Details of Drug

Details of Drug

 Drug General Information (ID: D1087)
  Drug Name
Montelukast
  Drug Type Small molecule
  Drug Synonymous
Brondilat; Montair; Singular; Apxi toxin; MK 0476; Brondilat (TN); MK-0476; Montelukast (INN); Montelukast [INN:BAN]; Singulair (TN); Sodium 1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropylacetate; {1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid; (R-(E))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid; 1-((((1R)-1-(3-((1E)-2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid; 2-[1-[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
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  Disease Class CA23: Asthma
  Therapeutic Class Antiasthmatic Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C35H36ClNO3S
  InChI 1S/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/b15-10+/t32-/m1/s1
  InChIKey UCHDWCPVSPXUMX-TZIWLTJVSA-N
  Canonical SMILES CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)SCC5(CC5)CC(=O)O)O
  External Link
Pubchem ID 5281040
CAS Number 158966-92-8
CHEBI ID 50730
TTD ID D00QET
VARIDT ID DR00382

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
  Relation Graph
 Full list of drugs interacting with Montelukast
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  39
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0667
 
Fluconazole
 
C13H12F2N6O
 
3365 
Moderate    Inter Info   
[2], [1]
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[3]
D0007
 
Abiraterone
 
C24H31NO
 
132971 
Moderate    Inter Info   
[2], [1]
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Moderate    Inter Info   
[2], [1]
D0432
 
Deferasirox
 
C21H15N3O4
 
214348 
Moderate    Inter Info   
[2], [1]
D0439
 
Delavirdine
 
C22H28N6O3S
 
5625 
Moderate    Inter Info   
[2], [1]
D0543
 
Duvelisib
 
C22H17ClN6O
 
50905713 
Moderate    Inter Info   
[5]
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Moderate    Inter Info   
[2], [1]
D0628
 
Etravirine
 
C20H15BrN6O
 
193962 
Moderate    Inter Info   
[2], [1]
D0642
 
Fenofibrate
 
C20H21ClO4
 
3339 
Moderate    Inter Info   
[2], [1]
D0699
 
Fostamatinib
 
C23H26FN6O9P
 
11671467 
Moderate    Inter Info   
[8]
D0715
 
Gemfibrozil
 
C15H22O3
 
3463 
Moderate    Inter Info   
[2], [1]
D0793
 
Imatinib
 
C29H31N7O
 
5291 
Moderate    Inter Info   
[2], [1]
D0858
 
Isoniazid
 
C6H7N3O
 
3767 
Moderate    Inter Info   
[2], [1]
D0869
 
Ivacaftor
 
C24H28N2O3
 
16220172 
Moderate    Inter Info   
[2], [1]
D0899
 
Lefamulin
 
C28H45NO5S
 
25185057 
Moderate    Inter Info   
[9], [10], [11]
D0900
 
Leflunomide
 
C12H9F3N2O2
 
3899 
Moderate    Inter Info   
[2], [1]
D0906
 
Letermovir
 
C29H28F4N4O4
 
45138674 
Moderate    Inter Info   
[2], [1]
D1051
 
Metronidazole
 
C6H9N3O3
 
4173 
Moderate    Inter Info   
[2], [1]
D1057
 
Miconazole
 
C18H14Cl4N2O
 
4189 
Moderate    Inter Info   
[2], [1]
D1063
 
Mifepristone
 
C29H35NO2
 
55245 
Moderate    Inter Info   
[15]
D1112
 
Nateglinide
 
C19H27NO3
 
5311309 
Moderate    Inter Info   
[2], [1]
D1274
 
Phenylbutazone
 
C19H20N2O2
 
4781 
Moderate    Inter Info   
[2], [1]
D1409
 
Ripretinib
 
C24H21BrFN5O2
 
71584930 
Moderate    Inter Info   
[2], [1]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Moderate    Inter Info   
[2], [1]
D1459
 
Selpercatinib
 
C29H31N7O3
 
134436906 
Moderate    Inter Info   
[2], [1]
D1515
 
Sulfamethizole
 
C9H10N4O2S2
 
5328 
Moderate    Inter Info   
[2], [1]
D1518
 
Sulfinpyrazone
 
C23H20N2O3S
 
5342 
Moderate    Inter Info   
[2], [1]
D1533
 
Tamoxifen
 
C26H29NO
 
2733526 
Moderate    Inter Info   
[2], [1]
D1556
 
Teriflunomide
 
C12H9F3N2O2
 
54684141 
Moderate    Inter Info   
[2], [1]
D1612
 
Toremifene
 
C26H28ClNO
 
3005573 
Moderate    Inter Info   
[2], [1]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Moderate    Inter Info   
[19]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Moderate    Inter Info   
[2], [1]
D1706
 
