Details of Drug

Drug General Information (ID: D1074)
Drug Name	Mirabegron
Drug Type	Small molecule
Drug Synonymous	Myrbetriq (TN) Click to Show/Hide
Disease Class	GC50: Functional bladder disorder
Therapeutic Class	Urinary Antispasmodics
Structure
Structure	3D Structure		2D Structure
Formula	C21H24N4O2S
InChI	1S/C21H24N4O2S/c22-21-25-18(14-28-21)12-20(27)24-17-8-6-15(7-9-17)10-11-23-13-19(26)16-4-2-1-3-5-16/h1-9,14,19,23,26H,10-13H2,(H2,22,25)(H,24,27)/t19-/m0/s1
InChIKey	PBAPPPCECJKMCM-IBGZPJMESA-N
Canonical SMILES	C1=CC=C(C=C1)C(CNCCC2=CC=C(C=C2)NC(=O)CC3=CSC(=N3)N)O
External Link
	Pubchem ID	9865528
	CAS Number	223673-61-8
	CHEBI ID	65349
	TTD ID	D0X5UN
	INTEDE ID	DR1097
	VARIDT ID	DR00699

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Mirabegron
Affected cellular transport
	Transporter inhibition					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[1]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[6], [7], [8]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[6], [7], [83]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[85]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[7], [87]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[89]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[90]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[91]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 138
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[2]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[3], [4]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[5], [4]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[9], [6], [7], [10], [11], [4]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [4], [38], [39], [40], [41], [42], [43], [44], [45]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [4], [56], [57]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[58]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[58]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[59]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[60], [61], [62]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[58]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[63]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[58]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[58]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[58]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[58]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[64], [65], [66], [67], [68], [69], [4], [70], [71], [72], [73], [74], [75]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[58]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[58]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[6], [7], [76], [77], [61], [78]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[58]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[58]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[58]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[79], [80]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[58]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[58]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[58]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[58]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[58]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[58]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[58]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[58]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[58]
D0952		Lorcaserin	C11H14ClN	11658860	Moderate		Inter Info	[81]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[58]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[58]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[58]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[58]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[58]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[58]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[58]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[82]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[86]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[7], [88]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[58]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[93], [94], [4], [95], [96]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[58]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[58]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[58]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[58]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[58]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[7], [97], [4]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[58]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[58]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[58]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[58]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[58]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[58]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[58]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[58]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[58]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[58]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[98], [99], [100]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[58]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[58]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[58]
D0066		Amiodarone	C25H29I2NO3	2157	Minor		Inter Info	[58]
D0080		Amprenavir	C25H35N3O6S	65016	Minor		Inter Info	[58]
D0100		Aprepitant	C23H21F7N4O3	135413536	Minor		Inter Info	[58]
D0116		Atazanavir	C38H52N6O7	148192	Minor		Inter Info	[58]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Minor		Inter Info	[58]
D0192		Boceprevir	C27H45N5O5	10324367	Minor		Inter Info	[58]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Minor		Inter Info	[58]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[58]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[58]
D0349		Clarithromycin	C38H69NO13	84029	Minor		Inter Info	[58]
D0367		Clotrimazole	C22H17ClN2	2812	Minor		Inter Info	[58]
D0386		Conivaptan	C32H26N4O2	151171	Minor		Inter Info	[58]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Minor		Inter Info	[58]
D0402		Cyclosporine	C62H111N11O12	5284373	Minor		Inter Info	[58]
D0413		Dalfopristin	C34H50N4O9S	6323289	Minor		Inter Info	[58]
D0416		Danazol	C22H27NO2	28417	Minor		Inter Info	[58]
D0426		Darunavir	C27H37N3O7S	213039	Minor		Inter Info	[58]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Minor		Inter Info	[58]
D0439		Delavirdine	C22H28N6O3S	5625	Minor		Inter Info	[58]
D0497		Diltiazem	C22H26N2O4S	39186	Minor		Inter Info	[58]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[101], [4], [102], [103]
D0534		Dronedarone	C31H44N2O5S	208898	Minor		Inter Info	[58]
D0597		Erythromycin	C37H67NO13	12560	Minor		Inter Info	[58]
D0667		Fluconazole	C13H12F2N6O	3365	Minor		Inter Info	[58]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Minor		Inter Info	[58]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Minor		Inter Info	[58]
D0740		Grepafloxacin	C19H22FN3O3	72474	Minor		Inter Info	[58]
D0793		Imatinib	C29H31N7O	5291	Minor		Inter Info	[58]
D0799		Indinavir	C36H47N5O4	5362440	Minor		Inter Info	[58]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Minor		Inter Info	[58]
D0858		Isoniazid	C6H7N3O	3767	Minor		Inter Info	[58]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Minor		Inter Info	[58]
D0869		Ivacaftor	C24H28N2O3	16220172	Minor		Inter Info	[58]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Minor		Inter Info	[58]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Minor		Inter Info	[58]
D0944		Lomitapide	C39H37F6N3O2	9853053	Minor		Inter Info	[58]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Minor		Inter Info	[58]
D1057		Miconazole	C18H14Cl4N2O	4189	Minor		Inter Info	[58]
D1063		Mifepristone	C29H35NO2	55245	Minor		Inter Info	[58]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Minor		Inter Info	[58]
D0375		Cobicistat	C40H53N7O5S2	25151504	Minor		Inter Info	[58]
D0543		Duvelisib	C22H17ClN6O	50905713	Minor		Inter Info	[58]
D0577		Entrectinib	C31H34F2N6O2	25141092	Minor		Inter Info	[58]
D0638		Fedratinib	C27H36N6O3S	16722836	Minor		Inter Info	[58]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Minor		Inter Info	[58]
D0789		Idelalisib	C22H18FN7O	11625818	Minor		Inter Info	[58]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Minor		Inter Info	[58]
D0901		Lemborexant	C22H20F2N4O2	56944144	Minor		Inter Info	[58]
D0906		Letermovir	C29H28F4N4O4	45138674	Minor		Inter Info	[58]
D1127		Netupitant	C30H32F6N4O	6451149	Minor		Inter Info	[58]
D1189		Osilodrostat	C13H10FN3	44139752	Minor		Inter Info	[58]
D1214		Palbociclib	C24H29N7O2	5330286	Minor		Inter Info	[58]
D1398		Ribociclib	C23H30N8O	44631912	Minor		Inter Info	[58]
D1432		Rucaparib	C19H18FN3O	9931954	Minor		Inter Info	[58]
D1459		Selpercatinib	C29H31N7O3	134436906	Minor		Inter Info	[58]
D1505		Stiripentol	C14H18O3	5311454	Minor		Inter Info	[58]
D1524		Suvorexant	C23H23ClN6O2	24965990	Minor		Inter Info	[58]
D1660		Tucatinib	C26H24N8O2	51039094	Minor		Inter Info	[58]
D1709		Voxelotor	C19H19N3O3	71602803	Minor		Inter Info	[58]
D1117		Nefazodone	C25H32ClN5O2	4449	Minor		Inter Info	[58]
D1119		Nelfinavir	C32H45N3O4S	64143	Minor		Inter Info	[58]
D1134		Nifedipine	C17H18N2O6	4485	Minor		Inter Info	[58]
D1136		Nilotinib	C28H22F3N7O	644241	Minor		Inter Info	[58]
D1315		Posaconazole	C37H42F2N8O4	468595	Minor		Inter Info	[58]
D1383		Ranolazine	C24H33N3O4	56959	Minor		Inter Info	[104]
D1444		Saquinavir	C38H50N6O5	441243	Minor		Inter Info	[58]
D1541		Telaprevir	C36H53N7O6	3010818	Minor		Inter Info	[58]
D1544		Telithromycin	C43H65N5O10	3002190	Minor		Inter Info	[58]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Minor		Inter Info	[58]
D1690		Verapamil	C27H38N2O4	2520	Minor		Inter Info	[58]
D1706		Voriconazole	C16H14F3N5O	71616	Minor		Inter Info	[58]
D1714		Zafirlukast	C31H33N3O6S	5717	Minor		Inter Info	[58]
	CYP450 enzyme induction					Drug Num: 46
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0545		Echinacea	NA	NA	Moderate		Inter Info	[6], [84]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[7], [92]
D0061		Aminoglutethimide	C13H16N2O2	2145	Minor		Inter Info	[58]
D0071		Amobarbital	C11H18N2O3	2164	Minor		Inter Info	[58]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[58]
D0178		Bexarotene	C24H28O2	82146	Minor		Inter Info	[58]
D0194		Bosentan	C27H29N5O6S	104865	Minor		Inter Info	[58]
D0224		Butabarbital	C10H16N2O3	2479	Minor		Inter Info	[58]
D0225		Butalbital	C11H16N2O3	2481	Minor		Inter Info	[58]
D0255		Carbamazepine	C15H12N2O	2554	Minor		Inter Info	[58]
D0300		Cenobamate	C10H10ClN5O2	11962412	Minor		Inter Info	[58]
D0432		Deferasirox	C21H15N3O4	214348	Minor		Inter Info	[58]
D0453		Dexamethasone	C22H29FO5	5743	Minor		Inter Info	[58]
D0554		Efavirenz	C14H9ClF3NO2	64139	Minor		Inter Info	[58]
D0628		Etravirine	C20H15BrN6O	193962	Minor		Inter Info	[58]
D0639		Felbamate	C11H14N2O4	3331	Minor		Inter Info	[58]
D0697		Fosphenytoin	C16H15N2O6P	56339	Minor		Inter Info	[58]
D0741		Griseofulvin	C17H17ClO6	441140	Minor		Inter Info	[58]
D1040		Methylphenobarbital	C13H14N2O3	8271	Minor		Inter Info	[58]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Minor		Inter Info	[58]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Minor		Inter Info	[58]
D0555		Elagolix	C32H30F5N3O5	11250647	Minor		Inter Info	[58]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Minor		Inter Info	[58]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Minor		Inter Info	[58]
D0953		Lorlatinib	C21H19FN6O2	71731823	Minor		Inter Info	[58]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Minor		Inter Info	[58]
D1538		Tazemetostat	C34H44N4O4	66558664	Minor		Inter Info	[58]
D1078		Mitotane	C14H10Cl4	4211	Minor		Inter Info	[58]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[58]
D1099		Nafcillin	C21H22N2O5S	8982	Minor		Inter Info	[58]
D1128		Nevirapine	C15H14N4O	4463	Minor		Inter Info	[58]
D1198		Oxcarbazepine	C15H12N2O2	34312	Minor		Inter Info	[58]
D1248		Pentobarbital	C11H18N2O3	4737	Minor		Inter Info	[58]
D1265		Phenobarbital	C12H12N2O3	4763	Minor		Inter Info	[58]
D1274		Phenylbutazone	C19H20N2O2	4781	Minor		Inter Info	[58]
D1283		Phenytoin	C15H12N2O2	1775	Minor		Inter Info	[58]
D1340		Primidone	C12H14N2O2	4909	Minor		Inter Info	[58]
D1399		Rifabutin	C46H62N4O11	135398743	Minor		Inter Info	[58]
D1400		Rifampicin	C43H58N4O12	135398735	Minor		Inter Info	[58]
D1401		Rifapentine	C47H64N4O12	135403821	Minor		Inter Info	[58]
D1433		Rufinamide	C10H8F2N4O	129228	Minor		Inter Info	[58]
D1453		Secobarbital	C12H18N2O3	5193	Minor		Inter Info	[58]
D1502		St. John's Wort	NA	NA	Minor		Inter Info	[58]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Minor		Inter Info	[58]
D1652		Troglitazone	C24H27NO5S	5591	Minor		Inter Info	[58]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Minor		Inter Info	[58]
Pharmacodynamic additive effects
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[58]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[58]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[58]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[58]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[58]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[58]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[58]

References
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2	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
3	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
4	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
5	Product Information. Olinvyk (oliceridine). Trevena Inc, Chesterbrook, PA.
6	Cerner Multum, Inc. "Australian Product Information.".
7	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
8	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
9	Canadian Pharmacists Association.
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