamic and safety profiles of bortezomib in patients with multiple myeloma or Non-Hodgkin's lymphoma." Clin Pharmacokinet 50 (2011): 781-91. [PMID: 22087865]
311	Pekol T, Daniels JS, Labutti J, et al "Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites." Drug Metab Dispos 33 (2005): 771-7. [PMID: 15764713]
312	Product Information. Velcade (bortezomib). Millennium Pharmaceuticals Inc, Cambridge, MA.
313	Uttamsingh V, Lu C, Miwa GT, Gan LS "Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4 to the hepatic metabolism of teh protosome inhibitor bortezomib." Drug Metab Dispos 33 (2005): 1723-8. [PMID: 16103134]
314	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
315	Heinonen J, Takki S, Jarho L "Plasma lidocaine levels in patients treated with potential inducers of microsomal enzymes." Acta Anaesthesiol Scand 14 (1970): 89-95. [PMID: 5428253]
316	Perucca E, Richens A "Reduction of oral bioavailability of lignocaine by induction of first pass metabolism in epileptic patients." Br J Clin Pharmacol 8 (1979): 21-31. [PMID: 552293]
317	Perucca E, Ruprah M, Richens A, Park BK, Betteridge DJ, Hedges AM "Effect of low-dose phenobarbitone on five indirect indices of hepatic microsomal enzyme induction and plasma lipoproteins in normal subjects." Br J Clin Pharmacol 12 (1981): 592-6. [PMID: 6117310]
318	Reichel C, Skodra T, Nacke A, Spengler U, Sauerbruch T "The lignocaine metabolite (MEGX) liver function test and P-450 induction in humans." Br J Clin Pharmacol 46 (1998): 535-9. [PMID: 9862241]
319	Kounas SP, Letsas KP, Sideris A, Efraimidis M, Kardaras F "QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone." Pacing Clin Electrophysiol 28 (2005): 472-3. [PMID: 15869686]
320	Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
321	Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
322	Crouch MA, Limon L, Cassano AT "Clinical relevance and management of drug-related QT interval prolongation." Pharmacotherapy 23 (2003): 881-908. [PMID: 12885102]
323	Darpo B "Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes." Eur Heart J Suppl 3(Suppl K) (2001): K70-80.
324	Lopez JA, Harold JG, Rosenthal MC, Oseran DS, Schapira JN, Peter T "QT prolongation and torsades de pointes after administration of trimethoprin-sulfamethoxazole." Am J Cardiol 59 (1987): 376-7. [PMID: 3492908]
325	Wiener I, Rubin D, Martinez E, et al "QT prolongation and paroxysmal ventricular tachycardia occurring during fever following trimethoprim-sulfamethoxazole administration." Mt Sinai J Med 48 (1981): 53-5. [PMID: 6970886]

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence