Details of Drug

Drug General Information (ID: D0870)
Drug Name	Ivermectin
Drug Type	Small molecule
Drug Synonymous	I 8898; Ivexterm (TN); MK-933; Mectizan (TN); Stromectol (TN) Click to Show/Hide
Disease Class	1F6B: Strongyloidiasis
Therapeutic Class	Antiprotozoal Agents
Structure
Structure	3D Structure		2D Structure
Formula	C48H74O14
InChI	1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
InChIKey	AZSNMRSAGSSBNP-XPNPUAGNSA-N
Canonical SMILES	CCC(C)C1C(CCC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C
External Link
	Pubchem ID	6321424
	CAS Number	71827-03-7
	CHEBI ID	63941
	TTD ID	D09YHJ
	INTEDE ID	DR0899
	VARIDT ID	DR00147

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism BM010 Transporter inhibition BM011 Transporter induction BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme
Relation Graph

Full list of drugs interacting with Ivermectin
Affected cellular transport
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[27], [28], [29]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 45
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[2], [3]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[2], [3]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[2], [3]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[4]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[2], [3]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[6], [7]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[2], [3]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[8]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[2], [3]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[2], [3]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[10]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[11]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[12]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[13], [14]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[2], [3]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[15]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[16]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[2], [3]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[6], [7]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[25]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[26]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[2], [30]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[2], [3]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[31]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[2], [3]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[32]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[17], [2], [33]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[34]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[35]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[36]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[17], [2], [38], [39]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[40]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[2], [3]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[56]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[2], [3]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[2], [58]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[63]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[64]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[65], [66]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[2], [3]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[2], [3]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[2], [3]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[2], [3]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[2], [3]
	CYP450 enzyme induction					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[1]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[2], [5]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[9]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[17], [18]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[19]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[20], [17], [2], [21]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[22]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[37]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[41], [42], [43]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[2], [44]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[54], [55]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[2], [57]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[17], [2], [61]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[17], [2], [62], [61]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[2], [67]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[17], [2], [68], [69]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[17], [2], [61]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[70], [71], [72], [73], [74]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[70], [71], [72], [73], [74]
	Competitive inhibition of metabolic enzyme					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[17], [23], [24]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[17], [23], [24]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[59], [60]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[59], [60]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[59], [60]

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