Details of Drug

Drug General Information (ID: D0825)
Drug Name	Interferon alfa-n3
Drug Type	Interferons
Drug Synonymous	Alferon LDO; Interferon alfa-n3 (oral); Interferon alfa-n3 (oral), Hemispherx; Interferon alfa-n3 (oral), InterferonSciences Click to Show/Hide
Disease Class	1C60-1C62: Human immunodeficiency virus disease
Therapeutic Class	Interferons
External Link
External Link	TTD ID	D07CMM

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM048 Increased risk of angioedema/anaphylactoid reactions BM069 Increased risk of lowers seizure threshold BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Interferon alfa-n3
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[32], [1], [33], [34], [35], [27], [36], [37], [38]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[32], [1], [33], [34], [35], [27], [36], [37], [38]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[55], [56]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[57], [58]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[32], [1], [33], [34], [35], [27], [36], [37], [38]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[1], [19]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[29]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[51]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[52]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[59]
	Additive myelosuppressive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1720		Zidovudine	C10H13N5O4	35370	Major		Inter Info	[1], [27], [28]
	Increased risk of angioedema/anaphylactoid reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0030		Aldesleukin	NA	NA	Major		Inter Info	[1], [2], [3]
	Increased risk of lowers seizure threshold					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[20], [21], [22], [23], [24]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[20], [21], [22], [23], [24]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[25], [17], [16], [26]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[30], [31]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[32], [1]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[48], [49], [50]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[53], [54], [1]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[53], [54], [1]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[53], [54], [1]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0130		Avatrombopag	C29H34Cl2N6O3S2	9852519	Moderate		Inter Info	[1], [39]

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50	Product Information. Kwell (lindane). Reed and Carnrick, Jersey City, NJ.
51	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
52	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
53	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
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56	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
57	Product Information. Noroxin (norfloxacin). Merck & Co, Inc, West Point, PA.
58	Product Information. Requip (ropinirole). SmithKline Beecham, Philadelphia, PA.
59	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.

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