Details of Drug

Drug General Information (ID: D0946)
Drug Name	Lonafarnib
Drug Type	Small molecule
Drug Synonymous	Sarasar; Lonafarnib [USAN]; Sch 66336; Sch66336; SCH-066336; Sch-66336; Lonafarnib (USAN/INN); (+)-4-(2-(4-(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-piperidin-1-yl))-2-oxoethyl)-piperidine-1-carboxamide; (+)-4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-1-piperidinecarboxamide; (+)-4[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6] cyclohepta[1,2-b]-pyridin-11(R)-yl-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide; 4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-1-piperidinecarboxamide; 4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxamide; 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE Click to Show/Hide
Disease Class	2C25: Lung cancer; 1E50-1E51: Hepatitis virus infection; 2A37: Myelodysplastic syndrome; LD2B: Premature ageing appearance
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C27H31Br2ClN4O2
InChI	1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1
InChIKey	DHMTURDWPRKSOA-RUZDIDTESA-N
Canonical SMILES	C1CN(CCC1CC(=O)N2CCC(CC2)C3C4=C(CCC5=C3N=CC(=C5)Br)C=C(C=C4Br)Cl)C(=O)N
External Link
	Pubchem ID	148195
	CAS Number	193275-84-2
	CHEBI ID	47097
	TTD ID	D0W4HZ
	INTEDE ID	DR1861

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM038 Additive CNS depression effects
Relation Graph

Full list of drugs interacting with Lonafarnib
Affected cellular transport
	Transporter inhibition					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Moderate		Inter Info	[20]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[20]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[20]
D0656		Fexofenadine	C32H39NO4	3348	Moderate		Inter Info	[20]
D0109		Artesunate	C19H28O8	6917864	Moderate		Inter Info	[20]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[20]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Moderate		Inter Info	[20]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[20]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[20]
D1388		Relugolix	C29H27F2N7O5S	10348973	Moderate		Inter Info	[20]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[20]
D1402		Rifaximin	C43H51N3O11	6436173	Moderate		Inter Info	[20]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[20]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 374
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14]
D0036		Alfuzosin	C19H27N5O4	2092	Major		Inter Info	[15], [16], [17], [18], [19]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[20]
D0069		Amlodipine	C20H25ClN2O5	2162	Major		Inter Info	[20]
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[20]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[20]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[20]
D0120		Atorvastatin	C33H35FN2O5	60823	Major		Inter Info	[20]
D0128		Avanafil	C23H26ClN7O3	9869929	Major		Inter Info	[15], [18], [21]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Major		Inter Info	[20]
D0215		Budesonide	C25H34O6	5281004	Major		Inter Info	[22], [15], [16], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[36]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Major		Inter Info	[37]
D0303		Cerivastatin	C26H34FNO5	446156	Major		Inter Info	[20], [38]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Major		Inter Info	[20]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[16], [39], [40], [41]
D0337		Cimetidine	C10H16N6S	2756	Major		Inter Info	[20]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[20]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[42], [43], [44]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[45], [46], [47]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[20]
D0367		Clotrimazole	C22H17ClN2	2812	Major		Inter Info	[20]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[15], [48], [18]
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[49], [50], [51], [15], [16], [52], [53], [54], [55], [56], [57], [58], [59], [32], [18], [33], [60], [61], [62], [63], [64], [65], [66]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[20]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[67]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[20]
D0416		Danazol	C22H27NO2	28417	Major		Inter Info	[20]
D0424		Darifenacin	C28H30N2O2	444031	Major		Inter Info	[15], [68], [69], [18]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[20]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[15], [18], [70]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[20]
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[71], [72], [73], [74], [16], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[20]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[96]
D0511		Docetaxel	C43H53NO14	148124	Major		Inter Info	[97], [15], [16], [98], [99], [18], [100], [101], [102], [103]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[15], [104], [18]
D0536		Drospirenone	C24H30O3	68873	Major		Inter Info	[15], [16], [105], [106], [107], [33], [108]
D0557		Eletriptan	C22H26N2O2S	77993	Major		Inter Info	[109]
D0585		Eplerenone	C24H30O6	443872	Major		Inter Info	[15], [110], [18]
D0592		Ergometrine	C19H23N3O2	443884	Major		Inter Info	[83], [87], [93]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[71], [72], [73], [74], [16], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[20]
D0612		Eszopiclone	C17H17ClN6O3	969472	Major		Inter Info	[111], [112], [75], [113], [114]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[15], [115], [116], [18]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[15], [117], [118], [119], [18], [120], [13]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[121]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[20]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[20]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[20]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[20]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[16], [122]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[123], [124], [125]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[126], [127]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[128]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[20]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[20]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[129], [15], [16], [130], [131], [132], [133]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Major		Inter Info	[16], [130], [131]
D0858		Isoniazid	C6H7N3O	3767	Major		Inter Info	[20]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[20]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[20]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[15], [18], [134]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[135], [20]
D0006		Abemaciclib	C27H32F2N8	46220502	Major		Inter Info	[136]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[137]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[15], [16], [138], [18]
D0108		Artemether	C16H26O5	68911	Major		Inter Info	[15], [16], [139]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[16], [140]
D0133		Axitinib	C22H18N4OS	6450551	Major		Inter Info	[15], [16], [141], [18]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[126], [127], [142]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[20]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[15], [16], [143], [18]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[144]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[145]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[15], [16], [146], [18]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[147]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[20]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[20]
D0389		Copanlisib	C23H28N8O4	135565596	Major		Inter Info	[148]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[20]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[16], [149], [150]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[16], [151]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[20]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[15], [16], [153], [18]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[154]
D0571		Enfortumab vedotin	NA	NA	Major		Inter Info	[16], [155], [156], [157]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[16], [158]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[20]
D0655		Fesoterodine	C26H37NO3	6918558	Major		Inter Info	[15], [18], [159], [160]
D0683		Fluticasone	C22H27F3O4S	5311101	Major		Inter Info	[161], [162], [163], [164], [23], [165], [166], [167], [168], [169], [170], [171], [172], [28], [173], [174], [175], [30], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D0684		Fluticasone (nasal)	C22H27F3O4S	5311101	Major		Inter Info	[184], [185], [197]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[20]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[20]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Major		Inter Info	[198]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[199]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[200]
D0735		Goldenseal	NA	NA	Major		Inter Info	[20]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[15], [201], [18]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[20]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[20]
D0866		Istradefylline	C20H24N4O4	5311037	Major		Inter Info	[202], [203], [150]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[15], [16], [204], [18]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[15], [16], [205], [206], [207], [208]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[209], [150]
D0891		Lanreotide	C54H69N11O10S2	71349	Major		Inter Info	[20]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Major		Inter Info	[15], [16], [210]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[20]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[15], [211]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[20]
D0920		Levomilnacipran	C15H22N2O	6917779	Major		Inter Info	[212]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[15], [213], [18]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[15], [16], [214], [18]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[215]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Major		Inter Info	[216]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[217], [218]
D1104		Naloxegol	C34H53NO11	56959087	Major		Inter Info	[15], [16], [219], [18]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[220], [15], [221]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[20]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[15], [16], [222], [18]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[223], [224]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[225], [203], [150]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[226]
D1214		Palbociclib	C24H29N7O2	5330286	Major		Inter Info	[227]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[228], [229]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[20]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[15], [18], [230]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[231]
D1306		Polatuzumab vedotin	NA	NA	Major		Inter Info	[232]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[15], [16], [233]
D1324		Pralsetinib	C27H32FN9O2	129073603	Major		Inter Info	[234], [20]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[20]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Major		Inter Info	[15], [235]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[20]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[236]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[237], [150]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[238]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[15], [239]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[240]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[15], [241]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[242]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[15], [16], [243], [18]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[15], [16], [244]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[20]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[20]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Major		Inter Info	[245]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[246]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[248]
D1696		Vilazodone	C26H27N5O2	6918314	Major		Inter Info	[249]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[15], [18], [250]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[20]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[251]
D0947		Loperamide	C29H33ClN2O2	3955	Major		Inter Info	[20], [252]
D0956		Lovastatin	C24H36O5	53232	Major		Inter Info	[20]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[253]
D0980		Maraviroc	C29H41F2N5O	3002977	Major		Inter Info	[254]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[83], [87], [93]
D1041		Methylprednisolone	C22H30O5	6741	Major		Inter Info	[255], [17], [256], [257], [258], [259], [260], [261]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[83], [87], [93]
D1060		Midazolam	C18H13ClFN3	4192	Major		Inter Info	[262], [263], [264], [265], [266], [267], [20], [268], [269], [270]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[20]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[20]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[20]
D1134		Nifedipine	C17H18N2O6	4485	Major		Inter Info	[20]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[15], [18], [271]
D1138		Nimodipine	C21H26N2O7	4497	Major		Inter Info	[272]
D1163		Octreotide	C49H66N10O10S2	448601	Major		Inter Info	[20]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[15], [16], [273]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[274]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[15], [275], [75], [276], [277], [278], [279], [280], [18]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[20]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[281], [282], [283], [284], [285], [286], [287], [288], [289]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[15], [16], [290], [18]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[20]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[15], [16], [291], [18], [292]
D1440		Salmeterol	C25H37NO4	5152	Major		Inter Info	[15], [16], [293], [18]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[20]
D1465		Sildenafil	C22H30N6O4S	135398744	Major		Inter Info	[15], [16], [294], [295], [296], [297], [298], [299], [18], [300], [301]
D1466		Silodosin	C25H32F3N3O4	5312125	Major		Inter Info	[15], [302], [18]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[20]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[15], [303], [304], [305], [306], [307], [18], [203], [33]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[15], [16], [18], [159], [308]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[309], [310], [311], [312], [313], [314], [15], [16], [304], [315], [316], [317], [115], [318], [319], [320], [321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345]
D1534		Tamsulosin	C20H28N2O5S	129211	Major		Inter Info	[15], [346], [347], [348], [18]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[20]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[20]
D1608		Tolvaptan	C26H25ClN2O3	216237	Major		Inter Info	[15], [350], [18], [351]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[352]
D1615		Trabectedin	C39H43N3O11S	108150	Major		Inter Info	[15], [16], [353]
D1628		Triamcinolone	C21H27FO6	31307	Major		Inter Info	[255], [354], [355], [17], [356], [357], [358], [359], [360], [361], [362], [363]
D1632		Triazolam	C17H12Cl2N4	5556	Major		Inter Info	[364], [262], [365], [366], [367], [75], [368], [369], [370], [371], [263], [264], [372], [265], [266], [373], [267], [374], [268], [375], [376], [269], [270], [377]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[20]
D1697		Vinblastine	C46H58N4O9	13342	Major		Inter Info	[378], [379], [380], [381], [382], [383], [129], [384], [15], [16], [385], [386], [387], [388], [389], [390], [391], [392], [393], [394], [395], [396], [397], [398], [399], [400], [401], [402], [403], [404], [18], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414]
D1698		Vincristine	C46H56N4O10	5978	Major		Inter Info	[378], [379], [380], [381], [382], [383], [129], [384], [15], [16], [385], [386], [387], [388], [389], [390], [391], [392], [393], [394], [395], [396], [397], [398], [399], [400], [401], [402], [403], [404], [18], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Major		Inter Info	[381], [403], [405]
D1700		Vinorelbine	C45H54N4O8	5311497	Major		Inter Info	[378], [379], [380], [381], [382], [383], [129], [384], [15], [16], [385], [386], [387], [388], [389], [390], [391], [392], [393], [394], [395], [396], [397], [398], [399], [400], [401], [402], [403], [404], [18], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414]
D1714		Zafirlukast	C31H33N3O6S	5717	Major		Inter Info	[20]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[20]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[20]
D0041		Almotriptan	C17H25N3O2S	123606	Moderate		Inter Info	[415]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[364], [262], [365], [366], [367], [75], [368], [369], [370], [371], [263], [264], [372], [265], [266], [373], [267], [374], [268], [375], [376], [269], [270], [377]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[416]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[20]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[20]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[255], [162], [22], [417], [418], [26], [17], [419], [420], [256], [169], [170], [421], [257], [258], [259], [422], [29], [423], [34], [35], [189], [424], [260], [261], [425], [426], [427], [196]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[428], [429], [430]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[20]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[22], [15], [16]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[431]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[20]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[20]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[432]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[15]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[20]
D0333		Ciclesonide	C32H44O7	6918155	Moderate		Inter Info	[255], [17], [433], [434]
D0334		Ciclesonide (nasal)	C32H44O7	6918155	Moderate		Inter Info	[435], [436], [433]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[437]
D0354		Clindamycin	C18H33ClN2O5S	446598	Moderate		Inter Info	[438]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[439]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[20]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[440], [441], [442], [443], [444], [445], [446], [447], [448], [449], [450], [451], [452], [453], [454], [455], [456], [457], [458]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[20]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[20]
D0454		Dexamethasone (nasal)	C22H29FO5	5743	Moderate		Inter Info	[26], [419], [189]
