Details of Drug

Drug General Information (ID: D1065)
Drug Name	Milk thistle
Drug Type	Small molecule
Drug Synonymous	Silybin B; Milk thistle; 142797-34-0; UNII-853OHH1429; Flavobion; Legalon 70; 853OHH1429; CCRIS 7096; Wild Artichoke; Silybum marianum; Silybin A and B; Milk thistle [NF]; Silymarin + Melatonin; AC1LU7MH; UNII-U946SH95EE; Milk Thistle (Silybum marianum) Extract or Powder; SCHEMBL751461; Silybin B, analytical standard; U946SH95EE; CHEMBL592675; Milk Thistle (Silybum marianum) Extract or Powder [seed]; DTXSID30858697; SEBFKMXJBCUCAI-WAABAYLZSA-N; MolPort-039-139-345; ZINC1530850; BDBM50088491; 2717AH; AKOS015912848 Click to Show/Hide
Disease Class	2A00-2F9Z: Solid tumour/cancer
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C25H22O10
InChI	1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20-,23-,24-,25+/m0/s1
InChIKey	SEBFKMXJBCUCAI-WAABAYLZSA-N
Canonical SMILES	COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
External Link
	Pubchem ID	1548994
	CAS Number	65666-07-1
	TTD ID	D0C5VQ
	VARIDT ID	DR00878

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism BM017 CYP450 enzyme inhibition BM019 UGT inhibition
Relation Graph

Full list of drugs interacting with Milk thistle
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[2]
	UGT inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0433		Deferiprone	C7H9NO2	2972	Moderate		Inter Info	[1]

References
1	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
2	Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.