Details of Drug

Drug General Information (ID: D0963)
Drug Name	Lusutrombopag
Drug Type	Small molecule
Drug Synonymous	LUSUTROMBOPAG; mulpleta; UNII-6LL5JFU42F; 6LL5JFU42F; 2-Propenoic acid, Lusutrombopag [USAN:INN]; SCHEMBL3062 Click to Show/Hide
Disease Class	3B64: Thrombocytopenia; DB90-DB9Z: Liver disease
Therapeutic Class	Platelet-Stimulating Agents
Structure
Structure	3D Structure		2D Structure
Formula	C29H32Cl2N2O5S
InChI	1S/C29H32Cl2N2O5S/c1-5-6-7-8-12-38-18(3)20-10-9-11-21(26(20)37-4)25-16-39-29(32-25)33-27(34)19-14-23(30)22(24(31)15-19)13-17(2)28(35)36/h9-11,13-16,18H,5-8,12H2,1-4H3,(H,35,36)(H,32,33,34)/b17-13+/t18-/m0/s1
InChIKey	NOZIJMHMKORZBA-KJCUYJGMSA-N
Canonical SMILES	CCCCCCOC(C)C1=CC=CC(=C1OC)C2=CSC(=N2)NC(=O)C3=CC(=C(C(=C3)Cl)C=C(C)C(=O)O)Cl
External Link
	Pubchem ID	49843517
	CAS Number	1110766-97-6
	CHEBI ID	136051
	TTD ID	D0TD1R
	VARIDT ID	DR00359

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM047 Additive thrombogenic effects
Relation Graph

Full list of drugs interacting with Lusutrombopag
Affected cellular transport
	Transporter inhibition					Drug Num: 103
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[4]
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[4]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[4]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[4]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[4]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[4]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[4]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[4]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[4]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[4]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[5]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[4]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[4]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[3], [6]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[4]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[4]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[4]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[4]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[4]
D0556		Elbasvir	C49H55N9O7	71661251	Moderate		Inter Info	[4]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[7], [8], [1], [9], [10]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[3], [11]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[4]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[4]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[4]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[4]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Moderate		Inter Info	[4]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[4]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[4]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[4]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[4]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[4]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[4]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[4]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[4]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[4]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[4]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[12]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[4]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[13]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[4]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[4]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[4]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[4]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[4]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[1], [14], [15]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[4]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[4]
D1539		Tedizolid	C17H15FN6O3	11234049	Moderate		Inter Info	[4]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[4]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[4]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[4]
D1074		Mirabegron	C21H24N4O2S	9865528	Moderate		Inter Info	[4]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[4]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[4]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[4]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[4]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[4]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[4]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[4]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[4]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[16]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[1], [3]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[4]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[4]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[4]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[4]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[4]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[4]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[4]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[4]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[4]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[4]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[4]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[4]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[17]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[4]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[4]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[4]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[4]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[4]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[4]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[4]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[4]
D1528		Tafamidis	C14H7Cl2NO3	11001318	Moderate		Inter Info	[4]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[4]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[4]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[4]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[4]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[4]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[4]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[4]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[4]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[4]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[4]
D1645		Trimethoprim	C14H18N4O3	5578	Moderate		Inter Info	[4]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[18]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[4]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[4]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[1], [3], [19], [20]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[4]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[4]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[4]
Pharmacodynamic additive effects
	Additive thrombogenic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[1], [2], [3]

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Product Information. Kyprolis (carfilzomib). Onyx Pharmaceuticals Inc, South San Francisco, CA.
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
5	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
6	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
7	Allred AJ, Bowen CJ, Park JW, et al. "Eltrombopag increases plasma rosuvastatin exposure in healthy volunteers." Br J Clin Pharmacol 72 (2011): 321-9. [PMID: 21434975]
8	Canadian Pharmacists Association.
9	Kalliokoski A, Niemi M "Impact of OATP transporters on pharmacokinetics." Br J Pharmacol 158 (2009): 693-705. [PMID: 19785645]
10	Product Information. Promacta (eltrombopag). GlaxoSmithKline, Research Triangle Park, NC.
11	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
12	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
13	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
14	Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
15	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
16	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
17	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
18	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
19	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
20	Product Information. Vandetanib (vandetanib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.

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