Details of Drug

Drug General Information (ID: D0920)
Drug Name	Levomilnacipran
Drug Type	Small molecule
Drug Synonymous	Fetzima; UNII-UGM0326TXX; Levomilnacipran HCl; 96847-54-0; UGM0326TXX; CHEMBL99946; F-2695; (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide; (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide; Levomilnacipran [USAN:INN]; Milnacipram; AC1OCEN8; F 2695; Levomilnacipran (USAN/INN); ZINC506; SCHEMBL1414867; GTPL7435; GJJFMKBJSRMPLA-DZGCQCFKSA-N; CHEBI:136040; BDBM50032379; SB17447; DB08918; f2-695; D10072 Click to Show/Hide
Disease Class	MG30: Chronic pain
Therapeutic Class	Snris/Antidepressants
Structure
Structure	3D Structure		2D Structure
Formula	C15H22N2O
InChI	1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3/t13-,15+/m0/s1
InChIKey	GJJFMKBJSRMPLA-DZGCQCFKSA-N
Canonical SMILES	CCN(CC)C(=O)C1(CC1CN)C2=CC=CC=C2
External Link
	Pubchem ID	6917779
	CAS Number	96847-54-0
	CHEBI ID	136040
	TTD ID	D02XOK
	INTEDE ID	DR0945
	VARIDT ID	DR00049

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM038 Additive CNS depression effects BM041 Additive hypertensive effects BM046 Additive serotonergic effects BM050 Increased risk of bleeding BM067 Increased risk of hyponatremia BM069 Increased risk of lowers seizure threshold BM078 Increased risk of rapid heart rate BM087 Antagonize the effect of antiepileptic agents BM089 Antagonize the effect of antihypertensive agents BM098 Antagonize the effect of serotonergic agents
Relation Graph

Full list of drugs interacting with Levomilnacipran
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[127]
D1821		Iobenguane (I-123)	C8H10IN3	60860	Moderate		Inter Info	[23], [170], [474]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[65]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[65]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[65]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[65]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[65]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[65]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[65]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[65]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[65]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[65]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[65]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[65]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[65]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[65]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[7], [8], [34], [54], [65], [89], [91]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[65]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[65]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[65]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[65]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[65]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[65]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[118], [119], [120]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[302], [224], [303], [304], [226], [45], [46], [14], [228], [219], [221], [32], [217], [28], [16], [2], [56], [227], [82], [222], [96], [305], [50], [306], [146], [8], [85], [307], [218], [308], [91], [84], [309], [310], [311], [220], [30], [312], [223], [313]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[302], [224], [303], [304], [226], [45], [46], [14], [228], [219], [221], [32], [217], [28], [16], [2], [56], [227], [82], [222], [96], [305], [50], [306], [146], [8], [85], [307], [218], [308], [91], [84], [309], [310], [311], [220], [30], [312], [223], [313]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[23], [170], [77]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[302], [224], [303], [304], [226], [45], [46], [14], [228], [219], [221], [32], [217], [28], [16], [2], [56], [227], [82], [222], [96], [305], [50], [306], [146], [8], [85], [307], [218], [308], [91], [84], [309], [310], [311], [220], [30], [312], [223], [313]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[302], [224], [303], [304], [226], [45], [46], [14], [228], [219], [221], [32], [217], [28], [16], [2], [56], [227], [82], [222], [96], [305], [50], [306], [146], [8], [85], [307], [218], [308], [91], [84], [309], [310], [311], [220], [30], [312], [223], [313]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[302], [224], [303]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[172], [23], [465], [122], [170]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[466]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[302], [226], [227], [303], [85], [224], [46], [310], [14], [28], [311], [45], [56], [82], [305], [228], [30], [220], [50], [146], [217], [221], [16], [312], [96], [222], [307], [84], [223], [306], [313], [309], [304], [219], [32], [2], [8], [218], [308], [91]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[302], [226], [227], [303], [85], [224], [46], [310], [14], [28], [311], [45], [56], [82], [305], [228], [30], [220], [50], [146], [217], [221], [16], [312], [96], [222], [307], [84], [223], [306], [313], [309], [304], [219], [32], [2], [8], [218], [308], [91]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[302], [224], [303]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[302], [224], [303]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[478]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[302], [224], [303], [304], [226], [45], [46], [14], [228], [219], [221], [32], [217], [28], [16], [2], [56], [227], [82], [222], [96], [305], [50], [306], [146], [8], [85], [307], [218], [308], [91], [84], [309], [310], [311], [220], [30], [312], [223], [313]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[302], [224], [303], [304], [226], [45], [46], [14], [228], [219], [221], [32], [217], [28], [16], [2], [56], [227], [82], [222], [96], [305], [50], [306], [146], [8], [85], [307], [218], [308], [91], [84], [309], [310], [311], [220], [30], [312], [223], [313]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[302], [226], [227], [303], [85], [224], [46], [310], [14], [28], [311], [45], [56], [82], [305], [228], [30], [220], [50], [146], [217], [221], [16], [312], [96], [222], [307], [84], [223], [306], [313], [309], [304], [219], [32], [2], [8], [218], [308], [91]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[302], [224], [303], [304], [226], [45], [46], [14], [228], [219], [221], [32], [217], [28], [16], [2], [56], [227], [82], [222], [96], [305], [50], [306], [146], [8], [85], [307], [218], [308], [91], [84], [309], [310], [311], [220], [30], [312], [223], [313]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[302], [224], [303], [304], [226], [45], [46], [14], [228], [219], [221], [32], [217], [28], [16], [2], [56], [227], [82], [222], [96], [305], [50], [306], [146], [8], [85], [307], [218], [308], [91], [84], [309], [310], [311], [220], [30], [312], [223], [313]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[302], [224], [303], [304], [226], [45], [46], [14], [228], [219], [221], [32], [217], [28], [16], [2], [56], [227], [82], [222], [96], [305], [50], [306], [146], [8], [85], [307], [218], [308], [91], [84], [309], [310], [311], [220], [30], [312], [223], [313]
	Additive hypertensive effects					Drug Num: 56
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0074		Amphetamine	C9H13N	3007	Major		Inter Info	[100], [101], [102]
D0465		Dextroamphetamine	C9H13N	5826	Major		Inter Info	[100], [101], [102]
D0486		Diethylpropion	C13H19NO	7029	Major		Inter Info	[100], [101], [102]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Major		Inter Info	[100], [101], [102]
D0981		Mazindol	C16H13ClN2O	4020	Major		Inter Info	[100], [101], [102]
D1012		Metamfetamine	C10H15N	10836	Major		Inter Info	[100], [101], [102]
D1262		Phendimetrazine	C12H17NO	30487	Major		Inter Info	[100], [101], [102]
D1270		Phentermine	C10H15N	4771	Major		Inter Info	[100], [101], [102]
D1281		Phenylpropanolamine	C9H13NO	26934	Major		Inter Info	[100], [101], [102]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D0505		Dipivefrin (ophthalmic)	C19H29NO5	3105	Moderate		Inter Info	[62], [65], [72]
D0510		Dobutamine	C18H23NO3	36811	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D0580		Ephedrine (nasal)	C10H15NO	9294	Moderate		Inter Info	[62], [65], [72]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D0582		Epinephrine (ophthalmic)	C9H13NO3	5816	Moderate		Inter Info	[62], [65], [72]
D0583		Epinephrine (topical)	C9H13NO3	5816	Moderate		Inter Info	[62], [65], [72]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D0857		Isometheptene	C9H19N	22297	Moderate		Inter Info	[62], [65], [72]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[62], [65], [72]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[121], [122], [475]
D0778		Hydroxyamphetamine (ophthalmic)	C9H13NO	3651	Moderate		Inter Info	[62], [65], [72]
D0913		Levmetamfetamine (nasal)	C10H15N	36604	Moderate		Inter Info	[62], [65], [72]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[62], [65], [72]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D1374		Racepinephrine	C9H13NO3	838	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D1492		Solriamfetol	C10H14N2O2	10130337	Moderate		Inter Info	[485]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[62], [65], [72]
D0921		Levonordefrin	C9H13NO3	164739	Moderate		Inter Info	[62], [65], [72]
D1002		Mephentermine	C11H17N	3677	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D1013		Metaraminol	C9H13NO2	5906	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D1027		Methoxamine	C11H17NO3	6082	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D1107		Naphazoline (nasal)	C14H14N2	4436	Moderate		Inter Info	[62], [65], [72]
D1108		Naphazoline (ophthalmic)	C14H14N2	4436	Moderate		Inter Info	[62], [65], [72]
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[62], [65], [72]
D1204		Oxymetazoline (nasal)	C16H24N2O	4636	Moderate		Inter Info	[62], [65], [72]
D1205		Oxymetazoline (ophthalmic)	C16H24N2O	4636	Moderate		Inter Info	[62], [65], [72]
D1206		Oxymetazoline (topical)	C16H24N2O	4636	Moderate		Inter Info	[62], [65], [72]
D1277		Phenylephrine (nasal)	C9H13NO2	6041	Moderate		Inter Info	[62], [65], [72]
D1278		Phenylephrine (ophthalmic)	C9H13NO2	6041	Moderate		Inter Info	[62], [65], [72]
D1280		Phenylephrine (topical)	C9H13NO2	6041	Moderate		Inter Info	[62], [65], [72]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D1358		Propylhexedrine (nasal)	C10H21N	7558	Moderate		Inter Info	[62], [65], [72]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[62], [65], [72]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[62], [64], [65], [72], [75], [77]
D1567		Tetryzoline (nasal)	C13H16N2	5419	Moderate		Inter Info	[62], [65], [72]
D1568		Tetryzoline (ophthalmic)	C13H16N2	5419	Moderate		Inter Info	[62], [65], [72]
D1712		Xylometazoline (nasal)	C16H24N2	5709	Moderate		Inter Info	[62], [65], [72]
	Additive serotonergic effects					Drug Num: 89
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0041		Almotriptan	C17H25N3O2S	123606	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0222		Buspirone	C21H31N5O2	2477	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0451		Desvenlafaxine	C16H25NO2	125017	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0457		Dexfenfluramine	C12H16F3N	66265	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0466		Dextromethorphan	C18H25NO	5360696	Major		Inter Info	[1], [2], [4], [5], [6], [8], [9], [10], [11], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [31], [32], [33], [34], [35], [37], [38], [39], [40], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [67], [68], [69], [70], [71], [72], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[105], [121], [122], [123], [124], [125], [126]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[10], [58], [60]
D0539		Duloxetine	C18H19NOS	60835	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0557		Eletriptan	C22H26N2O2S	77993	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0641		Fenfluramine	C12H16F3N	3337	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0702		Frovatriptan	C14H17N3O	77992	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0738		Granisetron	C18H24N4O	5284566	Major		Inter Info	[105], [121], [122], [123], [124], [125], [126]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[133], [134], [135], [136], [137], [138], [139], [140], [8], [11], [141], [142], [143], [144], [145], [17], [19], [146], [147], [148], [149], [150], [151], [152], [153], [154], [45], [47], [49], [50], [54], [155], [156], [157], [62], [63], [64], [65], [158], [75], [77], [78], [159], [160], [161], [162], [163], [164], [91], [165], [166], [167], [168], [169]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Major		Inter Info	[170], [171], [172]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[173], [9], [50]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[7], [122], [174], [175], [176], [177], [178], [179], [180], [181]
D1708		Vortioxetine	C18H22N2S	9966051	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[4], [5], [7], [122], [182], [13], [22], [183], [26], [27], [35], [40], [184], [45], [50], [51], [52], [185], [54], [57], [81], [87], [90], [91], [92], [93], [95], [99], [180]
D0952		Lorcaserin	C11H14ClN	11658860	Major		Inter Info	[186]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1066		Milnacipran	C15H22N2O	65833	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [121], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1110		Naratriptan	C17H25N3O2S	4440	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1181		Ondansetron	C18H19N3O	4595	Major		Inter Info	[105], [121], [122], [123], [124], [125], [126]
D1200		Oxitriptan	C11H12N2O3	439280	Major		Inter Info	[62], [69], [74]
D1216		Palonosetron	C19H24N2O	6337614	Major		Inter Info	[105], [121], [122], [123], [124], [125], [126]
D1229		Paroxetine	C19H20FNO3	43815	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1247		Pentazocine	C19H27NO	441278	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[133], [134], [135], [136], [137], [138], [139], [140], [8], [11], [141], [142], [143], [144], [145], [17], [19], [146], [147], [148], [149], [150], [151], [152], [153], [154], [45], [47], [49], [50], [54], [155], [156], [157], [62], [63], [64], [65], [158], [75], [77], [78], [159], [160], [161], [162], [163], [164], [91], [165], [166], [167], [168], [169]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[133], [134], [135], [136], [137], [138], [139], [140], [8], [11], [141], [142], [143], [144], [145], [17], [19], [146], [147], [148], [149], [150], [151], [152], [153], [154], [45], [47], [49], [50], [54], [155], [156], [157], [62], [63], [64], [65], [158], [75], [77], [78], [159], [160], [161], [162], [163], [164], [91], [165], [166], [167], [168], [169]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1385		Rasagiline	C12H13N	3052776	Major		Inter Info	[133], [134], [135], [136], [137], [138], [139], [140], [8], [11], [141], [142], [143], [144], [145], [17], [19], [146], [147], [148], [149], [150], [151], [152], [153], [154], [45], [47], [49], [50], [54], [155], [156], [157], [62], [63], [64], [65], [158], [75], [77], [78], [159], [160], [161], [162], [163], [164], [91], [165], [166], [167], [168], [169]
