Details of Drug

Details of Drug

 Drug General Information (ID: D1052)
  Drug Name
Metronidazole (topical)
  Drug Type Small molecule
  Drug Synonymous
APMN; Acromona; Anagiardil; Arilin; Atrivyl; Bexon; CONT; Clont; Danizol; Deflamon; Efloran; Elyzol; Entizol; Eumin; Flagemona; Flagesol; Flagil; Flagyl; Flegyl; Florazole; Fossyol; Giatricol; Gineflavir; Giniflavir; Klion; Klont; Meronidal; Methronidazole; Metric; MetroCream; MetroGel; MetroLotion; Metrodzhil; Metrogyl; Metrolag; Metrolyl; Metromidol; Metronidaz; Metronidazol; Metronidazolo; Metronidazolum; Metrotop; Metrozine; Metryl; Mexibol; Monagyl; Monasin; NIDA; Nalox; Nidagel; Noritate; Novonidazol; Orvagil; Protostat; Rathimed; Rosased; Sanatrichom; Satric; Takimetol; Trichazol; Trichex; Trichocide; Trichomol; Trichopal; Trichopol; Tricocet; Tricom; Trikacide; Trikamon; Trikojol; Trikozol; Trimeks; Trivazol; Vagilen; Vagimid; Vandazole; Vertisal; Wagitran; Zadstat; Zidoval; Flagyl Er; Ginefla vir; METRONIDAZOLE USP; Metro Cream; Metro Gel; Metronidazole Monohydrochloride; Metronidazole Phosphoester; Metronidazole in Plastic Container; Metronidazolo [DCIT]; Tricho cordes; Trichomonacid pharmachim; Tricowas B; Bayer 5360; Flagyl 375; M0924; Metric 21; RP 8823; SC 10295; Anabact (TN); Apo-Metronidazole; Deflamon-wirkstoff; Flagyl (TN); IDR-90105; METRO I.V; MetroGel (TN); MetroGel-Vaginal; Metronidazol [INN-Spanish]; Metronidazolum [INN-Latin]; Mexibol (silanes); Neo-Tric; Noritate (TN); RP-8823; Rozex (TN); Tricho-gynaedron; ZERO/004064; CB-01-14 MMX; FLAGYL I.V. RTU IN PLASTIC CONTAINER; Flagyl I.V.; Flagyl I.V. RTU; Metro I.V.; Metro I.V. In Plastic Container; Metrogel-vaginal (TN); Metronidazole (JP15/USP/INN); Metronidazole [USAN:INN:BAN:JAN]; Methyl-5-nitroimidazole-1-ethanol; 1-Hydroxyethyl-2-methyl-5-nitroimidazole; 2-(2-methyl-5-nitroimidazol-1-yl)ethanol; 2-Methyl-5-nitro-1-imidazoleethanol; 2-Methyl-5-nitroimidazole-1-ethanol; MNZ
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  Disease Class 1A36: Amoebiasis; DD70: Crohn disease
  Therapeutic Class Antiinfective Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C6H9N3O3
  InChI 1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
  InChIKey VAOCPAMSLUNLGC-UHFFFAOYSA-N
  Canonical SMILES CC1=NC=C(N1CCO)[N+](=O)[O-]
  External Link
Pubchem ID 4173
CAS Number 443-48-1
CHEBI ID 6909
TTD ID D0A2ZX
INTEDE ID DR1073

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
BM017  CYP450 enzyme inhibition
BM018  Non-CYP450 enzyme inhibition
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Metronidazole (topical)
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Moderate    Inter Info   
[9], [10], [11]
   Non-CYP450 enzyme inhibition Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0081
 
Amprenavir (oral solution)
 
C25H35N3O6S
 
65016 
Major    Inter Info   
[1], [2], [3]
D0617
 
Ethanol
 
C2H6O
 
702 
Moderate    Inter Info   
[6], [7], [8]
      Pharmacodynamic additive effects
   Increased risk of other adverse reactions (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0509
 
Disulfiram
 
C10H20N2S4
 
3117 
Moderate    Inter Info   
[2], [4], [5]
References
1 Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
2 Product Information. Metrogel-Vaginal (metronidazole). Curatek Pharmaceuticals Ltd, Elk Grove Village, IL.
3 Product Information. Tindamax (tinidazole). Presutti Laboratories Inc, Arlington Heights, IL.
4 Scher JM "Psychotic reaction to disulfiram." JAMA 201 (1967): 175.[PMID: 6072487]
5 Rothstein E, Clancy DD "Toxicity of disulfiram combined with metronidazole." N Engl J Med 280 (1969): 1006-7
6 Harries DP, Teale KF, Sunderland G "Metronidazole and alcohol: potential problems." Scott Med J 35 (1990): 179-80. [PMID: 2077651]
7 Krulewitch CJ "An unexpected adverse drug effect." J Midwifery Womens Health 48 (2003): 67-8. [PMID: 12589307]
8 Visapaa JP, Tillonen JS, Kaihovaara PS, Salaspuro MP "Lack of disulfiram-like reaction with metronidazole and ethanol." Ann Pharmacother 36 (2002): 971-4. [PMID: 12022894]
9 Hermans JJ, Thijssen HH "Human liver microsomal metabolism of the enantiomers of warfarin and acenocoumarol: P450 isozyme diversity determines the differences in their pharmacokinetics." Br J Pharmacol 110 (1993): 482-90. [PMID: 8220911]
10 Kelly JG, O'Malley K "Clinical pharmacokinetics of oral anticoagulants." Clin Pharmacokinet 4 (1979): 1-15. [PMID: 369763]
11 Wells PS, Holbrook AM, Crowther NR, Hirsh J "Interactions of warfarin with drugs and food." Ann Intern Med 121 (1994): 676-83. [PMID: 7944078]