Voriconazole
 
C16H14F3N5O
 
71616 
Moderate    Inter Info   
[2], [1]
D1714
 
Zafirlukast
 
C31H33N3O6S
 
5717 
Moderate    Inter Info   
[2], [1]
D1143
 
Nitisinone
 
C14H10F3NO5
 
115355 
Moderate    Inter Info   
[2], [1]
D1513
 
Sulfadiazine
 
C10H10N4O2S
 
5215 
Moderate    Inter Info   
[2], [1]
D1645
 
Trimethoprim
 
C14H18N4O3
 
5578 
Moderate    Inter Info   
[2], [1]
D1677
 
Valproic acid
 
C8H16O2
 
3121 
Moderate    Inter Info   
[2], [1]
   CYP450 enzyme induction Drug Num:  34
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0061
 
Aminoglutethimide
 
C13H16N2O2
 
2145 
Moderate    Inter Info   
[1]
D0178
 
Bexarotene
 
C24H28O2
 
82146 
Moderate    Inter Info   
[1]
D0224
 
Butabarbital
 
C10H16N2O3
 
2479 
Moderate    Inter Info   
[1]
D0225
 
Butalbital
 
C11H16N2O3
 
2481 
Moderate    Inter Info   
[1]
D0741
 
Griseofulvin
 
C17H17ClO6
 
441140 
Moderate    Inter Info   
[1]
D0044
 
Alpelisib
 
C19H22F3N5O2S
 
56649450 
Moderate    Inter Info   
[4]
D0194
 
Bosentan
 
C27H29N5O6S
 
104865 
Moderate    Inter Info   
[1]
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Moderate    Inter Info   
[1]
D0300
 
Cenobamate
 
C10H10ClN5O2
 
11962412 
Moderate    Inter Info   
[1]
D0406
 
Dabrafenib
 
C23H20F3N5O2S2
 
44462760 
Moderate    Inter Info   
[1]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Moderate    Inter Info   
[1]
D0545
 
Echinacea
 
NA
 
NA
Moderate    Inter Info   
[6], [7]
D0555
 
Elagolix
 
C32H30F5N3O5
 
11250647 
Moderate    Inter Info   
[1]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Moderate    Inter Info   
[1]
D0639
 
Felbamate
 
C11H14N2O4
 
3331 
Moderate    Inter Info   
[1]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Moderate    Inter Info   
[1]
D0872
 
Ivosidenib
 
C28H22ClF3N6O3
 
71657455 
Moderate    Inter Info   
[1]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Moderate    Inter Info   
[1]
D0958
 
Lumacaftor
 
C24H18F2N2O5
 
16678941 
Moderate    Inter Info   
[12], [13], [14]
D1078
 
Mitotane
 
C14H10Cl4
 
4211 
Moderate    Inter Info   
[1]
D1099
 
Nafcillin
 
C21H22N2O5S
 
8982 
Moderate    Inter Info   
[1]
D1198
 
Oxcarbazepine
 
C15H12N2O2
 
34312 
Moderate    Inter Info   
[1]
D1258
 
Pexidartinib
 
C20H15ClF3N5
 
25151352 
Moderate    Inter Info   
[1]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Moderate    Inter Info   
[1]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Moderate    Inter Info   
[1]
D1399
 
Rifabutin
 
C46H62N4O11
 
135398743 
Moderate    Inter Info   
[1]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Moderate    Inter Info   
[16], [17], [18]
D1401
 
Rifapentine
 
C47H64N4O12
 
135403821 
Moderate    Inter Info   
[1]
D1502
 
St. John's Wort
 
NA
 
NA
Moderate    Inter Info   
[1]
D1538
 
Tazemetostat
 
C34H44N4O4
 
66558664 
Moderate    Inter Info   
[1]
D1128
 
Nevirapine
 
C15H14N4O
 
4463 
Moderate    Inter Info   
[1]
D1248
 
Pentobarbital
 
C11H18N2O3
 
4737 
Moderate    Inter Info   
[1]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Moderate    Inter Info   
[1]
D1652
 
Troglitazone
 
C24H27NO5S
 
5591 
Moderate    Inter Info   
[1]
References
1 Product Information. Singulair (montelukast). Merck & Co, Inc, West Point, PA.
2 Karonen T, Filppula A, Laitila J, Niemi M, Neuvonen PJ, Backman JT "Gemfibrozil Markedly Increases the Plasma Concentrations of Montelukast: A Previously Unrecognized Role for CYP2C8 in the Metabolism of Montelukast." Clin Pharmacol Ther (2010):. [PMID: 20592724]
3 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
4 Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
5 Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
6 Cerner Multum, Inc. "Australian Product Information.".
7 Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
8 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
9 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
10 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
11 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
12 Cerner Multum, Inc. "Canadian Product Information.".
13 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
14 Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
15 Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
16 Jerntorp P, Almer LO "Chlorpropamide-alcohol flushing in relation to macroangiopathy and peripheral neuropathy in non-insulin dependent diabetes." Acta Med Scand 656 (1981): 33-6. [PMID: 6953748]
17 Product Information. Singulair (montelukast). Merck &amp Co, Inc, West Point, PA.
18 Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
19 Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.