D1390		Remifentanil	C20H28N2O5	60815	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1419		Rizatriptan	C15H19N5	5078	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1437		Safinamide	C17H19FN2O2	131682	Major		Inter Info	[133], [134], [135], [136], [137], [7], [138], [139], [121], [122], [140], [8], [11], [141], [187], [188], [142], [143], [144], [145], [189], [17], [19], [146], [190], [147], [148], [149], [191], [150], [151], [152], [192], [193], [36], [194], [195], [153], [196], [197], [154], [198], [45], [47], [49], [50], [54], [199], [200], [155], [156], [157], [201], [62], [63], [64], [202], [203], [65], [66], [204], [158], [205], [206], [207], [208], [209], [75], [77], [78], [210], [159], [160], [161], [162], [163], [164], [91], [165], [211], [166], [212], [167], [168], [169], [213], [214], [215]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[133], [134], [135], [136], [137], [138], [139], [140], [8], [11], [141], [142], [143], [144], [145], [17], [19], [146], [147], [148], [149], [150], [151], [152], [153], [154], [45], [47], [49], [50], [54], [155], [156], [157], [62], [63], [64], [65], [158], [75], [77], [78], [159], [160], [161], [162], [163], [164], [91], [165], [166], [167], [168], [169]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1464		Sibutramine	C17H26ClN	5210	Major		Inter Info	[8], [21], [23], [31], [45], [50], [54], [71], [91]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1512		Sufentanil	C22H30N2O2S	41693	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1521		Sumatriptan	C14H21N3O2S	5358	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[133], [134], [135], [136], [137], [138], [139], [140], [8], [11], [141], [142], [143], [144], [145], [17], [19], [146], [147], [148], [149], [150], [151], [152], [153], [154], [45], [47], [49], [50], [54], [155], [156], [157], [62], [63], [64], [65], [158], [75], [77], [78], [159], [160], [161], [162], [163], [164], [91], [165], [166], [167], [168], [169]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1658		Tryptophan	C11H12N2O2	6305	Major		Inter Info	[60], [61], [62], [64], [65], [68], [69], [72], [74], [75], [76], [77], [78], [79]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1728		Zolmitriptan	C16H21N3O2	60857	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[170], [77], [172]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[170], [77], [172]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[170], [77], [172]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[170], [77], [172]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[170], [77], [172]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[170], [77], [172]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[170], [77], [172]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[170], [77], [172]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[170], [77], [172]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[133], [134], [135], [136], [137], [7], [138], [139], [140], [8], [11], [141], [187], [188], [142], [143], [144], [145], [189], [17], [19], [146], [190], [147], [148], [149], [191], [150], [151], [109], [152], [192], [193], [36], [194], [195], [153], [196], [40], [197], [154], [198], [45], [47], [49], [50], [54], [199], [200], [155], [156], [157], [201], [479], [62], [63], [64], [202], [203], [65], [66], [204], [158], [205], [206], [207], [208], [72], [480], [209], [75], [77], [481], [78], [106], [482], [81], [159], [160], [161], [162], [163], [164], [91], [165], [211], [166], [212], [167], [168], [169], [99], [213], [214], [215]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[170], [77], [172]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[170], [77], [172]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[170], [77], [172]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[170], [77], [172]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[170], [77], [172]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[170], [77], [172]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[170], [77], [172]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[170], [77], [172]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[170], [77], [172]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[170], [77], [172]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[170], [77], [172]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[170], [77], [172]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[170], [77], [172]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[170], [77], [172]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[170], [77], [172]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[170], [77], [172]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[170], [77], [172]
	Increased risk of bleeding					Drug Num: 81
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[232], [247], [248]
D0047		Alteplase	NA	NA	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0088		Anistreplase	NA	NA	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0102		Ardeparin	C26H42N2O37S5	772	Moderate		Inter Info	[229], [230], [231], [237], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [79], [247], [248], [250], [251]
D0104		Argatroban	C23H36N6O5S	92722	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0250		Caplacizumab	NA	NA	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0414		Dalteparin	C26H42N2O37S5	772	Moderate		Inter Info	[229], [230], [231], [237], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [79], [247], [248], [250], [251]