D0455		Dexamethasone (ophthalmic)	C22H29FO5	5743	Moderate		Inter Info	[26], [419], [189]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[20]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[20]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[129], [16], [459]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[20]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[20]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[255], [460], [15], [16], [461], [462], [463]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[464]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[465], [466]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[129], [15], [16], [467], [468], [469], [470], [471], [472], [473], [474], [475], [476]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[20]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[20]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[20]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[20]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[20]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[20]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[20]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[20]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[20]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[20]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[20]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[20]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[20]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[255], [162], [22], [417], [418], [26], [17], [419], [420], [256], [169], [170], [421], [257], [258], [259], [422], [29], [423], [34], [35], [189], [424], [260], [261], [425], [426], [427], [196]
D0672		Flunisolide	C24H31FO6	82153	Moderate		Inter Info	[255], [162], [22], [417], [418], [26], [17], [419], [420], [256], [169], [170], [421], [257], [258], [259], [422], [29], [423], [34], [35], [189], [424], [260], [261], [425], [426], [427], [196]
D0673		Flunisolide (nasal)	C24H31FO6	82153	Moderate		Inter Info	[26], [419], [189]
D0674		Fluorometholone (ophthalmic)	C22H29FO4	9878	Moderate		Inter Info	[26], [419], [189]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[20]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[477]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[465], [478]
D0715		Gemfibrozil	C15H22O3	3463	Moderate		Inter Info	[20]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[20]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[20]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[20]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[255], [162], [22], [417], [418], [26], [17], [419], [420], [256], [169], [170], [421], [257], [258], [259], [422], [29], [423], [34], [35], [189], [424], [260], [261], [425], [426], [427], [196]
D0774		Hydrocortisone (ophthalmic)	C21H30O5	5754	Moderate		Inter Info	[26], [419], [189]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[15]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[20]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[20]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[20]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[479]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[20]
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[15], [16], [480]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[20]
D0900		Leflunomide	C12H9F3N2O2	3899	Moderate		Inter Info	[20]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[20]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[16], [481]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[20]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[20]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[482]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[129], [16], [483], [484]
D0130		Avatrombopag	C29H34Cl2N6O3S2	9852519	Moderate		Inter Info	[20]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[485]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[16], [156], [32]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[15], [486], [18]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[487]
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[489]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[16], [490]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[20]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[15], [16], [491]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[15], [18], [492]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[15], [493], [16], [494]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[495]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[15], [16], [496]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[498]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[20]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[499]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[181], [150], [194]
D0955		Loteprednol (ophthalmic)	C21H27ClO5	9865442	Moderate		Inter Info	[26], [419], [189]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[20]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[20]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[20]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[20]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[500], [501], [502], [503], [504], [505], [506], [507]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[20]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[508]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[509], [510], [511], [512], [513]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[20]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[20]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[20]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[20]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[20]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[20]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[20]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[514]
D1195		Oxandrolone	C19H30O3	5878	Moderate		Inter Info	[20]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[20]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[515], [516], [15], [517], [518], [519], [520], [101]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[515], [516], [15]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[20]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[16], [521]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[16], [522], [511]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[20]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[255], [162], [22], [417], [418], [26], [17], [419], [420], [256], [169], [170], [421], [257], [258], [259], [422], [29], [423], [34], [35], [189], [424], [260], [261], [425], [426], [427], [196]
D1333		Prednisolone (ophthalmic)	C21H28O5	5755	Moderate		Inter Info	[26], [419], [189]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[255], [162], [22], [417], [418], [26], [17], [419], [420], [256], [169], [170], [421], [257], [258], [259], [422], [29], [423], [34], [35], [189], [424], [260], [261], [425], [426], [427], [196]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[20]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[20]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[523], [524]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[20]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[20]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[20]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[20]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[15], [16], [525], [526], [527], [528], [529], [530], [531], [532], [533]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[534]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[535], [536], [537], [538], [539], [540], [541]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[542]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[16], [543]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[544], [545], [120]
D1513		Sulfadiazine	C10H10N4O2S	5215	Moderate		Inter Info	[20]
D1515		Sulfamethizole	C9H10N4O2S2	5328	Moderate		Inter Info	[20]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Moderate		Inter Info	[20]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[15], [18], [546]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[15], [547], [548], [18]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[20]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[20]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[20]
D1557		Testolactone	C19H24O3	13769	Moderate		Inter Info	[20]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[20]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[20]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[20]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[20]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[20]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[549], [550]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[15], [551], [18]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[20]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[552], [553], [554], [555], [556], [557], [558], [559], [560], [561], [562]
D1629		Triamcinolone (nasal)	C21H27FO6	31307	Moderate		Inter Info	[26], [419], [189]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[26], [419], [189]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[20]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[20]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[563], [564]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[15], [16], [565]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[20]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[20]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[20]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[566], [369], [567], [568], [569], [184], [570]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[571], [572]
D0053		Ambrisentan	C22H22N2O4	6918493	Minor		Inter Info	[573]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[574], [511], [575], [576]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[577]
D0248		Cannabidiol	C21H30O2	644019	Minor		Inter Info	[16], [578]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[579]
D0589		Eravacycline	C27H31FN4O8	54726192	Minor		Inter Info	[580]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[581]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[582]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[583]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[584], [585], [586], [587], [588], [589], [590]
D1464		Sibutramine	C17H26ClN	5210	Minor		Inter Info	[591], [592], [593]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[594], [595], [596], [597]
	CYP450 enzyme induction					Drug Num: 54
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[20]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[20]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[20]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[20]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[20]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[20]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[20]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[20]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[20]
D0555		Elagolix	C32H30F5N3O5	11250647	Major		Inter Info	[152], [20]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[20]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Major		Inter Info	[20]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[20]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[152], [20]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Major		Inter Info	[152], [20]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[20]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[20]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[20]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[20]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[20]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[20]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[20]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[20]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[152], [20]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[20]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[20]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[15], [18], [349]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[20]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[20]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[20]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[20]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[20]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[20]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[20]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[20]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[20]
D0280		Cefiderocol	C30H34ClN7O10S2	77843966	Moderate		Inter Info	[20]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[15], [488]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[20]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[20]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[20]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[20]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[20], [497]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[20]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[20], [497]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[20]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[20]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[20]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[20]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[20]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[20]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[20], [497]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[20]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[20]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[247]

References
1	Bartkowski RR, Goldberg ME, Larijani GE, Boerner T "Inhibition of alfentanil metabolism by erythromycin." Clin Pharmacol Ther 46 (1989): 99-102. [PMID: 2501060]
2	Bartkowski RR, McDonnell TE "Prolonged alfentanil effect following erythromycin administration." Anesthesiology 73 (1990): 566-8. [PMID: 2203286]
3	Kharasch ED, Thummel KE "Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance?" Anesth Analg 76 (1993): 1033-9. [PMID: 8484504]
4	Kharasch ED, Walker A, Hoffer C, Sheffels P "Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis." Clin Pharmacol Ther 76 (2004): 452-66. [PMID: 15536460]
5	Klees TM, Sheffels P, Dale O, Kharasch ED "Metabolism of alfentanil by cytochrome P4503A enzymes." Drug Metab Dispos 33 (2005): 303-11. [PMID: 15557344]
6	Klees TM, Sheffels P, Thummel KE, Kharasch ED "Pharmacogenetic Determinants of Human Liver Microsomal Alfentanil Metabolism and the Role of Cytochrome P450 3A5." Anesthesiology 102 (2005): 550-556. [PMID: 15731592]
7	Koehntop DE, Noormohamed SE, Fletcher CV "Effects of long-term drugs on alfentanil clearance in patients undergoing renal transplantation." Pharmacotherapy 14 (1994): 592-9. [PMID: 7997393]
8	Labroo RB, Thummel KE, Kunze KL, Podoll T, Trager WF, Kharasch ED "Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism." Drug Metab Dispos 23 (1995): 490-6. [PMID: 7600917]
9	Palkama VJ, Isohanni MH, Neuvonen PJ, Olkkola KT "The effect of intravenous and oral fluconazole on the pharmacokinetics and pharmacodynamics of intravenous alfentanil." Anesth Analg 87 (1998): 190-4. [PMID: 9661572]
10	Product Information. Alfenta (alfentanil). Janssen Pharmaceutica, Titusville, NJ.
11	Yate PM, Thomas D, Short SM, Sebel PS, Morton J "Comparison of infusions of alfentanil or pethidine for sedation of ventilated patients on the ITU." Br J Anaesth 58 (1986): 1091-9. [PMID: 2876719]
12	Yun CH, Wood M, Wood AJ, Guengerich FP "Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4: an explanation of the variable elimination clearance." Anesthesiology 77 (1992): 467-74. [PMID: 1519785]
13	Ibrahim AE, Feldman J, Karim A, Kharasch ED "Simultaneous Assessment of Drug Interactions with Low- and High-Extraction Opioids: Application to Parecoxib Effects on the Pharmacokinetics and Pharmacodynamics of Fentanyl and Alfentanil." Anesthesiology 98 (2003): 853-861. [PMID: 12657846]
14	Kharasch ED, Russell M, Mautz D, Thummel KE, Kunze KL, Bowdle A, Cox K "The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions." Anesthesiology 87 (1997): 36-50. [PMID: 9232132]
15	Cerner Multum, Inc. "Australian Product Information.".
16	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
17	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
18	Product Information. Sporanox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
19	Product Information. Uroxatral (alfuzosin). sanofi-aventis , Bridgewater, NJ.
20	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
21	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
22	Bolland MJ, Bagg W, Thomas MG, Lucas JA, Ticehurst R, Black PN "Cushing's syndrome due to interaction between inhaled corticosteroids and itraconazole." Ann Pharmacother 38 (2004): 46-9. [PMID: 14742792]
23	Daveluy A, Raignoux C, Miremont-Salame G, et al. "Drug interactions between inhaled corticosteroids and enzymatic inhibitors." Eur J Clin Pharmacol (2009):. [PMID: 19399485]
24	De Wachter E, Malfroot A, De Schutter I, Vanbesien J, De Schepper J "Inhaled budesonide induced Cushing's syndrome in cystic fibrosis patients, due to drug inhibition of cytochrome P450." J Calif Dent Assoc 2 (2003): 72-5. [PMID: 15463853]
25	De Wachter E, Vanbesien J, De Schutter I, Malfroot A, De Schepper J "Rapidly developing Cushing syndrome in a 4-year-old patient during combined treatment with itraconazole and inhaled budesonide." Eur J Pediatr (2003):. [PMID: 12719971]
26	Edsbacker S, Andersson T "Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease." Clin Pharmacokinet 43 (2004): 803-21. [PMID: 15355126]
27	Jonsson G, Astrom A, Andersson P "Budesonide is metabolized by cytochrome P450 3A (CYP3A) enzymes in human liver." Drug Metab Dispos 23 (1995): 137-42. [PMID: 7720517]
28	Kedem E, Shahar E, Hassoun G, Pollack S "Iatrogenic Cushing's syndrome due to coadministration of ritonavir and inhaled budesonide in an asthmatic human immunodeficiency virus infected patient." J Asthma 47 (2010): 830-1. [PMID: 20653496]
29	Main KM, Skov M, Sillesen IB, et al. "Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient." Acta Paediatr 91 (2002): 1008-11. [PMID: 12412882]
30	Molimard M, Girodet PO, Pollet C, et al. "Inhaled corticosteroids and adrenal insufficiency: prevalence and clinical presentation." Drug Saf 31 (2008): 769-74. [PMID: 18707191]
31	Product Information. Entocort (budesonide). AstraZeneca Pharma Inc, Mississauga, ON.
32	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
33	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
34	Raaska K, Niemi M, Neuvonen M, Neuvonen PJ, Kivisto KT "Plasma concentrations of inhaled budesonide and its effects on plasma cortisol are increased by the cytochrome P4503A4 inhibitor itraconazole." Clin Pharmacol Ther 72 (2002): 362-369. [PMID: 12386638]
35	Skov M, Main KM, Sillesen IB, Muller J, Koch C, Lanng S "Iatrogenic adrenal insufficiency as a side-effect of combined treatment of itraconazole and budesonide." Eur Respir J 20 (2002): 127-33. [PMID: 12166560]
36	Product Information. Butorphanol Tartrate (butorphanol). Apotex Corporation, Weston, FL.
37	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
38	Richter WO, Jacob BG, Schwandt P "Interaction between fibre and lovastatin." Lancet 338 (1991): 706. [PMID: 1679514]
39	Product Information. Pletal (cilostazol). Otsuka American Pharmaceuticals, Rockville, MD.
40	Suri A, Bramer SL "Effect of omeprazole on the metabolism of cilostazol." Clin Pharmacokinet 37 (1999): 53-9. [PMID: 10702887]
41	Suri A, Forbes WP, Bramer SL "Effects of CYP3A inhibition on the metabolism of cilostazol." Clin Pharmacokinet 37 (1999): 61-8. [PMID: 10702888]
42	Desta Z, Soukhova N, Mahal SK, Flockhart DA "Interaction of cisapride with the human cytochrome P450 system: metabolism and inhibition studies." Drug Metab Dispos 28 (2000): 789-800. [PMID: 10859153]
43	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.
44	Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
45	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Abnormal heart rhythms associated with high doses of Celexa (citalopram hydrobromide).".
