Details of Drug

Drug General Information (ID: D1139)
Drug Name	Nintedanib
Drug Type	Small molecule
Drug Synonymous	Nintedanib; Vargatef; 656247-17-5; BIBF-1120; BIBF 1120; 928326-83-4; BIBF1120; Nintedanib (BIBF 1120); OFEV; UNII-G6HRD2P839; (Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate; G6HRD2P839; CHEBI:85164; 1160294-26-7; Methyl (3z)-3-{[(4-{methyl[(4-Methylpiperazin-1-Yl)acetyl]amino}phenyl)amino](Phenyl)methylidene}-2-Oxo-2,3-Dihydro-1h-Indole-6-Carboxylate Click to Show/Hide
Disease Class	2B91: Colorectal cancer; CB03: Idiopathic interstitial pneumonitis; 2C73: Ovarian cancer; 2C25: Lung cancer; 2C51: Peritoneal cancer
Therapeutic Class	Multikinase Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C31H33N5O4
InChI	1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,33,38H,15-18,20H2,1-3H3
InChIKey	CPMDPSXJELVGJG-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O
External Link
	Pubchem ID	135423438
	CAS Number	656247-17-5
	CHEBI ID	85164
	TTD ID	D09HNV
	VARIDT ID	DR00137

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM050 Increased risk of bleeding BM055 Increased risk of hepatotoxicity
Relation Graph

Full list of drugs interacting with Nintedanib
Affected cellular transport
	Transporter inhibition					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[14], [45], [46]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[14], [50]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[51]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[13], [14], [53]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[14], [54]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[56]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[60]
	Transporter induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[1]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[14], [47]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[1]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[1]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[1]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[1]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[1]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[1]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[1]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[1]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[1]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[1]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[1]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[1]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[1]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[44]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[48]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[52]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[13], [14], [55]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[57], [58], [59]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[1]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[1]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[1]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[1]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[1]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[1]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[1]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[1]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[1]
	CYP450 enzyme induction					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[1]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[3], [8], [1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[3], [8], [1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[26]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[32], [13], [14], [33]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[13], [14], [42], [43]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[13], [49]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[13], [14], [61]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[13], [14], [62], [61]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[14], [63]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[13], [14], [61]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 45
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[2]
D0005		Abciximab	NA	NA	Moderate		Inter Info	[1]
D0047		Alteplase	NA	NA	Moderate		Inter Info	[1]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[1]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[1]
D0088		Anistreplase	NA	NA	Moderate		Inter Info	[1]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[1]
D0102		Ardeparin	C26H42N2O37S5	772	Moderate		Inter Info	[1]
D0104		Argatroban	C23H36N6O5S	92722	Moderate		Inter Info	[1]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[1]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Moderate		Inter Info	[1]
D0250		Caplacizumab	NA	NA	Moderate		Inter Info	[1]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[1]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[1]
D0414		Dalteparin	C26H42N2O37S5	772	Moderate		Inter Info	[1]
D0435		Defibrotide	C20H21N4O6P	135565962	Moderate		Inter Info	[1]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[28], [29]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[1]
D0506		Dipyridamole	C24H40N8O4	3108	Moderate		Inter Info	[1]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Moderate		Inter Info	[1]
D0574		Enoxaparin	C26H42N2O37S5	772	Moderate		Inter Info	[1]
D0588		Eptifibatide	C35H49N11O9S2	448812	Moderate		Inter Info	[1]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Moderate		Inter Info	[1]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[34]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[1]
D0904		Lepirudin	C287H440N80O111S6	118856773	Moderate		Inter Info	[1]
D0092		Antithrombin Alfa	NA	NA	Moderate		Inter Info	[1]
D0093		Antithrombin III human	NA	NA	Moderate		Inter Info	[1]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[1]
D0447		Desirudin	C287H440N80O110S6	16129703	Moderate		Inter Info	[1]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[1]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[1]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[28], [64]
D1328		Prasugrel	C20H20FNO3S	6918456	Moderate		Inter Info	[1]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[1]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[1]
D1506		Streptokinase	C11H19NO2	9815560	Moderate		Inter Info	[1]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[1]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[1]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[1]
D1588		Tinzaparin	C26H42N2O37S5	772	Moderate		Inter Info	[1]
D1593		Tirofiban	C22H36N2O5S	60947	Moderate		Inter Info	[1]
D1669		Urokinase	NA	NA	Moderate		Inter Info	[1]
D1705		Vorapaxar	C29H33FN2O4	10077130	Moderate		Inter Info	[1]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[1]
	Increased risk of hepatotoxicity					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[3], [4], [5]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[6]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[7]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[9]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[3], [4], [5]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[23]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[24]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[14], [25]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[27]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[30], [31]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[35]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[36], [37], [38], [39]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[36], [37], [38], [39]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[14], [40]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[41]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[36], [37], [38], [39]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[65], [66]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[14], [67]

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