D0415		Danaparoid	NA	NA	Moderate		Inter Info	[229], [230], [231], [237], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [79], [247], [248], [250], [251]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0435		Defibrotide	C20H21N4O6P	135565962	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[232], [247], [248]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0506		Dipyridamole	C24H40N8O4	3108	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0537		Drotrecogin alfa	NA	NA	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0574		Enoxaparin	C26H42N2O37S5	772	Moderate		Inter Info	[229], [230], [231], [237], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [79], [247], [248], [250], [251]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0588		Eptifibatide	C35H49N11O9S2	448812	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[229], [230], [231], [237], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [79], [247], [248], [250], [251]
D0784		Ibritumomab tiuxetan	NA	NA	Moderate		Inter Info	[232], [247], [248]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0904		Lepirudin	C287H440N80O111S6	118856773	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0092		Antithrombin Alfa	NA	NA	Moderate		Inter Info	[232], [247], [248]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0447		Desirudin	C287H440N80O110S6	16129703	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[232], [247], [248]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1705		Vorapaxar	C29H33FN2O4	10077130	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[232], [247], [248]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1305		Plicamycin	C52H76O24	163659	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1328		Prasugrel	C20H20FNO3S	6918456	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1380		Ramucirumab	NA	NA	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1506		Streptokinase	C11H19NO2	9815560	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1550		Tenecteplase	NA	NA	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1588		Tinzaparin	C26H42N2O37S5	772	Moderate		Inter Info	[229], [230], [231], [237], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [79], [247], [248], [250], [251]
D1593		Tirofiban	C22H36N2O5S	60947	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1613		Tositumomab	NA	NA	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1614		Tositumomab (I-131)	NA	NA	Moderate		Inter Info	[232], [247], [248]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[232], [247], [248]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1669		Urokinase	NA	NA	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[229], [230], [231], [232], [121], [9], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [60], [61], [62], [64], [65], [68], [69], [74], [75], [76], [77], [78], [79], [247], [248], [249], [250], [251], [252]
	Increased risk of hyponatremia					Drug Num: 26
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D0449		Desmopressin	C46H64N14O12S2	5311065	Moderate		Inter Info	[121], [315], [316], [317], [318], [319], [320], [321], [287], [322], [323], [324], [325], [326], [278], [247], [327], [260], [328], [329], [279], [330], [331], [332], [333], [334], [335], [336], [337], [280], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [286], [285], [351], [352], [353], [354], [355], [356], [269], [272], [289], [357], [273], [358], [359], [360], [361], [362], [271], [363], [364], [365], [366], [256], [367], [368], [369], [370], [371], [372], [373], [374], [375], [281], [376], [377], [277], [282], [378], [379], [261], [380], [381], [382], [383], [384], [385], [386], [387], [388], [389], [390], [391], [392], [393], [394], [395], [264], [396], [397], [398], [399], [400], [401], [402], [403], [404], [34], [268], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414], [415], [416], [417], [418], [419], [420], [421], [422], [423], [424], [425], [426], [284], [427], [428], [122], [429], [430], [253], [431], [432], [433], [434], [435], [436], [437], [438], [439], [265], [440], [441], [442], [443], [444], [445], [275], [446], [447], [274], [448], [276], [449], [450], [451], [452], [453], [454], [455], [456], [457], [458], [459], [460], [105], [461], [462], [255], [463], [464]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[77], [256], [253]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[77], [256], [253]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[77], [265], [253], [278], [256], [261], [254], [264], [75], [255], [288], [257], [289], [259], [272], [273], [62], [263], [276], [78], [79], [281], [60], [282], [61], [267], [283], [69], [287], [269], [274], [292], [275], [290], [291], [277], [279], [293], [74], [280], [284], [258], [260], [262], [64], [266], [268], [270], [271], [68], [65], [285], [286], [76]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D0978		Mannitol	C6H14O6	6251	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[77], [256], [253]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D1668		Urea	CH4N2O	1176	Moderate		Inter Info	[77], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [64], [263], [62], [78], [264], [61], [265], [266], [267], [268], [269], [270], [271], [272], [68], [273], [274], [275], [65], [276], [277], [278], [279], [280], [74], [281], [282], [60], [283], [284], [285], [69], [286], [287], [76], [75], [288], [289], [79], [290], [291], [292], [293]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[121], [315], [316], [317], [318], [319], [320], [321], [287], [322], [323], [324], [325], [326], [278], [247], [327], [260], [328], [329], [279], [330], [331], [332], [333], [334], [335], [336], [337], [280], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [286], [285], [351], [352], [353], [354], [355], [356], [269], [272], [289], [357], [273], [358], [359], [360], [361], [362], [271], [363], [364], [365], [366], [256], [367], [368], [369], [370], [371], [372], [373], [374], [375], [281], [376], [377], [277], [282], [378], [379], [261], [380], [381], [382], [383], [384], [385], [386], [387], [388], [389], [390], [391], [392], [393], [394], [395], [264], [396], [397], [398], [399], [400], [401], [402], [403], [404], [34], [268], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414], [415], [416], [417], [418], [419], [420], [421], [422], [423], [424], [425], [426], [284], [427], [428], [122], [429], [430], [253], [431], [432], [433], [434], [435], [436], [437], [438], [439], [265], [440], [441], [442], [443], [444], [445], [275], [446], [447], [274], [448], [276], [449], [450], [451], [452], [453], [454], [455], [456], [457], [458], [459], [460], [105], [461], [462], [255], [463], [464]
	Increased risk of lowers seizure threshold					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[128], [129], [130], [131], [132]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[128], [129], [130], [131], [132]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[8], [9], [15], [16], [216], [217], [218], [219], [220], [221], [222], [223], [45], [46], [50], [224], [62], [64], [65], [72], [75], [77], [225], [78], [226], [91], [227], [228]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[467], [468], [49], [469], [470], [471], [472], [473]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[476], [477]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[483], [484], [122]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[483], [484], [122]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[483], [484], [122]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[486], [487], [488]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antiepileptic agents					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D0912		Levetiracetam	C8H14N2O2	5284583	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D1032		Methsuximide	C12H13NO2	6476	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[77], [295], [294]
D1225		Paramethadione	C7H11NO3	8280	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D1260		Phenacemide	C9H10N2O2	4753	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D1269		Phensuximide	C11H11NO2	6839	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D1609		Topiramate	C12H21NO8S	5284627	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D1642		Trimethadione	C6H9NO3	5576	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[294], [295], [77], [296], [62], [75], [297], [61], [122], [74], [76], [69], [64], [65], [79], [298], [68], [299], [300], [301]
	Antagonize the effect of serotonergic agents					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[38], [91], [314]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[38], [91], [314]

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60	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
61	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
62	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
63	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
64	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
65	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
66	Product Information. Flexeril (cyclobenzaprine). Merck & Co, Inc, West Point, PA.
67	Product Information. Imitrex (sumatriptan). Glaxo Wellcome, Research Triangle Park, NC.
68	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
69	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
70	Product Information. Maxalt (rizatriptan). Merck & Co, Inc, West Point, PA.
71	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
72	Product Information. Nucynta (tapentadol). PriCara Pharmaceuticals, Raritan, NJ.
73	Product Information. Oleptro (traZODone). Labopharm Inc, Laval, AL.
74	Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
75	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
76	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
77	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
78	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
79	Product Information. Zoloft (sertraline). Roerig Division, New York, NY.
80	Product Information. Zomig (zolmitriptan). Zeneca Pharmaceuticals, Wilmington, DE.
81	Product Information. Zyvox (linezolid) Pharmacia and Upjohn, Kalamazoo, MI.
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477	Product Information. Firdapse (amifampridine). Catalyst Pharmaceuticals, Inc., Coral Gables, FL.
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480	Product Information. Ongentys (opicapone). Neurocrine Biosciences, Inc., San Diego, CA.
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482	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
483	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
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