46	Priskorn M, Larsen F, Segonzac A, Moulin M "Pharmacokinetic interaction study of citalopram and cimetidine in healhy subjects." Eur J Clin Pharmacol 52 (1997): 241-2. [PMID: 9218934]
47	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
48	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
49	Akdag I, Ersoy A, Kahvecioglu S, Gullulu M, Dilek K "Acute colchicine intoxication during clarithromycin administration in patients with chronic renal failure." J Nephrol 19 (2006): 515-7. [PMID: 17048210]
50	Boomershine KH "Colchicine-induced rhabdomyolysis." Ann Pharmacother 36 (2002): 824-6. [PMID: 11978160]
51	Caraco Y, Putterman C, Rahamimov R, Ben-Chetrit E "Acute colchicine intoxication: possible role of erythromycin administration." J Rheumatol 19 (1992): 494-6. [PMID: 1578471]
52	Cheng VC, Ho PL, Yuen KY "Two probable cases of serious drug interaction between clarithromycin and colchicine." South Med J 98 (2005): 811-3. [PMID: 16144178]
53	Cohen O, Locketz G, Hershko AY, Gorshtein A, Levy Y "Colchicine-clarithromycin-induced rhabdomyolysis in Familial Mediterranean Fever patients under treatment for Helicobacter pylori." Rheumatol Int (2015):. [PMID: 26210999]
54	Colchicine: serious interactions. Prescrire Int 17 (2008): 151-3. [PMID: 19492485]
55	Dogukan A, Oymak FS, Taskapan H, Guven M, Tokgoz B, Utas C "Acute fatal colchicine intoxication in a patient on continuous ambulatory peritoneal dialysis (CAPD). Possible role of clarithromycin administration." Clin Nephrol 55 (2001): 181-2. [PMID: 11269688]
56	Hung IF, Wu AK, Cheng VC, et al. "Fatal interaction between clarithromycin and colchicine in patients with renal insufficiency: a retrospective study." Clin Infect Dis 41 (2005): 291-300. [PMID: 16007523]
57	McKinnell J, Tayek JA "Short term treatment with clarithromycin resulting in colchicine-induced rhabdomyolysis." J Clin Rheumatol 15 (2009): 303-5. [PMID: 19734738]
58	Product Information. Biaxin (clarithromycin). Abbott Pharmaceutical, Abbott Park, IL.
59	Product Information. Colcrys (colchicine). AR Scientific Inc, Philadelphia, PA.
60	Putterman C, Ben-Chetrit E, Caraco Y, Levy M "Colchicine intoxication: clinical pharmacology, risk factors, features, and management." Semin Arthritis Rheum 21 (1991): 143-55. [PMID: 1788551]
61	Rollot F, Pajot O, Chauvelot-Moachon L, Nazal EM, Kelaidi C, Blanche P "Acute colchicine intoxication during clarithromycin administration." Ann Pharmacother 38 (2004): 2074-7. [PMID: 15494379]
62	Schiff D, Drislane FW "Rapid-onset colchicine myoneuropathy." Arthritis Rheum 35 (1992): 1535-6. [PMID: 1472131]
63	Severe colchicine-macrolide interactions. Prescrire Int 12 (2003): 18-9. [PMID: 12602385]
64	Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ "Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation." Biochem Pharmacol 53 (1996): 111-6. [PMID: 8960070]
65	van der Velden W, Huussen J, Ter Laak H, de Sevaux R "Colchicine-induced neuromyopathy in a patient with chronic renal failure: the role of clarithromycin." Neth J Med 66 (2008): 204-6. [PMID: 18490798]
66	Wilbur K, Makowsky M "Colchicine myotoxicity: case reports and literature review." Pharmacotherapy 24 (2004): 1784-92. [PMID: 15585444]
67	Product Information. Rescriptor (delavirdine). Pharmacia and Upjohn, Kalamazoo, MI.
68	Niwa T, Shiraga T, Takagi A "Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, CYP3A4 activities in human liver microsomes." Biol Pharm Bull 28 (2005): 1805-8. [PMID: 16141567]
69	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
70	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
71	Ausband SC, Goodman PE "An unusual case of clarithromycin associated ergotism." J Emerg Med 4 (2001): 411-3. [PMID: 11728770]
72	Bird PA, Sturgess AD "Clinical ergotism with severe bilateral upper limb ischaemia precipitated by an erythromycin - ergotamine drug interaction." Aust N Z J Med 30 (2000): 635-6. [PMID: 11108077]
73	Blanche P, Rigolet A, Gombert B, Ginsburg C, Salmon D, Sicard D "Ergotism related to a single dose of ergotamine tartrate in an AIDS patient treated with ritonavir." Postgrad Med J 75 (1999): 546-7. [PMID: 10616689]
74	Caballero-Granado FJ, Viciana P, Cordero E, Gomez-Vera MJ, del Nozal M, Lopez-Cortes LF "Ergotism related to concurrent administration of ergotamine tartrate and ritonavir in an AIDS patient." Antimicrob Agents Chemother 41 (1997): 1207. [PMID: 9145904]
75	Dresser GK, Spence JD, Bailey DG "Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition." Clin Pharmacokinet 38 (2000): 41-57. [PMID: 10668858]
76	Eadie MJ "Clinically significant drug interactions with agents specific for migraine attacks." Cns Drugs 15 (2001): 105-18. [PMID: 11460889]
77	Francis H, Tyndall A, Webb J "Severe vascular spasm due to erythromycin-ergotamine interaction." Clin Rheumatol 3 (1984): 243-6. [PMID: 6236021]
78	Hayton AC "Precipitation of acute ergotism by triacetyloleandomycin." N Z Med J 69 (1969): 42. [PMID: 5304704]
79	Horowitz RS, Dart RC, Gomez HF "Clinical ergotism with lingual ischemia induced by clarithromycin-ergotamine interaction." Arch Intern Med 156 (1996): 456-8. [PMID: 8607732]
80	Leroy F, Asseman P, Pruvost P, Adnet P, Lacroix D, Thery C "Dihydroergotamine-erythromycin-induced ergotism." Ann Intern Med 109 (1988): 249. [PMID: 3389610]
81	Liaudet L "Severe ergotism associated with interaction between ritonavir and ergotamine." BMJ 318 (1999): 771. [PMID: 10082701]
82	Liaudet L, Buclin T, Jaccard C, Eckert P "Severe ergotism associated with interaction between ritonavir and ergotamine." Br Med J 318 (1999): 771. [PMID: 10082701]
83	Matthews NT, Havill JH "Ergotism with therapeutic doses of ergotamine tartrate." N Z Med J 89 (1979): 476-7. [PMID: 314074]
84	Montero A, Giovannoni AG, Tvrde PL "Leg ischemia in a patient receiving ritonavir and ergotamine." Ann Intern Med 130 (1999): 329. [PMID: 10068398]
85	Mortier E, Pouchet J, Vinceneux P, Lalande M "Ergotism related to interaction between nelfinavir and ergotamine." Am J Med 110 (2001): 594. [PMID: 11347624]
86	Product Information. Cafergot (caffeine-ergotamine). Novartis Pharmaceuticals, East Hanover, NJ.
87	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
88	Product Information. Methergine (methylergonovine). Novartis Pharmaceuticals, East Hanover, NJ.
89	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
90	Rosenthal E, Sala F, Chichmanian RM, Batt M, Cassuto JP "Ergotism related to concurrent administration of ergotamine tartrate and indinavir." JAMA 281 (1999): 987. [PMID: 10086430]
91	Spiegel M, Schmidauer C, Kampfl A, Sarcletti M, Poewe W "Cerebral ergotism under treatment with ergotamine and ritonavir." Neurology 57 (2001): 743-4. [PMID: 11524501]
92	Srisuma S, Lavonas EJ, Wananukul W "Ergotism and factitious hypotension associated with interaction of ergotamine with CYP3A4 inhibitors." Clin Toxicol (Phila) (2014): 1-4. [PMID: 24978905]
93	Tribble MA, Gregg CR, Margolis DM, Amirkhan R, Smith JW "Fatal ergotism induced by an HIV protease inhibitor." Headache 42 (2002): 694-5. [PMID: 12482227]
94	Vila A, Mykietiuk A, Bonvehi P, Temporiti E, Uruena A, Herrera F "Clinical ergotism induced by ritonavir." Scand J Infect Dis 33 (2001): 788-9. [PMID: 11728055]
95	Ghali R, De Lean J, Douville Y, Noel HP, Labbe R "Erythromycin-associated ergotamine intoxication: arteriographic and electrophysiologic analysis of a rare cause of severe ischemia of the lower extremities and associated ischemic neuropathy." Ann Vasc Surg 7 (1993): 291-6. [PMID: 8391300]
96	Product Information. Norpace (disopyramide). Searle, Skokie, IL.
97	Aronson JK, Grahame-Smith DG "Clinical pharmacology: adverse drug interactions." Br Med J 282 (1981): 288-91. [PMID: 6779990]
98	Engels FK, Mathot RA, Loos WJ, van Schaik RH, Verweij J "Influence of high-dose ketoconazole on the pharmacokinetics of docetaxel." Cancer Biol Ther 5 (2006): 833-9. [PMID: 16775418]
99	McInnes GT, Brodie MJ "Drug interactions that matter: a critical reappraisal." Drugs 36 (1988): 83-110. [PMID: 3063497]
100	Product Information. Taxotere (docetaxel). Rhone-Poulenc Rorer, Collegeville, PA.
101	Starr SP, Hammann F, Gotta V, et al. "Pharmacokinetic interaction between taxanes and amiodarone leading to severe toxicity." Br J Clin Pharmacol 450 (2016): 22-27. [PMID: 27868228]
102	Vodovar D, Arnaout M, Mongardon N, et al. "Severe docetaxel overdose induced by pharmacokinetic interaction with dronedarone." J Clin Oncol 29 (2011): e694-5. [PMID: 21730272]
103	Yong WP, Wang LZ, Tham LS, et al. "A phase I study of docetaxel with ketoconazole modulation in patients with advanced cancers." Cancer Chemother Pharmacol 62 (2008): 243-51. [PMID: 17909805]
104	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
105	Product Information. Prezcobix (cobicistat-darunavir). Janssen Pharmaceuticals, Titusville, NJ.
106	Product Information. Slynd (drospirenone). Exeltis USA, Inc., Chatham, NJ.
107	Product Information. Symtuza (cobicistat/darunavir/emtricitabine/tenof). Janssen Pharmaceuticals, Titusville, NJ.
108	Product Information. Yasmin (drospirenone-ethinyl estradiol) Berlex Laboratories, Richmond, CA.
109	Product Information. Relpax (eletriptan). Pfizer U.S. Pharmaceuticals, New York, NY.
110	Product Information. Inspra (eplerenone). Searle, Chicago, IL.
111	Alderman CP, Gebauer MG, Gilbert AL, Condon JT "Possible interaction of zopiclone and nefazodone." Ann Pharmacother 35 (2001): 1378-80. [PMID: 11724087]
112	Becquemont L, Mouajjah S, Escaffre O, Beaune P, Funck-Bretano C, Jaillon P "Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism." Drug Metab Dispos 27 (1999): 1068-73. [PMID: 10460808]
113	Product Information. Imovane (zopiclone). Rhone-Poulenc Rorer Canada Inc, Laval, IN.
114	Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
115	Homma S, Takahashi KI, Nihei S, Kato F, Sugihara S, Nunoda S "The successful management of respiratory complications with long-term, low-dose macrolide administration in pediatric heart transplant recipients." Int Heart J (2014):. [PMID: 25297501]
116	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
117	Labroo RB, Paine MF, Thummel KE, Kharasch ED "Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implicaitons for interindividual variability in disposition, efficacy, and drug interactions." Drug Metab Dispos 25 (1997): 1072-80. [PMID: 9311623]
118	Product Information. Actiq (fentanyl). Abbott Pharmaceutical, Abbott Park, IL.
119	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
120	Tateishi T, Krivoruk Y, Ueng YF, Wood AJ, Guengerich FP, Wood M "Identification of human cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation." Anesth Analg 82 (1996): 167-72. [PMID: 8712396]
121	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
122	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
123	Charbit B, Becquemont L, Lepere B, Peytavin G, Funck-Bretano C "Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine." Clin Pharmacol Ther 72 (2002): 514-23. [PMID: 12426515]
124	Giao PT, de Vries PJ "Pharmacokinetic interactions of antimalarial agents." Clin Pharmacokinet 40 (2001): 343-73. [PMID: 11432537]
125	Product Information. Halfan (halofantrine). GlaxoSmithKline, Philadelphia, PA.
126	Hutchinson MR, Menelaou A, Foster DJ, Coller JK, Somogyi AA "CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes." Br J Clin Pharmacol 57 (2004): 287-97. [PMID: 14998425]
127	Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.
128	Product Information. Fanapt (iloperidone). Vanda Pharmaceuticals Inc, Rockville, MD.
129	Canadian Pharmacists Association.
130	Corona G, Vaccher E, Sandron S, et al. "Lopinavir-ritonavir dramatically affects the pharmacokinetics of irinotecan in HIV patients with Kaposi's sarcoma." Clin Pharmacol Ther 83 (2008): 601-6. [PMID: 17713471]
131	Phansalker S, Desai AA, Bell D, et al "High-priority drug-drug interactions for use in electronic health records." J Am Med Inform Assoc 19 (2012): 735-43. [PMID: 22539083]
132	Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI.
133	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
134	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
135	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
136	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
137	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
138	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
139	Product Information. Coartem (artemether-lumefantrine). Novartis Pharmaceuticals, East Hanover, NJ.
140	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
141	Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
142	Vizcaychipi MP, Walker S, Palazzo M "Serotonin syndrome triggered by tramadol." Br J Anaesth 99 (2007): 919. [PMID: 18006535]
143	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
144	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
145	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
146	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
147	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
148	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
149	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
150	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
151	Product Information. Emflaza (deflazacort). Marathon Pharmaceuticals, Deerfield, IL.
152	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
153	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
154	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
155	Han TH, Gopal AK, Ramchandren R, et al. "CYP3A-mediated drug-drug interaction potential and excretion of brentuximab vedotin, an antibody-drug conjugate, in patients with CD30-positive hematologic malignancies." J Clin Pharmacol 53 (2013): 866-77. [PMID: 23754575]
156	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
157	Product Information. Padcev (enfortumab vedotin). Seattle Genetics Inc, Bothell, WA.
158	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
159	Product Information. Sporonox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
160	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
161	Arrington-Sanders R, Hutton N, Siberry GK "Ritonavir-fluticasone interaction causing Cushing syndrome in HIV-infected children and adolescents." Pediatr Infect Dis J 25 (2006): 1044-1048. [PMID: 17072128]
162	Bhumbra NA, Sahloff EG, Oehrtman SJ, Horner JM "Exogenous Cushing syndrome with inhaled fluticasone in a child receiving lopinavir/ritonavir." Ann Pharmacother 41 (2007): 1306-9. [PMID: 17535841]
163	Boorsma M, Andersson N, Larsson P, Ullman A "Assessment of the relative systemic potency of inihaled fluticasone and budesonide." Eur Respir J 9 (1996): 1427-32. [PMID: 8836654]
164	Brus R "Effects of high-dose inhaled corticosteroids on plasma cortisol consentrations in healthy adults." Arch Intern Med 159 (1999): 1903-8. [PMID: 10493320]
165	Fardon TC, Lee DK, Haggart K, McFarlane LC, Lipworth BJ "Adrenal suppression with dry powder formulations of fluticasone propionate and mometasone furoate." Am J Respir Crit Care Med 170 (2004): 960-6. [PMID: 15184207]
166	Foisy MM, Yakiwchuk EM, Chiu I, Singh AE "Adrenal suppression and Cushing's syndrome secondary to an interaction between ritonavir and fluticasone: a review of the literature." HIV Med 9 (2008): 389-96. [PMID: 18459946]
167	Gillett MJ, Cameron PU, Nguyen HV, Hurley DM, Mallal SA "Iatrogenic Cushing's syndrome in an HIV-infected patient treated with ritonavir and inhaled fluticasone." AIDS 19 (2005): 740-1. [PMID: 15821405]
168	Grahnen A, Eckernas SA, Brundin RM, Ling-Andersson A "An assessment of the systemic activity of single doses of inhaled fluticasone propionate in healthy volunteers." Br J Clin Pharmacol 38 (1994): 521-5. [PMID: 7888290]
169	Gupta SK, Dube MP "Exogenous Cushing syndrome mimicking human immunodeficiency virus lipodystrophy." Clin Infect Dis 35 (2002): E69-71. [PMID: 12203188]
170	Hillebrand-Haverkort ME, Prummel MF, ten Veen JH "Ritonavir-induced Cushing's syndrome in a patient treated with nasal fluticasone." AIDS 13 (1999): 1803. [PMID: 10509596]
171	Jinno S, Goshima C "Progression of Kaposi sarcoma associated with iatrogenic Cushing syndrome in a person with HIV/AIDS." AIDS Read 18 (2008): 100-4. [PMID: 18333287]
172	Johnson SR, Marion AA, Vrchoticky T, Emmanuel PJ, Lujan-Zilbermann J "Cushing syndrome with secondary adrenal insufficiency from concomitant therapy with ritonavir and fluticasone." J Pediatr 148 (2006): 386-388. [PMID: 16615973]
173	Kelly HW "Comparison of inhaled corticosteroids." Ann Pharmacother 32 (1998): 220-32. [PMID: 9496409]
174	Li AM "Ritonavir and fluticasone: Beware of this potentially fatal combination." J Pediatr 148 (2006): 294-5. [PMID: 16615953]
175	Lipworth BJ "Systemic adverse effects of inhaled corticosteroid therapy - A systematic review and meta-analysis." Arch Intern Med 159 (1999): 941-55. [PMID: 10326936]
176	Naef R, Schmid C, Hofer M, Minder S, Speich R, Boehler A "Itraconazole comedication increases systemic levels of inhaled fluticasone in lung transplant recipients." Respiration 74 (2007): 418-22. [PMID: 17003527]
177	Nocent C, Raherison C, Dupon M, Taytard A "Unexpected effects of inhaled fluticasone in an HIV patient with asthma." J Asthma 41 (2004): 793-5. [PMID: 15641628]
178	Parmar JS, Howell T, Kelly J, Bilton D "Profound adrenal suppression secondary to treatment with low dose inhaled steroids and itraconazole in allergic bronchopulmonary aspergillosis in cystic fibrosis." Thorax 57 (2002): 749-50. [PMID: 12149540]
179	Pearce RE, Leeder JS, Kearns GL "Biotransformation of fluticasone: in vitro characterization." Drug Metab Dispos 34 (2006): 1035-40. [PMID: 16565171]
180	Pessanha TM, Campos JM, Barros AC, Pone MV, Garrido JR, Pone SM "Iatrogenic Cushing's syndrome in a adolescent with AIDSs on ritonavir and inhaled fluticasone. case report and literature review." AIDS 21 (2007): 529-32. [PMID: 17301576]
181	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
182	Product Information. Flonase (fluticasone). Glaxo Wellcome, Research Triangle Park, NC.
183	Product Information. Flovent (fluticasone). Glaxo Wellcome, Research Triangle Park, NC.
184	Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
185	Product Information. Veramyst (fluticasone nasal). GlaxoSmithKline, Research Triangle Park, NC.
186	Rouanet I, Peyriere H, Mauboussin JM, Vincent D "Cushing's syndrome in a patient treated by ritonavir/lopinavir and inhaled fluticasone." HIV Med 4 (2003): 149-50. [PMID: 12702137]
187	Sastre J "Pharmacology of fluticasone propionate." J Investig Allergol Clin Immunol 7 (1997): 382-4. [PMID: 9416555]
188	Schmid C, Naef R, Speich R, Boehler A "Addition of inhaled fluticasone propionate to systemic immunosuppression after lung transplantation: Cushing's Syndrome in patients on itraconazole comedication." Transplantation 76 (2003): 263-4. [PMID: 12865822]
189	Soldatos G, Sztal-Mazer S, Woolley I, Stockigt J "Exogenous glucocorticoid excess as a result of ritonavir-fluticasone interaction." Intern Med J 35 (2005): 67-8. [PMID: 15667475]
190	Todd GR, Acerini CL, Ross-Russell, Zahra S, Warner JT, McCance D "Survey of adrenal crisis associated witwh inhaled corticosteroids in the United Kingdom." Arch Dis Child 87 (2002): 457-61. [PMID: 12456538]
191	Vassiliadi D, Tsagarakis S "Unusual causes of Cushing's syndrome." Arq Bras Endocrinol Metabol 51 (2007): 1245-52. [PMID: 18209862]
192	Woods DR, Arun CS, Corris PA, Perros P "Cushing's syndrome without excess cortisol." BMJ 332 (2006): 469-70. [PMID: 16497762]
193	Bernecker C, West TB, Mansmann G, Scherbaum WA, Willenberg HS "Hypercortisolism caused by ritonavir associated inhibition of CYP 3A4 under inhalative glucocorticoid therapy. 2 case reports and a review of the literature." Exp Clin Endocrinol Diabetes 120 (2012): 125-7. [PMID: 22328106]
194	Kempsford R, Norris V, Siederer S "Vilanterol trifenatate, a novel inhaled long-acting beta2 adrenoceptor agonist, is well tolerated in healthy subjects and demonstrates prolonged bronchodilation in subjects with asthma and COPD." Pulm Pharmacol Ther 26 (2013): 256-64. [PMID: 23232038]
195	Lonnebo A, Grahnen A, Jansson B, Brundin RM, Lingandersson A, Eckernas SA "An assessment of the systemic effects of single and repeated doses of inhaled fluticasone propionate and inhaled budesonide in healthy volunteers." Eur J Clin Pharmacol 49 (1996): 459-63. [PMID: 8706770]
196	Samaras K, Pett S, Gowers A, McMurchie M, Cooper DA "Iatrogenic Cushing's syndrome with osteoporosis and secondary adrenal failure in HIV-infected patients receiving inhaled corticosteroids and ritonavir-boosted protease inhibitors: six cases." J Clin Endocrinol Metab 90 (2005): 4394-8. [PMID: 15755851]
197	Valin N, De Castro N, Garrait V, Bergeron A, Bouche C, Molina JM "Iatrogenic Cushing's syndrome in HIV-infected patients receiving ritonavir and inhaled fluticasone: description of 4 new cases and review of the literature." J Int Assoc Physicians AIDS Care 8 (2009): 113-21. [PMID: 19270151]
198	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
199	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
200	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
201	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
202	Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
203	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
204	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
205	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
206	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
207	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
208	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
209	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
210	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
211	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
212	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
213	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
214	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
215	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
216	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
217	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
218	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
219	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
220	Abbas R, Hug BA, Leister C, Burns J, Sonnichsen D "Pharmacokinetics of oral neratinib during co-administration of ketoconazole in healthy subjects." Br J Clin Pharmacol 71 (2011): 522-7. [PMID: 21395644]
221	Product Information. Nerlynx (neratinib). Puma Biotechnology, Inc., Los Angeles, CA.
222	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
223	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
224	Product Information. Olinvyk (oliceridine). Trevena Inc, Chesterbrook, PA.
225	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
226	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
227	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
228	Hamberg P, Woo MM, Chen LC, et al. "Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor." Cancer Chemother Pharmacol 68 (2011): 805-13. [PMID: 21706316]
229	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
230	Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
231	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
232	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
233	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
234	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
235	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
236	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
237	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
238	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
239	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
240	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
241	Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
242	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
243	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
244	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
245	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
246	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
247	Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA.
248	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
249	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
250	Product Information. Zontivity (vorapaxar). Merck & Company Inc, Whitehouse Station, NJ.
251	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
252	US Food and Drug Administration "FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse.".
253	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
254	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
255	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
256	Glynn AM, Slaughter RL, Brass C, et al "Effects of ketoconazole on methylprednisolone pharmacokinetics and cortisol secretion." Clin Pharmacol Ther 39 (1986): 654-9. [PMID: 3709030]
257	Kandrotas RJ, Slaughter RL, Brass C, Jusko WJ "Ketoconazole effects on methylprednisolone disposition and their joint suppression of endogenous cortisol." Clin Pharmacol Ther 42 (1987): 465-70. [PMID: 3311551]
258	Kotlyar M, Brewer ER, Golding M, Carson SW "Nefazodone inhibits methylprednisolone disposition and enhances its adrenal-suppressant effect." J Clin Psychopharmacol 23 (2003): 652-6. [PMID: 14624194]
259	LaForce CF, Szefler SJ, Miller MF, Ebling W, Brenner M "Inhibition of methylprednisolone elimination in the presence of erythromycin therapy." J Allergy Clin Immunol 72 (1983): 34-9. [PMID: 6602160]
260	Varis T, Backman JT, Kivisto KT, Neuvonen PJ "Diltiazem and mibefradil increase the plasma concentrations and greatly enhance the adrenal-suppressant effect of oral methylprednisolone." Clin Pharmacol Ther 67 (2000): 215-21. [PMID: 10741623]
261	Varis T, Kaukonen KM, Kivisto KT, Neuvonen PJ "Plasma concentrations and effects of oral methylprednisolone are considerably increased by itraconazole." Clin Pharmacol Ther 64 (1998): 363-8. [PMID: 9797792]
262	Backman JT, Kivisto KT, Olkkola KT, Neuvonen PJ "The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin." Eur J Clin Pharmacol 54 (1998): 53-8. [PMID: 9591931]
263	Merry C, Mulcahy F, Barry M, Gibbons S, Back D "Saquinavir interaction with midazolam: pharmacokinetic considerations when prescribing protease inhibitors for patients with HIV disease." AIDS 11 (1997): 268-9. [PMID: 9030388]
264	Michalets EL "Update: clinically significant cytochrome P-450 drug interactions." Pharmacotherapy 18 (1998): 84-112. [PMID: 9469685]
265	Olkkola KT, Backman JT, Neuvonen PJ "Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole." Clin Pharmacol Ther 55 (1994): 481-5. [PMID: 8181191]
266	Palkama VJ, Ahonen J, Neuvonen PJ, Olkkola KT "Effect of saquinavir on the pharmacokinetics and pharmacodynamics of oral and intravenous midazolam." Clin Pharmacol Ther 66 (1999): 33-9. [PMID: 10430107]
267	Product Information. Versed (midazolam). Roche Laboratories, Nutley, NJ.
268	Tsunoda SM, Velez RL, vonMoltke LL, Greenblatt DJ "Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: Effect of ketoconazole." Clin Pharmacol Ther 66 (1999): 461-71. [PMID: 10579473]
269	Vonmoltke LL, Greenblatt DJ, Schmider J, Duan SX, Wright CE, Harmatz JS, Shader RI "Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents." J Clin Pharmacol 36 (1996): 783-91. [PMID: 8889898]
270	Wrighton SA, Ring BJ "Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine." Pharm Res 11 (1994): 921-4. [PMID: 7937537]
271	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
272	Product Information. Nimotop (nimodipine). Bayer, West Haven, CT.
273	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
274	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
275	Desta Z, Kerbusch T, Flockhart DA "Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6)." Clin Pharmacol Ther 65 (1999): 10-20. [PMID: 9951426]
276	Flockhart DA, Drici MD, Kerbusch T, et al "Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with tourette syndrome." J Clin Psychopharmacol 20 (2000): 317-24. [PMID: 10831018]
277	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
278	Krahenbuhl S, Sauter B, Kupferschmidt H, Krause M, Wyss PA, Meier PJ "Case report: reversible QT prolongation with torsades de pointes in a patient with pimozide intoxication." Am J Med Sci 309 (1995): 315-6. [PMID: 7771501]
279	Mangum EM, Graham KK "Lopinavir-Ritonavir: a new protease inhibitor." Pharmacotherapy 21 (2001): 1352-63. [PMID: 11714208]
280	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
281	DeVane CL, Nemeroff CB "Clinical pharmacokinetics of quetiapine - An atypical antipsychotic." Clin Pharmacokinet 40 (2001): 509-22. [PMID: 11510628]
282	Geraci MJ, McCoy SL, Crum PM, Patel RA "Antipsychotic-induced priapism in an HIV patient: a cytochrome P450-mediated drug interaction." Int J Emerg Med 3 (2010): 81-4. [PMID: 20606815]
283	Grimm SW, Richtand NM, Winter HR, Stams KR, Reele SB "Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics." Br J Clin Pharmacol 61 (2006): 58-69. [PMID: 16390352]
284	Hantson P, Di Fazio V, Wallemacq P "Toxicokinetic interaction between quetiapine and antiretroviral therapy following quetiapine overdose." Drug Metab Lett 4 (2010): 7-8. [PMID: 20201782]
285	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
286	Spina E, de Leon J "Metabolic drug interactions with newer antipsychotics: a comparative review." Basic Clin Pharmacol Toxicol 100 (2007): 4-22. [PMID: 17214606]
287	Spina E, Scordo MG, D'Arrigo C "Metabolic drug interactions with new psychotropic agents." Fundam Clin Pharmacol 17 (2003): 517-38. [PMID: 14703714]
288	Urichuk L, Prior TI, Dursun S, Baker G "Metabolism of atypical antipsychotics: involvement of cytochrome p450 enzymes and relevance for drug-drug interactions." Curr Drug Metab 9 (2008): 410-8. [PMID: 18537577]
289	Schulz-Du Bois C, Schulz-Du Bois AC, Bewig B, et al. "Major increase of quetiapine steady-state plasma concentration following co-administration of clarithromycin: confirmation of the pharmacokinetic interaction potential of quetiapine." Pharmacopsychiatry 41 (2008): 258-9. [PMID: 19067264]
290	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
291	Product Information. Evotaz (atazanavir-cobicistat). Bristol-Myers Squibb, Princeton, NJ.
292	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
293	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
294	Hall MCS, Ahmad S "Interaction between sildenafil and HIV-1 combination therapy." Lancet 353 (1999): 2071-2. [PMID: 10376645]
295	Hyland R, Roe GH, Jones BC, Smith DA "Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil." Br J Clin Pharmaacol 51 (2001): 239-48. [PMID: 11298070]
296	Merry C, Barry MG, Ryan M, Tjia JF, Hennessy M, Eagling VA, Mulcahy F, Back DJ "Interaction of sildenafil and indinavir when co-administered to HIV-positive patients." AIDS 13 (1999): f101-7. [PMID: 10546851]
297	Muirhead GJ, Wulff MB, Fielding A, Kleinermans D, Buss N "Pharmacokinetic interactions between sildenafil and saquinavir/ritonavir." Br J Clin Pharmacol 50 (2000): 99-107. [PMID: 10930961]
298	Nandwani R, Gourlay Y "Possible interaction between sildenafil and HIV combination therapy." Lancet 353 (1999): 840. [PMID: 10459981]
299	Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
300	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
301	Warrington JS, Shader RI, vonMoltke LL, Greenblatt DJ "In vitro biotransformation of sildenafil (Viagra): Identification of human cytochromes and potential drug interactions." Drug Metab Disposition 28 (2000): 392-7. [PMID: 10725306]
302	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
303	Claesson K, Brattstrom C, Burke JT "Sirolimus and erythromycin interaction: two cases." Transplant Proc 33 (2001): 2136. [PMID: 11377477]
304	Dodds-Ashley E "Management of drug and food interactions with azole antifungal agents in transplant recipients." Pharmacotherapy 30 (2010): 842-54. [PMID: 20653361]
305	Floren LC, Christians U, Zimmerman JJ, et al "Sirolimus oral bioavailability increases ten-fold with concomitant ketoconazole." Clin Pharmacol Ther 65 (1999): 159.
306	Product Information. Noxafil (posaconazole). Schering-Plough Corporation, Kenilworth, NJ.
307	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
308	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
309	Albengres E, Le Louet H, Tillement JP "Systemic antifungal agents. Drug interactions of clinical significance." Drug Saf 18 (1998): 83-97. [PMID: 9512916]
310	Assan R, Fredj G, Larger E, Feutren G, Bismuth H "FK 506/fluconazole interaction enhances FK 506 nephrotoxicity." Diabete Metab 20 (1994): 49-52. [PMID: 7520007]
311	Barau C, Blouin P, Creput C, Taburet AM, Durrbach A, Furlan V "Effect of coadministered HIV-protease inhibitors on tacrolimus and sirolimus blood concentrations in a kidney transplant recipient." Fundam Clin Pharmacol 23 (2009): 423-5. [PMID: 19709321]
312	Billaud EM, Guillemain R, Tacco F, Chevalier P "Evidence for a pharmacokinetic interaction between itraconazole and tacrolimus in organ transplant patients." Br J Clin Pharmacol 46 (1998): 271-4. [PMID: 9764970]
313	Cakaloglu Y, Tredger JM, Devlin J, Williams R "Importance of cytochrome p-450IIIA activity in determining dosage and blood levels of FK 506 and cyclosporine in liver transplant recipients." Hepatology 20 (1994): 309-16. [PMID: 7519161]
314	Capone D, Gentile A, Imperatore P, Palmiero G, Basile V "Effects of itraconazole on tacrolimus blood concentrations in a renal transplant recipient." Ann Pharmacother 33 (1999): 1124-5. [PMID: 10534229]
315	Floren LC, Bekersky I, Benet LZ, et al. "Tacrolimus oral bioavailability doubles with coadministration of ketoconazole." Clin Pharmacol Ther 62 (1997): 41-9. [PMID: 9246018]
316	Furlan V, Perello L, Jacquemin E, Debray D, Taburet AM "Interactions between FK506 and rifampin or erythromycin in pediatric liver recipients." Transplantation 59 (1995): 1217-8. [PMID: 7537398]
317	Gomez G, Alvarez ML, Errasti P, Lavilla FJ, Garcia N, Ballester B, Garcia I, Purroy A "Acute tacrolimus nephrotoxicity in renal transplant patients treated with clarithromycin." Transplant Proc 31 (1999): 2250-1. [PMID: 10500563]
318	Ibrahim RB, Abella EM, Chandrasekar PH "Tacrolimus-clarithromycin interaction in a patient receiving bone marrow transplantation." Ann Pharmacother 36 (2002): 1971-1972. [PMID: 12452763]
319	Jain AB, Venkataramanan R, Eghtesad B, et al. "Effect of coadministered lopinavir and ritonavir (Kaletra) on tacrolimus blood concentration in liver transplantation patients." Liver Transpl 9 (2003): 954-60. [PMID: 12942457]
320	Jain AK, Venkataramanan R, Shapiro R, et al. "Interaction between tacrolimus and antiretroviral agents in human immunodeficiency virus-positive liver and kidney transplantation patients." Transplant Proc 34 (2002): 1540-1. [PMID: 12176474]
321	Jain AK, Venkataramanan R, Shapiro R, et al. "The interaction between antiretroviral agents and tacrolimus in liver and kidney transplant patients." Liver Transpl 8 (2002): 841-5. [PMID: 12200788]
322	Jensen C, Jordan M, Shapiro R, et al. "Interaction between tacrolimus and erythromycin." Lancet 344 (1994): 825. [PMID: 7521928]
323	Katari SR, Magnone M, Shapiro R, et al "Clinical features of acute reversible tacrolimus (FK 506) nephrotoxicity in kidney transplant recipients." Clin Transplant 11 (1997): 237-42. [PMID: 9193849]
324	Kunicki PK, Sobieszczanska-Malek M "Pharmacokinetic interaction between tacrolimus and clarithromycin in a heart transplant patient." Ther Drug Monit 27 (2005): 107-108. [PMID: 15665756]
325	Macias MO, Salvador P, Hurtado JL, Martin I "Tacrolimus-itraconazole interaction in a kidney transplant patient." Ann Pharmacother 34 (2000): 536. [PMID: 10772445]
326	Manez R, Martin M, Raman V, et al. "Fluconazole therapy in transplant recipients receiving FK506." Transplantation 57 (1994): 1521-3. [PMID: 7515201]
327	Mertz D, Battegay M, Marzolini C, Mayr M "Drug-Drug Interaction in a Kidney Transplant Recipient Receiving HIV Salvage Therapy and Tacrolimus." Am J Kidney Dis (2009):. [PMID: 19346040]
328	Mieles L, Venkataramanan R, Yokoyama I, Warty VJ, Starzl TE "Interaction between FK506 and clotrimazole in a liver transplant recipient." Transplantation 52 (1991): 1086-7. [PMID: 1721250]
329	Moreno M, Latorre A, Manzanares C, et al "Clinical management of tacrolimus drug interactions in renal transplant patients." Transplant Proc 31 (1999): 2252-3. [PMID: 10500564]
330	Olyaei AJ, deMattos AM, Norman DJ, Bennett WM "Interaction between tacrolimus and nefazodone in a stable renal transplant recipient." Pharmacotherapy 18 (1998): 1356-9. [PMID: 9855339]
331	Osowski CL, Dix SP, Lin LS, Mullins RE, Geller RB, Wingard JR "Evaluation of the drug interaction between intravenous high-dose fluconazole and cyclosporine or tacrolimus in bone marrow transplant patients." Transplantation 61 (1996): 1268-72. [PMID: 8610430]
332	Pai MP, Allen S "Voriconazole inhibition of tacrolimus metabolism." Clin Infect Dis 36 (2003): 1089-91. [PMID: 12684931]
333	Parissis H, Gould K, Dark J "Dangerous drug interactions leading to hemolytic uremic syndrome following lung transplantation." J Cardiothorac Surg 5 (2010): 70. [PMID: 20813025]
334	Pea F, Furlanut M "Pharmacokinetic aspects of treating infections in the intensive care unit: focus on drug interactions." Clin Pharmacokinet 40 (2001): 833-868. [PMID: 11735605]
335	Pea F, Tavio M, Pavan F, et al. "Drop in trough blood concentrations of tacrolimus after switching from nelfinavir to fosamprenavir in four HIV-infected liver transplant patients." Antivir Ther 13 (2008): 739-42. [PMID: 18771060]
336	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
337	Schonder KS, Shullo MA, Okusanya O "Tacrolimus and lopinavir/ritonavir interaction in liver transplantation." Ann Pharmacother 37 (2003): 1793-6. [PMID: 14632538]
338	Shaeffer MS, Collier D, Sorrell MF "Interaction between FK506 and erythromycin." Ann Pharmacother 28 (1994): 280-1. [PMID: 7513563]
339	Soltero L, Carbajal H, Rodriguez-Montalvo C, Valdes A "Coadministration of tacrolimus and ketoconazole in renal transplant recipients: cost analysis and review of metabolic effects." Transplant Proc 35 (2003): 1319-21. [PMID: 12826147]
340	Tsapepas DS, Webber AB, Aull MJ, Figueiro JM, Saal SD "Managing the atazanavir-tacrolimus drug interaction in a renal transplant recipient." Am J Health Syst Pharm 68 (2011): 138-42. [PMID: 21200061]
341	Vasquez EM, Pollak R, Benedetti E "Clotrimazole increases tacrolimus blood levels: a drug interaction in kidney transplant patients." Clin Transplant 15 (2001): 95-9. [PMID: 11264634]
342	Venkatakrishnan K, von Moltke LL, Greenblatt DJ "Effects of the antifungal agents on oxidative drug metabolism: clinical relevance." Clin Pharmacokinet 38 (2000): 111-80. [PMID: 10709776]
343	Venkataramanan R, Zang S, Gayowski T, Singh N "Voriconazole inhibition of the metabolism of tacrolimus in a liver transplant recipient and in human liver microsomes." Antimicrob Agents Chemother 46 (2002): 3091-3. [PMID: 12183280]
344	Wolter K, Wagner K, Philipp T, Fritschka E "Interaction between FK 506 and clarithromycin in a renal transplant patient." Eur J Clin Pharmacol 47 (1994): 207-8. [PMID: 7532134]
345	Teicher E, Vincent I, Bonhomme-Faivre L, et al. "Effect of Highly Active Antiretroviral Therapy on Tacrolimus Pharmacokinetics in Hepatitis C Virus and HIV Co-Infected Liver Transplant Recipients in the ANRS HC-08 Study." Clin Pharmacokinet 46 (2007): 941-52. [PMID: 17922559]
346	Franco-Salinas G, de la Rosette JJ, Michel MC "Pharmacokinetics and pharmacodynamics of tamsulosin in its modified-release and oral controlled absorption system formulations." Clin Pharmacokinet 49 (2010): 177-88. [PMID: 20170206]
347	Kamimura H, Oishi S, Matsushima H, et al. "Identification of cytochrome P450 isozymes involved in metabolism of the alpha1-adrenoceptor blocker tamsulosin in human liver microsomes." Xenobiotica 28 (1998): 909-22. [PMID: 9849639]
