Details of Drug

Drug General Information (ID: D1186)
Drug Name	Oritavancin
Drug Type	Small molecule
Drug Synonymous	Nuvocid; Oritavancin [INN]; LY333328; Chlorobiphenyl-chloroeremomycin; (3S,6R,7R,22R,23S,26S,36R,38aR)-22-(3-Amino-2,3,6-trideoxy-3-C-methyl-alpha-L-mannopyranosyloxy)-3-(carbamoylmethyl)-10,19-dichloro-44-[2-O-[3-(4'-chlorobiphenyl-4-ylmethylamino)-2,3,6-trideoxy-3-C-me; (4''R)-22-O-(3-Amino-2,3,6-trideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-N3''-(4'-chloro[1,1'-biphenyl]-4-ylmethyl)vancomycin; (4''R)-22-O-(3-Amino-2,3,6-trideoxy-3-C-methyl-alpha-L-arabinohexopyranosyl)-N3''-(p-(p-chlorophenyl)benzyl)vancomycin Click to Show/Hide
Disease Class	1A00-1C4Z: Bacterial infection; 1B74-1F40: Gram-positive bacterial infection
Therapeutic Class	Glycopeptide Antibiotics
Structure
Structure	3D Structure		2D Structure
Formula	C86H97Cl3N10O26
InChI	1S/C86H97Cl3N10O26/c1-35(2)22-51(92-7)77(110)98-67-69(105)42-15-20-55(49(88)24-42)120-57-26-44-27-58(73(57)125-84-74(71(107)70(106)59(34-100)122-84)124-62-32-86(6,76(109)37(4)119-62)93-33-38-8-10-39(11-9-38)40-12-17-45(87)18-13-40)121-56-21-16-43(25-50(56)89)72(123-61-31-85(5,91)75(108)36(3)118-61)68-82(115)97-66(83(116)117)48-28-46(101)29-54(103)63(48)47-23-41(14-19-53(47)102)64(79(112)99-68)96-80(113)65(44)95-78(111)52(30-60(90)104)94-81(67)114/h8-21,23-29,35-37,51-52,59,61-62,64-72,74-76,84,92-93,100-103,105-109H,22,30-34,91H2,1-7H3,(H2,90,104)(H,94,114)(H,95,111)(H,96,113)(H,97,115)(H,98,110)(H,99,112)(H,116,117)/t36-,37-,51+,52-,59+,61-,62-,64+,65+,66-,67+,68-,69+,70+,71-,72+,74+,75-,76-,84-,85-,86-/m0/s1
InChIKey	VHFGEBVPHAGQPI-LXKZPTCJSA-N
Canonical SMILES	CC1C(C(CC(O1)OC2C3C(=O)NC(C4=C(C(=CC(=C4)O)O)C5=C(C=CC(=C5)C(C(=O)N3)NC(=O)C6C7=CC(=C(C(=C7)OC8=C(C=C2C=C8)Cl)OC9C(C(C(C(O9)CO)O)O)OC1CC(C(C(O1)C)O)(C)NCC1=CC=C(C=C1)C1=CC=C(C=C1)Cl)OC1=C(C=C(C=C1)C(C(C(=O)NC(C(=O)N6)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)O)C(=O)O)(C)N)O
External Link
	Pubchem ID	16136912
	CAS Number	171099-57-3
	CHEBI ID	82699
	TTD ID	D02IBU

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Oritavancin
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[39], [40]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[1]
	CYP450 enzyme induction					Drug Num: 66
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[2]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[7], [8], [9]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[10], [11], [12], [13], [3], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[13], [3], [28]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[13], [3], [28]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[13], [3], [32]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[10], [11], [12], [13], [3], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[3], [33], [34]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[10], [11], [12], [13], [3], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[35], [36], [13], [3], [37], [38]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[10], [11], [12], [13], [3], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[13], [3], [28]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[13], [3], [28]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[36], [13], [3]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[41]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[42]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[43]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[3], [44]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[11], [17], [27]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[3], [45], [46]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[13], [3], [47]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[48], [49]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[50]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[36], [13], [3], [37], [51], [52], [53]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[54]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[55], [3], [56]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[57]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[58], [59]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[60]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Moderate		Inter Info	[13], [3], [61]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[62]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[63]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[64]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[65]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[13], [3], [66]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[67]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[13], [68]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[69]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[13], [3], [70]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[71]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[72]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[73], [74]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[10], [11], [12], [13], [3], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[75]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[3], [76]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[80]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[13], [3], [81]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[13], [55], [3], [82]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[13], [83]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[3], [84]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[85]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[13], [3], [86]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[87]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[13], [3], [88]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[36], [3], [89], [90], [91]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[92]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[93]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[94]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[95]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[10], [11], [12], [13], [3], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[96], [13], [97], [98]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[99]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[13], [3], [100]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[101], [13], [3], [102], [103]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[3], [104], [105], [106], [107]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[108]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[3], [4], [5]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[6]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[1]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[29], [30], [31]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[29], [30], [31]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[77], [78], [79]

