Details of Drug

Drug General Information (ID: D1042)
Drug Name	Methyltestosterone
Drug Type	Small molecule
Drug Synonymous	Android (TN) Click to Show/Hide
Disease Class	2A00-2F9Z: Solid tumour/cancer
Therapeutic Class	Androgens/Anabolic Steroids
Structure
Structure	3D Structure		2D Structure
Formula	C20H30O2
InChI	1S/C20H30O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h12,15-17,22H,4-11H2,1-3H3/t15-,16+,17+,18+,19+,20+/m1/s1
InChIKey	GCKMFJBGXUYNAG-HLXURNFRSA-N
Canonical SMILES	CC12CCC(=O)C=C1CCC3C2CCC4(C3CCC4(C)O)C
External Link
	Pubchem ID	6010
	CAS Number	58-18-4
	CHEBI ID	27436
	TTD ID	D0Z1XD
	INTEDE ID	DR1064

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM047 Additive thrombogenic effects BM055 Increased risk of hepatotoxicity BM064 Increased risk of hypoglycemia BM083 Potentiated the pharmacological effects (Unspecific) BM108 Increased risk of hypercalcemia
Relation Graph

Full list of drugs interacting with Methyltestosterone
Pharmacodynamic additive effects
	Additive thrombogenic effects					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[4], [5], [6]
D0762		Human C1-esterase inhibitor	NA	NA	Moderate		Inter Info	[130], [131], [132]
D0385		Conestat alfa	NA	NA	Moderate		Inter Info	[130], [151], [131], [132]
	Increased risk of hepatotoxicity					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[1], [2], [3]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[7]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[8]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[1], [2], [3]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[9]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[111], [112], [113], [4], [6], [114], [115], [116], [117], [118], [119], [120], [121]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[126]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[127], [128]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[4], [6], [129]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[140], [141], [142], [143]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[140], [141], [142], [143]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[6], [147]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[111], [112], [113], [4], [6], [114], [115], [116], [117], [118], [119], [120], [121]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[148]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[149]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[111], [112], [113], [4], [6], [114], [115], [116], [117], [118], [119], [120], [121]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[6], [150]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[152]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[140], [141], [142], [143]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[4], [6], [153], [154], [155]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[156]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[111], [112], [113], [4], [6], [114], [115], [116], [117], [118], [119], [120], [121]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[157], [158]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[6], [159]
	Increased risk of hypoglycemia					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[17], [74], [91]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[17], [74], [91]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [133], [21], [22], [23], [24], [25], [26], [27], [28], [30], [31], [32], [34], [35], [36], [37], [39], [40], [41], [43], [45], [46], [47], [48], [49], [50], [51], [52], [53], [55], [58], [60], [61], [62], [65], [66], [68], [69], [70], [72], [134], [74], [135], [136], [79], [137], [138], [85], [87], [88], [89], [91], [93], [95], [97], [98], [102], [103], [104], [105], [139], [106], [107], [109], [110]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [133], [21], [22], [23], [24], [25], [26], [27], [28], [30], [31], [32], [34], [35], [36], [37], [39], [40], [41], [43], [45], [46], [47], [48], [49], [50], [51], [52], [53], [55], [58], [60], [61], [62], [65], [66], [68], [69], [70], [72], [134], [74], [135], [136], [79], [137], [138], [85], [87], [88], [89], [91], [93], [95], [97], [98], [102], [103], [104], [105], [139], [106], [107], [109], [110]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [133], [21], [22], [23], [24], [25], [26], [27], [28], [30], [31], [32], [34], [35], [36], [37], [39], [40], [41], [43], [45], [46], [47], [48], [49], [50], [51], [52], [53], [55], [58], [60], [61], [62], [65], [66], [68], [69], [70], [72], [134], [74], [135], [136], [79], [137], [138], [85], [87], [88], [89], [91], [93], [95], [97], [98], [102], [103], [104], [105], [139], [106], [107], [109], [110]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[17], [74], [91]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[17], [74], [91]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[17], [74], [91]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[17], [74], [91]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[17], [74], [91]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[17], [74], [91]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [133], [21], [22], [23], [24], [25], [26], [27], [28], [30], [31], [32], [34], [35], [36], [37], [39], [40], [41], [43], [45], [46], [47], [48], [49], [50], [51], [52], [53], [55], [58], [60], [61], [62], [65], [66], [68], [69], [70], [72], [134], [74], [135], [136], [79], [137], [138], [85], [87], [88], [89], [91], [93], [95], [97], [98], [102], [103], [104], [105], [139], [106], [107], [109], [110]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[17], [74], [91]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [133], [21], [22], [23], [24], [25], [26], [27], [28], [30], [31], [32], [34], [35], [36], [37], [39], [40], [41], [43], [45], [46], [47], [48], [49], [50], [51], [52], [53], [55], [58], [60], [61], [62], [65], [66], [68], [69], [70], [72], [134], [74], [135], [136], [79], [137], [138], [85], [87], [88], [89], [91], [93], [95], [97], [98], [102], [103], [104], [105], [139], [106], [107], [109], [110]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[122], [123]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[122], [123]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[122], [123]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[122], [123]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[122], [123]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[122], [123]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[144], [145], [146]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[144], [145], [146]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[144], [145], [146]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[122], [123]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[122], [123]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[144], [145], [146]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[122], [123]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[122], [123]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[122], [123]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[122], [123]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[122], [123]
	Increased risk of hypercalcemia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1753		Calcipotriol (topical)	C27H40O3	5288783	Moderate		Inter Info	[124], [125]
D1754		Calcitriol (topical)	C27H44O3	5280453	Moderate		Inter Info	[124], [125]