348	Product Information. Flomax (tamsulosin). Boehringer-Ingelheim, Ridgefield, CT.
349	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
350	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
351	Product Information. Vaprisol (conivaptan). Cumberland Pharmaceuticals Inc, Nashville, TN.
352	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
353	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
354	Albert NE, Kazi S, Santoro J, Dougherty R "Ritonavir and Epidural Triamcinolone as a Cause of Iatrogenic Cushing's Syndrome." Am J Med Sci (2012):. [PMID: 22543594]
355	Dort K, Padia S, Wispelwey B, Moore CC "Adrenal suppression due to an interaction between ritonavir and injected triamcinolone: a case report." AIDS Res Ther 6 (2009): 10. [PMID: 19505306]
356	Fessler D, Beach J, Keel J, Stead W "Iatrogenic hypercortisolism complicating triamcinolone acetonide injections in patients with HIV on ritonavir-boosted protease inhibitors." Pain Physician 15 (2012): 489-93. [PMID: 23159966]
357	Hagan JB, Erickson D, Singh RJ "Triamcinolone Acetonide Induced Secondary Adrenal Insufficiency Related to Impaired CYP3A4 Metabolism by Coadministration of Nefazodone." Pain Med (2010):. [PMID: 20456080]
358	Hall JJ, Hughes CA, Foisy MM, Houston S, Shafran S "Iatrogenic Cushing syndrome after intra-articular triamcinolone in a patient receiving ritonavir boosted darunavir." Int J STD AIDS (2013):. [PMID: 23970582]
359	Levine D, Ananthakrishnan S, Garg A "Iatrogenic Cushing syndrome after a single intramuscular corticosteroid injection and concomitant protease inhibitor therapy." J Am Acad Dermatol 65 (2011): 877-8. [PMID: 21920248]
360	McConkey HZ, Williams H, Kulasegaram R, Graham E "Orbital floor triamcinolone causing Cushing's syndrome in a patient treated with Kaletra for HIV 1." BMJ Case Rep 2013 (2013):. [PMID: 23440982]
361	Sadarangani S, Berg ML, Mauck W, Rizza S "Iatrogenic Cushing Syndrome Secondary to Ritonavir-Epidural Triamcinolone Interaction: An Illustrative Case and Review." Interdiscip Perspect Infect Dis 2014 (2014): 849432. [PMID: 24895495]
362	Schwarze-Zander C, Klingmuller D, Klumper J, Strassburg CP, Rockstroh JK "Triamcinolone and ritonavir leading to drug-induced Cushing syndrome and adrenal suppression: description of a new case and review of the literature." Infection (2013):. [PMID: 23873267]
363	Grierson MJ, Harrast MA "Iatrogenic Cushing Syndrome After Epidural Steroid Injections for Lumbar Radiculopathy in an HIV-Infected Patient Treated With Ritonavir: A Case Report Highlighting Drug Interactions for Spine Interventionalists." PM R 4 (2012): 234-7. [PMID: 22443962]
364	Ahonen J, Olkkola KT, Neuvonen PJ "Effect of itraconazole and terbinafine on the pharmacokinetics and pharmacodynamics of midazolam in healthy volunteers." Br J Clin Pharmacol 40 (1995): 270-2. [PMID: 8527290]
365	Barry M, Mulcahy F, Merry C, Gibbons S, Back D "Pharmacokinetics and potential interactions amongst antiretroviral agents used to treat patients with HIV infection." Clin Pharmacokinet 36 (1999): 289-304. [PMID: 10320951]
366	Brown MW, Maldonado AL, Meredith CG, Speeg KV "Effect of ketoconazole on hepatic oxidative drug metabolism." Clin Pharmacol Ther 37 (1985): 290-7. [PMID: 3971653]
367	Decker CJ, Laitinen LM, Bridson GW, Raybuck SA, Tung RD, Chaturvedi PR "Metabolism of amprenavir in liver microsomes: role of CYP3A4 inhibition for drug interactions." J Pharm Sci 87 (1998): 803-7. [PMID: 9649346]
368	Eagling VA, Back DJ, Barry MG "Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir." Br J Clin Pharmacol 44 (1997): 190-4. [PMID: 9278209]
369	Greenblatt DJ, von Moltke LL, Harmatz JS, et al. "Differential impairment of triazolam and zolpidem clearance by ritonavir." J Acquir Immune Defic Syndr 24 (2000): 129-36. [PMID: 10935688]
370	Greenblatt DJ, Vonmoltke LL, Harmatz JS, Harrel LM, Tobias S, Shader RI, Wright CE "Interaction of triazolam and ketoconazole." Lancet 345 (1995): 191. [PMID: 7823684]
371	Malaty LI, Kuper JJ "Drug interactions of HIV protease inhibitors." Drug Safety 20 (1999): 147-69. [PMID: 10082072]
372	Neuvonen PJ, Varhe A, Olkkola KT "The effect of ingestion time interval on the interaction between itraconazole and triazolam." Clin Pharmacol Ther 60 (1996): 326-31. [PMID: 8841155]
373	Product Information. Halcion (triazolam). Pharmacia and Upjohn, Kalamazoo, MI.
374	Product Information. Xanax (alprazolam). Pharmacia and Upjohn, Kalamazoo, MI.
375	Varhe A, Olkkola KT, Neuvonen PJ "Fluconazole, but not terbinafine, enhances the effects of triazolam by inhibiting its metabolism." Br J Clin Pharmacol 41 (1996): 319-23. [PMID: 8730978]
376	Varhe A, Olkkola KT, Neuvonen PJ "Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole." Clin Pharmacol Ther 56 (1994): 601-7. [PMID: 7995001]
377	Greenblatt DJ, Wright CE, vonMoltke LL, Harmatz JS, Ehrenberg BL, Harrel LM, Corbett K, Counihan M, Tobias S, Shader RI "Ketoconazole inhibition of triazolam and alprazolam clearance: Differential kinetic and dynamic consequences." Clin Pharmacol Ther 64 (1998): 237-47. [PMID: 9757147]
378	Antoniou T, Tseng AL "Interactions between antiretrovirals and antineoplastic drug therapy." Clin Pharmacokinet 44 (2005): 111-145. [PMID: 15656694]
379	Ariffin H, Omar KZ, Ang EL, Shekhar K "Severe vincristine neurotoxicity with concomitant use of itraconazole." J Paediatr Child Health 39 (2003): 638-9. [PMID: 14629538]
380	Bashir H, Motl S, Metzger ML, et al. "Itraconazole-enhanced chemotherapy toxicity in a patient with Hodgkin lymphoma." J Pediatr Hematol Oncol 28 (2006): 33-35. [PMID: 16394890]
381	Bermudez M, Fuster JL, Llinares E, Galera A, Gonzalez C "Itraconazole-related increased vincristine neurotoxicity: case report and review of literature." J Pediatr Hematol Oncol 27 (2005): 389-392. [PMID: 16012330]
382	Bohme A, Ganser A, Hoelzer D "Aggravation of vincristine-induced neurotoxicity by itraconazole in the treatment of adult ALL." Ann Hematol 71 (1995): 311-2. [PMID: 8534764]
383	Bosque E "Possible drug interaction between itraconazole and vinorelbine tartrate leading to death after one dose of chemotherapy." Ann Intern Med 134 (2001): 427. [PMID: 11242511]
384	Carrion C, Espinosa E, Herrero A, Garcia B "Possible vincristine-isoniazid interaction." Ann Pharmacother 29 (1995): 201. [PMID: 7756727]
385	Chan JD "Pharmacokinetic drug interactions of vinca alkaloids: summary of case reports." Pharmacotherapy 18 (1998): 1304-7. [PMID: 9855331]
386	Chen S, Wu D, Sun A, et al "Itraconazole-enhanced vindesine neurotoxicity in adult acute lymphoblastic leukaemia." Am J Hematol 82 (2007): 942. [PMID: 17617780]
387	Corona G, Vaccher E, Spina M, Toffoli G "Potential hazard drug-drug interaction between boosted protease inhibitors and vinblastine in HIV patients with Hodgkin's lymphoma." AIDS 27 (2013): 1033-5. [PMID: 23698067]
388	Eiden C, Palenzuela G, Hillaire-Buys D, et al. "Posaconazole-increased vincristine neurotoxicity in a child: a case report." J Pediatr Hematol Oncol 31 (2009): 292-5. [PMID: 19346885]
389	Fedeli L, Colozza M, Boschetti E, et al. "Pharmacokinetics of vincristine in cancer patients treated with nifedipine." Cancer 64 (1989): 1805-11. [PMID: 2790693]
390	Gillies J, Hung KA, Fitzsimons E, Soutar R "Severe vincristine toxicity in combination with itraconazole." Clin Lab Haematol 20 (1998): 123-4. [PMID: 9681224]
391	Haddad A, Davis M, Lagman R "The pharmacological importance of cytochrome CYP3A4 in the palliation of symptoms: review and recommendations for avoiding adverse drug interactions." Support Care Cancer 15 (2007): 251-7. [PMID: 17139496]
392	Harnicar S, Adel N, Jurcic J "Modification of vincristine dosing during concomitant azole therapy in adult acute lymphoblastic leukemia patients." J Oncol Pharm Pract 15 (2009): 175-82. [PMID: 19282418]
393	Jain S, Kapoor G "Severe life threatening neurotoxicity in a child with acute lymphoblastic leukemia receiving posaconazole and vincristine." Pediatr Blood Cancer 54 (2010): 783. [PMID: 20205256]
394	Jeng MR, Feusner J "Itraconazole-enhanced vincristine neurotoxicity in a child with acute lymphoblastic leukemia." Pediatr Hematol Oncol 18 (2001): 137-42. [PMID: 11255732]
395	Kajita J, Kuwabara T, Kobayashi H, Kobayashi S "CYP3A4 is mainly responsibile for the metabolism of a new vinca alkaloid, vinorelbine, in human liver microsomes." Drug Metab Dispos 28 (2000): 1121-7. [PMID: 10950859]
396	Kamaluddin M, McNally P, Breatnach F, et al "Potentiation of vincristine toxicity by itraconazole in children with lymphoid malignancies." Acta Paediatr 90 (2001): 1204-7. [PMID: 11697438]
397	Kivisto KT, Kroemer HK, Eichelbaum M "The role of human cytochrome p450 enzymes in the metabolism of anticancer agents: implications for drug interactions." Br J Clin Pharmacol 40 (1995): 523-30. [PMID: 8703657]
398	Kotb R, Vincent I, Dulioust A, et al. "Life-threatening interaction between antiretroviral therapy and vinblastine in HIV-associated multicentric Castleman's disease." Eur J Haematol 76 (2006): 269-71. [PMID: 16451402]
399	Leveque D, Santucci R, Pavillet J, Herbrecht R, Bergerat JP "Paralytic ileus possibly associated with interaction between ritonavir/lopinavir and vincristine." Pharm World Sci 31 (2009): 619-21. [PMID: 19757141]
400	Mantadakis E, Amoiridis G, Kondi A, Kalmanti M "Possible increase of the neurotoxicity of vincristine by the concurrent use of posaconazole in a young adult with leukemia." J Pediatr Hematol Oncol 29 (2007): 130. [PMID: 17279013]
401	Moriyama B, Falade-Nwulia O, Leung J, et al. "Prolonged half-life of voriconazole in a CYP2C19 homozygous poor metabolizer receiving vincristine chemotherapy: avoiding a serious adverse drug interaction." Mycoses 54 (2011): e877-9. [PMID: 21615537]
402	Murphy JA, Ross LM, Gibson BE "Vincristine toxicity in five children with acute lymphoblastic leukaemia." Lancet 346 (1995): 443. [PMID: 7623589]
403	Porter CC, Carver AE, Albano EA "Vincristine induced peripheral neuropathy potentiated by voriconazole in a patient with previously undiagnosed CMT1X." Pediatr Blood Cancer 52 (2009): 298-300. [PMID: 18837430]
404	Product Information. Oncovin (vincristine). Lilly, Eli and Company, Indianapolis, IN.
405	Product Information. Velban (vinblastine). Lilly, Eli and Company, Indianapolis, IN.
406	Sathiapalan RK, Al-Nasser A, El-Solh H, Al-Mohsen I, Al-Jumaah S "Vincristine-itraconazole interaction: cause for increasing concern." J Pediatr Hematol Oncol 24 (2002): 591. [PMID: 12368705]
407	Sathiapalan RK, El-Solh H "Enhanced vincristine neurotoxicity from drug interactions: case report and review of literature." Pediatr Hematol Oncol 18 (2001): 543-6. [PMID: 11764105]
408	Takahashi N, Kameoka Y, Yamanaka Y, et al. "Itraconazole oral solution enhanced vincristine neurotoxicity in five patients with malignant lymphoma." Intern Med 47 (2008): 651-3. [PMID: 18379154]
409	Tobe SW, Siu LL, Jamal SA, Skorecki KL, Murphy GF, Warner E "Vinblastine and erythromycin: an unrecognized serious drug interaction." Cancer Chemother Pharmacol 35 (1995): 188-90. [PMID: 7805175]
410	Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y "Potentiation of vincristine and adriamycin effects in human hemopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors." Cancer Res 43 (1983): 2267-72. [PMID: 6831450]
411	van Schie RM, Bruggemann RJ, Hoogerbrugge PM, Te Loo DM "Effect of azole antifungal therapy on vincristine toxicity in childhood acute lymphoblastic leukaemia." J Antimicrob Chemother 66 (2011): 1853-6. [PMID: 21652620]
412	Yano R, Tani D, Watanabe K, et al. "Evaluation of potential interaction between vinorelbine and clarithromycin." Ann Pharmacother 43 (2009): 453-8. [PMID: 19261952]
413	Zhou XJ, Zhou-Pan XR, Gauthier T, Placidi M, Maurel P, Rahmani R "Human liver microsomal cytochrome P450 3A isozymes mediated vindesine biotransformation. Metabolic drug interactions." Biochem Pharmacol 45 (1993): 853-61. [PMID: 8452560]
414	Zhou-Pan XR, Seree E, Zhou XJ, et al "Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions." Cancer Res 53 (1993): 5121-6. [PMID: 8221648]
415	Product Information. Axert (almotriptan) Pharmacia and Upjohn, Kalamazoo, MI.
416	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
417	Busse KH, Formentini E, Alfaro RM, Kovacs JA, Penzak SR "Influence of antiretroviral drugs on the pharmacokinetics of prednisolone in HIV-infected individuals." J Acquir Immune Defic Syndr 48 (2008): 561-6. [PMID: 18645517]
418	Couturier J, Steele M, Hussey L, Pawliuk G "Steroid-induced mania in an adolescent: risk factors and management." Can J Clin Pharmacol 8 (2001): 109-12. [PMID: 11493940]
419	Finkenbine RD, Frye MD "Case of psychosis due to prednisone-clarithromycin interaction." Gen Hosp Psychiat 20 (1998): 325-6. [PMID: 9788033]
420	Garey KW, Rubinstein I, Gotfried MH, Khan IJ, Varma S, Danziger LH "Long-term clarithromycin decreases prednisone requirements in elderly patients with prednisone-dependent asthma." Chest 118 (2000): 1826-7. [PMID: 11115481]
421	Itkin IH, Menzel ML "The use of macrolide antibiotic substances in the treatment of asthma." J Allergy Clin Immunol 45 (1970): 146-62. [PMID: 5309312]
422	Lebrun-Vignes B, Archer VC, Diquest B, et al. "Effect of itraconazole on the pharmacokinetics of prednisolone and methylprednisolone and cortisol secretion in healthy subjects." Br J Clin Pharmacol 51 (2001): 443-50. [PMID: 11422002]
423	Penzak SR, Formentini E, Alfaro RM, Long M, Natarajan V, Kovacs J "Prednisolone pharmacokinetics in the presence and absence of ritonavir after oral prednisone administration to healthy volunteers." J Acquir Immune Defic Syndr 40 (2005): 573-80. [PMID: 16284534]
424	Ulrich B, Frey FJ, Speck RF, Frey BM "Pharmacokinetics/pharmacodynamics of ketoconazole-prednisolone interaction." J Pharmacol Exp Ther 260 (1992): 487-90. [PMID: 1738098]
425	Varis T, Kivisto KT, Neuvonen PJ "The effect of itraconazole on the pharmacokinetics and pharmacodynamics of oral prednisolone." Eur J Clin Pharmacol 56 (2000): 57-60. [PMID: 10853878]
426	Yamashita SK, Ludwig EA, Middleton E Jr, Jusko WJ "Lack of pharmacokinetic and pharmacodynamic interactions between ketoconazole and prednisolone." Clin Pharmacol Ther 49 (1991): 558-70. [PMID: 1827622]
427	Zurcher RM, Frey BM, Frey FJ "Impact of ketoconazole on the metabolism of prednisolone." Clin Pharmacol Ther 45 (1989): 366-72. [PMID: 2639662]
428	Pekol T, Daniels JS, Labutti J, et al "Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites." Drug Metab Dispos 33 (2005): 771-7. [PMID: 15764713]
429	Product Information. Velcade (bortezomib). Millennium Pharmaceuticals Inc, Cambridge, MA.
430	Uttamsingh V, Lu C, Miwa GT, Gan LS "Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4 to the hepatic metabolism of teh protosome inhibitor bortezomib." Drug Metab Dispos 33 (2005): 1723-8. [PMID: 16103134]
431	Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
432	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
433	Product Information. Alvesco (ciclesonide). Nycomed USA, Florham Park, NJ.
434	Product Information. Omnaris (ciclesonide nasal). Sepracor Inc, Marlborough, MA.
435	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
436	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
437	Product Information. Sensipar (cinacalcet). Amgen USA, Thousand Oaks, CA.
438	Product Information. Cleocin (clindamycin). Pharmacia and Upjohn, Kalamazoo, MI.
439	Product Information. Onfi (clobazam). Lundbeck Inc, Deerfield, IL.
440	Collet JP, Hulot JS, Pena A, et al. "Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study." Lancet 373 (2009): 309-17. [PMID: 19108880]
441	Frere C, Cuisset T, Morange PE, et al. "Effect of Cytochrome P450 Polymorphisms on Platelet Reactivity After Treatment With Clopidogrel in Acute Coronary Syndrome." Am J Cardiol 101 (2008): 1088-1093. [PMID: 18394438]
442	Gilard M, Arnaud B, Cornily JC, et al "Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study." J Am Coll Cardiol 51 (2008): 256-60. [PMID: 18206732]
443	Gilard M, Arnaud B, Le Gal G, Abgrall JF, Boschat J "Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin." J Thromb Haemost 4 (2006): 2508-9. [PMID: 16898956]
444	Hulot JS, Bura A, Villard E, et al. "Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects." Blood (2006):. [PMID: 16772608]
445	Juurlink DN, Gomes T, Ko DT, et al "A population-based study of the drug interaction between proton pump inhibitors and clopidogrel." CMAJ 180 (2009): 713-8. [PMID: 19176635]
446	Lau WC, Gurbel PA "The drug-drug interaction between proton pump inhibitors and clopidogrel." CMAJ 180 (2009): 699-700. [PMID: 19332744]
447	Li XQ, Andersson TB, Ahlstrom M, Weidolf L "Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities." Drug Metab Dispos 32 (2004): 821-7. [PMID: 15258107]
448	Mega JL, Close SL, Wiviott SD, et al. "Cytochrome p-450 polymorphisms and response to clopidogrel." N Engl J Med 360 (2009): 354-62. [PMID: 19106084]
449	Moayyedi P, Sadowski DC "Proton pump inhibitors and clopidogrel -- hazardous drug interaction or hazardous interpretation of data?" Can J Gastroenterol 23 (2009): 251-2. [PMID: 19373416]
450	Ohyama K, Nakajima M, Suzuki M, Shimada N, Yamazaki H, Yokoi T "Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: Prediction of in vivo drug interactions." Br J Clin Pharmacol 49 (2000): 244-53. [PMID: 10718780]
451	Pezalla E, Day D, Pulliadath I "Initial assessment of clinical impact of a drug interaction between clopidogrel and proton pump inhibitors." J Am Coll Cardiol 52 (2008): 1038-9. [PMID: 18786491]
452	Product Information. Cordarone (amiodarone). Wyeth-Ayerst Laboratories, Philadelphia, PA.
453	Product Information. Kapidex (dexlansoprazole). Takeda Pharmaceuticals America, Lincolnshire, IL.
454	Product Information. Plavix (clopidogrel). Bristol-Myers Squibb, Princeton, NJ.
455	Siller-Matula JM, Spiel AO, Lang IM, Kreiner G, Christ G, Jilma B "Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel." Am Heart J 157 (2009): 148.e1-5. [PMID: 19081411]
456	Simon T, Verstuyft C, Mary-Krause M, et al "Genetic determinants of response to clopidogrel and cardiovascular events." N Engl J Med 360 (2009): 363-75. [PMID: 19106083]
457	Small DS, Farid NA, Payne CD, et al. "Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel." J Clin Pharmacol 48 (2008): 475-84. [PMID: 18303127]
458	Varenhorst C, Janes S, Erlinge D, et al "Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary artery disease." Eur Heart J 30 (2009): 1744-52. [PMID: 19429918]
459	Product Information. Cardura (doxazosin). Pfizer US Pharmaceuticals, New York, NY.
460	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
461	Lemma GL, Desta Z, Jones DR, Gorski JC, Hall SD "Droperidol is predominantly metabolized by human CYP3A enzymes." Clin Pharmacol Ther 73 (2003): 16.
462	Product Information. Droperidol (droperidol). Abbott Pharmaceutical, Abbott Park, IL.
463	Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
464	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
465	Li J, Zhao M, He P, Hidalgo M, Baker SD "Differential metabolism of gefitinib and erlotinib by human cytochrome p450 enzymes." Clin Cancer Res 13 (2007): 3731-7. [PMID: 17575239]
466	Product Information. Tarceva (erlotinib). Genentech, South San Francisco, CA.
467	Chan BSH, Graudins A, Whyte IM, Dawson AH, Braitberg G, Duggin GG "Serotonin syndrome resulting from drug interactions." Med J Aust 169 (1998): 523-5. [PMID: 9861909]
468	Corkeron MA "Serotonin syndrome - a potentially fatal complication of antidepressant therapy." Med J Aust 163 (1995): 481-2. [PMID: 7476638]
469	Laird LK "Issues in the monopharmacotherapy and polypharmacotherapy of obsessive-compulsive disorder." Psychopharmacol Bull 32 (1996): 569-78. [PMID: 8993077]
470	Lane R, Baldwin D "Selective serotonin reuptake inhibitor--induced serotonin syndrome: review." J Clin Psychopharmacol 17 (1997): 208-21. [PMID: 9169967]
471	Martin TG "Serotonin syndrome." Ann Emerg Med 28 (1996): 520-6. [PMID: 8909274]
472	Mills KC "Serotonin syndrome: A clinical update." Crit Care Clin 13 (1997): 763. [PMID: 9330840]
473	Nierenberg DW, Semprebon M "The central nervous system serotonin syndrome." Clin Pharmacol Ther 53 (1993): 84-8. [PMID: 8257462]
474	Nijhawan PK, Katz G, Winter S "Psychiatric illness and the serotonin syndrome: an emerging adverse drug effect leading to intensive care unit admission." Crit Care Med 24 (1996): 1086-9. [PMID: 8681579]
475	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
476	Sternbach H "The serotonin syndrome." Am J Psychiatry 148 (1991): 705-13. [PMID: 2035713]
477	Product Information. Reminyl (galantamine) Janssen Pharmaceuticals, Titusville, NJ.
478	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
479	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
480	Product Information. Vimpat (lacosamide). UCB Pharma Inc, Smyrna, GA.
481	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
482	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
483	Product Information. Tekturna (aliskiren). Novartis Pharmaceuticals, East Hanover, NJ.
484	Tapaninen T, Backman JT, Kurkinen K, Neuvonen P, Niemi M "Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren." J Clin Pharmacol 51 (2011): 359-67. [PMID: 20400651]
485	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
486	Product Information. Jevtana (cabazitaxel). sanofi-aventis , Bridgewater, NJ.
487	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
488	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
489	Product Information. Viberzi (eluxadoline). Actavis Pharma, Inc., Parsippany, NJ.
490	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
491	Product Information. Pomalyst (pomalidomide). QLT Phototherapeutics Inc, Vancouver, AZ.
492	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
493	Cerner Multum, Inc. "Canadian Product Information.".
494	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
495	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
496	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
497	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
498	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
499	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
500	Bell J, Seres V, Bowron P, Lewis J, Batey R "The use of serum methadone levels in patients receiving methadone maintenance." Clin Pharmacol Ther 43 (1988): 623-9. [PMID: 3378383]
501	Ehret GB, Desmeules JA, Broers B "Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology." Expert Opin Drug Saf 6 (2007): 289-303. [PMID: 17480178]
502	Foster DJ, Somogyi AA, Bochner F "Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4." Br J Clin Pharmacol 47 (1999): 403-12. [PMID: 10233205]
503	Iribarne C, Berthou F, Baird S, Dreano Y, Picart D, Bail JP, Beaune P, Menez JF "Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes." Chem Res Toxicol 9 (1996): 365-73. [PMID: 8839037]
504	Krantz MJ, Lewkowiez L, Hays H, et al "Torsade de pointes associated with very-high-dose methadone." Ann Intern Med 137 (2002): 501-4. [PMID: 12230351]
505	Moody DE, Alburges ME, Parker RJ, Collings JM, Strong JM "The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), norLAAM, and methadone." Drug Metab Dispos 25 (1997): 1347-53. [PMID: 9394023]
506	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
507	Oda Y, Kharasch ED "Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation." J Pharmacol Exp Ther 298 (2001): 1021-32. [PMID: 11504799]
508	Product Information. ORAVIG (miconazole). Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc., Woodcliff Lake, NJ.
509	Okubo M, Murayama N, Miura J, Chiba Y, Yamazaki H "Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients." Biochem Pharmacol 93 (2015): 104-9. [PMID: 25475885]
510	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
511	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
512	Sitsen JM, Maris FA, Timmer CJ "Concomitant use of mirtazapine and cimetidine: a drug-drug interaction study in healthy male subjects." Eur J Clin Pharmacol 56 (2000): 389-94. [PMID: 11009047]
513	Stormer E, von Moltke LL, Shader RI, Greenblatt DJ "Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4" Drug Metab Dispos 28 (2000): 1168-75. [PMID: 10997935]
514	Product Information. Osphena (ospemifene). Shionogi USA Inc, Florham Park, NJ.
515	Bergmann TK, Filppula AM, Launiainen T, Nielsen F, Backman J, Brosen K "Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60 year old Caucasian woman with ovarian carcinoma." Br J Clin Pharmacol (2015):. [PMID: 26446447]
516	Bun SS, Ciccolini J, Bun H, Aubert C, Catalin J "Drug interactions of paclitaxel metabolism in human liver microsomes." J Chemother 15 (2003): 266-74. [PMID: 12868554]
517	Jamis-Dow CA, Klecker RW, Katki AG, Collins JM "Metabolism of Taxol by human liver microsomes and effect of inhibitors (Meeting abstract)." Proc Annu Meet Am Assoc Cancer Res 34 (1993): a21981993.
518	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
519	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
520	Spencer CM, Faulds D "Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer." Drugs 48 (1994): 794-847. [PMID: 7530632]
521	Product Information. Zemplar (paricalcitol). Abbott Pharmaceutical, Abbott Park, IL.
522	Product Information. Esbriet (pirfenidone). Intermune Inc, Brisbane, CA.
523	Product Information. Rythmol SR (propafenone). GlaxoSmithKline, Research Triangle Park, NC.
524	Botsch S, Gautier JC, Beaune P, Eichelbaum M, Kroemer HK "Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites." Mol Pharmacol 43 (1993): 120-6. [PMID: 8423765]
525	Mirghani RA, Ericsson O, Tybring G, Gustafsson LL, Bertilsson L "Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man." Eur J Clin Pharmacol 59 (2003): 23-8. [PMID: 12743670]
526	Mirghani RA, Hellgren U, Bertilsson L, Gustafsson LL, Ericsson O "Metabolism and elimination of quinine in healthy volunteers." Eur J Clin Pharmacol (2003):. [PMID: 12920491]
527	Mirghani RA, Hellgren U, Westerberg PA, Ericsson O, Bertilsson L, Gustafsson LL "The roles of cytochrome P450 3A4 and 1A2 in the 3-hydroxylation of quinine in vivo." Clin Pharmacol Ther 66 (1999): 454-60. [PMID: 10579472]
528	Mirghani RA, Yasar U, Zheng T, et al "Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway." Drug Metab Dispos 30 (2002): 1368-71. [PMID: 12433805]
529	Product Information. Qualaquin (quinine). AR Scientific Inc, Philadelphia, PA.
530	Wanwimolruk S, Paine MF, Pusek SN, Watkins PB "Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?" Br J Clin Pharmacol 54 (2002): 643-51. [PMID: 12492613]
531	Zhang H, Coville PF, Walker RJ, Miners JO, Birkett DJ, Wanwimolruk S "Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine." Br J Clin Pharmacol 43 (1997): 245-52. [PMID: 9088578]
532	Zhao XJ, Ishizaki T "A further interaction study of quinine with clinically important drugs by human liver microsomes: determinations of inhibition constant (K-i) and type of inhibition." Eur J Drug Metab Pharm 24 (1999): 272-8. [PMID: 10716067]
533	Zhao XJ, Ishizaki T "Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes." Br J Clin Pharmacol 44 (1997): 505-11. [PMID: 9384469]
534	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
535	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
536	Hatorp V, Hansen KT, Thomsen MS "Influence of drugs interacting with CYP3A4 on the pharmacokinetics, pharmacodynamics, and safety of the prandial glucose regulator repaglinide." J Clin Pharmacol 43 (2003): 649-60. [PMID: 12817528]
537	Khamaisi M, Leitersdorf E "Severe hypoglycemia from clarithromycin-repaglinide drug interaction." Pharmacotherapy 28 (2008): 682-4. [PMID: 18447665]
538	Niemi M, Neuvonen PJ, Kivisto KT "The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide." Clin Pharmacol Ther 70 (2001): 58-65. [PMID: 11452245]
539	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
540	Tornio A, Niemi M, Neuvonen M, et al. "The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo." Clin Pharmacol Ther 84 (2008): 403-11. [PMID: 18388877]
541	Niemi M, Backman JT, Neuvonen M, Neuvonen PJ "Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide." Diabetologia 46 (2003): 347-51. [PMID: 12687332]
542	Product Information. Istodax (romidepsin). Gloucester Pharmaceuticals, Cambridge, MA.
543	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
544	Bartkowski RR, Goldberg ME, Huffnagle S, Epstein RH "Sufentanil disposition. Is it affected by erythromycin administration?" Anesthesiology 78 (1993): 260-5. [PMID: 8439020]
545	Product Information. Sufenta (sufentanil). Janssen Pharmaceutica, Titusville, NJ.
546	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
547	Product Information. Adcirca (tadalafil). United Therapeutics Corporation, Silver Spring, MD.
548	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
549	Brynne N, Forslund C, Hallen B, Gustafsson LL, Bertilsson L "Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity." Br J Clin Pharmacol 48 (1999): 564-72. [PMID: 10583027]
550	Product Information. Detrol (tolterodine). Pharmacia and Upjohn, Kalamazoo, MI.
551	Product Information. Kadcyla (ado-trastuzumab). Genentech, South San Francisco, CA.
552	Adamson PC "Pharmacokinetics of all-trans-retinoic acid: clinical implications in acute promyelocytic leukemia." Semin Hematol 31 (1994): 14-7. [PMID: 7831580]
553	Cordoba R, Ramirez E, Lei SH, et al. "Hypercalcemia due to an interaction of all-trans retinoic acid (ATRA) and itraconazole therapy for acute promyelocytic leukemia successfully treated with zoledronic acid." Eur J Clin Pharmacol 64 (2008): 1031-2. [PMID: 18584165]
554	Dixon KS, Hassoun A "Pseudotumor cerebri due to the potentiation of all-trans retinoic acid by voriconazole." J Am Pharm Assoc (2003) 50 (2010): 742-4. [PMID: 21071321]
555	Hameed DA, el-Metwally TH "The effectiveness of retinoic acid treatment in bladder cancer: impact on recurrence, survival and TGFalpha and VEGF as end-point biomarkers." Cancer Biol Ther 7 (2008): 92-100. [PMID: 18347417]
556	Kizaki M, Ueno H, Yamazoe Y, et al "Mechanisms of retinoid resistance in leukemic cells: possible role of cytochrome P450 and P-glycoprotein." Blood 87 (1996): 725-33. [PMID: 8555497]
557	Lotan Y, Lotan R "Prevention of bladder cancer recurrence by retinoic acid-ketoconazole: a promising strategy?" Cancer Biol Ther 7 (2008): 101-2. [PMID: 18347420]
558	Marill J, Cresteil T, Lanotte M, Chabot GG "Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites." Mol Pharmacol 58 (2000): 1341-8. [PMID: 11093772]
559	Moresco G, Martinello F, Souza LC "[Acute renal failure in patient treated with ATRA and amphotericin B: case report]." J Bras Nefrol 33 (2011): 276-81. [PMID: 21789447]
560	Muindi JRF, Young CW, Warrell RP "Clinical pharmacology of all-trans retinoic acid." Leukemia 8 (1994): 1807-12. [PMID: 7967726]
561	Product Information. Vesanoid (tretinoin). Roche Laboratories, Nutley, NJ.
562	Rigas JR, Francis PA, Muindi JR, Kris MG, Huselton C, DeGrazia F, Orazem JP, Young CW, Warrell RP Jr "Constitutive variability in the pharmacokinetics of the natural retinoid, all-trans-retinoic acid, and its modulation by ketoconazole." J Natl Cancer Inst 85 (1993): 1921-6. [PMID: 8230282]
563	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
564	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
565	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
566	Farkas D, Volak L, Harmatz J, von Moltke L, Court M, Greenblatt D "Short-term clarithromycin administration impairs clearance and enhances pharmacodynamic effects of trazodone but not of zolpidem." Clin Pharmacol Ther 85 (2009): 644-50. [PMID: 19242403]
567	Greenblatt DJ, vonMoltke LL, Harmatz JS, Mertzanis P, Graf JA, Durol ALB, Counihan M, RothSchechter B, Shader RI "Kinetic and dynamic interaction study of zolpidem with ketoconazole, itraconazole, and fluconazole." Clin Pharmacol Ther 64 (1998): 661-71. [PMID: 9871431]
568	Luurila H, Kivisto KT, Neuvonen PJ "Effect of itraconazole on the pharmacokinetics and pharmacodynamics of zolpidem." Eur J Clin Pharmacol 54 (1998): 163-6. [PMID: 9626922]
569	Product Information. Ambien (zolpidem). sanofi-aventis, Bridgewater, NJ.
570	Saari TI, Laine K, Leino K, Valtonen M, Neuvonen PJ, Olkkola KT "Effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem in healthy subjects." Br J Clin Pharmacol 63 (2007): 116-20. [PMID: 16822278]
571	Nakasa H, Nakamura H, Ono S, Tsutsui M, Kiuchi M, Ohmori S, Kitada M "Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data." Eur J Clin Pharmacol 54 (1998): 177-83. [PMID: 9626925]
572	Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
573	Product Information. Letairis (ambrisentan). Gilead Sciences, Foster City, CA.
574	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
575	Rojas-Fernandez C, Fisher C "Drug interactions and donepezil." J Am Geriat Soc 40 (2000): 597-8. [PMID: 10811561]
576	Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses." Br J Clin Pharmacol 46 (1998): 30-4. [PMID: 9839763]
577	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
578	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
579	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
580	Product Information. Xerava (eravacycline). Tetraphase Pharmaceuticals, Inc, Watertown, MA.
581	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
582	Product Information. Elidel (pimecrolimus topical). Novartis Pharmaceuticals, East Hanover, NJ.
583	Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.
584	Ekstrom G, Gunnarsson UB "Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes." Drug Metab Dispos 24 (1996): 955-61. [PMID: 8886604]
585	Halldin MM, Bredberg E, Angelin B, Arvidsson T, Askemark Y, Elofsson S, Widman M "Metabolism and excretion of ropivacaine in humans." Drug Metab Dispos 24 (1996): 962-8. [PMID: 8886605]
586	Jokinen MJ, Ahonen J, Neuvonen PJ, Olkkola KT "The effect of erythromycin, fluvoxamine, and their combination on the pharmacokinetics of ropivacaine." Anesth Analg 91 (2000): 1207-12. [PMID: 11049910]
587	McClure JH "Ropivacaine." Br J Anaesth 76 (1996): 300-7. [PMID: 8777115]
588	Oda Y, Furuichi K, Tanaka K, Hiroi T, Imaoka S, Asada A, Fujimori M, Funae Y "Metabolism of a new local anesthetic, ropivacaine, by human hepatic cytochrome P450." Anesthesiology 82 (1995): 214-20. [PMID: 7832304]
589	Product Information. Naropin (ropivacaine). Astra USA, Westborough, MA.
590	Arlander E, Ekstrom G, Alm C, Carrillo JA, Bielenstein M, Bottiger Y, Bertilsson L, Gustafsson LL "Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: An interaction study with fluvoxamine and ketoconazole as in vivo inhibitors." Clin Pharmacol Ther 64 (1998): 484-91. [PMID: 9834040]
591	Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
592	Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
593	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
594	Miceli JJ, Smith M, Robarge L, Morse T, Laurent A "The effects of ketoconazole on ziprasidone pharmacokinetics--a placebo-controlled crossover study in healthy volunteers." Br J Clin Pharmacol 49(suppl 1) (2000): s71-6. [PMID: 10771458]
595	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
596	Wilner KD, Hansen RA, Folger CJ, Geoffroy P "The pharmacokinetics of ziprasidone in healthy volunteers treated with cimetidine or antacid." Br J Clin Pharmacol 49(Suppl 1) (2000): 57S-60S. [PMID: 10771455]
597	Prakash C, Kamel A, Cui D, Whalen RD, Miceli JJ, Tweedie D "Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions." Br J Clin Pharmacol 49(Suppl 1) (2000): 35S-42S. [PMID: 10771452]

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