Details of Drug

Drug General Information (ID: D1128)
Drug Name	Nevirapine
Drug Type	Small molecule
Drug Synonymous	NEV; NVP; Viramune; Cahill May Roberts Brand of Nevirapine; Promeco Brand of Nevirapine; BI RG 587; BIRG 0587; BIRG 587; BIRG587; BIRG-0587; BIRG-587; NON-NUCLEOSIDE RT INHIBITOR NEVIRAPINE; Nevirapine & PRO 140; Nevirapine [USAN:INN]; Viramune (TN); Viramune(TM); BI-RG-587; Nevirapine & CD4-IgG; Nevirapine (JAN/USP/INN); Viramune, BI-RG 587, Nevirapine; BI-RG-587 & CD4-IgG; N11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one & CD4-immunoadhesin; 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE; 11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one; 11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one & PRO 140 (Anti-CCR5 monoclonal antibody); 11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one; 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one Click to Show/Hide
Disease Class	1C60-1C62: Human immunodeficiency virus disease
Therapeutic Class	Anti-Hiv Agents
Structure
Structure	3D Structure		2D Structure
Formula	C15H14N4O
InChI	1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
InChIKey	NQDJXKOVJZTUJA-UHFFFAOYSA-N
Canonical SMILES	CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4
External Link
	Pubchem ID	4463
	CAS Number	129618-40-2
	CHEBI ID	63613
	TTD ID	D0O2EM
	INTEDE ID	DR1142
	VARIDT ID	DR00447

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM009 Altered absorption (Unspecific) BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM024 Competitive inhibition of metabolic enzyme BM055 Increased risk of hepatotoxicity
Relation Graph

Full list of drugs interacting with Nevirapine
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1187		Orlistat	C29H53NO5	3034010	Moderate		Inter Info	[335]
Affected cellular transport
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[4], [5], [7], [8], [9]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[40]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[114], [115]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[126]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[143]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[4], [5], [7], [25], [174], [72], [175], [56], [176], [9]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[181]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[231]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[4], [5], [174], [72], [9]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[234], [235]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[236], [56], [9], [237]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[270]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[288], [4], [289], [290], [291], [292], [293], [294], [295]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[4], [5], [306]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[325], [326]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[5]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[379]
D1328		Prasugrel	C20H20FNO3S	6918456	Minor		Inter Info	[5], [451]
	CYP450 enzyme induction					Drug Num: 308
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2], [3]
D0108		Artemether	C16H26O5	68911	Major		Inter Info	[4], [5], [6]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[5], [10]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[11], [12], [13]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[4], [5], [14]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[15]
D0268		Caspofungin	C52H88N10O15	2826718	Major		Inter Info	[16]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[4], [5], [17]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[4], [18]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[5]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Major		Inter Info	[19], [20], [21]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Major		Inter Info	[22]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[23]
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[24]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[25]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[26], [4], [5], [27], [28], [29], [11], [12], [13], [30]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[31]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[5], [32], [33]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[26], [4], [5], [27], [28], [29], [11], [12], [13], [30]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[34]
D0948		Lopinavir	C37H48N4O5	92727	Major		Inter Info	[35], [36], [37]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[38]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[39]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[4], [42]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[4], [5], [43]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[26], [4], [5], [27], [28], [29], [11], [12], [13], [30]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[26], [4], [5], [27], [28], [29], [11], [12], [13], [30]
D1227		Paritaprevir	C40H43N7O7S	45110509	Major		Inter Info	[4], [5], [44]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[5], [45]
D1336		Pretomanid	C14H12F3N3O5	456199	Major		Inter Info	[47]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[48]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[5], [49], [50]
D1407		Rimegepant	C28H28F2N6O3	51049968	Major		Inter Info	[51]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[5], [53]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[54]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[55], [56]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[4], [57]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[58]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [36], [70], [71], [72], [8], [73], [74], [75], [50], [76]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[77]
D1686		Velpatasvir	C49H54N8O8	67683363	Major		Inter Info	[5], [80], [46]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[81]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[82]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[83]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[4], [5], [9], [95]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[4], [5], [9], [95]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[4], [5], [9], [95]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[4], [5], [9], [95]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[59], [35], [116], [117], [118], [119], [66], [70], [9], [120], [76]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[125], [56]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[127]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[4], [5], [9], [95]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[128]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[4], [5], [9], [95]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[129], [130], [131], [132]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[133]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[4], [5], [9], [95]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[4], [5], [9], [95]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[59], [35], [116], [117], [118], [119], [66], [70], [9], [120], [76]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[134]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[135]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[136], [137]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[138]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[139], [140]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[4], [5], [9], [95]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[4], [5], [9], [95]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[125], [56]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[141]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[4], [5], [9], [95]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[4], [5], [9], [95]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[5], [144], [145]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[146], [147]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[4], [5], [148]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[149]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[4], [5], [9], [95]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[151]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[4], [152], [5], [153], [154], [155], [156], [157], [56], [158], [159], [160]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[161], [162], [163]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[164]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[4], [5], [165], [166]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[168], [169], [9]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[170]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[171]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[172]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[125], [56]
D0342		Cisapride	C23H29ClFN3O4	6917698	Moderate		Inter Info	[4], [5], [9], [95]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[35], [9]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[4], [5], [9], [95]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[5], [9], [95]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[177], [4], [152], [5], [178], [179], [180]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [61], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[228]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[152], [5], [229]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[4], [5], [9], [95]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[4], [5], [9], [95]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[5], [230]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[232]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[233]
D0450		Desogestrel	C22H30O	40973	Moderate		Inter Info	[35], [238], [9]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[4], [5], [9], [95]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[177], [4], [5]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[190], [239], [240], [56], [217]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[4], [5], [9], [95]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[241]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[4], [5], [9], [95]
D0527		Doxercalciferol	C28H44O2	5281107	Moderate		Inter Info	[4], [5], [9], [95]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[5], [242], [243], [244]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[242], [243], [244]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[245]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[35], [198], [9]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[4], [5], [9], [95]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[246]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[4], [247]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[248]
D0556		Elbasvir	C49H55N9O7	71661251	Moderate		Inter Info	[249]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[250]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Moderate		Inter Info	[4], [5], [251]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[252]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[253]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[4], [5], [9], [95]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[4], [5], [255]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[4], [5], [255]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[256], [257]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[4], [5], [9], [95]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [61], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [61], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[186], [196], [220]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [61], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[258]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[35], [238], [9]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[4], [5], [9], [95]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[35], [198], [9]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[4], [5], [9], [95]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[4], [5], [259]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[260]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[4], [5], [9], [95]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[4], [5], [9], [95]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[261]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[262]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[4], [5], [9], [95]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[4], [5], [9], [95]
D0683		Fluticasone	C22H27F3O4S	5311101	Moderate		Inter Info	[4], [5], [9], [95]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[59], [35], [116], [117], [118], [119], [66], [70], [9], [120], [76]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[256], [265]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[266]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[267]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[4], [5], [9], [95]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Moderate		Inter Info	[4], [5], [9], [95]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[4], [5], [9], [95]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[4], [5], [9], [95]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[268]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[4], [5], [9], [95]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[272], [273], [278]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[286]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[4], [5], [9], [95]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[4], [5], [9], [95]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[287]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[5], [296]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[297], [298], [299], [300]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[4], [5], [9], [95]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[301]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[302]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[4], [5], [303]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[4], [5], [304]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[305]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[4], [5], [9], [95]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[4], [5], [9], [95]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[35], [198], [9]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[307]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[4], [5], [9], [95]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[4], [5], [308]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[309]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[310], [311]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[312], [313], [227]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[314]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[186], [196], [220]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[35], [238], [9]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[315], [35], [316], [317], [318], [319], [320], [321]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[4], [5], [255]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[4], [5], [9], [95]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[4], [5], [255]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[4], [5], [9], [95]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[323], [324]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[327], [328], [329], [330]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[139], [140]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[331]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[4], [5], [9], [95]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[332]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[4], [5], [9], [95]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[4], [5], [9], [95]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[334]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[4], [5], [9], [95]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[4], [5], [9], [95]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[26], [4], [5]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[35], [238], [9]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[35], [198], [9]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[4], [5], [9], [95]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[336]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[337]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[338], [339], [340]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[4], [5], [9], [95]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[341], [342], [343], [344]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[341], [342], [343]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[4], [5], [345]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[346]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[4], [5], [9], [95]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[347]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[5], [348]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[168], [9]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[349]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[5], [350]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[4], [5], [9], [95]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[4], [5], [351]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[352]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[353], [4], [354], [355]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[4], [5], [9], [95]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[4], [5], [9], [95]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [61], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[186], [196], [220]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[4], [356], [357], [358], [359]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [61], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[4], [5], [9], [95]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[360], [361], [13], [362], [363], [364]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[4], [5], [9], [95]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[365]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[369], [370], [371]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[4], [5], [372]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[373], [374]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[375]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[4], [376]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[377]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[5], [378]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[4], [5], [9], [95]
D1428		Ropivacaine	C17H26N2O	175805	Moderate		Inter Info	[4], [5], [9], [95]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[380]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[59], [35], [116], [117], [118], [119], [66], [70], [9], [120], [76]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[381]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[4], [5], [9], [95]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[4], [5], [382]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[125], [56]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[4], [5], [383], [384]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[385]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[4], [5], [386]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[4], [5], [387], [386]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[388]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[5], [389], [390]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[4], [5], [391]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[392]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[4], [5], [383], [384]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[5], [393], [394]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[395], [396], [397], [398]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[4], [5], [9], [95]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[146], [147]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[399], [400]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[5], [401]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[4], [5], [402]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[4], [5], [9], [95]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[4], [5], [9], [95]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[4], [5], [9], [95]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[4], [5], [9], [95]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[26], [5], [403], [404], [405]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[4], [5], [9], [95]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[4], [5], [9], [95]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[4], [408]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[4], [5], [9], [95]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[5], [409]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[410], [4], [5], [396], [411]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[4], [5], [9], [95]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[4], [5], [9], [95]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[4], [5], [9], [95]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[4], [5], [9], [95]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[4], [5], [9], [95]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[413]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[414]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[5], [415]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[416]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[4], [5], [9], [95]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[4], [5], [9], [95]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[4], [5], [9], [95]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[417]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[4], [5], [9], [95]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[4], [5], [9], [95]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[5], [9], [95]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[418]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[419]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[419]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[419]
D1705		Vorapaxar	C29H33FN2O4	10077130	Moderate		Inter Info	[4], [5], [9], [95]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[420]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[421]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[4], [5], [9], [95]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[5], [422], [423], [424]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[425], [426]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[125], [56]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[427], [428], [429], [430]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[4], [5], [386]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[431], [432], [433], [434], [435], [436], [437]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[5], [438], [439], [440], [441]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[442]
D0178		Bexarotene	C24H28O2	82146	Minor		Inter Info	[398]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[443], [297], [300]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[444]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[445]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[446], [447], [448], [449]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[450]
D1399		Rifabutin	C46H62N4O11	135398743	Minor		Inter Info	[35], [453], [9], [454]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[455], [456]
	UGT induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1435		Sacituzumab govitecan	C76H104N12O24S	91668186	Major		Inter Info	[52]
D1377		Raltegravir	C20H21FN6O5	54671008	Minor		Inter Info	[26], [4], [5], [452]
	Competitive inhibition of metabolic enzyme					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[4], [263], [264]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[41]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[46]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[26], [78], [79]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[84], [85], [86], [4], [5], [87], [88], [89], [90], [91], [92], [93], [94]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[121], [122], [123], [124]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[121], [122], [123], [124]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[84], [85], [86], [4], [5], [87], [88], [89], [90], [91], [92], [93], [94]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[142]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[150]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[84], [85], [86], [4], [5], [87], [88], [89], [90], [91], [92], [93], [94]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[5], [167]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[173]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[4], [5], [254]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[269]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[5], [322]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[333]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[121], [122], [123], [124]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[4], [5], [366], [367], [368]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[406], [407]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[5], [412]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[84], [85], [86], [4], [5], [87], [88], [89], [90], [91], [92], [93], [94]

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158	Product Information. Wellbutrin (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
159	Product Information. Wellbutrin SR (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
160	Product Information. Zyban (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
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164	Product Information. Jevtana (cabazitaxel). sanofi-aventis , Bridgewater, NJ.
