Details of Drug | MecDDI

Drug General Information (ID: D1131)
Drug Name		Niclosamide
Drug Type		Small molecule
Drug Synonymous		niclosamide; 50-65-7; Niclocide; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; Tredemine; Bayluscid; Phenasal; Yomesan; Fenasal; Dichlosale; Helmiantin; Sagimid; Iomezan; Devermine; Atenase; Vermitid; Radeverm; Mansonil; Iomesan; Devermin; Cestocid; Sulqui; Lintex; Nasemo; Mato; Fedal-Telmin; Bayer 73; Radewerm; Zestocarp; Bayer 2353; 2',5-Dichloro-4'-nitrosalicylanilide; Chemagro 2353; BAY 2353; Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-; 5-Chloro-2'-chloro-4'-nitrosalicylanilide; nicolsamide; HL 2447; Niclosamidum [I Click to Show/Hide
Disease Class		1F70-1F76: Cestodes infection
Therapeutic Class		Anthelmintics
Structure
Structure		3D Structure				2D Structure
Formula		C13H8Cl2N2O4
InChI		1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChIKey		RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Canonical SMILES		C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
External Link
		Pubchem ID		4477
		CAS Number		50-65-7
		CHEBI ID		7553
		TTD ID		D0J9ZR
		INTEDE ID		DR1146

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism BM017 CYP450 enzyme inhibition
Relation Graph

Full list of drugs interacting with Niclosamide
Affected intra/extra-hepatic metabolism
					CYP450 enzyme inhibition																																																																Drug Num: 6
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D1596															Tizanidine															C9H8ClN5S															5487															Major															Inter Info													[1], [2], [3], [4], [5], [6], [7], [8]
D0043															Alosetron															C17H18N4O															2099															Moderate															Inter Info													[9]
D0157															Bendamustine															C16H21Cl2N3O2															65628															Moderate															Inter Info													[10]
D0539															Duloxetine															C18H19NOS															60835															Moderate															Inter Info													[11], [12], [13], [14]
D1378															Ramelteon															C16H21NO2															208902															Moderate															Inter Info													[15]
D1427															Ropinirole															C16H24N2O															5095															Moderate															Inter Info													[16], [17]

References
1	Granfors MT, Backman JT, Laitila J, Neuvonen PJ "Tizanidine is mainly metabolized by cytochrome P450 1A2 in vitro." Br J Clin Pharmacol 57 (2004): 349-53. [PMID: 14998432]
2	Granfors MT, Backman JT, Neuvonen M, Ahonen J, Neuvonen PJ "Fluvoxamine drastically increases concentrations and effects of tizanidine: A potentially hazardous interaction." Clin Pharmacol Ther 75 (2004): 331-41. [PMID: 15060511]
3	Granfors MT, Backman JT, Neuvonen M, Neuvonen PJ "Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism." Clin Pharmacol Ther 76 (2004): 598-606. [PMID: 15592331]
4	Momo K, Doki K, Hosono H, Homma M, Kohda Y "Drug interaction of tizanidine and fluvoxamine." Clin Pharmacol Ther 76 (2004): 509-10. [PMID: 15536467]
5	Momo K, Homma M, Kohda Y, Ohkoshi N, Yoshizawa T, Tamaoka A "Drug interaction of tizanidine and ciprofloxacin: Case report." Clin Pharmacol Ther 80 (2006): 717-9. [PMID: 17178273]
6	Product Information. Vioxx (rofecoxib). Merck & Co, Inc, West Point, PA.
7	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
8	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
9	Product Information. Lotronex (alosetron). Glaxo Wellcome, Research Triangle Park, NC.
10	Product Information. Treanda (bendamustine). Cephalon Inc, West Chester, PA.
11	Brosen K, Skjelbo E, Rasmussen BB, Poulsen HE, Loft S "Fluvoxamine is a potent inhibitor of cytochrome P4501A2." Biochem Pharmacol 45 (1993): 1211-4. [PMID: 8466541]
12	Martinez C, Albet C, Agundez JA, et al. "Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2-receptor antagonists." Clin Pharmacol Ther 65 (1999): 369-76. [PMID: 10223772]
13	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
14	Uwe F, Strobl G, Manaut F, et al "Quinolone antibacterial agents: relationship between structure and in vitro inhibition of the human cytochrome P450 isofaorm CYP1A2." Mol Pharmacol 43 (1993): 191-9. [PMID: 8429824]
15	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
16	Product Information. Noroxin (norfloxacin). Merck & Co, Inc, West Point, PA.
17	Product Information. Requip (ropinirole). SmithKline Beecham, Philadelphia, PA.