Details of Drug

Drug General Information (ID: D0788)
Drug Name	Idarubicin
Drug Type	Small molecule
Drug Synonymous	DMDR; Idamycin; Idarubicina; Idarubicine; Idarubicinum; Zavedos; Idarubicin Hcl; Idarubicin Hcl Pfs; Idarubicin hydrochloride; DM5; I 1656; IMI 30; IMI-30; Idamycin (TN); Idarubicin (INN); Idarubicin [INN:BAN]; Idarubicina [INN-Spanish]; Idarubicine [INN-French]; Idarubicinum [INN-Latin]; Zavedos (TN); (1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside; (1s,3s)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-A-l-lyxo-hexopyranoside; (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione; (7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione; 4-DMD; 4-Demethoxydaunomycin; 4-Demethoxydaunorubicin; 4-Desmethoxydaunorubicin Click to Show/Hide
Disease Class	2A60: Acute myeloid leukaemia
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C26H27NO9
InChI	1S/C26H27NO9/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31/h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3/t10-,15-,16-,17-,21+,26-/m0/s1
InChIKey	XDXDZDZNSLXDNA-TZNDIEGXSA-N
Canonical SMILES	CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O
External Link
	Pubchem ID	42890
	CAS Number	58957-92-9
	CHEBI ID	42068
	TTD ID	D01XDL
	INTEDE ID	DR0852
	VARIDT ID	DR00386

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM006 Altered intestinal mucosa BM010 Transporter inhibition BM012 Competitive inhibition of transporters BM038 Additive CNS depression effects BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM047 Additive thrombogenic effects BM049 Increased risk of atrioventricular block BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Idarubicin
Affected gastrointestinal absorption
	Altered intestinal mucosa					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0340		Cinoxacin	C12H10N2O5	2762	Minor		Inter Info	[354]
D0573		Enoxacin	C15H17FN4O3	3229	Minor		Inter Info	[354]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Minor		Inter Info	[354]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Minor		Inter Info	[354]
D1102		Nalidixic acid	C12H12N2O3	4421	Minor		Inter Info	[354]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Minor		Inter Info	[354]
Affected cellular transport
	Transporter inhibition					Drug Num: 52
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[212], [213], [214], [215]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[212], [213], [214], [215]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[212], [213], [214], [215]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[212], [213], [214], [215]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[212], [213], [214], [215]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[212], [213], [214], [215]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[212], [213], [214], [215]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[212], [213], [214], [215]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[212], [213], [214], [215]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[212], [213], [214], [215]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[212], [213], [214], [215]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[212], [213], [214], [215]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[212], [213], [214], [215]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[212], [213], [214], [215]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[212], [213], [214], [215]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[212], [213], [214], [215]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[281]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[212], [213], [214], [215]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[283]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[212], [214], [215]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[212], [213], [214], [215]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[212], [213], [214], [215]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[212], [213], [214], [215]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[212], [213], [214], [215]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[289]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[212], [213], [214], [215]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[212], [213], [214], [215]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[212], [213], [214], [215]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[212], [213], [214], [215]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[212], [213], [214], [215]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[312]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[212], [213], [214], [215]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[212], [213], [214], [215]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[212], [213], [214], [215]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[212], [213], [214], [215]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[212], [213], [214], [215]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[212], [214], [215]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[212], [213], [214], [215]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[212], [213], [214], [215]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[212], [213], [214], [215]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[212], [213], [214], [215]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[212], [213], [214], [215]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[212], [213], [214], [215]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[212], [213], [214], [215]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[212], [213], [214], [215]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[212], [213], [214], [215]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[212], [213], [214], [215]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[212], [213], [214], [215]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[212], [213], [214], [215]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[212], [213], [214], [215]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[212], [213], [214], [215]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[212], [213], [214], [215]
	Competitive inhibition of transporters					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1791		Gadobenic acid	C22H28GdN3O11	9852779	Moderate		Inter Info	[256], [257]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[277]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[318]
	Additive immunosuppressive effects					Drug Num: 84
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[9], [48]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[8], [9], [93]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[138], [139]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[140]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[141]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[138], [139]
D1111		Natalizumab	NA	NA	Major		Inter Info	[156]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[9], [113], [203]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[128], [204], [205]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[206]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[208], [209], [210]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[8], [9]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Moderate		Inter Info	[9], [113], [203]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[9], [113], [203]
D0249		Capecitabine	C15H22FN3O6	60953	Moderate		Inter Info	[9], [113], [203]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[9], [113], [203]
D0264		Carmustine	C5H9Cl2N3O2	2578	Moderate		Inter Info	[9], [113], [203]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Moderate		Inter Info	[9], [113], [203]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[8], [9], [216]
D0314		Chloramphenicol (ophthalmic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[8], [9], [216]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[9], [113], [203]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[9], [113], [203]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[9], [113], [203]
