Details of Drug

Drug General Information (ID: D1101)
Drug Name	Naldemedine
Drug Type	Small molecule
Drug Synonymous	NALDEMEDINE; UNII-03KSI6WLXH; 03KSI6WLXH; S-297,995; 916072-89-4; Naldemedine [USAN:INN]; Naldemedine (USAN/INN); S 297995; SCHEMBL9880572; GTPL9150; CHEMBL2105755; AKOS032945757; DB11691; Morphinan-7-carboxamide, 17-(cyclopropylmethyl)-6,7-didehydro-4,5-epoxy-3,6,14- trihydroxy-N-(1-methyl-1-(3-phenyl-1,2,4-oxadiazol-5-yl)ethyl)-,(5alpha)-; J3.573.009E; D10188 Click to Show/Hide
Disease Class	6C43: Opioid use disorder
Therapeutic Class	Peripheral Opioid Receptor Antagonists
Structure
Structure	3D Structure		2D Structure
Formula	C32H34N4O6
InChI	1S/C32H34N4O6/c1-30(2,29-33-27(35-42-29)18-6-4-3-5-7-18)34-28(39)20-15-32(40)22-14-19-10-11-21(37)25-23(19)31(32,26(41-25)24(20)38)12-13-36(22)16-17-8-9-17/h3-7,10-11,17,22,26,37-38,40H,8-9,12-16H2,1-2H3,(H,34,39)/t22-,26+,31+,32-/m1/s1
InChIKey	AXQACEQYCPKDMV-RZAWKFBISA-N
Canonical SMILES	CC(C)(C1=NC(=NO1)C2=CC=CC=C2)NC(=O)C3=C(C4C56CCN(C(C5(C3)O)CC7=C6C(=C(C=C7)O)O4)CC8CC8)O
External Link
	Pubchem ID	54732242
	CAS Number	916072-89-4
	TTD ID	D0Q3PD

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM083 Potentiated the pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Naldemedine
Affected cellular transport
	Transporter inhibition					Drug Num: 27
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[3], [1]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[3], [1]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[3], [1]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[3], [1]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[3], [1]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[3], [1]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[3], [1]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[3], [1]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[3], [1]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[3], [11], [12]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[3], [14], [15]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[16]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[3], [1]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[3], [18]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[19]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[7], [3], [21]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[3], [22]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[3], [1]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[24]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[3], [1]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[3], [1]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[3], [1]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[35]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[3], [1]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[3], [1]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[7], [3], [37], [38]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[3], [1]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 68
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[3], [1]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[3], [1]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[3], [1]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[3], [1]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[3], [1]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[3], [1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[3], [1]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[3], [1]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[3], [1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[3], [1]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[3], [1]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[3], [1]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[3], [1]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[3], [1]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[3], [1]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[3], [1]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[3], [1]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[3], [1]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[3], [1]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[3], [1]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[3], [1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[3], [1]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[3], [1]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[3], [1]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[3], [1]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[3], [1]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[3], [1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[3], [1]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[3], [1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[3], [1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[3], [1]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[3], [1]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[3], [1]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[3], [1]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[7], [3], [8], [9]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[10]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[13]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[3], [1]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[3], [1]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[3], [1]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[20]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[7], [3], [23]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[25]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[3], [1]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[3], [1]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[27]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[3], [28]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[3], [1]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[3], [1]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[3], [1]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[3], [1]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[3], [1]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[3], [1]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[7], [3]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[3], [1]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[3], [1]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[3], [1]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[3], [1]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[3], [1]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[3], [1]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[3], [1]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[3], [1]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[3], [1]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[3], [1]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[3], [1]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[3], [1]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[3], [1]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[3], [1]
	CYP450 enzyme induction					Drug Num: 32
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[2], [1]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[2], [1]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[3], [4], [5]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[3], [1]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[3], [6]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[3], [1]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[3], [1]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[3], [1]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[3], [1]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[7], [17]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[3], [1]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[26]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[7], [3], [29]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[3], [30]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[7], [3], [32], [33]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[3], [34]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[3], [1]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[7], [3], [29]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[7], [3], [36], [29]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[39], [40], [41], [42], [43], [44], [45]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[46], [47], [48], [49], [50]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[46], [47], [48], [49], [50]
Pharmacodynamic additive effects
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1103		Nalmefene	C21H25NO3	5284594	Moderate		Inter Info	[31]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[31]
D1105		Naloxone	C19H21NO4	5284596	Moderate		Inter Info	[31]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[31]

References
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11	Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
12	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
13	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
14	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
15	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
16	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
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18	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
19	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
20	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
21	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
22	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
23	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
24	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
25	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
26	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
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28	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
29	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
30	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
31	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
32	Product Information. Viramune (nevirapine). Boehringer-Ingelheim, Ridgefield, CT.
33	Product Information. Viramune XR (nevirapine). Boehringer Ingelheim, Ridgefield, CT.
34	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
35	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
36	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
37	Product Information. Jynarque (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
38	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
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48	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
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