Details of Drug

Drug General Information (ID: D0869)
Drug Name	Ivacaftor
Drug Type	Small molecule
Drug Synonymous	Kalydeco (TN) Click to Show/Hide
Disease Class	CA25: Cystic fibrosis
Therapeutic Class	Cftr Combinations
Structure
Structure	3D Structure		2D Structure
Formula	C24H28N2O3
InChI	1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)
InChIKey	PURKAOJPTOLRMP-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C
External Link
	Pubchem ID	16220172
	CAS Number	873054-44-5
	CHEBI ID	66901
	TTD ID	D0W7WC
	INTEDE ID	DR0898
	VARIDT ID	DR00466

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM055 Increased risk of hepatotoxicity
Relation Graph

Full list of drugs interacting with Ivacaftor
Affected cellular transport
	Transporter inhibition					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[7], [8], [9]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[16]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[2], [17], [18], [19]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[1], [22]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[24]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[1], [2], [28]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[3]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[92], [93], [94], [95]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[92], [94], [95]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[48], [3], [49]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[48], [3], [49]
D0656		Fexofenadine	C32H39NO4	3348	Moderate		Inter Info	[3]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[92], [93], [94], [95]
D0109		Artesunate	C19H28O8	6917864	Moderate		Inter Info	[3]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[157]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[1], [2], [158]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[3]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[191]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[197]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[219]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[221]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[235]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[1], [2], [256]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 274
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[2], [3], [4], [5], [6]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Major		Inter Info	[2], [3], [4], [5], [6]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[10]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[2], [3], [5]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[2], [3], [4], [5], [6]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[2], [3], [4], [5], [6]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[2], [3], [4], [5], [6]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[2], [3], [4], [5], [6]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[2], [3], [4], [5], [6]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[2], [3], [4], [5], [6]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[11], [12], [13], [14], [15]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[2], [3], [4], [5], [6]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[2], [3], [4], [5], [6]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[2], [3], [4], [5], [6]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[2], [3], [4], [5], [6]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[2], [3], [4], [5], [6]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[3], [5], [6]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[1], [20]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[2], [3], [4], [5], [6]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[21]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[2], [3], [5]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[2], [3], [4], [5], [6]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[2], [3], [4], [5], [6]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[2], [3], [4], [5], [6]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[3], [4]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[3], [4], [5], [6]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[3]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[30], [31], [2], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[3]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[3]
D0053		Ambrisentan	C22H22N2O4	6918493	Moderate		Inter Info	[3]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[3], [4]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[3]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[2], [46], [41]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[47]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[48], [3], [49]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[3]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[3]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[2], [61]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[3]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[3]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[3], [4]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[2], [62]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[3]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[63], [1], [2], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[63], [1], [2]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[77]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[3]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[3]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[78]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[2], [79]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[3], [4], [5], [6]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[3]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[3], [4], [5], [6]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[80], [81], [82], [83], [84], [85], [86], [87], [88]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[3], [4]
D0342		Cisapride	C23H29ClFN3O4	6917698	Moderate		Inter Info	[3]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[3]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[48], [3], [49]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[3], [4]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[90]
D0378		Cocaine (topical)	C17H21NO4	446220	Moderate		Inter Info	[48], [3], [49]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[3]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[48], [3], [49]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[3]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[3], [4]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[3], [4], [5], [6]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[91], [41]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[3]
D0450		Desogestrel	C22H30O	40973	Moderate		Inter Info	[48], [3], [49]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[3]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[3], [4], [5], [6]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[3]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[48], [3], [49]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[3]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[121], [1], [2], [122], [123], [124], [125], [126], [127]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[128]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[3]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[48], [3], [49]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[129]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[130]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[3]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[103], [105], [116]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[3]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[3]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[3]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[48], [3], [49]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[3]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[3]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[48], [3], [49]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[3]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[3]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[3]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[132], [41]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[3]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[133], [134], [135], [136], [44]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[137]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[3]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[3], [4], [5], [6]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[1], [2], [138], [139]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[3], [4]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[140], [141]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[3], [4], [5], [6]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[3], [4], [5], [6]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[3], [4], [5], [6]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[3]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[3], [4]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[2], [142]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[3]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[3]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[3]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[3], [4], [5], [6]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[3]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[3], [4], [5], [6]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[3], [4], [5], [6]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[25], [1], [2], [147], [148], [149], [150]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[1], [2], [147]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[3], [4]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[3], [4], [5], [6]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[3]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[151]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[152], [41]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[25], [2], [153], [154]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[2], [155]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[48], [3], [49]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[159], [160], [161]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[1], [2], [162]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[166]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[3], [4]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[169]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[2], [170]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[171]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[3], [4]
D0739		Grazoprevir	C38H50N6O9S	44603531	Moderate		Inter Info	[172], [173]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[174], [41]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[2], [175]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[3], [4]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[176]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[177]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[3]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[178]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[179]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[2], [180]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[181]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[1], [2]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[3], [4]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[3], [4]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[2], [183]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[184]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[185]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[1], [189], [2], [190]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[1], [2], [192]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[1], [193]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[3], [4]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[3], [4]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[194]
D1474		Siponimod	C29H35F3N2O3	44599207	Moderate		Inter Info	[3], [4], [5], [6]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[195]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[2], [32], [196]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[198]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[199]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[201]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[202]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[3]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[3]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[3]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[3]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[3]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[3]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[3]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[3]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[3], [4], [5], [6]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[3]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[203]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[1], [2], [204], [41]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[205]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[3], [4], [5], [6]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[3]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[48], [3], [49]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[3], [4], [5], [6]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[103], [105], [116]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[3]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[103], [105], [116]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[3], [4]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[3]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[207], [208]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[1], [2], [209], [210]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[211], [212]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[3], [4], [5], [6]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[3], [4], [5], [6]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[3]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[3]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[214]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[3]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[25], [1], [2]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[1], [2], [215]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[216], [217]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[3]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[218]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[3], [4], [5], [6]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[3], [4], [5], [6]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[3]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[3]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[3]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[220]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[222], [223], [224], [225]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[226]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[3]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[3]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[227]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Moderate		Inter Info	[3], [4], [5], [6]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[3]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[228]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[3], [4], [5], [6]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[229]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[3]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[2], [230]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[3]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[3], [4], [5], [6]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[3], [4], [5], [6]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[233], [234]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[236], [237], [238]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[239]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[2], [240], [241]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[3]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[3]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[3], [4], [5], [6]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[242], [41]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[1], [2], [243]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[244]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[3]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[3]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[48], [3], [49]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[3]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[1], [189], [2], [3], [5]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[3], [4]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[3], [4], [5], [6]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[3], [4], [5], [6]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[1], [245], [246]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[247], [248]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[249], [250], [251], [252]
D0599		Escitalopram	C20H21FN2O	146570	Minor		Inter Info	[247], [248]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[253]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[254]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[255]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[257]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[258]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[1], [245], [246]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[259]
	CYP450 enzyme induction					Drug Num: 46
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[1], [4], [5]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[3], [4], [5], [6]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[3], [4], [5], [6]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[3], [4], [5], [6]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[3], [4], [5], [6]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[3], [4], [5], [6]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[3], [4], [5], [6]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[3], [4], [5], [6]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[3], [4], [5], [6]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[3], [4], [5], [6]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[3], [4], [5], [6]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[3], [4], [5], [6]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[2], [164]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[1], [165]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[3], [4], [5], [6]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[167]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[168]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[3], [4], [5], [6]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[3], [4], [5], [6]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[3], [4], [5], [6]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[2], [182]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[4], [5], [6]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[3], [4], [5], [6]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[2], [200]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[3], [4], [5], [6]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[4], [5], [6]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[3], [4], [5], [6]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[3], [4], [5], [6]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[3], [4], [5], [6]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[3], [4], [5], [6]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[3], [4], [5], [6]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[3], [4], [5], [6]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[4], [5], [6]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[3], [4], [5], [6]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[3], [4], [5], [6]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[23]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[25], [26], [27]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[25], [26], [27]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[29]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[50], [51], [52], [1], [2], [53], [54], [55], [56], [57], [58], [59], [60]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[89]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[1], [2], [131]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[143], [144], [145], [146]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[143], [144], [145], [146]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[50], [51], [52], [1], [2], [53], [54], [55], [56], [57], [58], [59], [60]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[156]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[50], [51], [52], [1], [2], [53], [54], [55], [56], [57], [58], [59], [60]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[2], [163]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[143], [144], [145], [146]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[1], [2], [186], [187], [188]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[2], [206]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[213]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[50], [51], [52], [1], [2], [53], [54], [55], [56], [57], [58], [59], [60]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[231], [232]

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57	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
58	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
59	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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90	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
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93	Product Information. Cerubidine (daunorubicin). Wyeth-Ayerst Laboratories, Philadelphia, PA.
94	Product Information. Daunoxome (daunorubicin liposomal). Nexstar Pharmaceuticals Inc, Boulder, CO.
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113	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
114	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
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128	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
129	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
130	Product Information. Relpax (eletriptan). Pfizer U.S. Pharmaceuticals, New York, NY.
131	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
132	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
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134	Product Information. Actiq (fentanyl). Abbott Pharmaceutical, Abbott Park, IL.
135	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
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139	Product Information. Lescol (fluvastatin). Novartis Pharmaceuticals, East Hanover, NJ.
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141	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
142	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
143	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
144	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
145	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
146	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
147	Corona G, Vaccher E, Sandron S, et al. "Lopinavir-ritonavir dramatically affects the pharmacokinetics of irinotecan in HIV patients with Kaposi's sarcoma." Clin Pharmacol Ther 83 (2008): 601-6. [PMID: 17713471]
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149	Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI.
150	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
151	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
152	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
153	Product Information. Tekturna (aliskiren). Novartis Pharmaceuticals, East Hanover, NJ.
154	Tapaninen T, Backman JT, Kurkinen K, Neuvonen P, Niemi M "Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren." J Clin Pharmacol 51 (2011): 359-67. [PMID: 20400651]
155	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
156	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
157	Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.
158	Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
159	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
160	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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162	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
163	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
164	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
165	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
166	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
167	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
168	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
169	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
170	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
171	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
172	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
173	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
174	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
175	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
176	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
177	Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
178	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
179	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
180	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
181	Product Information. Ofev (nintedanib). Boehringer Ingelheim, Ridgefield, CT.
182	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
183	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
184	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
185	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
186	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
187	Gilead Sciences, Inc "About Remdesivir.".
188	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
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190	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
191	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
192	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
193	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
194	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
195	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
196	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
197	Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
198	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
199	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
200	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
201	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
202	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
203	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
204	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
205	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
206	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
207	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
208	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
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213	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
214	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
215	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
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218	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
219	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
220	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
221	Product Information. Istodax (romidepsin). Gloucester Pharmaceuticals, Cambridge, MA.
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224	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
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227	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
228	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
229	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
230	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
231	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
232	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
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242	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
243	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
244	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
245	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
246	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
247	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
248	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
249	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
250	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
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253	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
254	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
255	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
256	Product Information. Dificid (fidaxomicin). Optimer Pharmaceuticals, San Diego, CA.
257	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
258	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
259	Product Information. Elidel (pimecrolimus topical). Novartis Pharmaceuticals, East Hanover, NJ.

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