References
1	Product Information. Orbactiv (oritavancin). The Medicines Company, Parsippany, NJ.
2	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	UK government "Typhoid.".
5	American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
6	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
7	Kivisto KT, Lamberg TS, Neuvonen PJ "Interactions of buspirone with itraconazole and rifampicin: Effects on the pharmacokinetics of the active 1-(2-pyrimidinyl)-piperazine metabolite of buspirone." Pharmacol Toxicol 84 (1999): 94-7. [PMID: 10068153]
8	Lamberg TS, Kivisto KT, Neuvonen PJ "Concentrations and effects of buspirone are considerably reduced by rifampicin." Br J Clin Pharmacol 45 (1998): 381-5. [PMID: 9578186]
9	Product Information. Buspar (buspirone). Bristol-Myers Squibb, Princeton, NJ.
10	Altice FL, Friedland GH, Cooney EL "Nevirapine induced opiate withdrawal among injection drug users with HIV infection receiving methadone." AIDS 13 (1999): 957-62. [PMID: 10371177]
11	Bell J, Seres V, Bowron P, Lewis J, Batey R "The use of serum methadone levels in patients receiving methadone maintenance." Clin Pharmacol Ther 43 (1988): 623-9. [PMID: 3378383]
12	Bending MR, Skacel PO "Rifampicin and methadone withdrawal." Lancet 1 (1977): 1211. [PMID: 68314]
13	Cerner Multum, Inc. "Australian Product Information.".
14	Finelli PF "Phenytoin and methadone tolerance." N Engl J Med 294 (1976): 227. [PMID: 1244546]
15	Holmes VF "Rifampin-induced methadone withdrawal in AIDS." J Clin Psychopharmacol 10 (1991): 443-4. [PMID: 2286719]
16	Kreek MJ, Garfield JW, Gutjahr CL, Giusti LM "Rifampin-induced methadone withdrawal." N Engl J Med 294 (1976): 1104-6. [PMID: 1256526]
17	Liu S-J, Wang RI "Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome." Am J Psychiatry 141 (1984): 1287-8. [PMID: 6486271]
18	Otero MJ, Fuertes A, Sanchez R, Luna G "Nevirapine-induced withdrawal symptoms in HIV patients on methadone maintenance programme: an alert." AIDS 13 (1999): 1004-5. [PMID: 10371190]
19	Pinzani V, Faucherre V, Peyriere H, Blayac JP "Methadone withdrawal symptoms with nevirapine and efavirenz." Ann Pharmacother 34 (2000): 405-7. [PMID: 10917395]
20	Product Information. Butorphanol Tartrate (butorphanol). Apotex Corporation, Weston, FL.
21	Product Information. Diskets (methadone). Cebert Pharmaceuticals Inc, Birmingham, AL.
22	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
23	Product Information. Ionsys (fentanyl). Ortho McNeil Pharmaceutical, Raritan, NJ.
24	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
25	Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.
26	Raistrick D, Hay A, Wolff K "Methadone maintenance and tuberculosis treatment." BMJ 313 (1996): 925-6. [PMID: 8876100]
27	Tong TG, Pond SM, Kreek MJ, et al "Phenytoin-induced methadone withdrawal." Ann Intern Med 94 (1981): 349-51. [PMID: 7224382]