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73	Product Information. Amaryl (glimepiride). Hoechst Marion-Roussel Inc, Kansas City, MO.
74	Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
75	Product Information. Diabeta (glyburide). Hoechst Marion-Roussel Inc, Kansas City, MO.
76	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
77	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
78	Product Information. Glucotrol (glipizide). Pfizer US Pharmaceuticals, New York, NY.
79	Product Information. Increlex (mecasermin). Tercica Inc, Brisbane, CA.
80	Product Information. Micronase (glyburide). Pharmacia and Upjohn, Kalamazoo, MI.
81	Product Information. Orinase (tolbutamide) Pharmacia and Upjohn, Kalamazoo, MI.
82	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
83	Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
84	Product Information. Tolinase (tolazamide) Pharmacia and Upjohn, Kalamazoo, MI.
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117	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
118	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
119	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
120	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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123	Product Information. Oxandrin (oxandrolone). Bio-Tech, Levittown, PA.
124	Product Information. Vectical (calcitriol topical). Galderma Laboratories Inc, Cranbury, NJ.
125	Product Information. Dovonex (calcipotriene). Westwood Squibb Pharmaceutical Corporation, Eatontown, NJ.
126	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
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128	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
129	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
130	Product Information. Berinert (complement C1 esterase inhibitor). CSL Behring, King of Prussia, PA.
131	Product Information. Ruconest (conestat alfa). Valeant Pharmaceuticals, Costa Mesa, CA.
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135	Product Information. Humalog (insulin lispro). Lilly, Eli and Company, Indianapolis, IN.
136	Product Information. Humulin 70/30 (insulin isophane-insulin regular). Lilly, Eli and Company, Indianapolis, IN.
137	Product Information. Ryzodeg 70/30 FlexTouch (insulin aspart-insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
138	Product Information. Tresiba FlexTouch (insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
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140	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
141	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
142	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
143	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
144	Product Information. Armour thyroid (thyroid desiccated). Forest Pharmaceuticals, St. Louis, MO.
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147	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
148	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
149	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
150	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
151	Product Information. Cinryze (complement C1 esterase inhibitor). ViroPharma Incorporated, Exton, PA.
152	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
153	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
154	Gilead Sciences, Inc "About Remdesivir.".
155	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
156	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
157	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
158	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
159	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.

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