D0404		Cytarabine	C9H13N3O5	6253	Moderate		Inter Info	[9], [113], [203]
D0405		Cytarabine (liposomal)	C9H13N3O5	6253	Moderate		Inter Info	[9], [113], [203]
D0407		Dacarbazine	C6H10N6O	135398738	Moderate		Inter Info	[9], [113], [203]
D0410		Dactinomycin	C62H86N12O16	457193	Moderate		Inter Info	[9], [113], [203]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[221]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[9], [113], [203]
D0666		Floxuridine	C9H11FN2O5	5790	Moderate		Inter Info	[9], [113], [203]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[9], [113], [203]
D0714		Gemcitabine	C9H11F2N3O4	60750	Moderate		Inter Info	[9], [113], [203]
D0780		Hydroxyurea	CH4N2O2	3657	Moderate		Inter Info	[9], [113], [203]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[9], [113], [203]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[208], [209], [210]
D0431		Decitabine	C8H12N4O4	451668	Moderate		Inter Info	[9], [113], [203]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[276]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[278]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[278]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[9], [113], [203]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[9], [113], [203]
D0851		Isatuximab	NA	NA	Moderate		Inter Info	[9], [113], [203]
D0945		Lomustine	C9H16ClN3O2	3950	Moderate		Inter Info	[9], [113], [203]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[9], [113], [203]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[9], [113], [203]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[278]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[9], [113], [203]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[9], [113], [203]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[291]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[292]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[9], [293]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[294]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[310]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[208], [209], [210]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[9], [311]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[9], [113], [203]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[314]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[8], [9], [212]
D1575		Thiotepa	C6H12N3PS	5453	Moderate		Inter Info	[9], [113], [203]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[317]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[9], [113], [203]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[9], [113], [203]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[9], [113], [203]
D0986		Mechlorethamine	C5H11Cl2N	4033	Moderate		Inter Info	[9], [113], [203]
D0996		Melphalan	C13H18Cl2N2O2	460612	Moderate		Inter Info	[9], [113], [203]
D1007		Mercaptopurine	C5H4N4S	667490	Moderate		Inter Info	[9], [113], [203]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[9], [113], [203]
D1077		Mitomycin	C15H18N4O5	5746	Moderate		Inter Info	[9], [113], [203]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[9], [113], [203]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[332]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[9], [113], [203]
D1250		Pentostatin	C11H16N4O4	439693	Moderate		Inter Info	[9], [113], [203]
D1508		Streptozocin	C8H15N3O7	29327	Moderate		Inter Info	[9], [113], [203]
D1548		Temozolomide	C6H6N6O2	5394	Moderate		Inter Info	[9], [113], [203]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[9], [113], [203]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[347]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[9], [113], [203]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[9], [113], [203]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[8], [9], [353]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[49], [50]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[8], [97], [98]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[121]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[8], [9], [258], [259]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[8], [9], [258], [259]
	Additive thrombogenic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181]
	Increased risk of atrioventricular block					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[9], [105], [329]
	Increased risk of prolong QT interval					Drug Num: 159
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[7], [8], [9], [20]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[23], [9], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[7], [8], [9], [42], [43], [44]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[7], [8], [9], [45], [46], [19], [47]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[7], [8], [9], [51]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[7], [8], [9], [52]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[7], [8], [9], [53], [54], [19]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[55]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[7], [56], [8], [9], [57], [58], [19]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[59], [60], [61], [7], [8], [9], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[7], [8], [9], [82], [83], [84], [85], [86], [87], [19]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[7], [8], [9], [88]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[89]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[94]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[7], [8], [9], [95]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[96]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[7], [8], [9], [99]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[101], [7], [8], [9], [102], [103], [104], [105], [106]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[23], [9], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[7], [8], [9], [107], [19]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[110]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[111]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[9], [112], [19]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[8], [9], [113]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[114]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[7], [8], [9], [50]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[115]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[117]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[7], [8], [9], [118]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[7], [8], [9], [53], [66], [119], [120], [19]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[122], [123], [7], [8], [9], [124], [125]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[9], [126]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[60], [7], [8], [9], [130], [131], [64], [66], [68], [132], [69], [70], [133], [72], [73], [74], [75], [134], [79], [135], [136]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[7], [8], [9], [142]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[7], [8], [9], [143]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[7], [8], [9], [144], [19]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[7], [8], [9], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [19]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[7], [8], [9], [155]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[59], [60], [61], [7], [8], [9], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[157], [158], [159], [160], [161], [162], [163], [164]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[9], [53], [165], [19]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[7], [8], [9], [182], [53], [183], [184], [185], [19]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[7], [8], [9], [186]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[7], [8], [9], [53], [189], [19]
D0003		Abarelix	C72H95ClN14O14	16131215	Moderate		Inter Info	[9], [190], [191], [192], [193], [194], [195], [196]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[7], [8], [9], [207], [19]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[7], [8], [9], [211], [19]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[9], [190], [191], [192], [193], [194], [195], [196]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[217]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[66], [120], [19]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[66], [120], [19]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[66], [120], [19]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[8], [9], [222]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[9], [190], [191], [192], [193], [194], [195], [196]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[9], [190], [191], [192], [193], [194], [195], [196]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[66], [120], [19]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[9], [190], [191], [192], [193], [194], [195], [196]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[8], [9], [262], [263], [264], [265], [266], [267]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[7], [8], [9], [268], [19]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[275]
D0437		Degarelix	C82H103ClN18O16	16136245	Moderate		Inter Info	[9], [190], [191], [192], [193], [194], [195], [196]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[279]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[8], [9], [280]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[9], [190], [191], [192], [193], [194], [195], [196]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[7], [8], [9], [282]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[284]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[285]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[286]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[9], [190], [191], [192], [193], [194], [195], [196]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[9], [288]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[9]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[7], [8], [9], [290], [19]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[9], [295]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[305]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1342		Probucol	C31H48O2S2	4912	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[7], [8], [9], [53], [306], [307], [308], [309], [19]
D1388		Relugolix	C29H27F2N7O5S	10348973	Moderate		Inter Info	[9], [190], [191], [192], [193], [194], [195], [196]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[7], [8], [9], [313]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[7], [8], [9], [315]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[7], [8], [9], [316], [19]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[9], [190], [191], [192], [193], [194], [195], [196]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[9], [190], [191], [192], [193], [194], [195], [196]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[60], [7], [8], [9], [64], [65], [66], [319], [320], [69], [70], [321], [71], [322], [72], [73], [74], [75], [323], [324], [325], [79], [135]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[326], [327]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[330]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[9], [190], [191], [192], [193], [194], [195], [196]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[60], [7], [8], [9], [64], [65], [66], [319], [320], [69], [70], [321], [71], [322], [72], [73], [74], [75], [323], [324], [325], [79], [135]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[60], [7], [8], [9], [64], [65], [66], [319], [320], [69], [70], [321], [71], [322], [72], [73], [74], [75], [323], [324], [325], [79], [135]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[8], [9], [331]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[335], [336]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[337], [338], [339], [340], [341], [342], [343], [344], [345], [346]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[348], [349], [262], [350], [351], [352], [19]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[7], [8], [9], [53], [66], [120], [19]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[8], [355], [356], [357]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[7], [8], [9], [358], [359], [360], [361]
	Increased risk of ventricular arrhythmias					Drug Num: 27
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[21], [22]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[100], [47]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[9], [108], [109]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[9], [116]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[8], [127]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[7], [197], [8], [9], [198], [199], [200], [42], [201], [202]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[7], [8], [9], [218], [219], [220]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[7], [8], [9], [218], [219], [220]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[239], [249], [252]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[9], [303], [304]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[9], [303], [304]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[9], [303], [304]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[239], [249], [252]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[239], [249], [252]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[239], [249], [252]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[7], [8], [9], [218], [219], [220]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[239], [249], [252]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[7], [8], [9], [218], [219], [220]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1621		Trastuzumab	NA	NA	Major		Inter Info	[8], [187], [188]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[287]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[90], [91], [92]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[90], [91], [92]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[90], [91], [92]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[90], [91], [92]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[90], [91], [92]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[128], [8], [129]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[137]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[90], [91], [92]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[90], [91], [92]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[90], [91], [92]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[128], [260], [261]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[128], [260], [261]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[128], [260], [261]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[128], [260], [261]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[128], [260], [261]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[128], [260], [261]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[128], [260], [261]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[128], [260], [261]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[296], [128], [8], [297], [298], [299], [260], [300], [301], [302], [261]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[128], [260], [261]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[128], [260], [261]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[128], [260], [261]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[328]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[269], [270], [271]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[269], [270], [271]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[272], [273], [274]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[272], [273], [274]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[272], [273], [274]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[272], [273], [274]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[223], [224], [225]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[333], [334]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[223], [224], [225]

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112	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
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116	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
