Details of Drug

Drug General Information (ID: D1050)
Drug Name	Metreleptin
Drug Type	Hormones
Disease Class	5A2Y: Acute diabete complication
Therapeutic Class	Metabolic Agents
External Link
External Link	TTD ID	D0Z9EO

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM064 Increased risk of hypoglycemia
Relation Graph

Full list of drugs interacting with Metreleptin
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[3]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[3]
D0450		Desogestrel	C22H30O	40973	Moderate		Inter Info	[38], [39], [3]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[38], [39], [3]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[3]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[38], [39], [3]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[3]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[3]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[3]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[38], [39], [3]
D0485		Dienogest	C20H25NO2	68861	Moderate		Inter Info	[38], [39], [3]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[3]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[38], [39], [3]
D1156		Norgestimate	C23H31NO3	6540478	Moderate		Inter Info	[38], [39], [3]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[3]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[3]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[3]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[3]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[3]
	CYP450 enzyme induction					Drug Num: 88
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[1]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[5], [6], [7], [8]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[9], [10], [11]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[31], [32]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[16], [33]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[34]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[35], [16], [36]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[15], [16], [37]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[15], [16], [40]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[16], [41], [42], [43]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[41], [42], [43]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[15], [16], [40]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[15], [16], [40]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[44]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[16], [45], [46]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[47], [48], [15], [16], [49], [50]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[52], [53], [58]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[66]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[67], [68], [69], [70]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[71]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[15], [16], [72]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[15], [16], [40]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[15], [16], [40]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[73]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[74]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[75]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[16], [76]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[13], [20], [30]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[16], [77], [78]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[15], [16], [79]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[80]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[81]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[82], [83]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[84]
D0556		Elbasvir	C49H55N9O7	71661251	Moderate		Inter Info	[85]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[86]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[87]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[88]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[89]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[90]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[16], [91]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[92]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[15], [93]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[94]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[95]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[96]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[15], [16], [97]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[98]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[15], [16], [99]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[16], [100]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[15], [16], [101]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[15], [102]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[103]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[16], [104]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[105]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[106]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[107]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[108]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[109]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[110]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[111]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[112], [113]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[114]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[48], [15], [16]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[115]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[116]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[117], [15], [118], [119]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[15], [120], [121], [122], [123]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[124]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[15], [35], [16], [125]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[126]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[15], [16], [127]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[128]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[129], [130]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[48], [16], [131], [132], [133]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[16], [134]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[135], [15], [16], [136], [137]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[16], [138], [139]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[140]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[16], [141], [142], [143], [144]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[145]
Pharmacodynamic additive effects
	Increased risk of hypoglycemia					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[2], [3], [4]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[2], [3], [4]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[2], [3], [4]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[2], [3], [4]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[2], [3], [4]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[2], [3], [4]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[2], [3], [4]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[2], [3], [4]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[2], [3], [4]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[2], [3], [4]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[2], [3], [4]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[2], [3], [4]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[2], [3], [4]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[2], [3], [4]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[2], [3], [4]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[2], [3], [4]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[2], [3], [4]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[2], [3], [4]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[2], [3], [4]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[2], [3], [4]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[2], [3], [4]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[2], [3], [4]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[2], [3], [4]

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