Details of Drug

Drug General Information (ID: D1132)
Drug Name	Nicotinamide
Drug Type	Small molecule
Drug Synonymous	Aminicotin; Amixicotyn; Amnicotin; Benicot; Dipegyl; Endobion; Enduramide; Hansamid; Mediatric; Niacevit; Niacinamide; Niacotinamide; Niamide; Nicamina; Nicamindon; Nicasir; Nicobion; Nicofort; Nicogen; Nicomidol; Nicosylamide; Nicota; Nicotamide; Nicotilamide; Nicotililamido; Nicotinamid; Nicotinamida; Nicotinamidum; Nicotinsaeureamid; Nicotinsaureamid; Nicotol; Nicotylamide; Nicotylamidum; Nicovit; Nicovitina; Nicovitol; Nicozymin; Nikasan; Nikazan; Nikotinamid; Nikotinsaeureamid; Niocinamide; Niozymin; Papulex; Pelmin; Pelmine; Savacotyl; Amid kyseliny nikotinove; Amid kyseliny nikotinove [Czech]; Amide PP; Astra Brand of Niacinamide; Austrovit PP; Delonin amide; Factor pp; Inovitan PP; Jenapharm Brand of Niacinamide; Merck Brand of Niacinamide; Niacinamide Astra Brand; Niacinamide Jenapharm Brand; Niacinamide Merck Brand; Niacinamide Pharmagenix Brand; Niacinamide [USAN]; Niavit PP; Nicotine acid amide; Nicotine amide; Nicotinic acid amide; Nicotinic amide; Nicotinsaureamid Jenapharm; Nicotinsaureamid [German]; Nikotinsaeureamid [German]; Pelonin amide; Pharmagenix Brand of Niacinamide; Vitamin B; Vitamin PP; Witamina PP; Nicosan 2; Vitamin H1; B 3, Vitamin; B3, Vitamin; Beta-Pyridinecarboxamide; Jenapharm, Nicotinsaureamid; Nandervit-N; Niacin-Vitamin B3; Niacinamide (USP); Nicotinamida [INN-Spanish]; Nicotinamide (Niacinamide); Nicotinamidum [INN-Latin]; Niko-tamin; PP-Faktor; Vi-Nicotyl; Vitamin B (VAN); M-(Aminocarbonyl)pyridine; Niacinamide, Nicotinic acid amide, Nicotinamide; Nicotinamide (JP15/INN); Nicotinamide, niacin, vitamin B3; Nicotinamide-carbonyl-14C; Pyridine-3-carboxamide; Pyridine-3-carboxylic acid amide; 3 Pyridinecarboxamide; 3-Carbamoylpyridine; 3-Pyridinecarboxamide; 3-Pyridinecarboxylic acid amide Click to Show/Hide
Disease Class	EF20: Acquired cutaneous blood vessel malformation
Therapeutic Class	Antiinflammatory Agents
Structure
Structure	3D Structure		2D Structure
Formula	C6H6N2O
InChI	1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
InChIKey	DFPAKSUCGFBDDF-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CN=C1)C(=O)N
External Link
	Pubchem ID	936
	CAS Number	98-92-0
	CHEBI ID	17154
	TTD ID	D06NVJ

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM055 Increased risk of hepatotoxicity BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents
Relation Graph

Full list of drugs interacting with Nicotinamide
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Minor		Inter Info	[32], [33], [34]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[1], [2], [3]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[4]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[5]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[6]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[1], [2], [3]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[13]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[14], [15]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[11], [16], [17]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[18], [19], [20]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[18], [19], [20]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[16], [21], [22]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[23]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[24], [25]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[26]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[16], [27]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[24], [28]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[18], [19], [20]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[16], [29]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[10], [11], [12]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[30], [31]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[7], [8], [9]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[7], [8], [9]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[7], [8], [9]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[7], [8], [9]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[7], [8], [9]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[7], [8], [9]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[7], [8], [9]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[7], [8], [9]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[7], [8], [9]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[7], [8], [9]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [8], [9]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [8], [9]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [8], [9]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [8], [9]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [8], [9]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[7], [8], [9]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[7], [8], [9]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[7], [8], [9]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[7], [8], [9]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[7], [8], [9]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[7], [8], [9]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[7], [8], [9]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[7], [8], [9]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[7], [8], [9]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[7], [8], [9]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[7], [8], [9]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[7], [8], [9]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[7], [8], [9]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[7], [8], [9]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[7], [8], [9]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[7], [8], [9]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[7], [8], [9]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[7], [8], [9]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[7], [8], [9]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[7], [8], [9]
	Antagonize the effect of antihypertensive agents					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[7], [8], [9]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[7], [8], [9]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[7], [8], [9]

References
1	Canadian Pharmacists Association.
2	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
3	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
4	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
5	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
6	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
7	Jori A, Carrara MC "On the mechanism of the hyperglycaemic effect of chlorpromazine." J Pharm Pharmacol 18 (1966): 623-4. [PMID: 4381950]
8	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
9	Product Information. Thorazine (chlorpromazine). SmithKline Beecham, Philadelphia, PA.
10	Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
11	Cerner Multum, Inc. "Australian Product Information.".
12	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
13	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
14	Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
15	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
16	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
17	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
18	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
19	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
20	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
21	Nesher G, Mates M, Zevin S "Effect of caffeine consumption on efficacy of methotrexate in rheumatoid arthritis." Arthritis Rheum 48 (2003): 571-572. [PMID: 12571869]
22	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
23	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
24	Product Information. Hivid (zalcitabine). Roche Laboratories, Nutley, NJ.
25	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
26	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
27	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
28	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
29	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
30	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
31	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
32	Bourgeois BF, Dodson WE, Ferrendellis JA "Interactions between primidone, carbamazepine, and nicotinamide." Neurology 32 (1982): 1122-6. [PMID: 6214728]
33	Garg SK, Kumar N, Bhargava VK, Prabhakar SK "Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy." Clin Pharmacol Ther 64 (1998): 286-8. [PMID: 9757152]
34	Product Information. Tegretol (carbamazepine). Novartis Pharmaceuticals, East Hanover, NJ.

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