165	Product Information. Cabometyx (cabozantinib). Exelixis Inc, S San Francisco, CA.
166	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
167	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
168	L'homme RF, Dijkema T, van der Ven AJ, Burger DM "Enzyme inducers reduce elimination half-life after a single dose of nevirapine in healthy women." J Acquir Immune Defic Syndr 43 (2006): 193-6. [PMID: 16940857]
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170	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
171	Product Information. Xcopri (cenobamate). SK Life Science, Inc., Paramus, NJ.
172	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
173	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
174	Product Information. Prezcobix (cobicistat-darunavir). Janssen Pharmaceuticals, Titusville, NJ.
175	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
176	Product Information. Tybost (cobicistat). Gilead Sciences, Foster City, CA.
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178	Product Information. Acetaminophen-Codeine Phosphate (acetaminophen-codeine). Qualitest Pharmaceuticals Inc, Huntsville, ON.
179	Product Information. Codeine Sulfate (codeine). Lannett Company Inc, Philadelphia, PA.
180	Product Information. Tuzistra XR (chlorpheniramine-codeine). Vernalis Pharmaceuticals Inc, Morristown, NJ.
181	Product Information. Vaprisol (conivaptan). Cumberland Pharmaceuticals Inc, Nashville, TN.
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229	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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231	Product Information. Synercid (dalfopristin-quinupristin) Rhone-Poulenc Rorer, Collegeville, PA.
232	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
233	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
234	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
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243	Product Information. Doxil (doxorubicin liposomal). Sequis Pharmaceuticals Inc, Menlo Park, CA.
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251	Product Information. Vitekta (elvitegravir). Gilead Sciences, Foster City, CA.
252	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
253	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
254	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
255	Product Information. Methergine (methylergonovine). Novartis Pharmaceuticals, East Hanover, NJ.
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260	Product Information. Aromasin (exemestane) Pharmacia & Upjohn, Kalamazoo, MI.
261	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
262	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
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265	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
266	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
267	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
268	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
269	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
270	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
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281	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
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287	Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
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297	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
298	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
299	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
300	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
301	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
302	Product Information. Ninlaro (ixazomib). Takeda Pharmaceuticals America, Lincolnshire, IL.
303	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
304	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
305	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
306	Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
307	Product Information. Tradjenta (linagliptin). Boehringer Ingelheim, Ridgefield, CT.
308	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
309	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
310	Bruderer S, Aanismaa P, Homery MC, et al. "Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist." AAPS J 14 (2012): 68-78. [PMID: 22189899]
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313	Product Information. Provera (medroxyprogesterone). Pharmacia and Upjohn, Kalamazoo, MI.
314	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
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322	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
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326	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
327	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
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332	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
333	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
334	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
335	MHRA. Medicines and Healthcare Products Regulatory Agency "Orlistat: theoretical interaction with antiretroviral HIV medicines.".
336	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
337	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
338	Product Information. Trileptal (oxcarbazepine) Novartis Pharmaceuticals, East Hanover, NJ.
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342	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
343	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
344	Spencer CM, Faulds D "Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer." Drugs 48 (1994): 794-847. [PMID: 7530632]
345	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
346	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
347	Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
348	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
349	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
350	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
351	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
352	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
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354	Product Information. Biltricide (praziquantel). Bayer, West Haven, CT.
355	Ridtitid W, Wongnawa M, Mahatthanatrakul W, Punyo J, Sunbhanich M "Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers." Clin Pharmacol Ther 72 (2002): 505-13. [PMID: 12426514]
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357	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
358	Quetiapine for schizophrenia. Med Lett Drugs Ther 39 (1997): 117-8. [PMID: 9422044]
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361	Product Information. Qualaquin (quinine). AR Scientific Inc, Philadelphia, PA.
362	Pukrittayakamee S, Prakongpan S, Wanwimolruk S, Clemens R, Looareesuwan S, White NJ "Adverse effect of rifampin on quinine efficacy in uncomplicated falciparum malaria." Antimicrob Agents Chemother 47 (2003): 1509-1513. [PMID: 12709315]
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365	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
366	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
367	Gilead Sciences, Inc "About Remdesivir.".
368	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
369	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
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371	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
372	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
373	Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO.
374	Thijssen HH, Flin ois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Dispos 28 (2000): 1284-90. [PMID: 11038154]
375	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
376	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
377	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
378	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
379	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
380	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
381	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
382	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
383	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
384	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
385	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
386	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
387	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
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