Details of Drug

Drug General Information (ID: D1104)
Drug Name	Naloxegol
Drug Type	Small molecule
Drug Synonymous	NKTR-118 Click to Show/Hide
Disease Class	DB32: Large intestine motility disorder
Therapeutic Class	Peripheral Opioid Receptor Antagonists
Structure
Structure	3D Structure		2D Structure
Formula	C34H53NO11
InChI	1S/C34H53NO11/c1-3-9-35-10-8-33-30-26-4-5-27(36)31(30)46-32(33)28(6-7-34(33,37)29(35)25-26)45-24-23-44-22-21-43-20-19-42-18-17-41-16-15-40-14-13-39-12-11-38-2/h3-5,28-29,32,36-37H,1,6-25H2,2H3/t28-,29+,32-,33-,34+/m0/s1
InChIKey	XNKCCCKFOQNXKV-ZRSCBOBOSA-N
Canonical SMILES	COCCOCCOCCOCCOCCOCCOCCOC1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC=C)O
External Link
	Pubchem ID	56959087
	CAS Number	854601-70-0
	CHEBI ID	82975
	TTD ID	D07LCF
	VARIDT ID	DR01266

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM048 Increased risk of angioedema/anaphylactoid reactions BM083 Potentiated the pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Naloxegol
Affected cellular transport
	Transporter inhibition					Drug Num: 26
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[2], [11]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[12]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[14]
D0139		Azithromycin	C38H72N2O12	447043	Minor		Inter Info	[3]
D0170		Bepridil	C24H34N2O	2351	Minor		Inter Info	[3]
D0230		Cabozantinib	C28H24FN3O5	25102847	Minor		Inter Info	[3]
D0559		Eliglustat	C23H36N2O4	23652731	Minor		Inter Info	[3]
D0640		Felodipine	C18H19Cl2NO4	3333	Minor		Inter Info	[3]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Minor		Inter Info	[3]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Minor		Inter Info	[3]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Minor		Inter Info	[3]
D0408		Daclatasvir	C40H50N8O6	25154714	Minor		Inter Info	[3]
D0720		Gilteritinib	C29H44N8O3	49803313	Minor		Inter Info	[3]
D0725		Glasdegib	C21H22N6O	25166913	Minor		Inter Info	[3]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Minor		Inter Info	[3]
D1124		Neratinib	C30H29ClN6O3	9915743	Minor		Inter Info	[3]
D1423		Rolapitant	C25H26F6N2O2	10311306	Minor		Inter Info	[3]
D1686		Velpatasvir	C49H54N8O8	67683363	Minor		Inter Info	[3]
D1134		Nifedipine	C17H18N2O6	4485	Minor		Inter Info	[3]
D1313		Ponatinib	C29H27F3N6O	24826799	Minor		Inter Info	[3]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Minor		Inter Info	[3]
D1524		Suvorexant	C23H23ClN6O2	24965990	Minor		Inter Info	[3]
D1526		Tacrolimus	C44H69NO12	445643	Minor		Inter Info	[3]
D1664		Ulipristal	C28H35NO3	13559281	Minor		Inter Info	[3]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Minor		Inter Info	[3]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Minor		Inter Info	[3]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 81
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3], [4]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[2], [3]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1], [2], [3], [4]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Major		Inter Info	[2], [3]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[2], [3]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1], [2], [3], [4]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1], [2], [3], [4]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[2], [3]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[2], [3]
D0416		Danazol	C22H27NO2	28417	Major		Inter Info	[2], [3]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[1], [2], [3]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1], [2], [3], [4]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[2], [3]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[2], [3]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[2], [3]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[2], [3]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[1], [2], [3], [4]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[2], [3]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1], [2], [3], [4]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[2], [3]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1], [2], [3], [4]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1], [2], [3], [4]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1], [2], [3], [4]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[5], [6], [7]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[2], [3]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1], [2], [3], [4]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1], [2], [3], [4]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[2], [3]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[2], [3]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[2], [3]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1], [2], [3], [4]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[2], [3]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[2], [3]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[2], [3]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1], [2], [3], [4]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1], [2], [3], [4]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[2], [3]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2], [3], [4]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1], [2], [3], [4]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[2], [3]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1], [2], [3], [4]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1], [2], [3], [4]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1], [2], [3], [4]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1], [2], [3], [4]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1], [2], [3], [4]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[2], [3]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1], [2], [3], [4]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[9]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[13]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[3]
D0007		Abiraterone	C24H31NO	132971	Minor		Inter Info	[3]
D0066		Amiodarone	C25H29I2NO3	2157	Minor		Inter Info	[3]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Minor		Inter Info	[3]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[3]
D0402		Cyclosporine	C62H111N11O12	5284373	Minor		Inter Info	[3]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Minor		Inter Info	[3]
D0665		Flibanserin	C20H21F3N4O	6918248	Minor		Inter Info	[3]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Minor		Inter Info	[3]
D0858		Isoniazid	C6H7N3O	3767	Minor		Inter Info	[3]
D0869		Ivacaftor	C24H28N2O3	16220172	Minor		Inter Info	[3]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Minor		Inter Info	[3]
D0944		Lomitapide	C39H37F6N3O2	9853053	Minor		Inter Info	[3]
D1062		Midostaurin	C35H30N4O4	9829523	Minor		Inter Info	[3]
D0251		Capmatinib	C23H17FN6O	25145656	Minor		Inter Info	[3]
D0577		Entrectinib	C31H34F2N6O2	25141092	Minor		Inter Info	[3]
D0735		Goldenseal	NA	NA	Minor		Inter Info	[3]
D0866		Istradefylline	C20H24N4O4	5311037	Minor		Inter Info	[3]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Minor		Inter Info	[3]
D1189		Osilodrostat	C13H10FN3	44139752	Minor		Inter Info	[3]
D1432		Rucaparib	C19H18FN3O	9931954	Minor		Inter Info	[3]
D1459		Selpercatinib	C29H31N7O3	134436906	Minor		Inter Info	[3]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Minor		Inter Info	[3]
D1136		Nilotinib	C28H22F3N7O	644241	Minor		Inter Info	[3]
D1232		Pazopanib	C21H23N7O2S	10113978	Minor		Inter Info	[3]
D1371		Quinidine	C20H24N2O2	441074	Minor		Inter Info	[3]
D1372		Quinine	C20H24N2O2	3034034	Minor		Inter Info	[3]
D1383		Ranolazine	C24H33N3O4	56959	Minor		Inter Info	[3]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Minor		Inter Info	[3]
D1533		Tamoxifen	C26H29NO	2733526	Minor		Inter Info	[3]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Minor		Inter Info	[3]
D1608		Tolvaptan	C26H25ClN2O3	216237	Minor		Inter Info	[3]
	CYP450 enzyme induction					Drug Num: 49
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[2], [3]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[2], [3]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[2], [3]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[2], [3]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[2], [3]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[2], [3]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[2], [3]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[2], [3]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[2], [3]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[3]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[3]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[3]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[3]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[3]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[3]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[3]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[3]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[3]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[3]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[3]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[3]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[3]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[3]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[3], [8]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[3]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[3]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[1], [10]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[3]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[3]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[3]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[3], [8]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[3]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[3]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[3], [8]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[3]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[3]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[2], [16]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[3]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[3]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[3]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[3]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[3]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[3]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[3]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[3], [8]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[3]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[3]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[17], [18], [19], [20], [21]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[17], [18], [19], [20], [21]
Pharmacodynamic additive effects
	Increased risk of angioedema/anaphylactoid reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1861		Pegvaliase	C15H30N2O5	86278362	Moderate		Inter Info	[15]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1103		Nalmefene	C21H25NO3	5284594	Moderate		Inter Info	[3]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[3]
D1105		Naloxone	C19H21NO4	5284596	Moderate		Inter Info	[3]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[3]

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4	Product Information. Sporanox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
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6	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
7	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
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9	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
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13	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
14	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
15	Product Information. Palynziq (pegvaliase). BioMarin Pharmaceutical Inc, Novato, CA.
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18	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
19	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
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