Details of Drug

Details of Drug

 Drug General Information (ID: D0997)
  Drug Name
Melphalan flufenamide
  Drug Type Small molecule
  Drug Synonymous
J-1; Dipeptide-conjugated melphalan prodrug (iv formulation, ovary tumor), Oncopeptides
    Click to Show/Hide
  Disease Class 2C73: Ovarian cancer; 2A83: Multiple myeloma
  Therapeutic Class Alkylating Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C24H30Cl2FN3O3
  InChI 1S/C24H30Cl2FN3O3/c1-2-33-24(32)22(16-18-3-7-19(27)8-4-18)29-23(31)21(28)15-17-5-9-20(10-6-17)30(13-11-25)14-12-26/h3-10,21-22H,2,11-16,28H2,1H3,(H,29,31)/t21-,22-/m0/s1
  InChIKey YQZNKYXGZSVEHI-VXKWHMMOSA-N
  Canonical SMILES CCOC(=O)C(CC1=CC=C(C=C1)F)NC(=O)C(CC2=CC=C(C=C2)N(CCCl)CCCl)N
  External Link
Pubchem ID 9935639
CAS Number 380449-51-4
TTD ID D01HPY

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM006  Altered intestinal mucosa
BM043  Additive immunosuppressive effects
BM100  Antagonize the effect of vaccine/toxoid
BM105  Antagonize the effect of probiotics
BM106  Diminish the response to diagnostic skin test antigens
BM110  Antagonize the effects of immunosuppressants
  Relation Graph
 Full list of drugs interacting with Melphalan flufenamide
      Affected gastrointestinal absorption
   Altered intestinal mucosa Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0712
 
Gatifloxacin
 
C19H22FN3O4
 
5379 
Minor    Inter Info   
[21]
D1657
 
Trovafloxacin
 
C20H15F3N4O3
 
62959 
Minor    Inter Info   
[21]
      Pharmacodynamic additive effects
   Additive immunosuppressive effects Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0404
 
Cytarabine
 
C9H13N3O5
 
6253 
Moderate    Inter Info   
[9], [10], [11]
D0405
 
Cytarabine (liposomal)
 
C9H13N3O5
 
6253 
Moderate    Inter Info   
[9], [10], [11]
D0407
 
Dacarbazine
 
C6H10N6O
 
135398738 
Moderate    Inter Info   
[9], [10], [11]
D0790
 
Ifosfamide
 
C7H15Cl2N2O2P
 
3690 
Moderate    Inter Info   
[9], [10], [11]
D1697
 
Vinblastine
 
C46H58N4O9
 
13342 
Moderate    Inter Info   
[9], [10], [11]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  9
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1839
 
Measles virus vaccine live attenuated
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D1890
 
Smallpox (Vaccinia) Vaccine, Live
 
NA
 
NA
Major    Inter Info   
[4], [5], [6]
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D0366
 
Clostridium tetani toxoid antigen (formaldehyde inactivated)
 
NA
 
NA
Moderate    Inter Info   
[4], [7], [8]
D0755
 
Hepatitis A Vaccine
 
NA
 
NA
Moderate    Inter Info   
[4], [7], [8]
D0756
 
Hepatitis B Vaccine (Recombinant)
 
NA
 
NA
Moderate    Inter Info   
[4], [7], [8]
D0803
 
Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
 
NA
 
NA
Moderate    Inter Info   
[4], [7], [8]
D0804
 
Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)
 
NA
 
NA
Moderate    Inter Info   
[4], [7], [8]
D1307
 
Poliovirus type 1 antigen (formaldehyde inactivated)
 
NA
 
NA
Moderate    Inter Info   
[4], [7], [8]
   Antagonize the effect of probiotics Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1827
 
Lactobacillus acidophilus
 
NA
 
NA
Moderate    Inter Info   
[12], [13], [14]
   Diminish the response to diagnostic skin test antigens Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1912
 
Trichophyton mentagrophytes
 
NA
 
NA
Moderate    Inter Info   
[15], [16], [17]
   Antagonize the effects of immunosuppressants Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0545
 
Echinacea
 
NA
 
NA
Minor    Inter Info   
[18], [19], [20]
D1723
 
Zinc chloride
 
Cl2Zn
 
5727 
Minor    Inter Info   
[18], [19], [20]
D1724
 
Zinc gluconate
 
C12H22O14Zn
 
443445 
Minor    Inter Info   
[18], [19], [20]
D1725
 
Zinc sulfate
 
O4SZn
 
24424 
Minor    Inter Info   
[18], [19], [20]
References
1 Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998).
2 Product Information. Attenuvax (measles virus vaccine, live, attenuated). Merck &amp Co, Inc, West Point, PA.
3 Product Information. YF-Vax (yellow fever vaccine). sanofi pasteur, Swiftwater, PA.
4 CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
5 Cerner Multum, Inc. "Australian Product Information.".
6 Product Information. Dryvax (smallpox vaccine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
7 Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
8 Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations.".
9 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
10 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
11 Product Information. Fluorouracil injection (fluorouracil). Roche Laboratories, Nutley, NJ.
12 Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
13 Schlegel L, Lemerle S, Geslin P "Lactobacillus species as opportunistic pathogens in immunocompromised patients." Eur J Clin Microbiol Infect Dis 17 (1998): 887-8. [PMID: 10052559]
14 Salminen MK, Tynkkynen S, Rautelin H, et al. "Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland." Clin Infect Dis 35 (2002): 1155-60. [PMID: 12410474]
15 Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
16 Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
17 Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
18 Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75. [PMID: 11772128]
19 Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
20 Pepping J "Echinacea." Am J Health Syst Pharm 56 (1999): 121-2
21 Johnson EJ, MacGowan AP, Potter MN, et al "Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy." J Antimicrob Chemother 25 (1990): 837-42. [PMID: 2373666]