Details of Drug

Details of Drug

 Drug General Information (ID: D0985)
  Drug Name
Mecasermin rinfabate
  Drug Type Hormones
  Drug Synonymous
DB14751; Mecasermin rinfabate; Mecasermin rinfabate recombinant; rhIGF-I/rhIGFBP-3
    Click to Show/Hide
  Therapeutic Class Insulin-Like Growth Factors

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
BM064  Increased risk of hypoglycemia
  Relation Graph
 Full list of drugs interacting with Mecasermin rinfabate
      Pharmacodynamic additive effects
   Increased risk of hypoglycemia Drug Num:  19
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0325
 
Chlorpropamide
 
C10H13ClN2O3S
 
2727 
Moderate    Inter Info   
[1], [2], [3]
D0727
 
Glimepiride
 
C24H34N4O5S
 
3476 
Moderate    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [1], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [2], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [3], [94], [95], [96], [97], [98], [99], [100], [101]
D0728
 
Glipizide
 
C21H27N5O4S
 
3478 
Moderate    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [1], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [2], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [3], [94], [95], [96], [97], [98], [99], [100], [101]
D0730
 
Glyburide
 
C23H28ClN3O5S
 
3488 
Moderate    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [1], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [2], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [3], [94], [95], [96], [97], [98], [99], [100], [101]
D0808
 
Insulin aspart (aspart)
 
C256H381N65O79S6
 
118984445 
Moderate    Inter Info   
[11], [66], [83]
D0809
 
Insulin degludec
 
C274H411N65O81S6
 
118984462 
Moderate    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [102], [15], [16], [1], [17], [18], [19], [20], [21], [23], [24], [25], [27], [28], [29], [30], [31], [32], [33], [35], [37], [38], [39], [40], [41], [42], [43], [44], [45], [47], [50], [52], [53], [54], [57], [58], [60], [61], [62], [64], [103], [66], [104], [105], [71], [106], [107], [77], [79], [80], [81], [83], [85], [87], [89], [90], [3], [94], [95], [96], [108], [97], [98], [100], [101]
D0810
 
Insulin detemir
 
C267H402N64O76S6
 
16137271 
Moderate    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [102], [15], [16], [1], [17], [18], [19], [20], [21], [23], [24], [25], [27], [28], [29], [30], [31], [32], [33], [35], [37], [38], [39], [40], [41], [42], [43], [44], [45], [47], [50], [52], [53], [54], [57], [58], [60], [61], [62], [64], [103], [66], [104], [105], [71], [106], [107], [77], [79], [80], [81], [83], [85], [87], [89], [90], [3], [94], [95], [96], [108], [97], [98], [100], [101]
D0811
 
Insulin glargine
 
C267H404N72O78S6
 
118984454 
Moderate    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [102], [15], [16], [1], [17], [18], [19], [20], [21], [23], [24], [25], [27], [28], [29], [30], [31], [32], [33], [35], [37], [38], [39], [40], [41], [42], [43], [44], [45], [47], [50], [52], [53], [54], [57], [58], [60], [61], [62], [64], [103], [66], [104], [105], [71], [106], [107], [77], [79], [80], [81], [83], [85], [87], [89], [90], [3], [94], [95], [96], [108], [97], [98], [100], [101]
D0812
 
Insulin glulisine
 
C258H384N64O78S6
 
16136701 
Moderate    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [102], [15], [16], [1], [17], [18], [19], [20], [21], [23], [24], [25], [27], [28], [29], [30], [31], [32], [33], [35], [37], [38], [39], [40], [41], [42], [43], [44], [45], [47], [50], [52], [53], [54], [57], [58], [60], [61], [62], [64], [103], [66], [104], [105], [71], [106], [107], [77], [79], [80], [81], [83], [85], [87], [89], [90], [3], [94], [95], [96], [108], [97], [98], [100], [101]
D0814
 
Insulin human (inhalation, rapid acting)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[11], [66], [83]
D0815
 
Insulin human (isophane)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[11], [66], [83]
D0816
 
Insulin human (regular)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[11], [66], [83]
D0817
 
Insulin human (zinc extended)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[11], [66], [83]
D0818
 
Insulin human (zinc)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[11], [66], [83]
D0819
 
Insulin lispro
 
C257H389N65O77S6
 
16132438 
Moderate    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [102], [15], [16], [1], [17], [18], [19], [20], [21], [23], [24], [25], [27], [28], [29], [30], [31], [32], [33], [35], [37], [38], [39], [40], [41], [42], [43], [44], [45], [47], [50], [52], [53], [54], [57], [58], [60], [61], [62], [64], [103], [66], [104], [105], [71], [106], [107], [77], [79], [80], [81], [83], [85], [87], [89], [90], [3], [94], [95], [96], [108], [97], [98], [100], [101]
D1112
 
Nateglinide
 
C19H27NO3
 
5311309 
Moderate    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [1], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [2], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [3], [94], [95], [96], [97], [98], [99], [100], [101]
D1392
 
Repaglinide
 
C27H36N2O4
 
65981 
Moderate    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [1], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [2], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [3], [94], [95], [96], [97], [98], [99], [100], [101]
D1601
 
Tolazamide
 
C14H21N3O3S
 
5503 
Moderate    Inter Info   
[1], [2], [3]
D1603
 
Tolbutamide
 
C12H18N2O3S
 
5505 
Moderate    Inter Info   
[1], [2], [3]
References
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65 Product Information. Amaryl (glimepiride). Hoechst Marion-Roussel Inc, Kansas City, MO.
66 Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
67 Product Information. Diabeta (glyburide). Hoechst Marion-Roussel Inc, Kansas City, MO.
68 Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
69 Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
70 Product Information. Glucotrol (glipizide). Pfizer US Pharmaceuticals, New York, NY.
71 Product Information. Increlex (mecasermin). Tercica Inc, Brisbane, CA.
72 Product Information. Micronase (glyburide). Pharmacia and Upjohn, Kalamazoo, MI.
73 Product Information. Orinase (tolbutamide) Pharmacia and Upjohn, Kalamazoo, MI.
74 Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
75 Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
76 Product Information. Tolinase (tolazamide) Pharmacia and Upjohn, Kalamazoo, MI.
77 Quevedo SF, Krauss DS, Chazan JA, et al "Fasting hypoglycemia secondary to disopyramide therapy." JAMA 245 (1981): 2424. [PMID: 6785461]
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79 Richardson T, Foster J, Mawer GE "Enhancement by sodium salicylate of the blood glucose lowering effect of chlorpropamide-drug interaction or summation of similar effects." Br J Clin Pharmacol 22 (1986): 43-8. [PMID: 3527244]
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106 Product Information. Ryzodeg 70/30 FlexTouch (insulin aspart-insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
107 Product Information. Tresiba FlexTouch (insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
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