Details of Drug

Details of Drug

 Drug General Information (ID: D1105)
  Drug Name
Naloxone
  Drug Type Small molecule
  Drug Synonymous
Nalone; Nalossone; Naloxona; Naloxonum; Narcan; Narcanti; Narcon; DBL Naloxone; Nalossone [DCIT]; Naloxone HCl; EN 1530base; DBL Naloxone (TN); L-Naloxone; N-Allylnoroxymorphone; Nalone (TN); Naloxona [INN-Spanish]; Naloxone (INN); Naloxone [INN:BAN]; Naloxonum [INN-Latin]; Narcan (TN); Narcanti (TN); N-Allyl-noroxymorphone; L-N-Allyl-14-hydroxynordihydromorphinone; L-N-Allyl-7,8-dihydro-14-hydroxynormorphinone; N-Allyl-4,5alpha-epoxy-3,14-dihydroxy-6-morphinanon; Morphinan-6-one, 17-allyl-4,5alpha-epoxy-3,14-dihydroxy-(8CI); Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-(9CI); (-)-N-allyl-14-hydroxynordihydroxymorphinan-6-one; (-)-Naloxone; (5alpha)-3,14-dihydroxy-17-prop-2-en-1-yl-4,5-epoxymorphinan-6-one; (5alpha)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one; 1-N-Allyl-14-hydroxynordihydromorphinone; 1-N-Allyl-7,8-dihydro-14-hydroxynormorphinone; 12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro(4,5-bcd)furanone; 12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro[4,5-bcd]furan-5(6H)-one; 17-Allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-one; 17-Allyl-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one; 17-allyl-3,14-dihydroxy-4,5alpha-epoxymorphinan-6-one; 3,14-dihydroxy-17-(prop-2-en-1-yl)-4,5alpha-epoxymorphinan-6-one
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  Disease Class 6A70-6A7Z: Depression; 6C43: Opioid use disorder; MD11: Breathing abnormality; EC90: Pruritus
  Therapeutic Class Antinarcotic Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C19H21NO4
  InChI 1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1
  InChIKey UZHSEJADLWPNLE-GRGSLBFTSA-N
  Canonical SMILES C=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O
  External Link
Pubchem ID 5284596
CAS Number 465-65-6
CHEBI ID 7459
TTD ID D0X3FX
INTEDE ID DR1127
VARIDT ID DR00698

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM076  Increased risk of prolong QT interval
BM083  Potentiated the pharmacological effects (Unspecific)
BM096  Antagonize the effect of opioid receptor agonists
  Relation Graph
 Full list of drugs interacting with Naloxone
      Pharmacodynamic additive effects
   Increased risk of prolong QT interval Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0535
 
Droperidol
 
C22H22FN3O2
 
3168 
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
   Potentiated the pharmacological effects (Unspecific) Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1101
 
Naldemedine
 
C32H34N4O6
 
54732242 
Moderate    Inter Info   
[9]
D1104
 
Naloxegol
 
C34H53NO11
 
56959087 
Moderate    Inter Info   
[9]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of opioid receptor agonists Drug Num:  25
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0035
 
Alfentanil
 
C21H32N6O3
 
51263 
Moderate    Inter Info   
[2], [7], [8]
D0226
 
Butorphanol
 
C21H29NO2
 
5361092 
Moderate    Inter Info   
[2], [7], [8]
D0379
 
Codeine
 
C18H21NO3
 
5284371 
Moderate    Inter Info   
[2], [7], [8]
D0646
 
Fentanyl
 
C22H28N2O
 
3345 
Moderate    Inter Info   
[2], [7], [8]
D0772
 
Hydrocodone
 
C18H21NO3
 
5284569 
Moderate    Inter Info   
[2], [7], [8]
D0776
 
Hydromorphone
 
C17H19NO3
 
5284570 
Moderate    Inter Info   
[2], [7], [8]
D0923
 
Levorphanol
 
C17H23NO
 
5359272 
Moderate    Inter Info   
[2], [7], [8]
D1001
 
Meperidine
 
C15H21NO2
 
4058 
Moderate    Inter Info   
[2], [7], [8]
D1017
 
Methadone
 
C21H27NO
 
4095 
Moderate    Inter Info   
[2], [7], [8]
D1089
 
Morphine
 
C17H19NO3
 
5288826 
Moderate    Inter Info   
[2], [7], [8]
D1100
 
Nalbuphine
 
C21H27NO4
 
5311304 
Moderate    Inter Info   
[2], [7], [8]
D0161
 
Benzhydrocodone
 
C25H25NO4
 
49836084 
Moderate    Inter Info   
[2], [7], [8]
D0470
 
Dezocine
 
C16H23NO
 
3033053 
Moderate    Inter Info   
[2], [7], [8]
D0471
 
Diamorphine
 
C21H23NO5
 
5462328 
Moderate    Inter Info   
[2], [7], [8]
D0493
 
Dihydrocodeine
 
C18H23NO3
 
5284543 
Moderate    Inter Info   
[2], [7], [8]
D0909
 
Levacetylmethadol
 
C23H31NO2
 
15130 
Moderate    Inter Info   
[2], [7], [8]
D1169
 
Oliceridine
 
C22H30N2O2S
 
66553195 
Moderate    Inter Info   
[2], [7], [8]
D1183
 
Opium
 
NA
 
NA
Moderate    Inter Info   
[2], [7], [8]
D1208
 
Oxymorphone
 
C17H19NO4
 
5284604 
Moderate    Inter Info   
[2], [7], [8]
D1535
 
Tapentadol
 
C14H23NO
 
9838022 
Moderate    Inter Info   
[2], [3], [10]
D1203
 
Oxycodone
 
C18H21NO4
 
5284603 
Moderate    Inter Info   
[2], [7], [8]
D1247
 
Pentazocine
 
C19H27NO
 
441278 
Moderate    Inter Info   
[2], [7], [8]
D1390
 
Remifentanil
 
C20H28N2O5
 
60815 
Moderate    Inter Info   
[2], [7], [8]
D1512
 
Sufentanil
 
C22H30N2O2S
 
41693 
Moderate    Inter Info   
[2], [7], [8]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Moderate    Inter Info   
[2], [3], [10]
References
1 Canadian Pharmacists Association.
2 Cerner Multum, Inc. "Australian Product Information.".
3 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4 Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
5 Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
6 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
7 Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
8 Product Information. Narcan (naloxone). DuPont Pharmaceuticals, Wilmington, DE.
9 Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
10 Product Information. Ultram (tramadol). McNeil Pharmaceutical, Raritan, NJ.