Details of Drug

Drug General Information (ID: D0866)
Drug Name	Istradefylline
Drug Type	Small molecule
Drug Synonymous	KW 6002; Istradefylline [USAN:INN]; Istradefylline (JAN/USAN/INN); (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione; (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methylxanthine; 8-((1E)-2-(3,4-Dimethoxyphenyl)ethenyl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione; 8-(2-(3,4-dimethoxyphenyl)ethenyl)-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione; 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione Click to Show/Hide
Disease Class	6C4Z: Unspecific substance use disorder; 8A00: Parkinsonism
Therapeutic Class	Antiparkinson Agents
Structure
Structure	3D Structure		2D Structure
Formula	C20H24N4O4
InChI	1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+
InChIKey	IQVRBWUUXZMOPW-PKNBQFBNSA-N
Canonical SMILES	CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)C=CC3=CC(=C(C=C3)OC)OC)C
External Link
	Pubchem ID	5311037
	CAS Number	155270-99-8
	CHEBI ID	134726
	TTD ID	D0F4ZY
	INTEDE ID	DR0892
	VARIDT ID	DR00611

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme
Relation Graph

Full list of drugs interacting with Istradefylline
Affected cellular transport
	Transporter inhibition					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[4], [5], [6]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[8], [9], [10]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[17], [18]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[23], [24], [25], [26]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[23], [25], [26]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[27], [1]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[23], [24], [25], [26]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[33]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[38]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[46]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[47]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[49]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[8], [9], [55]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 57
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1], [2], [3]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[1]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1], [2], [3]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1], [2], [3]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1], [2], [3]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1], [2], [3]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[1]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[11], [9], [12], [13]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[9], [14], [15]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[9], [16]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[1]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[1]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[19]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[20]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[22], [1]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[1]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[1]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[29], [15]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[1]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[1]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[30]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[31]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[32]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[1]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[1]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[9], [36]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[37]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[1]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[9], [39]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[1]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[42]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[43]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[1]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[44]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[1]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[1]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[1]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[1]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[56]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[57]
	CYP450 enzyme induction					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[7], [1]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[7], [1]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[1]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[9], [21]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[1]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[28]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[1]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[1]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[8], [9], [40]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[9], [41]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[1]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[1]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[9], [45]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[8], [9], [40]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[8], [9], [48], [40]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[50], [51], [52], [53], [54]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[50], [51], [52], [53], [54]
	Competitive inhibition of metabolic enzyme					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[8], [34], [35]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[8], [34], [35]

References
1	Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
2	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
3	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
4	Garrouste C, Philipponnet C, Kaysi S, Enache I, Tiple A, Heng AE "Severe colchicine intoxication in a renal transplant recipient on cyclosporine." Transplant Proc 44 (2012): 2851-2. [PMID: 23146540]
5	Jonsson J, Gelpi JR, Light JA, Aquino A, Maszaros S "Colchicine-induced myoneuropathy in a renal transplant patient." Transplantation 53 (1992): 1369-71. [PMID: 1604496]
6	Kuncl RW, Duncan G, Watson D, et al "Colchicine myopathy and neuropathy." N Engl J Med 316 (1987): 1562-8. [PMID: 3035372]
7	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
8	Cerner Multum, Inc. "Australian Product Information.".
9	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
10	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
11	Canadian Pharmacists Association.
12	Product Information. Tekturna (aliskiren). Novartis Pharmaceuticals, East Hanover, NJ.
13	Tapaninen T, Backman JT, Kurkinen K, Neuvonen P, Niemi M "Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren." J Clin Pharmacol 51 (2011): 359-67. [PMID: 20400651]
14	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
15	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
16	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
17	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
18	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
19	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
20	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
21	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
22	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
23	Multum Information Services, Inc. Expert Review Panel.
24	Product Information. Cerubidine (daunorubicin). Wyeth-Ayerst Laboratories, Philadelphia, PA.
25	Product Information. Daunoxome (daunorubicin liposomal). Nexstar Pharmaceuticals Inc, Boulder, CO.
26	Product Information. Idamycin (idarubicin). Pharmacia and Upjohn, Kalamazoo, MI.
27	Darcy PF "Nutrient-drug interactions." Adverse Drug React Toxicol Rev 14 (1995): 233-54. [PMID: 8845456]
28	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
29	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
30	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
31	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
32	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
33	Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.
34	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
35	Product Information. Akynzeo for Injection (fosnetupitant-palonosetron). Helsinn Therapeutics Inc, Woodbridge Township, NJ.
36	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
37	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
38	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
39	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
40	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
41	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
42	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
43	Product Information. ORAVIG (miconazole). Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc., Woodcliff Lake, NJ.
44	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
45	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
46	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
47	Product Information. Istodax (romidepsin). Gloucester Pharmaceuticals, Cambridge, MA.
48	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
49	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
50	Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53. [PMID: 11978143]
51	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
52	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
53	Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers." Clin Pharmacol Ther 71 (2002): 46-56. [PMID: 11823757]
54	Robertson P, Decory HH, Madan A, Parkinson A "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos 28 (2000): 664-71. [PMID: 10820139]
55	Product Information. Dificid (fidaxomicin). Optimer Pharmaceuticals, San Diego, CA.
56	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
57	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence