Details of Drug

Drug General Information (ID: D1099)
Drug Name	Nafcillin
Drug Type	Small molecule
Drug Synonymous	Nafcilina; Nafcilline; Nafcillinum; Nallpen; Naphcillin; Naphthamidopenicillin; Unipen; NAFCILLIN SODIUM; Nafcillin sodium for injection; Nallpen In Plastic Container; Nafcilin-1; Nafcilina [INN-Spanish]; Nafcillin & VRC3375; Nafcillin (INN); Nafcillin [INN:BAN]; Nafcilline [INN-French]; Nafcillinum [INN-Latin]; Nafcillin, Monosodium Salt, Anhydrous; (2-Ethoxy-1-naphthyl)penicillin; (2-ethoxy-1-naphthalenyl)penicillin; (2S,5R,6R)-6-({[2-(ethyloxy)naphthalen-1-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-[(2-ethoxynaphthalene-1-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-(2-ethoxy-1-naphthamido)penicillanic acid; 6-[(2-Ethoxy-naphthalene-1-carbonyl)-amino]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid anion; 6beta-(2-ethoxynaphthalene-1-carboxamido)-2,2-dimethylpenam-3alpha-carboxylic acid Click to Show/Hide
Disease Class	FA20: Rheumatoid arthritis
Therapeutic Class	Antibiotics
Structure
Structure	3D Structure		2D Structure
Formula	C21H22N2O5S
InChI	1S/C21H22N2O5S/c1-4-28-13-10-9-11-7-5-6-8-12(11)14(13)17(24)22-15-18(25)23-16(20(26)27)21(2,3)29-19(15)23/h5-10,15-16,19H,4H2,1-3H3,(H,22,24)(H,26,27)/t15-,16+,19-/m1/s1
InChIKey	GPXLMGHLHQJAGZ-JTDSTZFVSA-N
Canonical SMILES	CCOC1=C(C2=CC=CC=C2C=C1)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
External Link
	Pubchem ID	8982
	CAS Number	147-52-4
	CHEBI ID	7447
	TTD ID	D0A0JH
	VARIDT ID	DR01384

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM011 Transporter induction BM013 Competitive binding of plasma proteins BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM028 Competitive inhibition of renal tubular secretion BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Nafcillin
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[269], [270]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[269], [270]
Affected cellular transport
	Transporter induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[25], [80], [16], [258]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1283		Phenytoin	C15H12N2O2	1775	Minor		Inter Info	[373]
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[228]
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[229], [230], [231]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[53]
	CYP450 enzyme induction					Drug Num: 213
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[13], [14], [15]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[16], [17]
D0133		Axitinib	C22H18N4OS	6450551	Major		Inter Info	[18], [19]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[16], [20]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[21], [22], [23]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[24]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[25], [16], [26]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[27], [25], [16], [28], [29], [30], [21], [22], [23], [31]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[32]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[25], [16], [33]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[16], [34]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[16]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Major		Inter Info	[16], [35], [36]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[37]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[38]
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[39]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[16], [40]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[27], [25], [16], [28], [29], [30], [21], [22], [23], [31]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[41]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[42], [43], [44]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[16], [45], [46]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[27], [25], [16], [28], [29], [30], [21], [22], [23], [31]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[47]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[48], [49]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[50]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[51]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[52]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[25], [54]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[25], [16], [55]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[27], [25], [16], [28], [29], [30], [21], [22], [23], [31]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[16], [56]
D1336		Pretomanid	C14H12F3N3O5	456199	Major		Inter Info	[57]
D1407		Rimegepant	C28H28F2N6O3	51049968	Major		Inter Info	[58]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[16], [60]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[61]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[25], [62]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[63]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[64]
D1686		Velpatasvir	C49H54N8O8	67683363	Major		Inter Info	[16], [67], [68]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[70]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[27], [25], [16], [28], [29], [30], [21], [22], [23], [31]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[71]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[72], [73], [74]
D0268		Caspofungin	C52H88N10O15	2826718	Moderate		Inter Info	[75]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[79], [25], [80], [16], [81], [82], [83]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[131]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[132]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[137], [138]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[139]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[137], [140]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[141], [142], [143], [27], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[157]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[88], [98], [123]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[25], [16], [158]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[25], [16], [158]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[159], [160], [161], [162]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[163]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[164]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[165]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[166], [167], [168], [169]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[141], [142], [143], [27], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[170]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[171]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[172], [173]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[174]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[175], [176]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[25], [16], [177]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[141], [142], [143], [27], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[178], [179], [180], [181], [182]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[183]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[16], [184], [185]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[186]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[187]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[188], [189]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[190]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[191]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[27], [25], [16], [192], [193], [194], [195]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[196]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[80], [16], [197]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[198]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[25], [16], [199]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[200], [201]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[79], [25], [16]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[202], [203], [204], [205], [206]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[207]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[16], [208], [209], [210]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[208], [209], [210]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[211]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[212]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[213]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[214]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Moderate		Inter Info	[25], [16], [215]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[216]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[25], [16], [158]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[25], [16], [158]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[88], [98], [123]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[88], [98], [123]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[88], [98], [123]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[217]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[25], [16], [218]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[219]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[132]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[220]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[221]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[141], [142], [143], [27], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[172], [173]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[222]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[223]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[224]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[225]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[226], [27], [25], [16], [192], [227]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[233], [234], [239]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[247]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[16], [248]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[249], [250], [251], [252]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[253]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[254]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[25], [16], [255]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[25], [16], [256]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[257]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[259]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[25], [16], [260]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[261]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[262], [263]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[25], [264]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[265], [266]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[267], [268]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[175], [176]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[16], [271]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[272]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[132]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[132]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[273]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[88], [98], [123]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[274]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[275]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[276], [277], [278], [279]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[276], [277], [278]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[25], [16], [280]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[281]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[282]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[68]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[287]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[25], [16], [288]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[289]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[290], [25], [291], [292]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[25], [293], [294], [295], [296]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[297]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[25], [16], [298]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[25], [80], [16], [299]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[300]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[25], [301]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[302]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[303]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[304]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[141], [142], [143], [27], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[305]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[25], [16], [306]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[25], [16], [307], [308]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[309]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[16], [192], [310]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[25], [16], [311]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[312]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[25], [16], [307], [308]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[16], [313], [314]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[315], [316], [317], [318]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[319]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[320], [321]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[25], [16], [322]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[27], [16], [323], [324], [325]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[141], [142], [143], [27], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[25], [326]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[16], [327]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[16], [328], [329]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[330]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[331]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[332]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[132]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[333]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[334]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[335], [336]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[141], [142], [143], [27], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[27], [25], [16]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[88], [98], [123]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[337], [338], [23], [339], [340], [341]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[141], [142], [143], [27], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[342], [343], [344], [345]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[346]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[347], [25], [16], [316], [348]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[349]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[16], [350], [351], [352]
D0178		Bexarotene	C24H28O2	82146	Minor		Inter Info	[318]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[16], [353], [354], [355], [356]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[357]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[358], [249], [252]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[359], [360], [361], [362]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[363]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[364]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[365]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[366]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[374], [375]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1435		Sacituzumab govitecan	C76H104N12O24S	91668186	Major		Inter Info	[59]
Affected excretion pathways
	Competitive inhibition of renal tubular secretion					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[136]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[283]
D1341		Probenecid	C13H19NO4S	4911	Minor		Inter Info	[367], [368], [369], [370], [371], [372]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[16], [65], [66]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[69]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[76], [77], [78]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[133], [134], [135]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Moderate		Inter Info	[133], [134], [135]
D1070		Minocycline	C23H27N3O7	54675783	Moderate		Inter Info	[133], [134], [135]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[284], [285], [286]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[133], [134], [135]
D1564		Tetracycline	C22H24N2O8	54675776	Moderate		Inter Info	[133], [134], [135]
D1209		Oxytetracycline	C22H24N2O9	54675779	Moderate		Inter Info	[133], [134], [135]

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148	Product Information. Crixivan (indinavir). Merck & Co, Inc, West Point, PA.
149	Product Information. Fortovase (saquinavir) Roche Laboratories, Nutley, NJ.
150	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
151	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
152	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
153	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
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173	Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
174	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
175	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
176	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
177	Product Information. Coartem (artemether-lumefantrine). Novartis Pharmaceuticals, East Hanover, NJ.
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183	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
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185	Product Information. Viread (tenofovir). Gilead Sciences, Foster City, CA.
186	Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
187	Product Information. Jevtana (cabazitaxel). sanofi-aventis , Bridgewater, NJ.
188	Product Information. Cabometyx (cabozantinib). Exelixis Inc, S San Francisco, CA.
189	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
190	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
191	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
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193	Product Information. Genvoya (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
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199	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
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207	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
208	Product Information. Adriamycin PFS (doxorubicin). Pharmacia and Upjohn, Kalamazoo, MI.
209	Product Information. Doxil (doxorubicin liposomal). Sequis Pharmaceuticals Inc, Menlo Park, CA.
210	Kaytser V, Zhang P. Non-interacting, Non-opioid, and Non-barbiturate Containing Acute Medication Combinations in Headache: A Pilot Combinatorics Approach Based on DrugBank Database.?Front Neurol. 2021;12:632830. [PMID: 33679591]
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212	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
213	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
214	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
215	Product Information. Vitekta (elvitegravir). Gilead Sciences, Foster City, CA.
216	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
217	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
218	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
219	Product Information. Aromasin (exemestane) Pharmacia & Upjohn, Kalamazoo, MI.
220	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
221	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
222	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
223	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
224	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
225	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
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228	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
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241	Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI.
242	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
243	Hofland KF, Hansen S, Sorensen M, et al. Neoadjuvant bevacizumab and irinotecan versus bevacizumab and temozolomide followed by concomitant chemoradiotherapy in newly diagnosed glioblastoma multiforme: A randomized phase II study.?Acta Oncol. 2014;53(7):939-944. [PMID: 24456504]
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247	Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
248	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
249	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
250	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
251	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
252	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
253	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
254	Product Information. Ninlaro (ixazomib). Takeda Pharmaceuticals America, Lincolnshire, IL.
255	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
256	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
257	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
258	Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
259	Product Information. Tradjenta (linagliptin). Boehringer Ingelheim, Ridgefield, CT.
260	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
261	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
262	Bruderer S, Aanismaa P, Homery MC, et al. "Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist." AAPS J 14 (2012): 68-78. [PMID: 22189899]
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264	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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267	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
268	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
269	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
270	Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
271	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
272	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
273	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
274	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
275	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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277	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
278	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
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280	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
281	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
282	Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
283	Product Information. Alimta (pemetrexed). Lilly, Eli and Company, Indianapolis, IN.
284	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
285	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
286	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
287	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
288	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
289	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
290	Bittencourt PR, Gracia CM, Martins R, et al "Phenytoin and carbamazepine decrease oral bioavailability of praziquantel." Neurology 42 (1992): 492-6. [PMID: 1549207]
291	Product Information. Biltricide (praziquantel). Bayer, West Haven, CT.
292	Ridtitid W, Wongnawa M, Mahatthanatrakul W, Punyo J, Sunbhanich M "Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers." Clin Pharmacol Ther 72 (2002): 505-13. [PMID: 12426514]
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294	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
295	Quetiapine for schizophrenia. Med Lett Drugs Ther 39 (1997): 117-8. [PMID: 9422044]
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297	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
298	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
299	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
300	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
301	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
302	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
303	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
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366	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
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