Details of Drug

Drug General Information (ID: D0901)
Drug Name	Lemborexant
Drug Type	Small molecule
Drug Synonymous	E2006 Click to Show/Hide
Disease Class	8A20: Alzheimer disease; 7A00-7A0Z: Insomnia
Therapeutic Class	Anxiolytics/Sedatives/Hypnotics
Structure
Structure	3D Structure		2D Structure
Formula	C22H20F2N4O2
InChI	1S/C22H20F2N4O2/c1-13-19(11-25-14(2)27-13)30-12-22(15-4-3-5-16(23)8-15)9-18(22)21(29)28-20-7-6-17(24)10-26-20/h3-8,10-11,18H,9,12H2,1-2H3,(H,26,28,29)/t18-,22+/m0/s1
InChIKey	MUGXRYIUWFITCP-PGRDOPGGSA-N
Canonical SMILES	CC1=NC(=NC=C1OCC2(CC2C(=O)NC3=NC=C(C=C3)F)C4=CC(=CC=C4)F)C
External Link
	Pubchem ID	56944144
	CAS Number	1369764-02-2
	TTD ID	D0A7ZK

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM036 Additive cardiorespiratory depression effects BM038 Additive CNS depression effects
Relation Graph

Full list of drugs interacting with Lemborexant
Affected cellular transport
	Transporter inhibition					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[69]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[31], [80]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[31], [108], [109]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[115]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[116]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[121]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[31], [124]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[163]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 125
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[2], [3]
D0069		Amlodipine	C20H25ClN2O5	2162	Major		Inter Info	[2], [3]
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[2], [3]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[2], [3]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[2], [3]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Major		Inter Info	[2], [3]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[2], [3]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[2], [3]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Major		Inter Info	[2], [3]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Major		Inter Info	[2], [3]
D0337		Cimetidine	C10H16N6S	2756	Major		Inter Info	[2], [3]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[2], [3]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[2], [3]
D0367		Clotrimazole	C22H17ClN2	2812	Major		Inter Info	[2], [3]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[2], [3]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[2], [3]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[2], [3]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[2], [3]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[3]
D0416		Danazol	C22H27NO2	28417	Major		Inter Info	[2], [3]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[2], [3]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[2], [3]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[2], [3]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[2], [3]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[2], [3]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[2], [3]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[2], [3]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[2], [3]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[2], [3]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[2], [3]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[2], [3]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[2], [3]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[2], [3]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[2], [3]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[2], [3]
D0858		Isoniazid	C6H7N3O	3767	Major		Inter Info	[2], [3]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[2], [3]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[2], [3]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[2], [3]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[2], [3]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[2], [3]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[2], [3]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[2], [3]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[2], [3]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[3]
D0735		Goldenseal	NA	NA	Major		Inter Info	[2], [3]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Major		Inter Info	[2], [3]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[2], [3]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[2], [3]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[2], [3]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[2], [3]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[2], [3]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[2], [3]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[2], [3]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[2], [3]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[2], [3]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[3]
D1134		Nifedipine	C17H18N2O6	4485	Major		Inter Info	[2], [3]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[2], [3]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[2], [3]
D1214		Palbociclib	C24H29N7O2	5330286	Major		Inter Info	[2], [3]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[2], [3]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[2], [3]
D1381		Ranitidine	C13H22N4O3S	3001055	Major		Inter Info	[24], [3]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[2], [3]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[2], [3]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[2], [3]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[2], [3]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[2], [3]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[2], [3]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[2], [3]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[2], [3]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[2], [3]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[2], [3]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[2], [3]
D1714		Zafirlukast	C31H33N3O6S	5717	Major		Inter Info	[2], [3]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[27]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[24], [28]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[31], [35]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[47], [48], [49]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[31], [53]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[31], [57]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[47], [48], [49]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[73], [74], [75]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[31], [76]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[83], [84], [85]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[86]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[89]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[90]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[91]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[83], [84], [85]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[83], [84], [85]
D0739		Grazoprevir	C38H50N6O9S	44603531	Moderate		Inter Info	[24], [107]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[2], [31], [112]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[2], [31], [112]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[31], [113]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[31], [118]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[122]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[31], [123]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[24], [127]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[128]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[129]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[132]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[133], [134]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[47], [48], [49]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[2], [31], [135]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[136]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[83], [84], [85]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[83], [84], [85]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[140], [141]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[143], [2], [31]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[31], [144]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[24], [147]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[148], [24], [149]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[24], [150]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[31], [165], [45]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[166], [24]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[167], [168], [169]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[47], [48], [49]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[24], [172]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[24], [173]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[175], [176]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[31], [185], [186]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[194]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[195]
	CYP450 enzyme induction					Drug Num: 131
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[23]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[2], [3]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[2], [3]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[3]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[40]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[41], [42]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[43], [44], [45]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[2], [31], [46]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[50], [51], [52]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[54]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[2], [3]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[31], [55], [56]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[3]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[2], [59], [31], [60], [61], [62], [63], [64], [65], [66], [67], [68]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[2], [3]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[2], [3]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[3]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[31], [70]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[3]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[77], [78], [79]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[2], [3]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[3]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[81], [82], [45]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[2], [3]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[3]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[2], [3]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[87], [88]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[77], [78], [79]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[3]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Moderate		Inter Info	[2], [31], [92]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[93], [45]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[3]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[94], [95], [96]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[77], [78], [79]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[77], [78], [79]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[77], [78], [79]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[77], [78], [79]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[77], [78], [79]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[77], [78], [79]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[77], [78], [79]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[3]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[2], [3]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[95], [98], [45]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[3]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[94], [95], [106]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[2], [3]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[2], [3]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[2], [3]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[2], [3]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[81], [114], [45]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[117]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[2], [3]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[119]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[81], [120], [45]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[2], [3]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[3]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[125]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[2], [3]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[2], [3]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[3]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[126]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[3]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[2], [130], [131]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[3], [95]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[2], [3]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[3], [95]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[2], [3]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[77], [78], [79]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[2], [3]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[137], [138], [139]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[77], [78], [79]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[3], [95]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[2], [3]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[2], [3]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[3]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[3]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[3]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[142], [45]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[3]
D1133		Nicotine	C10H14N2	89594	Moderate		Inter Info	[2], [3]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[77], [78], [79]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[77], [78], [79]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[2], [3]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[2], [3]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[2], [3]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[3]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[2], [3]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[3]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[151], [152], [153]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[2], [3]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[154], [2], [155]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[3]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[77], [78], [79]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[77], [78], [79]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[77], [78], [79]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[156], [157], [158]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[3]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[159], [3]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[3]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[59], [31], [160]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[161], [95], [45]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[162]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[2], [3]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[164]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[2], [3]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[2], [3]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[2], [31], [170]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[2], [31], [171]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[3], [95]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[2], [3]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[2], [3]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[3]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[2], [3]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[2], [31], [174]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[2], [31], [171]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[2], [3]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[2], [31], [177]
D1575		Thiotepa	C6H12N3PS	5453	Moderate		Inter Info	[2], [3]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[2], [3]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[179], [180], [181]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[31], [183]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[2], [31], [184]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[2], [3]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[31], [95], [187]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[3]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[2], [3]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[188]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[31], [189], [190]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[191]
D0585		Eplerenone	C24H30O6	443872	Minor		Inter Info	[2], [166], [192]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[95], [193], [45]
Pharmacodynamic additive effects
	Additive cardiorespiratory depression effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0698		Fospropofol	C13H21O5P	3038498	Moderate		Inter Info	[100], [101], [102], [103], [104], [105]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[100], [101], [102], [103], [104], [105]
	Additive CNS depression effects					Drug Num: 209
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [1], [12], [13], [14], [15], [16], [17], [18]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[1]
D0379		Codeine	C18H21NO3	5284371	Major		Inter Info	[1]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[19], [20], [21]
D0470		Dezocine	C16H23NO	3033053	Major		Inter Info	[1]
D0493		Dihydrocodeine	C18H23NO3	5284543	Major		Inter Info	[22]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[1]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[1]
D0776		Hydromorphone	C17H19NO3	5284570	Major		Inter Info	[1]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[22]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[1]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[22]
D0923		Levorphanol	C17H23NO	5359272	Major		Inter Info	[1]
D1001		Meperidine	C15H21NO2	4058	Major		Inter Info	[1]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1]
D1089		Morphine	C17H19NO3	5288826	Major		Inter Info	[1]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Major		Inter Info	[22]
D1100		Nalbuphine	C21H27NO4	5311304	Major		Inter Info	[1]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[1]
D1208		Oxymorphone	C17H19NO4	5284604	Major		Inter Info	[1]
D1247		Pentazocine	C19H27NO	441278	Major		Inter Info	[1]
D1390		Remifentanil	C20H28N2O5	60815	Major		Inter Info	[1]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[25], [26]
D1512		Sufentanil	C22H30N2O2S	41693	Major		Inter Info	[1]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[1]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[32], [33], [34]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[32], [33], [34]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[32], [33], [34]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[32], [33], [34]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[36], [37]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[38], [31], [39]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[32], [33], [34]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[32], [33], [34]
D0137		Azelastine (nasal)	C22H24ClN3O	2267	Moderate		Inter Info	[32], [33], [34]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[32], [33], [34]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[32], [33], [34]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[32], [33], [34]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[58]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[32], [33], [34]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[38], [31], [39]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[38], [31], [39]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[32], [33], [34]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[32], [33], [34]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[32], [33], [34]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[32], [33], [34]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[32], [33], [34]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[32], [33], [34]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[32], [33], [34]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[71], [72]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[32], [33], [34]
D0316		Chlorcyclizine	C18H21ClN2	2710	Moderate		Inter Info	[32], [33], [34]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[32], [33], [34]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[32], [33], [34]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[32], [33], [34]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[32], [33], [34]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[32], [33], [34]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[32], [33], [34]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[32], [33], [34]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[32], [33], [34]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[32], [33], [34]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[32], [33], [34]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[32], [33], [34]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[32], [33], [34]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[32], [33], [34]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[32], [33], [34]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[32], [33], [34]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[32], [33], [34]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[32], [33], [34]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[32], [33], [34]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[32], [33], [34]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[32], [33], [34]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[32], [33], [34]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[32], [33], [34]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[32], [33], [34]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[32], [33], [34]
D0488		Difenoxin	C28H28N2O2	34328	Moderate		Inter Info	[32], [33], [34]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[32], [33], [34]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[32], [33], [34]
D0504		Diphenoxylate	C30H32N2O2	13505	Moderate		Inter Info	[32], [33], [34]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[32], [33], [34]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[32], [33], [34]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[32], [33], [34]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[32], [33], [34]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[32], [33], [34]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[32], [33], [34]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[32], [33], [34]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[32], [33], [34]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[2], [97]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[32], [33], [34]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[32], [33], [34]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[2], [3]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[32], [33], [34]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[32], [33], [34]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[32], [33], [34]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[32], [33], [34]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[32], [33], [34]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[99]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[32], [33], [34]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[32], [33], [34]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[32], [33], [34]
D0705		Gabapentin	C9H17NO2	3446	Moderate		Inter Info	[32], [33], [34]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[32], [33], [34]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[32], [33], [34]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[32], [33], [34]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[32], [33], [34]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[110], [42], [111]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[32], [33], [34]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[32], [33], [34]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[32], [33], [34]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[32], [33], [34]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[32], [33], [34]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[32], [33], [34]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[32], [33], [34]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[32], [33], [34]
D1675		Valerian	NA	NA	Moderate		Inter Info	[32], [33], [34]
D0912		Levetiracetam	C8H14N2O2	5284583	Moderate		Inter Info	[32], [33], [34]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[71], [72]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[32], [33], [34]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[32], [33], [34]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[32], [33], [34]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[32], [33], [34]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[32], [33], [34]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[32], [33], [34]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[32], [33], [34]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[32], [33], [34]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[32], [33], [34]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[32], [33], [34]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[32], [33], [34]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[32], [33], [34]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[32], [33], [34]
D1032		Methsuximide	C12H13NO2	6476	Moderate		Inter Info	[32], [33], [34]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[32], [33], [34]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[32], [33], [34]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[32], [33], [34]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[32], [33], [34]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[32], [33], [34]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[32], [33], [34]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[32], [33], [34]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[32], [33], [34]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[42], [145], [146]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[32], [33], [34]
D1183		Opium	NA	NA	Moderate		Inter Info	[32], [33], [34]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[32], [33], [34]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[32], [33], [34]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[32], [33], [34]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[32], [33], [34]
D1225		Paramethadione	C7H11NO3	8280	Moderate		Inter Info	[32], [33], [34]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[32], [33], [34]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[32], [33], [34]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[32], [33], [34]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[32], [33], [34]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[32], [33], [34]
D1260		Phenacemide	C9H10N2O2	4753	Moderate		Inter Info	[32], [33], [34]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[32], [33], [34]
D1264		Phenindamine	C19H19N	11291	Moderate		Inter Info	[32], [33], [34]
D1269		Phensuximide	C11H11NO2	6839	Moderate		Inter Info	[32], [33], [34]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[32], [33], [34]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[32], [33], [34]
D1325		Pramipexole	C10H17N3S	119570	Moderate		Inter Info	[32], [33], [34]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[32], [33], [34]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[32], [33], [34]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[32], [33], [34]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[32], [33], [34]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[32], [33], [34]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[32], [33], [34]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[32], [33], [34]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[32], [33], [34]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[32], [33], [34]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[32], [33], [34]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[32], [33], [34]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[32], [33], [34]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[32], [33], [34]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[32], [33], [34]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[32], [33], [34]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[32], [33], [34]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[32], [33], [34]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[32], [33], [34]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[32], [33], [34]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[178]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[32], [33], [34]
D1573		Thiopental	C11H18N2O2S	3000715	Moderate		Inter Info	[32], [33], [34]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[32], [33], [34]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[32], [33], [34]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[182]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[32], [33], [34]
D1609		Topiramate	C12H21NO8S	5284627	Moderate		Inter Info	[32], [33], [34]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[32], [33], [34]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[32], [33], [34]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[32], [33], [34]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[32], [33], [34]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[32], [33], [34]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[32], [33], [34]
D1642		Trimethadione	C6H9NO3	5576	Moderate		Inter Info	[32], [33], [34]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[32], [33], [34]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[32], [33], [34]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[32], [33], [34]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[32], [33], [34]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[32], [33], [34]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[32], [33], [34]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[32], [33], [34]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[32], [33], [34]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[32], [33], [34]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[32], [33], [34]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[32], [33], [34]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[32], [33], [34]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[32], [33], [34]

References
1	US Food and Drug Administration "FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines requires its strongest warning.".
2	Cerner Multum, Inc. "Australian Product Information.".
3	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
4	Sekar M, Mimpriss TJ "Buprenorphine, benzodiazepines and prolonged respiratory depression." Anaesthesia 42 (1987): 567-8. [PMID: 3592200]
5	Pirnay S, Borron SW, Giudicelli CP, Tourneau J, Baud FJ, Ricordel I "A critical review of the causes of death among post-morten toxicological investigations: analysis of 34 buprenorphine-associated and 35 methadone-associated deaths." Addiction 99 (2004): 978-88. [PMID: 15265095]
6	Schuman-Olivier Z, Hoeppner BB, Weiss RD, Borodovsky J, Shaffer HJ, Albanese MJ "Benzodiazepine use during buprenorphine treatment for opioid dependence: clinical and safety outcomes." Drug Alcohol Depend 132 (2013): 580-6. [PMID: 23688843]
7	Reynaud M, Petit G, Potard D, Courty P "Six deaths linked to concomitant use of buprenorphine and benzodiazepines." Addiction 93 (1998): 1385-92. [PMID: 9926544]
8	Kintz P "A new series of 13 buprenorphine-related deaths." Clin Biochem 35 (2002): 513-6. [PMID: 12493578]
9	Kilicarslan T, Sellers EM "Lack of interaction of buprenorphine with flunitrazepam metabolism." Am J Psychiatry 157 (2000): 1164-6. [PMID: 10873929]
10	Product Information. Suboxone (buprenorphine-naloxone). Reckitt and Colman Pharmaceuticals Inc, Richmond, VA.
11	Reynaud M, Tracqui A, Petit G, Potard D, Courty P "Six deaths linked to misuse of buprenorphine-benzodiazepine combinations." Am J Psychiatry 155 (1998): 448-9. [PMID: 9501765]
12	Hakkinen M, Launiainen T, Vuori E, Ojanpera I "Benzodiazepines and alcohol are associated with cases of fatal buprenorphine poisoning." Eur J Clin Pharmacol 68 (2012): 301-9. [PMID: 21927835]
13	Gueye PN, Borron SW, Risede P, et al "Buprenorphine and midazolalm act in combination to depress respiration in rats." Toxicol Sci 65 (2002): 107-14. [PMID: 11752690]
14	Tracqui A, Kintz P, Ludes B "Buprenorphine-related deaths among drug addicts in France: a report on 20 fatalities." J Anal Toxicol 22 (1998): 430-4. [PMID: 9788517]
15	Martin HA "The possible consequences of combining lorazepam and buprenorphine/naloxone: a case review." J Emerg Nurs 37 (2011): 200-2. [PMID: 21397143]
16	Center for Substance Abuse Treatment.?Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction. Rockville (MD): Substance Abuse and Mental Health Services Administration (US); 2004. [PMID: 22514846]
17	Ferrant O, Papin F, Clin B, et al "Fatal poisoning due to snorting buprenorphine and alcohol consumption." Forensic Sci Int 204 (2011): e8-11. [PMID: 20554411]
18	Kintz P "Deaths involving buprenorphine: a compendium of French cases." Forensic Sci Int 121 (2001): 65-9. [PMID: 11516889]
19	Hansen BS, Dam M, Brandt J, et al "Influence of dextropropoxyphene on steady state serum levels and protein binding of three anti-epileptic drugs in man." Acta Neurol Scand 61 (1980): 357-67. [PMID: 6998251]
20	Peterson GR, Covault HP, Hostetler RM "Acute inhibition of microsomal drug metabolism by propoxphene in narcotic tolerant/dependent mice." Life Sci 22 (1978): 2087-96. [PMID: 566834]
21	Abernethy DR, Greenblatt DJ, Morse DS, Shader RI "Interaction of propoxyphene with diazepam, alprazolam and lorazepam." Br J Clin Pharmacol 19 (1985): 51-7. [PMID: 2858217]
22	US Food and Drug Administration "FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines requires its strongest warning.".
23	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
24	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
25	Product Information. Xyrem (sodium oxybate). Orphan Medical, Minnetonka, MN.
26	Product Information. Xywav (calcium/magnesium/potass/sodium oxybates). Jazz Pharmaceuticals, Palo Alto, CA.
27	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
28	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
29	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
30	Product Information. Proleukin (aldesleukin). Chiron Therapeutics, Emeryville, CA.
31	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
32	Divoll M, Greenblatt DJ, Lacasse Y, Shader RI "Benzodiazepine overdosage: plasma concentrations and clinical outcome." Psychopharmacology (Berl) 73 (1981): 381-3. [PMID: 6789361]
33	Grabowski BS, Cady WJ, Young WW, Emery JF "Effects of acute alcohol administration on propranolol absorption." Int J Clin Pharmacol Ther Toxicol 18 (1980): 317-9. [PMID: 7429677]
34	Product Information. Belsomra (suvorexant). Merck &amp Company Inc, Whitehouse Station, NJ.
35	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
36	Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.
37	Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.
38	Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
39	Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
40	Product Information. Otezla (apremilast). Celgene Corporation, Summit, NJ.
41	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
42	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
43	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
44	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
45	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
46	Product Information. Coartem (artemether-lumefantrine). Novartis Pharmaceuticals, East Hanover, NJ.
47	Andreou ER, Ledger S "Potential drug interaction between simvastatin and danazol causing rhabdomyolysis." Can J Clin Pharmacol 10 (2003): 172-4. [PMID: 14712320]
48	Ayanian JZ, Fuchs CS, Stone RM "Lovastatin and rhabdomyolysis." Ann Intern Med 109 (1988): 682-3. [PMID: 3421582]
49	Yeo KR, Yeo WW, Wallis EJ, Ramsay LE "Enhanced cholesterol reduction by simvastatin in diltiazem-treated patients." Br J Clin Pharmacol 48 (1999): 610-5. [PMID: 10583033]
50	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
51	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
52	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
53	Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
54	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
55	Product Information. Biktarvy (bictegravir/emtricitabine/tenofovir). Gilead Sciences, Foster City, CA.
56	Product Information. Viread (tenofovir). Gilead Sciences, Foster City, CA.
57	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
58	Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
59	Cerner Multum, Inc. "Canadian Product Information.".
60	James WA, Lippmann S "Bupropion: overview and prescribing guidelines in depression." South Med J 84 (1991): 222-4. [PMID: 1899294]
61	Ketter TA, Jenkins JB, Schroeder DH, Pazzaglia PJ, Marangell LB, George MS, Callahan AM, Hinton ML, Chao J, Post RM "Carbamazepine but not valproate induces bupropion metabolism." J Clin Psychopharmacol 15 (1995): 327-33. [PMID: 8830063]
62	Product Information. Aplenzin (buPROPion). sanofi-aventis , Bridgewater, NJ.
63	Product Information. Contrave (buPROPion-naltrexone). Orexigen Therapeutics Inc, La Jolla, CA.
64	Product Information. Forfivo XL (buPROPion (bupropion)). Almatica Pharma Inc, Parsippany, NJ.
65	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
66	Product Information. Wellbutrin (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
67	Product Information. Wellbutrin SR (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
68	Product Information. Zyban (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
69	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
70	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
71	Product Information. Zyrtec (cetirizine). Pfizer US Pharmaceuticals, New York, NY.
72	Product Information. Xyzal (levocetirizine). UCB Pharma Inc, Smyrna, GA.
73	Herrlin K, Segerdahl M, Gustafsson LL, Kalso E "Methadone, ciprofloxacin, and adverse drug reactions." Lancet 356 (2000): 2069-70. [PMID: 11145498]
74	Product Information. Pletal (cilostazol). Otsuka American Pharmaceuticals, Rockville, MD.
75	Suri A, Bramer SL "Effect of omeprazole on the metabolism of cilostazol." Clin Pharmacokinet 37 (1999): 53-9. [PMID: 10702887]
76	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
77	Back DJ, Breckenridge AM, Crawford FE, MacIver M, Orne ML, Rowe PH "Interindividual variation and drug interactions with hormonal steroid contraceptives." Drugs 21 (1981): 46-61. [PMID: 7009137]
78	Dickinson BD, Altman RD, Nielsen NH, Sterling ML "Drug interactions between oral contraceptives and antibiotics." Obstet Gynecol 98(5 Pt 1) (2001): 853-60. [PMID: 11704183]
79	van Dijke CP, Weber JC "Interaction between oral contraceptives and griseofulvin." Br Med J (Clin Res Ed) 288 (1984): 1125-6. [PMID: 2143563]
80	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
81	Jerntorp P, Almer LO "Chlorpropamide-alcohol flushing in relation to macroangiopathy and peripheral neuropathy in non-insulin dependent diabetes." Acta Med Scand 656 (1981): 33-6. [PMID: 6953748]
82	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
83	Francis H, Tyndall A, Webb J "Severe vascular spasm due to erythromycin-ergotamine interaction." Clin Rheumatol 3 (1984): 243-6. [PMID: 6236021]
84	Horowitz RS, Dart RC, Gomez HF "Clinical ergotism with lingual ischemia induced by clarithromycin-ergotamine interaction." Arch Intern Med 156 (1996): 456-8. [PMID: 8607732]
85	Spiegel M, Schmidauer C, Kampfl A, Sarcletti M, Poewe W "Cerebral ergotism under treatment with ergotamine and ritonavir." Neurology 57 (2001): 743-4. [PMID: 11524501]
86	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
87	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
88	Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses." Br J Clin Pharmacol 46 (1998): 30-4. [PMID: 9839763]
89	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
90	Product Information. Relpax (eletriptan). Pfizer U.S. Pharmaceuticals, New York, NY.
91	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
92	Product Information. Vitekta (elvitegravir). Gilead Sciences, Foster City, CA.
93	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
94	Li J, Zhao M, He P, Hidalgo M, Baker SD "Differential metabolism of gefitinib and erlotinib by human cytochrome p450 enzymes." Clin Cancer Res 13 (2007): 3731-7. [PMID: 17575239]
95	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
96	Product Information. Tarceva (erlotinib). Genentech, South San Francisco, CA.
97	Product Information. Spravato (esketamine). Janssen Pharmaceuticals, Titusville, NJ.
98	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
99	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
100	Gill SS, Wright EM, Reilly CS "Pharmacokinetic interaction of propofol and fentanyl: single bolus injection study." Br J Anaesth 65 (1990): 760-5. [PMID: 2265045]
101	Hamaoka N, Oda Y, Hase I, Mizutani K, Nakamoto T, Ishizaki T, Asada A "Propofol decreases the clearance of midazolam by inhibiting CYP3A4: An in vivo and in vitro study." Clin Pharmacol Ther 66 (1999): 110-7. [PMID: 10460064]
102	McClune S, McKay AC, Wright PM, et al "Synergistic interaction between midazolam and propofol." Br J Anaesth 69 (1992): 240-5. [PMID: 1389840]
103	Pavlin DJ, Coda B, Shen DD, et al "Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers." Anesthesiology 84 (1996): 23-37. [PMID: 8572340]
104	Product Information. Diprivan (propofol). Zeneca Pharmaceuticals, Wilmington, DE.
105	Product Information. Lusedra (fospropofol). Eisai Inc, Teaneck, NJ.
106	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
107	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
108	Pohjola-Sintonen S, Viitasalo M, Toivonene L, Neuvonen P "Torsades de pointes after terfenadine-itraconazole interaction." BMJ 306 (1993): 186. [PMID: 8382980]
109	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
110	Product Information. Ifex (ifosfamide). Bristol-Myers Squibb, Princeton, NJ.
111	Simonian NA, Gilliam FG, Chiappa KH "Ifosfamide causes a diazepam-sensitive encephalopathy." Neurology 43 (1993): 2700-2
112	Corona G, Vaccher E, Sandron S, et al. "Lopinavir-ritonavir dramatically affects the pharmacokinetics of irinotecan in HIV patients with Kaposi's sarcoma." Clin Pharmacol Ther 83 (2008): 601-6. [PMID: 17713471]
113	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
114	Product Information. Ninlaro (ixazomib). Takeda Pharmaceuticals America, Lincolnshire, IL.
115	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
116	Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.
117	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
118	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
119	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
120	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
121	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
122	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
123	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
124	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
125	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
126	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
127	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
128	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
129	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
130	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
131	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
132	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
133	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
134	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
135	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
136	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
137	Kobayashi K, Mimura N, Fujii H, et al "Role of human cytochrome P450 3A4 in metabolism of medroxyprogesterone acetate." Clin Cancer Res 6 (2000): 3297-303. [PMID: 10955816]
138	Product Information. Provera (medroxyprogesterone). Pharmacia and Upjohn, Kalamazoo, MI.
139	Lundgren S, Lonning PE, Aakvaag A, Kvinnsland S, Lnning PE "Influence of aminoglutethimide on the metabolism of medroxyprogesterone acetate and megestrol acetate in postmenopausal patients with advanced breast cancer." Cancer Chemother Pharmacol 27 (1990): 101-5. [PMID: 2249324]
140	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
141	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
142	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
143	Canadian Pharmacists Association.
144	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
145	Product Information. Patanase (olopatadine nasal). Alcon Laboratories Inc, Fort Worth, TX.
146	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
147	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
148	Hamberg P, Woo MM, Chen LC, et al. "Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor." Cancer Chemother Pharmacol 68 (2011): 805-13. [PMID: 21706316]
149	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
150	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
151	Jori A, Carrara MC "On the mechanism of the hyperglycaemic effect of chlorpromazine." J Pharm Pharmacol 18 (1966): 623-4. [PMID: 4381950]
152	Product Information. Actos (pioglitazone) Takeda Pharmaceuticals America, Lincolnshire, IL.
153	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
154	Bittencourt PR, Gracia CM, Martins R, et al "Phenytoin and carbamazepine decrease oral bioavailability of praziquantel." Neurology 42 (1992): 492-6. [PMID: 1549207]
155	Ridtitid W, Wongnawa M, Mahatthanatrakul W, Punyo J, Sunbhanich M "Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers." Clin Pharmacol Ther 72 (2002): 505-13. [PMID: 12426514]
156	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
157	Niemi M, Backman JT, Neuvonen M, Neuvonen PJ, Kivisto KT "Rifampin decreases the plasma concentrations and effects of repaglinide." Clin Pharmacol Ther 68 (2000): 495-500. [PMID: 11103752]
158	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
159	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
160	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
161	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
162	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
163	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
164	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
165	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
166	Multum Information Services, Inc. Expert Review Panel.
167	Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
168	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
169	Warrington JS, Shader RI, vonMoltke LL, Greenblatt DJ "In vitro biotransformation of sildenafil (Viagra): Identification of human cytochromes and potential drug interactions." Drug Metab Disposition 28 (2000): 392-7. [PMID: 10725306]
170	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
171	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
172	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
173	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
174	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
175	Product Information. Adcirca (tadalafil). United Therapeutics Corporation, Silver Spring, MD.
176	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
177	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
178	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
179	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
180	Sommadossi JP "HIV protease inhibitors: pharmacologic and metabolic distinctions." AIDS 13 (1999): s29-40. [PMID: 10546783]
181	Durant J, Clevenbergh P, Garraffo R, Halfon P, Icard S, DelGiudice P, Montagne N, Schapiro JM, Dellamonica P "Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: pharmacological data from the Viradapt Study." Aids 14 (2000): 1333-9. [PMID: 10930147]
182	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
183	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
184	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
185	Machiels JP, Staddon A, Herremans C, et al. "Impact of cytochrome P450 3A4 inducer and inhibitor on the pharmacokinetics of trabectedin in patients with advanced malignancies: open-label, multicenter studies." Cancer Chemother Pharmacol 74 (2014): 729-37. [PMID: 25100135]
186	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
187	Product Information. ella (ulipristal). Afaxys Inc., Charleston, SC.
188	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
189	Hellmann A, Rule S, Walewski J, et al. "Effect of cytochrome P450 3A4 inducers on the pharmacokinetic, pharmacodynamic and safety profiles of bortezomib in patients with multiple myeloma or Non-Hodgkin's lymphoma." Clin Pharmacokinet 50 (2011): 781-91. [PMID: 22087865]
190	Uttamsingh V, Lu C, Miwa GT, Gan LS "Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4 to the hepatic metabolism of teh protosome inhibitor bortezomib." Drug Metab Dispos 33 (2005): 1723-8. [PMID: 16103134]
191	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
192	Product Information. Casodex (bicalutamide). Zeneca Pharmaceuticals, Wilmington, DE.
193	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
194	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
195	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.

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