Details of Drug

Details of Drug

 Drug General Information (ID: D1103)
  Drug Name
Nalmefene
  Drug Type Small molecule
  Drug Synonymous
Alcofene; Arthene; Cervene; Cessal; Incystene; Nalmefeno; Nalmefenum; Nalmetrene; Nalmetreno; Nalmetrenum; Revex; Soberal; JF 1; ORF 11676; JF-1; NIH-10365; Nalmefeno [INN-Spanish]; Nalmefenum [INN-Latin]; Nalmetreno [INN-Spanish]; Nalmetrenum [INN-Latin]; ORF-11676; Revex (TN); Nalmefene (USAN/INN); Nalmefene [USAN:BAN:INN]; (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol; (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinon-3,14-diol; (5alpha)-17-(cyclopropylmethyl)-6-methylidene-4,5-epoxymorphinan-3,14-diol; 17-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol; 6-Desoxy-6-methylenenaltrexone; 9a-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylen-3,14-morphinandiol
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  Disease Class 6C43: Opioid use disorder
  Therapeutic Class Antidotes
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C21H25NO3
  InChI 1S/C21H25NO3/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13/h4-5,13,16,19,23-24H,1-3,6-11H2/t16-,19+,20+,21-/m1/s1
  InChIKey WJBLNOPPDWQMCH-MBPVOVBZSA-N
  Canonical SMILES C=C1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC6CC6)O
  External Link
Pubchem ID 5284594
CAS Number 55096-26-9
CHEBI ID 7457
TTD ID D05VIL

Drug-Drug Interaction Network
  Sunburst Graph
AM003  Affected organization distribution
AM006  Pharmacodynamic additive effects
BM013  Competitive binding of plasma proteins
BM076  Increased risk of prolong QT interval
BM083  Potentiated the pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Nalmefene
      Affected organization distribution
   Competitive binding of plasma proteins Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0727
 
Glimepiride
 
C24H34N4O5S
 
3476 
Moderate    Inter Info   
[7]
      Pharmacodynamic additive effects
   Increased risk of prolong QT interval Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0535
 
Droperidol
 
C22H22FN3O2
 
3168 
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
   Potentiated the pharmacological effects (Unspecific) Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1101
 
Naldemedine
 
C32H34N4O6
 
54732242 
Moderate    Inter Info   
[8]
D1104
 
Naloxegol
 
C34H53NO11
 
56959087 
Moderate    Inter Info   
[8]
References
1 Canadian Pharmacists Association.
2 Cerner Multum, Inc. "Australian Product Information.".
3 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4 Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
5 Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
6 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
7 Product Information. Amaryl (glimepiride). Hoechst Marion-Roussel Inc, Kansas City, MO.
8 Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.