Details of Drug

Drug General Information (ID: D1127)
Drug Name	Netupitant
Drug Type	Small molecule
Drug Synonymous	R-1124; NK1 antagonist (emesis), Roche; Ro-67-3189 Click to Show/Hide
Disease Class	MD90: Nausea/vomiting
Therapeutic Class	Antiemetics
Structure
Structure	3D Structure		2D Structure
Formula	C30H32F6N4O
InChI	1S/C30H32F6N4O/c1-19-8-6-7-9-23(19)24-17-26(40-12-10-38(4)11-13-40)37-18-25(24)39(5)27(41)28(2,3)20-14-21(29(31,32)33)16-22(15-20)30(34,35)36/h6-9,14-18H,10-13H2,1-5H3
InChIKey	WAXQNWCZJDTGBU-UHFFFAOYSA-N
Canonical SMILES	CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C
External Link
	Pubchem ID	6451149
	CAS Number	290297-26-6
	CHEBI ID	85155
	TTD ID	D0G3YC
	INTEDE ID	DR1141

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme
Relation Graph

Full list of drugs interacting with Netupitant
Affected cellular transport
	Transporter inhibition					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[3], [4], [97]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[112]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[121]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 144
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0128		Avanafil	C23H26ClN7O3	9869929	Major		Inter Info	[1], [2]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[3], [4], [5]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[6], [7]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[4], [10], [11]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[4], [12]
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[13], [14], [15]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[16]
D0585		Eplerenone	C24H30O6	443872	Major		Inter Info	[17]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[18]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[19]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[4], [20], [21]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[22], [23], [24]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[4], [25], [26]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[27], [7]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[3], [28], [29]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[7]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[30]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[31]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[4], [32]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[33], [34]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[3], [4], [35]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[4], [36]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[37]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[4], [38]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[39]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[40]
D1104		Naloxegol	C34H53NO11	56959087	Major		Inter Info	[4], [41]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[42], [3], [43]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[3], [4], [44]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[45]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[46]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[47], [7]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[48]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[49]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[3], [4], [50]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[51]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[3], [4], [52]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[53], [54]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[55]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[56], [4], [57]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[56], [4], [58]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[4], [59]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[60], [61]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[62], [63], [64]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[65], [66], [67]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[4], [68]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[70], [3], [4]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[70], [3], [4]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[71]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[4], [72]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[65], [66], [67]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[73]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[4], [74]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[8], [9]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[75], [76], [77]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[78], [79], [80]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[81]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[75], [76], [77]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[75], [76], [77]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[82], [83], [84]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[85]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[86]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[60], [61]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[87], [88]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[4], [89]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[3], [4], [90]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[3], [4], [90]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[91]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[92]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[4], [93]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[65], [66], [67]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[94]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[75], [76], [77]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[75], [76], [77]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[95]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[96]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[98]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[99]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[3], [4], [100]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[101]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[103]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[4], [104], [105]
D0683		Fluticasone	C22H27F3O4S	5311101	Moderate		Inter Info	[3], [106], [107]
D0684		Fluticasone (nasal)	C22H27F3O4S	5311101	Moderate		Inter Info	[3], [106], [107]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[108]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[3], [4], [109]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[110]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[56], [4], [58]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[4], [111]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[4], [113]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[4], [114]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[115]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[116]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[117]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[3], [118], [119]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[122]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[124]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[125]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[126], [127], [3]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[126], [127], [3]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[128]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[129], [7], [130]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[131], [132], [133]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[3], [4], [134]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[4], [135], [136]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[137], [138], [139]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[140]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[65], [66], [67]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[3], [141], [142]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[3], [141], [142]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[143], [1]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[144], [145], [146]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[147]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[4], [148]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[3], [4], [149]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[150], [151]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[152]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[4], [153], [154]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[155], [156], [34]
D0080		Amprenavir	C25H35N3O6S	65016	Minor		Inter Info	[8]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[3], [157], [158]
D0116		Atazanavir	C38H52N6O7	148192	Minor		Inter Info	[8]
D0192		Boceprevir	C27H45N5O5	10324367	Minor		Inter Info	[8]
D0386		Conivaptan	C32H26N4O2	151171	Minor		Inter Info	[8]
D0439		Delavirdine	C22H28N6O3S	5625	Minor		Inter Info	[8]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Minor		Inter Info	[8]
D0799		Indinavir	C36H47N5O4	5362440	Minor		Inter Info	[8]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[159]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[3], [157], [158]
D1119		Nelfinavir	C32H45N3O4S	64143	Minor		Inter Info	[8]
D0248		Cannabidiol	C21H30O2	644019	Minor		Inter Info	[4], [160]
D0375		Cobicistat	C40H53N7O5S2	25151504	Minor		Inter Info	[8]
D0425		Darolutamide	C19H19ClN6O2	67171867	Minor		Inter Info	[161]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[162]
D0638		Fedratinib	C27H36N6O3S	16722836	Minor		Inter Info	[163], [118], [164]
D0789		Idelalisib	C22H18FN7O	11625818	Minor		Inter Info	[8]
D1653		Troleandomycin	C41H67NO15	202225	Minor		Inter Info	[8]
D1660		Tucatinib	C26H24N8O2	51039094	Minor		Inter Info	[8]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[165]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[166]
D1415		Ritonavir	C37H48N6O5S2	392622	Minor		Inter Info	[8]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[167], [168], [169]
D1434		Ruxolitinib	C17H18N6	25126798	Minor		Inter Info	[4], [170]
D1541		Telaprevir	C36H53N7O6	3010818	Minor		Inter Info	[8]
	CYP450 enzyme induction					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[3], [8], [9]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[3], [8], [9]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[3], [8], [9]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[3], [8], [9]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[3], [8], [9]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[3], [8], [9]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[3], [8], [9]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[3], [8], [9]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[3], [8], [9]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[3], [8], [9]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[3], [8], [9]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[69]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[3], [102]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[3], [4], [120]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[3], [4], [120]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[4], [123]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[3], [4], [120]
	Competitive inhibition of metabolic enzyme					Drug Num: 79
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[3], [8], [9]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[3], [8], [9]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[3], [8], [9]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[3], [8], [9]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[3], [8], [9]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[3], [8], [9]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[3], [8], [9]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[3], [8], [9]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[3], [8], [9]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[3], [8], [9]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[3], [8], [9]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[3], [8], [9]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[3], [8], [9]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[3], [8], [9]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[3], [8], [9]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[3], [8], [9]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[3], [8], [9]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[3], [8], [9]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[3], [8], [9]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[3], [8], [9]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[3], [8], [9]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[3], [8], [9]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[3], [8], [9]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[3], [8], [9]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[3], [8], [9]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[3], [8], [9]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[3], [8], [9]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[3], [8], [9]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[3], [8], [9]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[3], [8], [9]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[3], [8], [9]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[3], [8], [9]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[3], [8], [9]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[3], [8], [9]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[3], [8], [9]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[3], [8], [9]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[3], [8], [9]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[3], [8], [9]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[3], [8], [9]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[3], [8], [9]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[3], [8], [9]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[3], [8], [9]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[3], [8], [9]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[3], [8], [9]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[3], [8], [9]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[3], [8], [9]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[3], [8], [9]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[3], [8], [9]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[3], [8], [9]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[3], [8], [9]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[3], [8], [9]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[3], [8], [9]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[3], [8], [9]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[3], [8], [9]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[3], [8], [9]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[3], [8], [9]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[3], [8], [9]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[3], [8], [9]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[3], [8], [9]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[3], [8], [9]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[3], [8], [9]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[3], [8], [9]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[3], [8], [9]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[3], [8], [9]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[3], [8], [9]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[3], [8], [9]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[3], [8], [9]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[3], [8], [9]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[3], [8], [9]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[3], [8], [9]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[3], [8], [9]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[3], [8], [9]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[3], [8], [9]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[3], [8], [9]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[3], [8], [9]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[3], [8], [9]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[3], [8], [9]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[3], [8], [9]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[3], [8], [9]

References
1	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
2	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
3	Cerner Multum, Inc. "Australian Product Information.".
4	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
6	Product Information. Butorphanol Tartrate (butorphanol). Apotex Corporation, Weston, FL.
7	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
8	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
9	Product Information. Akynzeo for Injection (fosnetupitant-palonosetron). Helsinn Therapeutics Inc, Woodbridge Township, NJ.
10	Suri A, Bramer SL "Effect of omeprazole on the metabolism of cilostazol." Clin Pharmacokinet 37 (1999): 53-9. [PMID: 10702887]
11	Suri A, Forbes WP, Bramer SL "Effects of CYP3A inhibition on the metabolism of cilostazol." Clin Pharmacokinet 37 (1999): 61-8. [PMID: 10702888]
12	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
13	Dogukan A, Oymak FS, Taskapan H, Guven M, Tokgoz B, Utas C "Acute fatal colchicine intoxication in a patient on continuous ambulatory peritoneal dialysis (CAPD). Possible role of clarithromycin administration." Clin Nephrol 55 (2001): 181-2. [PMID: 11269688]
14	Severe colchicine-macrolide interactions. Prescrire Int 12 (2003): 18-9. [PMID: 12602385]
15	Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ "Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation." Biochem Pharmacol 53 (1996): 111-6. [PMID: 8960070]
16	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
17	Product Information. Inspra (eplerenone). Searle, Chicago, IL.
18	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
19	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
20	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
21	Product Information. Tenex (guanfacine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
22	Hutchinson MR, Menelaou A, Foster DJ, Coller JK, Somogyi AA "CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes." Br J Clin Pharmacol 57 (2004): 287-97. [PMID: 14998425]
23	Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.
24	Vizcaychipi MP, Walker S, Palazzo M "Serotonin syndrome triggered by tramadol." Br J Anaesth 99 (2007): 919. [PMID: 18006535]
25	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
26	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
27	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
28	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
29	Product Information. Sporanox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
30	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
31	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
32	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
33	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
34	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
35	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
36	Product Information. Emflaza (deflazacort). Marathon Pharmaceuticals, Deerfield, IL.
37	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
38	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
39	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
40	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
41	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
42	Abbas R, Hug BA, Leister C, Burns J, Sonnichsen D "Pharmacokinetics of oral neratinib during co-administration of ketoconazole in healthy subjects." Br J Clin Pharmacol 71 (2011): 522-7. [PMID: 21395644]
43	Product Information. Nerlynx (neratinib). Puma Biotechnology, Inc., Los Angeles, CA.
44	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
45	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
46	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
47	Multum Information Services, Inc. Expert Review Panel.
48	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
49	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
50	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
51	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
52	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
53	European Medicines Agency "CHMP Assessment Report for Latixa. International nonproprietary name: ranolazine.".
54	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
55	Product Information. Belsomra (suvorexant). Merck &amp Company Inc, Whitehouse Station, NJ.
56	Canadian Pharmacists Association.
57	Tapaninen T, Backman JT, Kurkinen K, Neuvonen P, Niemi M "Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren." J Clin Pharmacol 51 (2011): 359-67. [PMID: 20400651]
58	Sasaki M, Maeda A, Fujimura A "Influence of diltiazem on the pharmacokinetics of amlodipine in elderly hypertensive patients." Eur J Clin Pharmacol 57 (2001): 85-6. [PMID: 11372598]
59	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
60	Product Information. Emend (aprepitant). Merck &amp Company Inc, West Point, PA.
61	Product Information. Emend for Injection (fosaprepitant). Merck &amp Company Inc, West Point, PA.
62	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
63	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
64	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
65	Andreou ER, Ledger S "Potential drug interaction between simvastatin and danazol causing rhabdomyolysis." Can J Clin Pharmacol 10 (2003): 172-4. [PMID: 14712320]
66	Ayanian JZ, Fuchs CS, Stone RM "Lovastatin and rhabdomyolysis." Ann Intern Med 109 (1988): 682-3. [PMID: 3421582]
67	Yeo KR, Yeo WW, Wallis EJ, Ramsay LE "Enhanced cholesterol reduction by simvastatin in diltiazem-treated patients." Br J Clin Pharmacol 48 (1999): 610-5. [PMID: 10583033]
68	Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
69	Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
70	Bolland MJ, Bagg W, Thomas MG, Lucas JA, Ticehurst R, Black PN "Cushing's syndrome due to interaction between inhaled corticosteroids and itraconazole." Ann Pharmacother 38 (2004): 46-9. [PMID: 14742792]
71	Product Information. Jevtana (cabazitaxel). sanofi-aventis , Bridgewater, NJ.
72	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
73	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
74	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
75	Francis H, Tyndall A, Webb J "Severe vascular spasm due to erythromycin-ergotamine interaction." Clin Rheumatol 3 (1984): 243-6. [PMID: 6236021]
76	Horowitz RS, Dart RC, Gomez HF "Clinical ergotism with lingual ischemia induced by clarithromycin-ergotamine interaction." Arch Intern Med 156 (1996): 456-8. [PMID: 8607732]
77	Spiegel M, Schmidauer C, Kampfl A, Sarcletti M, Poewe W "Cerebral ergotism under treatment with ergotamine and ritonavir." Neurology 57 (2001): 743-4. [PMID: 11524501]
78	Aronson JK, Grahame-Smith DG "Clinical pharmacology: adverse drug interactions." Br Med J 282 (1981): 288-91. [PMID: 6779990]
79	Product Information. Taxotere (docetaxel). Rhone-Poulenc Rorer, Collegeville, PA.
80	Starr SP, Hammann F, Gotta V, et al. "Pharmacokinetic interaction between taxanes and amiodarone leading to severe toxicity." Br J Clin Pharmacol 450 (2016): 22-27. [PMID: 27868228]
81	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
82	Becquemont L, Mouajjah S, Escaffre O, Beaune P, Funck-Bretano C, Jaillon P "Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism." Drug Metab Dispos 27 (1999): 1068-73. [PMID: 10460808]
83	Dresser GK, Spence JD, Bailey DG "Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition." Clin Pharmacokinet 38 (2000): 41-57. [PMID: 10668858]
84	Product Information. Imovane (zopiclone). Rhone-Poulenc Rorer Canada Inc, Laval, IN.
85	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
86	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
87	Li J, Zhao M, He P, Hidalgo M, Baker SD "Differential metabolism of gefitinib and erlotinib by human cytochrome p450 enzymes." Clin Cancer Res 13 (2007): 3731-7. [PMID: 17575239]
88	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
89	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
90	Corona G, Vaccher E, Sandron S, et al. "Lopinavir-ritonavir dramatically affects the pharmacokinetics of irinotecan in HIV patients with Kaposi's sarcoma." Clin Pharmacol Ther 83 (2008): 601-6. [PMID: 17713471]
91	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
92	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
93	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
94	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
95	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
96	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
97	Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
98	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
99	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
100	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
101	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
102	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
103	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
104	Han TH, Gopal AK, Ramchandren R, et al. "CYP3A-mediated drug-drug interaction potential and excretion of brentuximab vedotin, an antibody-drug conjugate, in patients with CD30-positive hematologic malignancies." J Clin Pharmacol 53 (2013): 866-77. [PMID: 23754575]
105	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
106	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
107	St Clair K, Maguire JD "Role of fluconazole in a case of rapid onset ritonavir and inhaled fluticasone-associated secondary adrenal insufficiency." Int J STD AIDS 23 (2012): 371-2. [PMID: 22648897]
108	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
109	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
110	Product Information. Prevymis (letermovir). Merck &amp Company Inc, Whitehouse Station, NJ.
111	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
112	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
113	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
114	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
115	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
116	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
117	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
118	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
119	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
120	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
121	Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
122	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
123	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
124	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
125	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
126	Bergmann TK, Filppula AM, Launiainen T, Nielsen F, Backman J, Brosen K "Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60 year old Caucasian woman with ovarian carcinoma." Br J Clin Pharmacol (2015):. [PMID: 26446447]
127	Bun SS, Ciccolini J, Bun H, Aubert C, Catalin J "Drug interactions of paclitaxel metabolism in human liver microsomes." J Chemother 15 (2003): 266-74. [PMID: 12868554]
128	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
129	Product Information. Rythmol SR (propafenone). GlaxoSmithKline, Research Triangle Park, NC.
130	Botsch S, Gautier JC, Beaune P, Eichelbaum M, Kroemer HK "Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites." Mol Pharmacol 43 (1993): 120-6. [PMID: 8423765]
131	Hatorp V, Hansen KT, Thomsen MS "Influence of drugs interacting with CYP3A4 on the pharmacokinetics, pharmacodynamics, and safety of the prandial glucose regulator repaglinide." J Clin Pharmacol 43 (2003): 649-60. [PMID: 12817528]
132	Khamaisi M, Leitersdorf E "Severe hypoglycemia from clarithromycin-repaglinide drug interaction." Pharmacotherapy 28 (2008): 682-4. [PMID: 18447665]
133	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
134	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
135	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
136	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
137	Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
138	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
139	Warrington JS, Shader RI, vonMoltke LL, Greenblatt DJ "In vitro biotransformation of sildenafil (Viagra): Identification of human cytochromes and potential drug interactions." Drug Metab Disposition 28 (2000): 392-7. [PMID: 10725306]
140	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
141	Christians U, Schmidt G, Bader A, et al "Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes." Br J Clin Pharmacol 41 (1996): 187-90. [PMID: 8866917]
142	Product Information. Parlodel (bromocriptine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
143	Product Information. Adcirca (tadalafil). United Therapeutics Corporation, Silver Spring, MD.
144	Franco-Salinas G, de la Rosette JJ, Michel MC "Pharmacokinetics and pharmacodynamics of tamsulosin in its modified-release and oral controlled absorption system formulations." Clin Pharmacokinet 49 (2010): 177-88. [PMID: 20170206]
145	Kamimura H, Oishi S, Matsushima H, et al. "Identification of cytochrome P450 isozymes involved in metabolism of the alpha1-adrenoceptor blocker tamsulosin in human liver microsomes." Xenobiotica 28 (1998): 909-22. [PMID: 9849639]
146	Product Information. Flomax (tamsulosin). Boehringer-Ingelheim, Ridgefield, CT.
147	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
148	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
149	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
150	Brynne N, Forslund C, Hallen B, Gustafsson LL, Bertilsson L "Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity." Br J Clin Pharmacol 48 (1999): 564-72. [PMID: 10583027]
151	Product Information. Detrol (tolterodine). Pharmacia and Upjohn, Kalamazoo, MI.
152	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
153	Machiels JP, Staddon A, Herremans C, et al. "Impact of cytochrome P450 3A4 inducer and inhibitor on the pharmacokinetics of trabectedin in patients with advanced malignancies: open-label, multicenter studies." Cancer Chemother Pharmacol 74 (2014): 729-37. [PMID: 25100135]
154	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
155	Nakasa H, Nakamura H, Ono S, Tsutsui M, Kiuchi M, Ohmori S, Kitada M "Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data." Eur J Clin Pharmacol 54 (1998): 177-83. [PMID: 9626925]
156	Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
157	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
158	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
159	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
160	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
161	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
162	Product Information. Pifeltro (doravirine). Merck &amp Company Inc, Whitehouse Station, NJ.
163	Bailey DG, Arnold JMO, Spence JD "Grapefruit juice and drugs - how significant is the interaction." Clin Pharmacokinet 26 (1994): 91-8. [PMID: 8162660]
164	Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
165	Product Information. Elidel (pimecrolimus topical). Novartis Pharmaceuticals, East Hanover, NJ.
166	Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.
167	Ekstrom G, Gunnarsson UB "Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes." Drug Metab Dispos 24 (1996): 955-61. [PMID: 8886604]
168	Jokinen MJ, Ahonen J, Neuvonen PJ, Olkkola KT "The effect of erythromycin, fluvoxamine, and their combination on the pharmacokinetics of ropivacaine." Anesth Analg 91 (2000): 1207-12. [PMID: 11049910]
169	Arlander E, Ekstrom G, Alm C, Carrillo JA, Bielenstein M, Bottiger Y, Bertilsson L, Gustafsson LL "Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: An interaction study with fluvoxamine and ketoconazole as in vivo inhibitors." Clin Pharmacol Ther 64 (1998): 484-91. [PMID: 9834040]
170	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence