Details of Drug

Details of Drug

 Drug General Information (ID: D1115)
  Drug Name
Necitumumab
  Drug Type Monoclonal antibody
  Drug Synonymous
LY3012211
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  Disease Class 2B91: Colorectal cancer
  Therapeutic Class Egfr Inhibitors
  External Link
TTD ID D03WPP

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
BM043  Additive immunosuppressive effects
BM047  Additive thrombogenic effects
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Necitumumab
      Pharmacodynamic additive effects
   Additive immunosuppressive effects Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1855
 
Palifermin
 
NA
 
NA
Moderate    Inter Info   
[5]
   Additive thrombogenic effects Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1569
 
Thalidomide
 
C13H10N2O4
 
5426 
Major    Inter Info   
[1], [2], [3]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Moderate    Inter Info   
[4]
References
1 Figg WD, Arlen P, Gulley J, et al. "A randomized phase II trial of docetaxel (taxotere) plus thalidomide in androgen-independent prostate cancer." Semin Oncol 28(4 Suppl 15) (2001): 62-6. [PMID: 11685731]
2 Fine HA, Wen PY, Maher EA, et al. "Phase II Trial of Thalidomide and Carmustine for Patients With Recurrent High-Grade Gliomas." J Clin Oncol 21 (2003): 2299-304. [PMID: 12805330]
3 Zangari M, Siegel E, Barlogie B, et al "Thrombogenic activity of doxorubicin in myeloma patients receiving thalidomide: implications for therapy." Blood 100 (2002): 1168-71. [PMID: 12149193]
4 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
5 Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.