Details of Drug

Drug General Information (ID: D0905)
Drug Name	Lesinurad
Drug Type	Small molecule
Drug Synonymous	LESINURAD; 878672-00-5; RDEA594; Zurampic; RDEA 594; UNII-09ERP08I3W; RDEA-594; 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid; 09ERP08I3W; AK323774; C17H14BrN3O2S; 2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetic acid; 2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid; 2-(5-Bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid Click to Show/Hide
Disease Class	5C55: Inborn purine/pyrimidine/nucleotide metabolism error
Therapeutic Class	Antihyperuricemic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C17H14BrN3O2S
InChI	1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23)
InChIKey	FGQFOYHRJSUHMR-UHFFFAOYSA-N
Canonical SMILES	C1CC1C2=CC=C(C3=CC=CC=C23)N4C(=NN=C4Br)SCC(=O)O
External Link
	Pubchem ID	53465279
	CAS Number	878672-00-5
	CHEBI ID	90929
	TTD ID	D0C3SW
	INTEDE ID	DR0926
	VARIDT ID	DR01130

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction
Relation Graph

Full list of drugs interacting with Lesinurad
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 26
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[5]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[5]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[5]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[5]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[5]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[5]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[5]
D0715		Gemfibrozil	C15H22O3	3463	Moderate		Inter Info	[5]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[5]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[5]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[5]
D0900		Leflunomide	C12H9F3N2O2	3899	Moderate		Inter Info	[5]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[5]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[5]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[5]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[96]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[5]
D1195		Oxandrolone	C19H30O3	5878	Moderate		Inter Info	[5]
D1513		Sulfadiazine	C10H10N4O2S	5215	Moderate		Inter Info	[5]
D1515		Sulfamethizole	C9H10N4O2S2	5328	Moderate		Inter Info	[106], [5]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Moderate		Inter Info	[106], [5]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[106], [5]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[5]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[5]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[5]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[5]
	CYP450 enzyme induction					Drug Num: 118
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0518		Doravirine	C17H11ClF3N5O3	58460047	Major		Inter Info	[1], [2], [3]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[4]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[5]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[5]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[6], [5]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[7], [8], [9]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[10]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[11]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[5]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[12]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[13], [14]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[15], [1], [16]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [7], [30], [8], [9]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[31]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[32], [33]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[5]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[34], [35], [36]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[5]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[6], [5]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[37], [38], [39], [15], [1], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[54], [55]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[5]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[56], [1], [57]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[15], [1], [58]
D0485		Dienogest	C20H25NO2	68861	Moderate		Inter Info	[59], [60], [5]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[15], [1], [61]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[5]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[5]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[15], [1], [61]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[15], [1], [61]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[59], [60], [5]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[5]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[5]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[5]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[37], [38], [39], [15], [1], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [7], [30], [8], [9]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[5]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[1], [62], [63]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[37], [38], [39], [15], [1], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [7], [30], [8], [9]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[5]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[64]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[65]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[1], [66]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[38], [43], [53]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[1], [67], [68]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[15], [1], [69]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[70]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[71]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[72]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[73]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[74]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[1], [75]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[76], [77], [78]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[79]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[80]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[15], [1], [81]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[82]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[15], [83]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[5]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[15], [1], [84]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[85]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[86]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[38], [43], [53]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[76], [87], [78]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[88]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[15], [89]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[76], [90]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[76], [91], [78]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[92]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[93]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[5]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[5]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[94]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[5]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[15], [1], [95]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[59], [60], [5]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[37], [38], [39], [15], [1], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[15], [1], [61]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[6], [5]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[15], [1], [61]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[5]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [7], [30], [8], [9]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[5]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[5]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[5]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[5]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[59], [60], [5]
D1156		Norgestimate	C23H31NO3	6540478	Moderate		Inter Info	[59], [60], [5]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[59], [60], [5]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[5]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[5]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[5]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[97]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[98], [15], [99], [100]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[5]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[6], [5]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[5]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[15], [56], [1], [101]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [7], [30], [8], [9]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [7], [30], [8], [9]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[6], [5]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[15], [1], [102]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[5]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[5]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[103]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[5]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[1], [104], [105]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[15], [1], [107]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[5]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[5]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[20], [1], [108], [109], [110]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [7], [30], [8], [9]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[5]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[111]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[1], [112], [113], [114]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[1], [115], [116], [117], [118]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[76], [119], [78]

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