Details of Drug

Drug General Information (ID: D1149)
Drug Name	Nitrous oxide
Drug Type	Small molecule
Drug Synonymous	Distickstoffmonoxid; Lachgas; Stickdioxyd; Dinitrogen monoxide; Dinitrogen oxide; Factitious air; Gaz hilarant; Hyponitrous acid anhydride; Laughing gas; Nitrogen hypoxide; Nitrogenium oxydulatum; Nitrous oxide [JAN]; Oxido nitroso; Oxido nitroso [Spanish]; Oxyde nitreux; Stickdioxyd [German]; N2O; Nitrous oxide [UN1070] [Nonflammable gas]; Diazyne 1-oxide; Gas, Laughing; NITROUS-OXIDE; Nitrogen oxide (N2O); Nitrous oxide (TN); Nitrous oxide [Anaesthetics, volatile]; Nitrous oxide, compressed; Nitrous oxide, refrigerated liquid; Nitrous oxide, refrigerated liquid [UN2201] [Nonflammable gas]; Oxide, Nitrous; Protoxyde d'azote; Protoxyde d'azote [French]; Nitrous oxide (JP15/USP); Oxidodinitrogen(N-N); Stickstoff(I)-oxid Click to Show/Hide
Disease Class	6B00-6B0Z: Anxiety disorder
Therapeutic Class	Respiratory Agents
Structure
Structure	3D Structure		2D Structure
Formula	N2O
InChI	1S/N2O/c1-2-3
InChIKey	GQPLMRYTRLFLPF-UHFFFAOYSA-N
Canonical SMILES	[N-]=[N+]=O
External Link
	Pubchem ID	948
	CAS Number	10024-97-2
	CHEBI ID	17045
	TTD ID	D0O8DI

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM036 Additive cardiorespiratory depression effects BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Nitrous oxide
Pharmacodynamic additive effects
	Additive cardiorespiratory depression effects					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[9], [10], [11]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[9], [10], [11]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[9], [10], [11]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[9], [10], [11]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[9], [10], [11]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[9], [10], [11]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[9], [10], [11]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[9], [10], [11]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[9], [10], [11]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[9], [10], [11]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[9], [10], [11]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[9], [10], [11]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[9], [10], [11]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[9], [10], [11]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[9], [10], [11]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[9], [10], [11]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[9], [10], [11]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[9], [10], [11]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[9], [10], [11]
D1183		Opium	NA	NA	Moderate		Inter Info	[9], [10], [11]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[9], [10], [11]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[9], [10], [11]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[9], [10], [11]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[9], [10], [11]
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[7], [8]
	Additive hypotensive effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[18], [19]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[18], [19]
	Additive neuromuscular blocking effects					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[15], [16], [17]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[15], [16], [17]
D1047		Metocurine	C40H48N2O6+2	21233	Moderate		Inter Info	[15], [16], [17]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[15], [16], [17]
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[15], [16], [17]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[15], [16], [17]
D1295		Pipecuronium	C35H62N4O4+2	50192	Moderate		Inter Info	[15], [16], [17]
D1384		Rapacuronium	C37H61N2O4+	5311399	Moderate		Inter Info	[15], [16], [17]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[15], [16], [17]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[15], [16], [17]
D1659		Tubocurarine	C37H41N2O6+	6000	Moderate		Inter Info	[15], [16], [17]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[15], [16], [17]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[1], [2], [3]
D1025		Methotrexate	C20H22N8O5	126941	Major		Inter Info	[4], [5], [6]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[1], [2], [3]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[1], [2], [3]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[1], [2], [3]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[12], [13], [14]

References
1	Product Information. Azilect (rasagiline). Teva Pharmaceuticals USA, North Wales, PA.
2	Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
3	Product Information. Nardil (phenelzine). Parke-Dvis, Morris Plains, NJ.
4	Canadian Pharmacists Association "e-CPS."
5	Goldhirsch A, Gelber RD, Tattersall MN, Rudenstam CM "Methotrexate/nitrous-oxide toxic interaction in perioperative chemotherapy for early breast cancer." Lancet ii (1987): 151.[PMID: 2885607]
6	Ermens AA, Schoester M, Spijkers LJ, Lindemans J, Abels J "Toxicity of methotrexate in rats preexposed to nitrous oxide." Cancer Res 49 (1989): 6337-41.[PMID: 2804978]
7	Product Information. Xywav (calcium/magnesium/potass/sodium oxybates). Jazz Pharmaceuticals, Palo Alto, CA.
8	Product Information. Xyrem (sodium oxybate). Orphan Medical, Minnetonka, MN.
9	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
10	Product Information. Ultane (sevoflurane). Abbott Pharmaceutical, Abbott Park, IL.
11	Inagaki Y, Kuzukawa A "Effects of epidural and intravenous buprenorphine on halothane minimum alveolar anesthetic concentration and hemodynamic responses." Anesth Analg 84 (1997): 100-5
12	Cerner Multum, Inc. "Australian Product Information.".
13	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
14	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
15	Kronenfeld MA, Thomas SJ, Turndorf H "Recurrence of neuromuscular blockade after reversal of vecuronium in a patient receiving polymyxin/amikacin sternal irrigation." Anesthesiology 65 (1986): 93-4. [PMID: 2873764]
16	Mirakhur RK, Ferres CJ, Clarke RS, Bali IM, Dundee JW. Clinical evaluation of Org NC 45. Br J Anaesth. 1983 Feb;55(2):119-24.
17	Withington DE, Donati F, Bevan DR, Varin F "Potentiation of atracurium neuromuscular blockade by enflurane: time-course of effect." Anesth Analg 72 (1991): 469-73
18	Ziegler CH, Lovette JB "Operative complications after therapy with reserpine and reserpine compounds." JAMA 176 (1961): 114-7
19	Jahr JS, Weber S "Ventricular dysrhythmias following an alfentanil anesthetic in a patient on reserpine for hypertension." Acta Anaesthesiol Scand 35 (1991): 788-9

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence