Details of Drug

Drug General Information (ID: D1063)
Drug Name	Mifepristone
Drug Type	Small molecule
Drug Synonymous	Mifedren; HRA-052015; Mifepristone (Cushing's disease); ACTH modulator (Cushing's disease), HRA; Adrenocorticotropic hormone modulator (Cushing's disease), HRA Pharma; Mifepristone (Cushing's disease), HRA pharma Click to Show/Hide
Disease Class	5A70: Cushing syndrome
Therapeutic Class	Uterotonic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C29H35NO2
InChI	1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
InChIKey	VKHAHZOOUSRJNA-GCNJZUOMSA-N
Canonical SMILES	CC#CC1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)O
External Link
	Pubchem ID	55245
	CAS Number	84371-65-3
	CHEBI ID	50692
	TTD ID	D0Z4EI
	INTEDE ID	DR1091
	VARIDT ID	DR00714

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM050 Increased risk of bleeding BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM083 Potentiated the pharmacological effects (Unspecific) BM092 Antagonize the effect of corticosteroids BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Mifepristone
Affected cellular transport
	Transporter inhibition					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[2], [3], [136]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[4]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[2], [3], [152]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[153], [154]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[179]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[196]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 265
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[4], [26]
D0115		Astemizole	C28H31FN4O	2247	Major		Inter Info	[27], [4], [26]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[28]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[29], [30], [31], [32], [33], [34], [35], [9], [36], [37], [38], [39], [40], [41]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[27], [4], [26]
D0424		Darifenacin	C28H30N2O2	444031	Major		Inter Info	[2], [42], [43], [44]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[4], [26]
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[27], [4], [26]
D0557		Eletriptan	C22H26N2O2S	77993	Major		Inter Info	[27], [4], [26]
D0585		Eplerenone	C24H30O6	443872	Major		Inter Info	[27], [4], [26]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[27], [4], [26]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[27], [4], [26]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[4], [26]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[1], [2], [3], [45], [46], [47], [48]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Major		Inter Info	[3], [45], [46]
D0956		Lovastatin	C24H36O5	53232	Major		Inter Info	[27], [4], [26]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[27], [4], [26]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[27], [4], [26]
D1060		Midazolam	C18H13ClFN3	4192	Major		Inter Info	[27], [4], [26]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[49]
D0108		Artemether	C16H26O5	68911	Major		Inter Info	[2], [3], [50]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[4], [26]
D0128		Avanafil	C23H26ClN7O3	9869929	Major		Inter Info	[2], [44], [51]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[3], [52]
D0133		Axitinib	C22H18N4OS	6450551	Major		Inter Info	[2], [3], [53], [44]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[54], [55], [56]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[4], [26]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[2], [3], [57], [44]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[58]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[59]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[60]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Major		Inter Info	[61]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[4], [26]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[3], [62], [63], [64]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[4], [26]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[4], [26]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[2], [65], [44]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[2], [66], [44], [67]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[2], [44], [68]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[3], [69]
D0511		Docetaxel	C43H53NO14	148124	Major		Inter Info	[72], [2], [3], [73], [74], [44], [75], [76], [77], [78]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[27], [4], [26]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[79]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[2], [3], [80]
D0592		Ergometrine	C19H23N3O2	443884	Major		Inter Info	[27], [4], [26]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[83]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[4], [26]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[3], [84]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[54], [55]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[4], [26]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[4], [26]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[88]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[4], [26]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Major		Inter Info	[2], [3], [90]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[91], [92]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[2], [93], [44]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[92]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[2], [3], [94], [44]
D1104		Naloxegol	C34H53NO11	56959087	Major		Inter Info	[27], [4], [26]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[4], [26]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[96], [2], [97]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[98], [99]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[4], [26]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[27], [4], [26]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[108]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Major		Inter Info	[2], [109]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[4], [26]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[27], [4], [26]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[27], [4], [26]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[4], [26]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[4], [26]
D1608		Tolvaptan	C26H25ClN2O3	216237	Major		Inter Info	[2], [66], [44], [67]
D1632		Triazolam	C17H12Cl2N4	5556	Major		Inter Info	[27], [4], [26]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[4], [26]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[4], [26]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Major		Inter Info	[135]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[4], [26]
D1141		Nisoldipine	C20H24N2O6	4499	Major		Inter Info	[27], [4], [26]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[2], [3], [137]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[4], [26]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[27], [4], [26]
D1555		Terfenadine	C32H41NO2	5405	Major		Inter Info	[27], [4], [26]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[4], [26]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[4]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[2], [3], [27], [26]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[2], [3], [27], [26]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[2], [3], [27], [26]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[4], [26]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[2], [3], [27], [26]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[27], [26]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[2], [3], [27], [26]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[27], [26]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[4]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[4], [26]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[4]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[4], [26]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[3], [27], [26]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[2], [3], [27], [26]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[3], [27], [26]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[4]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[2], [3], [27], [26]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[4]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[4], [26]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[2], [3], [27], [26]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[3], [27], [26]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[2], [3], [27], [26]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[2], [3], [27], [26]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[2], [3], [27], [26]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[2], [3], [27], [26]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[4]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[4], [26]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[2], [3], [27], [26]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[2], [3], [27], [26]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[4]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[4], [26]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[4]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[2], [3], [27], [26]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[2], [3], [27], [26]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[2], [3], [27], [26]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[2], [3], [27], [26]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[4]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[4]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[3], [27], [26]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[4]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[4]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[148]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[2], [3], [27], [26]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[2], [3], [27], [26]
D0041		Almotriptan	C17H25N3O2S	123606	Moderate		Inter Info	[149]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[150]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[2], [3], [27], [26]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[4], [26]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[2], [3], [151]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[2], [3], [27], [26]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[155], [2], [3]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[156], [2], [3], [157], [158], [159], [160], [161], [68], [162], [163], [164]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[2], [3], [27], [26]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[2], [165], [44]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[166]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[2], [3], [27], [26]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[2], [3], [27], [26]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[167], [4], [26]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[4], [26]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[4], [26]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[168], [169]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[3], [27], [26]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[3], [27], [26]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[2], [3], [27], [26]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[2], [3], [27], [26]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[170]
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[171]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[2], [3], [27], [26]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[3], [27], [26]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[3], [27], [26]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[2], [3], [27], [26]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[2], [3], [27], [26]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[2], [3], [173], [174]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[4], [26]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[2], [3], [27], [26]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[4]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[4]
D0739		Grazoprevir	C38H50N6O9S	44603531	Moderate		Inter Info	[3], [27], [26]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[2], [3], [27], [26]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[4]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[4]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[4], [26]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[4], [26]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[2], [3], [27], [26]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[2], [3], [27], [26]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[2], [3], [27], [26]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[4], [26]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[4]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[4], [26]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[2], [3], [27], [26]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[2], [3], [27], [26]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[2], [3], [27], [26]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[178]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[180]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[2], [3], [27], [26]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[4], [26]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[2], [3], [27], [26]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[181]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[2], [3], [27], [26]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[182]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[2], [3], [27], [26]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[3], [27], [26]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[3], [183]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[4]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[3], [186], [99]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[187]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[2], [3], [27], [26]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[188]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[2], [3], [27], [26]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[4]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[2], [3], [27], [26]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[2], [3], [27], [26]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[4]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[193]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[2], [3], [27], [26]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[2], [3], [27], [26]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[2], [3], [27], [26]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[3], [194], [195]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[2], [3], [27], [26]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[197]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[2], [3], [27], [26]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[2], [3], [27], [26]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[2], [3], [27], [26]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[2], [3], [27], [26]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[2], [3], [27], [26]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[4]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[4]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[2], [3], [27], [26]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[2], [3], [27], [26]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[2], [200], [44]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[2], [3], [27], [26]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[2], [3], [27], [26]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[4], [26]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[2], [3], [27], [26]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[2], [3], [27], [26]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[2], [3], [27], [26]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[4]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[4]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[4]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[27], [26]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[2], [3], [27], [26]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[2], [3], [27], [26]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[2], [3], [27], [26]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[4], [26]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[4]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[2], [3], [27], [26]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[3], [27], [26]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[4]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[27], [26]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[4]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[2], [3], [27], [26]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[2], [3], [27], [26]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[2], [3], [27], [26]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[2], [3], [27], [26]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[2], [3], [27], [26]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[2], [3], [27], [26]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[3], [27], [26]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[4], [26]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[4]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[2], [3], [27], [26]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[27], [26]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[4]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[4], [26]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[2], [3], [27], [26]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[3], [27], [26]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[2], [3], [27], [26]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[4], [26]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[2], [3], [27], [26]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[2], [3], [27], [26]
D0053		Ambrisentan	C22H22N2O4	6918493	Minor		Inter Info	[201]
D0248		Cannabidiol	C21H30O2	644019	Minor		Inter Info	[3], [202]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[203]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[189], [99], [204], [205]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[206]
D0589		Eravacycline	C27H31FN4O8	54726192	Minor		Inter Info	[207]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[211]
D1434		Ruxolitinib	C17H18N6	25126798	Minor		Inter Info	[3], [212]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[2], [217], [218]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[219]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[220], [221], [222], [223], [224], [225], [226]
	CYP450 enzyme induction					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[89]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[4], [26]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[4], [26]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[4], [26]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[4], [26]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[4], [26]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[4], [26]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[4], [26]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[27], [26]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[4], [26]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[2], [175]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[4], [26]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[4], [26]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[4], [26]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[3], [192]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[4], [26]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[4], [26]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[4], [26]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[4], [26]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[3], [198]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[4], [26]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[4], [26]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[4], [26]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[4], [26]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[4], [26]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[4], [26]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[4], [26]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[4], [26]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[4], [26]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[4], [26]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[4], [26]
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[4], [26]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[4], [26]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[4], [26]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[4], [26]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[4], [26]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[4], [26]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[4], [26]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[4], [26]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[4], [26]
D0415		Danaparoid	NA	NA	Major		Inter Info	[4], [26]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[4], [26]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[4], [26]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[4], [26]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[4], [26]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[4], [26]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[4], [26]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[4], [26]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[4], [26]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[4], [26]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[4], [26]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[4], [26]
	Increased risk of prolong QT interval					Drug Num: 146
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0003		Abarelix	C72H95ClN14O14	16131215	Major		Inter Info	[1], [2], [3], [4]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1], [2], [3], [4]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1], [2], [3], [4]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1], [2], [3], [4]
D0097		Apomorphine	C17H17NO2	6005	Major		Inter Info	[1], [2], [3], [4]
D0119		Atomoxetine	C17H21NO	54841	Major		Inter Info	[1], [2], [3], [4]
D0139		Azithromycin	C38H72N2O12	447043	Major		Inter Info	[1], [2], [3], [4]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[1], [2], [3], [4]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[1], [2], [3], [4]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[1], [2], [3], [4]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[1], [2], [3], [4]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1], [2], [3], [4]
D0429		Daunorubicin	C27H29NO10	30323	Major		Inter Info	[1], [2], [3], [4]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Major		Inter Info	[2], [3], [4]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[2], [3], [4]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[1], [2], [3], [4]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[1], [2], [3], [4]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[1], [2], [3], [4]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[1], [2], [3], [4]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[1], [2], [3], [4]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[1], [2], [3], [4]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1], [2], [3], [4]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[1], [2], [3], [4]
D0682		Flutamide	C11H11F3N2O3	3397	Major		Inter Info	[1], [2], [3], [4]
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[1], [2], [3], [4]
D0737		Goserelin	C59H84N18O14	5311128	Major		Inter Info	[1], [2], [3], [4]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[1], [2], [3], [4]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[1], [2], [3], [4]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Major		Inter Info	[1], [2], [3], [4]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[1], [2], [3], [4]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1], [2], [3], [4]
D0908		Leuprolide	C59H84N16O12	657181	Major		Inter Info	[1], [2], [3], [4]
D0992		Mefloquine	C17H16F6N2O	4046	Major		Inter Info	[1], [2], [3], [4]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1], [2], [3], [4]
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[1], [2], [3], [4]
D0037		Alimemazine	C18H22N2S	5574	Major		Inter Info	[2], [3], [4]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2], [3], [4]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[1], [2], [3], [4]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1], [2], [3], [4]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[1], [2], [3], [4]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[1], [2], [3], [4]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[1], [2], [3], [4]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[1], [2], [3], [4]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Major		Inter Info	[1], [2], [3], [4]
D0358		Clofazimine	C27H22Cl2N4	2794	Major		Inter Info	[1], [2], [3], [4]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1], [2], [3], [4]
D0437		Degarelix	C82H103ClN18O16	16136245	Major		Inter Info	[1], [2], [3], [4]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1], [2], [3], [4]
D0452		Deutetrabenazine	C19H27NO3	73437646	Major		Inter Info	[1], [2], [3], [4]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[1], [2], [3], [4]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[2], [3], [4]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[1], [2], [3], [4]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Major		Inter Info	[2], [3], [4]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[1], [2], [3], [4]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1], [2], [3], [4]
D0594		Eribulin	C40H59NO11	11354606	Major		Inter Info	[1], [2], [3], [4]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[1], [2], [3], [4]
D0632		Ezogabine	C16H18FN3O2	121892	Major		Inter Info	[1], [2], [3], [4]
D0664		Flecainide	C17H20F6N2O3	3356	Major		Inter Info	[1], [2], [3], [4]
D0700		Fostemsavir	C25H26N7O8P	11319217	Major		Inter Info	[1], [2], [3], [4]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[1], [2], [3], [4]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Major		Inter Info	[1], [2], [3], [4]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[1], [2], [3], [4]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[1], [2], [3], [4]
D0738		Granisetron	C18H24N4O	5284566	Major		Inter Info	[1], [2], [3], [4]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[1], [2], [3], [4]
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[1], [2], [3], [4]
D0758		Histrelin	C66H86N18O12	25077993	Major		Inter Info	[1], [2], [3], [4]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[1], [2], [3], [4]
D0788		Idarubicin	C26H27NO9	42890	Major		Inter Info	[1], [2], [3], [4]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[1], [2], [3], [4]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[1], [2], [3], [4]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[1], [2], [3], [4]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[1], [2], [3], [4]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Major		Inter Info	[1], [2], [3], [4]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[1], [2], [3], [4]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Major		Inter Info	[1], [2], [3], [4]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[2], [3], [4]
D0942		Lofexidine	C11H12Cl2N2O	30668	Major		Inter Info	[1], [2], [3], [4]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Major		Inter Info	[1], [2], [3], [4]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[95]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[1], [2], [3], [4]
D1026		Methotrimeprazine	C19H24N2OS	72287	Major		Inter Info	[1], [2], [3], [4]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[1], [2], [3], [4]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[1], [2], [3], [4]
D1155		Norfloxacin	C16H18FN3O3	4539	Major		Inter Info	[1], [2], [3], [4]
D1165		Ofloxacin	C18H20FN3O4	4583	Major		Inter Info	[1], [2], [3], [4]
D1181		Ondansetron	C18H19N3O	4595	Major		Inter Info	[1], [2], [3], [4]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[1], [2], [3], [4]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[1], [2], [3], [4]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[1], [2], [3], [4]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[1], [2], [3], [4]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[100], [101], [102], [103], [104], [105], [106], [107]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[1], [2], [3], [4]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[1], [2], [3], [4]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[1], [2], [3], [4]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[1], [2], [3], [4]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[1], [2], [3], [4]
D1339		Primaquine	C15H21N3O	4908	Major		Inter Info	[1], [2], [3], [4]
D1342		Probucol	C31H48O2S2	4912	Major		Inter Info	[1], [2], [3], [4]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[1], [2], [3], [4]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[1], [2], [3], [4]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[1], [2], [3], [4]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[1], [2], [3], [4]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1], [2], [3], [4]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[1], [2], [3], [4]
D1424		Romidepsin	C24H36N4O6S2	5352062	Major		Inter Info	[1], [2], [3], [4]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[1], [2], [3], [4]
D1438		Salbutamol	C13H21NO3	2083	Major		Inter Info	[2], [3], [4]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1], [2], [3], [4]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[1], [2], [3], [4]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[1], [2], [3], [4]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[1], [2], [3], [4]
D1554		Terbutaline	C12H19NO3	5403	Major		Inter Info	[1], [2], [3], [4]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[1], [2], [3], [4]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Major		Inter Info	[1], [2], [3], [4]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[1], [2], [3], [4]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[1], [2], [3], [4]
D1682		Vardenafil	C23H32N6O4S	135400189	Major		Inter Info	[1], [2], [3], [4]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[1], [2], [3], [4]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[1], [2], [3], [4]
D1137		Nilutamide	C12H10F3N3O4	4493	Major		Inter Info	[1], [2], [3], [4]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1], [2], [3], [4]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[1], [2], [3], [4]
D1210		Oxytocin	C43H66N12O12S2	439302	Major		Inter Info	[1], [2], [3], [4]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[1], [2], [3], [4]
D1254		Perflutren	C3F8	6432	Major		Inter Info	[138], [139]
D1346		Prochlorperazine	C20H24ClN3S	4917	Major		Inter Info	[1], [2], [3], [4]
D1351		Promazine	C17H20N2S	4926	Major		Inter Info	[1], [2], [3], [4]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1], [2], [3], [4]
D1372		Quinine	C20H24N2O2	3034034	Major		Inter Info	[1], [2], [3], [4]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[1], [2], [3], [4]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[1], [2], [3], [4]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[1], [2], [3], [4]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[1], [2], [3], [4]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[1], [2], [3], [4]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[1], [2], [3], [4]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1], [2], [3], [4]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[1], [2], [3], [4]
D1637		Trifluoperazine	C21H24F3N3S	5566	Major		Inter Info	[1], [2], [3], [4]
D1683		Vasopressin	C46H65N15O12S2	644077	Major		Inter Info	[1], [2], [3], [4]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[1], [2], [3], [4]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[2], [3], [172]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[176], [177]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[2], [208], [209], [210]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[1], [2], [3], [213], [214], [215], [216]
	Increased risk of ventricular arrhythmias					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0025		Adenosine	C10H13N5O4	60961	Major		Inter Info	[5], [3], [6], [7], [8], [9], [10], [11]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[1], [2], [3], [81], [82]
D0859		Isoprenaline	C11H17NO3	3779	Major		Inter Info	[85], [86], [87]
D1414		Ritodrine	C17H21NO3	33572	Major		Inter Info	[85], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [86], [128], [129], [130], [131], [87], [132], [133]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[2], [134]
D1185		Orciprenaline	C11H17NO3	4086	Major		Inter Info	[85], [86], [87]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[85], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [142], [143], [122], [123], [124], [125], [126], [144], [127], [86], [128], [129], [130], [131], [87], [132], [133]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[85], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [142], [143], [122], [123], [124], [125], [126], [144], [127], [86], [128], [129], [130], [131], [87], [132], [133]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[85], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [142], [143], [122], [123], [124], [125], [126], [144], [127], [86], [128], [129], [130], [131], [87], [132], [133]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[2], [3], [147]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[85], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [142], [143], [122], [123], [124], [125], [126], [144], [127], [86], [128], [129], [130], [131], [87], [132], [133]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[85], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [142], [143], [122], [123], [124], [125], [126], [144], [127], [86], [128], [129], [130], [131], [87], [132], [133]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[1], [2], [3], [145], [146], [147]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[3], [184], [185]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[85], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [142], [143], [122], [123], [124], [125], [126], [144], [127], [86], [128], [129], [130], [131], [87], [132], [133]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[3], [184], [185]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[2], [3], [147]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[1], [2], [3], [189], [190], [191]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[85], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [142], [143], [122], [123], [124], [125], [126], [144], [127], [86], [128], [129], [130], [131], [87], [132], [133]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[3], [184], [185]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[2], [3], [199]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[142], [128], [131]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[1], [2], [3], [189], [190], [191]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1777		Dinoprostone (topical)	C20H32O5	5280360	Major		Inter Info	[70], [71]
Pharmacodynamic antagonistic effects
	Antagonize the effect of corticosteroids					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0148		Beclomethasone dipropionate	C28H37ClO7	21700	Major		Inter Info	[4], [26]
D0172		Betamethasone	C22H29FO5	9782	Major		Inter Info	[4], [26]
D0671		Fludrocortisone	C21H29FO5	31378	Major		Inter Info	[4], [26]
D0672		Flunisolide	C24H31FO6	82153	Major		Inter Info	[4], [26]
D0773		Hydrocortisone	C21H30O5	5754	Major		Inter Info	[4], [26]
D0215		Budesonide	C25H34O6	5281004	Major		Inter Info	[4], [26]
D0392		Corticotropin	C207H308N56O58S	16132265	Major		Inter Info	[4], [26]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[4], [26]
D1041		Methylprednisolone	C22H30O5	6741	Major		Inter Info	[4], [26]
D1332		Prednisolone	C21H28O5	5755	Major		Inter Info	[4], [26]
D1563		Tetracosactide	C136H210N40O31S	16133802	Major		Inter Info	[4], [26]
D1334		Prednisone	C21H26O5	5865	Major		Inter Info	[4], [26]
D1628		Triamcinolone	C21H27FO6	31307	Major		Inter Info	[4], [26]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[140], [141], [4]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[140], [141], [4]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[140], [141], [4]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[140], [141], [4]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[140], [141], [4]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[140], [141], [4]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[140], [141], [4]

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180	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
181	Product Information. Ofev (nintedanib). Boehringer Ingelheim, Ridgefield, CT.
182	Product Information. Osphena (ospemifene). Shionogi USA Inc, Florham Park, NJ.
183	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
184	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
185	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
186	Product Information. Esbriet (pirfenidone). Intermune Inc, Brisbane, CA.
187	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
188	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
189	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
190	Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
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197	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
198	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
199	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
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201	Product Information. Letairis (ambrisentan). Gilead Sciences, Foster City, CA.
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210	Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
211	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
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