Details of Drug

Drug General Information (ID: D0958)
Drug Name	Lumacaftor
Drug Type	Small molecule
Drug Synonymous	VRT-325; VRT-422; VRT-532; VX-809 Click to Show/Hide
Disease Class	CA25: Cystic fibrosis
Therapeutic Class	Cftr Combinations
Structure
Structure	3D Structure		2D Structure
Formula	C24H18F2N2O5
InChI	1S/C24H18F2N2O5/c1-13-5-8-19(27-20(13)14-3-2-4-15(11-14)21(29)30)28-22(31)23(9-10-23)16-6-7-17-18(12-16)33-24(25,26)32-17/h2-8,11-12H,9-10H2,1H3,(H,29,30)(H,27,28,31)
InChIKey	UFSKUSARDNFIRC-UHFFFAOYSA-N
Canonical SMILES	CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O
External Link
	Pubchem ID	16678941
	CAS Number	936727-05-8
	CHEBI ID	90951
	TTD ID	D0X0CB
	VARIDT ID	DR01156

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction
Relation Graph

Full list of drugs interacting with Lumacaftor
Affected cellular transport
	Transporter inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1539		Tedizolid	C17H15FN6O3	11234049	Moderate		Inter Info	[7], [170], [171]
	Transporter induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1381		Ranitidine	C13H22N4O3S	3001055	Moderate		Inter Info	[7], [2], [10]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[71], [72]
	CYP450 enzyme induction					Drug Num: 210
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[1], [2], [3]
D0069		Amlodipine	C20H25ClN2O5	2162	Major		Inter Info	[4], [5], [6]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[7], [8]
D0099		Apremilast	C22H24N2O7S	11561674	Major		Inter Info	[1], [9], [10]
D0133		Axitinib	C22H18N4OS	6450551	Major		Inter Info	[11], [12]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[7], [13], [14]
D0193		Bortezomib	C19H25BN4O4	387447	Major		Inter Info	[15], [16], [17]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[7], [18]
D0222		Buspirone	C21H31N5O2	2477	Major		Inter Info	[19], [20], [21]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[4], [22], [5]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[23], [24], [10]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[25], [7], [26]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[25], [7], [2]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[7], [27], [10]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[25], [7], [28]
D0536		Drospirenone	C24H30O3	68873	Major		Inter Info	[7], [29], [2]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[25], [30]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Major		Inter Info	[31], [32], [33]
D0619		Ethinylestradiol	C20H24O2	5991	Major		Inter Info	[7], [29], [2]
D0626		Etonogestrel	C22H28O2	6917715	Major		Inter Info	[7], [29], [2]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[13], [34]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[35], [25], [7]
D0640		Felodipine	C18H19Cl2NO4	3333	Major		Inter Info	[4], [5], [6]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[4], [22], [5]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[13], [36]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[7], [37], [38]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[39], [40], [2]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[4], [22], [5]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[7], [41]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[42], [43], [44]
D0865		Isradipine	C19H21N3O5	3784	Major		Inter Info	[4], [5], [6]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[7], [45], [46]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[13], [47]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Major		Inter Info	[4], [5], [6]
D0922		Levonorgestrel	C21H28O2	13109	Major		Inter Info	[7], [29], [2]
D0956		Lovastatin	C24H36O5	53232	Major		Inter Info	[25], [7], [2]
D0006		Abemaciclib	C27H32F2N8	46220502	Major		Inter Info	[1], [10], [48]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[49]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Major		Inter Info	[7], [50]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[7], [51]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[25], [7], [52]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[1], [53], [10]
D0389		Copanlisib	C23H28N8O4	135565596	Major		Inter Info	[13], [54]
D0425		Darolutamide	C19H19ClN6O2	67171867	Major		Inter Info	[1], [55], [10]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[7], [10]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Major		Inter Info	[56], [10]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[57]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[7], [58]
D0589		Eravacycline	C27H31FN4O8	54726192	Major		Inter Info	[13], [59]
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[13], [60]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Major		Inter Info	[13], [61]
D0700		Fostemsavir	C25H26N7O8P	11319217	Major		Inter Info	[13], [62]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[13], [63]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[13], [64]
D0866		Istradefylline	C20H24N4O4	5311037	Major		Inter Info	[13], [65]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[13], [66]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Major		Inter Info	[13], [67]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Major		Inter Info	[25], [7], [68]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[13], [69]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[7], [70]
D1101		Naldemedine	C32H34N4O6	54732242	Major		Inter Info	[13], [73]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[25], [74]
D1157		Norgestrel	C21H28O2	13109	Major		Inter Info	[7], [29], [2]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[4], [22], [5]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[13], [75]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[25], [7], [76]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[13], [77]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[7], [13], [78]
D1324		Pralsetinib	C27H32FN9O2	129073603	Major		Inter Info	[13], [79]
D1407		Rimegepant	C28H28F2N6O3	51049968	Major		Inter Info	[80], [71]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Major		Inter Info	[81], [13], [82]
D1423		Rolapitant	C25H26F6N2O2	10311306	Major		Inter Info	[7], [83]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[13], [84]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[85], [13]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[25], [13], [86]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[87], [71]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Major		Inter Info	[13], [88]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[13], [89]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[13], [90]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[91]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[25], [7], [92]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Major		Inter Info	[93], [13], [94]
D0980		Maraviroc	C29H41F2N5O	3002977	Major		Inter Info	[95]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Major		Inter Info	[7], [29], [2]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[96], [97], [98]
D1060		Midazolam	C18H13ClFN3	4192	Major		Inter Info	[25], [7], [2]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[99], [100]
D1104		Naloxegol	C34H53NO11	56959087	Major		Inter Info	[7], [101]
D1130		Nicardipine	C26H29N3O6	4474	Major		Inter Info	[4], [5], [6]
D1134		Nifedipine	C17H18N2O6	4485	Major		Inter Info	[4], [5], [6]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[13], [102]
D1138		Nimodipine	C21H26N2O7	4497	Major		Inter Info	[103], [104], [105]
D1139		Nintedanib	C31H33N5O4	135423438	Major		Inter Info	[35], [106], [107]
D1154		Norethisterone	C20H26O2	6230	Major		Inter Info	[7], [29], [2]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[25], [7], [108]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[4], [22], [5]
D1330		Praziquantel	C19H24N2O2	4891	Major		Inter Info	[25], [109], [110]
D1336		Pretomanid	C14H12F3N3O5	456199	Major		Inter Info	[13], [111]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[112], [113], [114]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[115], [116]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[117], [13], [118]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[25], [7], [119]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[35], [25], [7]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[35], [120], [121]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[25], [7], [2]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[25], [7], [2]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[13], [122]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[7], [123], [124]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[25], [7], [125]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[13], [126]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[25], [7], [2]
D1536		Tasimelteon	C15H19NO2	10220503	Major		Inter Info	[13], [127]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[25], [7], [128]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[13], [129], [130]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[25], [13], [131]
D1608		Tolvaptan	C26H25ClN2O3	216237	Major		Inter Info	[7], [13], [132]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[133], [25], [7]
D1615		Trabectedin	C39H43N3O11S	108150	Major		Inter Info	[7], [134], [135]
D1632		Triazolam	C17H12Cl2N4	5556	Major		Inter Info	[25], [7], [2]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[25], [7], [136]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[13], [137]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[138], [139]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[140], [141], [142]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[1], [143], [10]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[117], [7], [2]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[1], [144], [10]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[117], [7], [2]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[145], [10]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[117], [7], [2]
D0268		Caspofungin	C52H88N10O15	2826718	Moderate		Inter Info	[13], [146]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[117], [7], [2]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[117], [7], [2]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[25], [13]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[117], [7], [2]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[117], [7], [2]
D0354		Clindamycin	C18H33ClN2O5S	446598	Moderate		Inter Info	[147], [148], [10]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[117], [7], [2]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[117], [7], [2]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[149], [25], [7]
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Moderate		Inter Info	[117], [7], [2]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[25], [7], [150]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[151], [152]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[153], [154], [155]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[156], [5], [157]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[117], [7], [2]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[25], [7], [150]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[158], [115], [159]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[117], [7], [2]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[117], [7], [2]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[160], [161], [162]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[163], [115], [142]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[164], [165], [166]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[13], [167]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[117], [7], [2]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[117], [7], [2]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[117], [7], [2]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[25], [13]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[117], [7], [2]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[117], [7], [2]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[117], [7], [2]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[117], [7], [2]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[117], [7], [2]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[115], [168], [142]
D0130		Avatrombopag	C29H34Cl2N6O3S2	9852519	Moderate		Inter Info	[7], [1], [10]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[160], [161], [162]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[115], [169], [142]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[117], [7], [2]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[160], [161], [162]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[117], [7], [2]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[25], [7], [150]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[172], [173], [174]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[117], [7], [2]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[117], [7], [2]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[35], [25], [7]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[117], [7], [2]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[13], [175]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[117], [7], [2]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[117], [7], [2]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[117], [7], [2]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[117], [7], [2]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[13], [176]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[25], [7], [177]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[117], [7], [2]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[160], [161], [162]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[160], [161], [162]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[117], [7], [2]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[160], [161], [162]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[178], [179], [180]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[117], [7], [2]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[117], [7], [2]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[13], [181]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[117], [7], [2]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[182], [13], [183]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[13], [184]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[117], [7], [2]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[185]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[117], [7], [2]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[117], [7], [2]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[25], [7], [186]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[13], [187]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[117], [7], [2]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[117], [7], [2]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[117], [7], [2]
D1645		Trimethoprim	C14H18N4O3	5578	Moderate		Inter Info	[188], [189], [190]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[191], [13], [192]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[117], [7], [2]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[193]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[194], [115], [142]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[195], [1], [10]
D0571		Enfortumab vedotin	NA	NA	Minor		Inter Info	[196], [197], [198]

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186	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
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198	Product Information. Padcev (enfortumab vedotin). Seattle Genetics Inc, Bothell, WA.

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