28	Product Information. Methergine (methylergonovine). Novartis Pharmaceuticals, East Hanover, NJ.
29	Back DJ, Breckenridge AM, Crawford FE, MacIver M, Orne ML, Rowe PH "Interindividual variation and drug interactions with hormonal steroid contraceptives." Drugs 21 (1981): 46-61. [PMID: 7009137]
30	Barnett ML "Inhibition of oral contraceptive effectiveness by concurrent antibiotic administration." J Periodontol 56 (1985): 18-20. [PMID: 3882930]
31	King VJ "OC failure rates and oral antibiotics." J Fam Pract 45 (1997): 104-5. [PMID: 9267366]
32	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
33	Kiechel JR, Lavene D, Guerret M, Comoy E, Godin M, Fillastre JP "Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure." Eur J Clin Pharmacol 25 (1983): 463-6. [PMID: 6360692]
34	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
35	Bolton AE, Peng B, Hubert M, et al. "Effect of rifampicin on the pharmacokinetics of imatinib mesylate (Gleevec, STI571) in healthy subjects." Cancer Chemother Pharmacol 53 (2004): 102-6. [PMID: 14605865]
36	Canadian Pharmacists Association.
37	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
38	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
39	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
40	Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
41	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
42	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
43	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
44	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
45	Product Information. Biktarvy (bictegravir/emtricitabine/tenofovir). Gilead Sciences, Foster City, CA.
46	Product Information. Viread (tenofovir). Gilead Sciences, Foster City, CA.
47	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
48	Product Information. Cabometyx (cabozantinib). Exelixis Inc, S San Francisco, CA.
49	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
50	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
51	Product Information. Genvoya (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
52	Product Information. Tybost (cobicistat). Gilead Sciences, Foster City, CA.
53	Smith DS, Fujimoto JM "Alterations produced by novobiocin during biliary excretion of morphine, morphine-3-glucuronide and other compounds." J Pharmacol Exp Ther 188 (1974): 504-15. [PMID: 4273910]
54	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
55	Cerner Multum, Inc. "Canadian Product Information.".
56	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
57	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
58	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
59	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
60	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
61	Product Information. Vitekta (elvitegravir). Gilead Sciences, Foster City, CA.
62	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
63	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
64	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
65	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
66	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
67	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
68	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
69	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
70	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
71	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
72	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
73	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
74	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
75	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
76	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
77	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
78	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
79	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
80	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
81	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
82	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
83	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
84	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
85	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
86	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
87	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
88	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
89	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
90	Teng R, Mitchell P, Butler K "Effect of rifampicin on the pharmacokinetics and pharmacodynamics of ticagrelor in healthy subjects." Eur J Clin Pharmacol 69 (2013): 877-83. [PMID: 23093043]
91	Weeks P, Sieg A, Vahdat K, Raissi F, Nathan S "Improved ticagrelor antiplatelet effect on discontinuation of phenytoin." Ann Pharmacother 48 (2014): 644-7. [PMID: 24477376]
92	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
93	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
94	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
95	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
96	Bittencourt PR, Gracia CM, Martins R, et al "Phenytoin and carbamazepine decrease oral bioavailability of praziquantel." Neurology 42 (1992): 492-6. [PMID: 1549207]
97	Product Information. Biltricide (praziquantel). Bayer, West Haven, CT.
98	Ridtitid W, Wongnawa M, Mahatthanatrakul W, Punyo J, Sunbhanich M "Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers." Clin Pharmacol Ther 72 (2002): 505-13. [PMID: 12426514]
99	Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
100	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
101	Berthou F, Dreano Y, Belloc C, Kangas L, Gautier JC, Beaune P "Involvement of cytochrome P450 3A enzyme family in the major metabolic pathways of toremifene in human liver microsomes." Biochem Pharmacol 47 (1994): 1883-95. [PMID: 8204106]
102	Kivisto KT, Villikka K, Nyman L, Anttila M, Neuvonen PJ "Tamoxifen and toremifene concentrations in plasma are greatly decreased by rifampin." Clin Pharmacol Ther 64 (1998): 648-54. [PMID: 9871429]
103	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
104	Hellmann A, Rule S, Walewski J, et al. "Effect of cytochrome P450 3A4 inducers on the pharmacokinetic, pharmacodynamic and safety profiles of bortezomib in patients with multiple myeloma or Non-Hodgkin's lymphoma." Clin Pharmacokinet 50 (2011): 781-91. [PMID: 22087865]
105	Pekol T, Daniels JS, Labutti J, et al "Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites." Drug Metab Dispos 33 (2005): 771-7. [PMID: 15764713]
106	Product Information. Velcade (bortezomib). Millennium Pharmaceuticals Inc, Cambridge, MA.
107	Uttamsingh V, Lu C, Miwa GT, Gan LS "Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4 to the hepatic metabolism of teh protosome inhibitor bortezomib." Drug Metab Dispos 33 (2005): 1723-8. [PMID: 16103134]
108	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.

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