Details of Drug

Drug General Information (ID: D0950)
Drug Name	Loratadine
Drug Type	Small molecule
Drug Synonymous	Aerotina; Alarin; Alavert; Alerpriv; Allertidin; Anhissen; Biloina; Bonalerg; Civeran; Claratyne; Clarinase; Claritin; Claritine; Clarityn; Clarityne; Clarium; Fristamin; Histaloran; Lergy; Lertamine; Lesidas; Lisino; Loracert; Loradex; Loradif; Loranox; Lorantis; Lorastine; Loratadina; Loratadinum; Loratidine; Loratyne; Loraver; Lorfast; Loritine; Lowadina; Nularef; Optimin; Polaratyne; Pylor; Restamine; Rhinase; Rinomex; Roletra; Sanelor; Sensibit; Sohotin; Tadine; Velodan; Versal; Zeos; Bedix Loratadina; Claratyne Cold; Claratyne Decongestant; Clarinase Reperabs; Claritin D; Claritin Hives Relief; Claritin Hives Relief Reditab; Claritin Reditabs; Claritin reditab; Clarityne Dy Repetabs; Loratadina [Spanish]; Loratadine Redidose; Loratadine Wyeth Brand; Loratadinum [Latin]; Sinhistan Dy; Talorat Dy; Wyeth Brand of Loratadine; L 9664; Sch 29851; Sch29851; Alavert (TN); AllergyX (TN); Children's Claritin; Claritin (TN); Claritine (TN); Clarityn (TN); Clarityne (TN); Clarityne-D; Flonidan (TN); Fristamin (TN); Lomilan (TN); Lorfast (TN); Rinolan (TN); Roletra (TN); Sch-29851; Symphoral (TN); Tidilor (TN); Alavert, Claritin, Loratadine; Loratadine [USAN:BAN:INN]; Loratadine (JAN/USAN/INN); Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate; Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate; 1-Piperidenecarboxylic acid, 4-(8-chloro-5,6-duhydro-11H-benzo [5,6]cyclohepta[1,2-b]-pyridin-11-ylidene)-, ethyl ester; 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester; 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester; 1-piperidinecarboxylic acid,4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-,ethyl ester; 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester; 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acidethyl ester; 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cycloheptal[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester Click to Show/Hide
Disease Class	4A80-4A8Z: Allergic/hypersensitivity disorder; CA08: Vasomotor/allergic rhinitis
Therapeutic Class	Antihistamines
Structure
Structure	3D Structure		2D Structure
Formula	C22H23ClN2O2
InChI	1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChIKey	JCCNYMKQOSZNPW-UHFFFAOYSA-N
Canonical SMILES	CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
External Link
	Pubchem ID	3957
	CAS Number	79794-75-5
	CHEBI ID	6538
	TTD ID	D06ABF
	INTEDE ID	DR0977
	VARIDT ID	DR00541

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM007 Pharmacodynamic antagonistic effects BM011 Transporter induction BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Loratadine
Affected cellular transport
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[44], [19], [45]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 40
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[1], [2], [3], [4], [5]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[6], [7]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[8]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[9]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[15]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[21]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[22]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[23]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[24]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[25]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[26], [27]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[28]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[29]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[13], [36]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[13], [39]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[42]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[43]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[13], [46]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[47]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[30], [13], [48]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[49]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[50]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Moderate		Inter Info	[30], [13], [52]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[30], [13], [53], [54]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[55]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[71]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[13], [73]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[78]
D1553		Terbinafine	C21H25N	1549008	Moderate		Inter Info	[80], [81], [82], [83]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[84]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[30], [13], [85]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[86]
D0597		Erythromycin	C37H67NO13	12560	Minor		Inter Info	[96], [97], [98]
D0667		Fluconazole	C13H12F2N6O	3365	Minor		Inter Info	[98], [99], [100], [101]
D0349		Clarithromycin	C38H69NO13	84029	Minor		Inter Info	[96], [97], [98]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Minor		Inter Info	[98], [99], [100], [101]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Minor		Inter Info	[98], [99], [100], [101]
D1057		Miconazole	C18H14Cl4N2O	4189	Minor		Inter Info	[98], [99], [100], [101]
D1653		Troleandomycin	C41H67NO15	202225	Minor		Inter Info	[96], [97], [98]
	CYP450 enzyme induction					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[13], [14]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[16]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[17]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[30], [31]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[32]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[33], [30], [13], [34]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[35]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[51]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[56], [57], [58]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[13], [59]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[69], [70]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[13], [72]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[30], [13], [76]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[30], [13], [77], [76]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[13], [79]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[30], [13], [87], [88]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[30], [13], [76]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[89], [90], [91], [92], [93], [94], [95]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[102], [103], [104], [105], [106]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[102], [103], [104], [105], [106]
	Competitive inhibition of metabolic enzyme					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[10], [11], [12]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[30], [37], [38]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[30], [37], [38]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[74], [75]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[74], [75]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[74], [75]
Pharmacodynamic antagonistic effects
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[18], [19], [20]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[18], [19], [20]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[18], [19], [20]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[18], [19], [20]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1807		Histamine	C5H9N3	774	Moderate		Inter Info	[40], [19], [41]
D1812		Hyaluronidase	C17H24BrNO2	91820602	Minor		Inter Info	[107], [108], [109]

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