117	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
118	Product Information. Signifor (pasireotide). Novartis Pharmaceuticals, East Hanover, NJ.
119	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
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139	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
140	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
141	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
142	Product Information. Vandetanib (vandetanib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
143	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
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189	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
190	Product Information. Eligard (leuprolide). Sanofi Winthrop Pharmaceuticals, New York, NY.
191	Product Information. Firmagon (degarelix). Ferring Pharmaceuticals Inc, Tarrytown, NY.
192	Product Information. Lupron (leuprolide). TAP Pharmaceuticals Inc, Deerfield, IL.
193	Product Information. Plenaxis (abarelix). Praecis Pharmaceuticals Inc, Waltham, MA.
194	Product Information. Trelstar (triptorelin) Pharmacia and Upjohn, Kalamazoo, MI.
195	Product Information. Vantas (histrelin). Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc), Lexington, MA.
196	Product Information. Zoladex (goserelin). Zeneca Pharmaceuticals, Wilmington, DE.
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207	Product Information. Uroxatral (alfuzosin). sanofi-aventis , Bridgewater, NJ.
208	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
209	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
210	Product Information. Kineret (anakinra). Amgen, Thousand Oaks, CA.
211	Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.
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220	Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
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240	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
241	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
242	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
243	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
244	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
245	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
246	Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
247	Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
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256	Product Information. Multihance (gadobenate dimeglumine). Bracco Diagnostics Inc, Princeton, NJ.
257	Huisman MT, Smit JW, Crommentuyn KM, et al. "Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs." AIDS 16 (2002): 2295-2301. [PMID: 12441801]
258	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
259	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
260	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
261	Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations.".
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267	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
268	Product Information. Saphris (asenapine). Schering-Plough Corporation, Kenilworth, NJ.
269	Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
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272	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
273	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
274	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
275	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
276	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
277	Product Information. Austedo (deutetrabenazine). Teva Pharmaceuticals USA, North Wales, PA.
278	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
279	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
280	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
281	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
282	Product Information. Halaven (eribulin). Eisai Inc, Teaneck, NJ.
283	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
284	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
285	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
286	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
287	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
288	Product Information. Besponsa (inotuzumab ozogamicin). Wyeth Laboratories, Philadelphia, PA.
289	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
290	Product Information. Lucemyra (lofexidine). US WorldMeds LLC, Louisville , KY.
291	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
292	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
293	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
294	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
295	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
296	CDC Centers for Disease Control and Prevention "General Best Practice Guidelines for Immunization: Altered Immunocompetence." .
297	Product Information. Biothrax (anthrax vaccine adsorbed). Emergent BioSolutions Inc., Lansing, MI.
298	Product Information. Fluzone Influenza Vaccine (influenza virus vaccine). Connaught, Swiftwater, PA.
299	Product Information. Havrix (hepatitis A vaccine). SmithKline Beecham, Philadelphia, PA.
300	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
301	Product Information. Omnihib (haemophilus b conjugate vaccine). SmithKline Beecham, Philadelphia, PA.
302	CDC Centers for Disease Control and Prevention "Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States.".
303	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
304	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
305	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
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332	Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.
333	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
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335	Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
336	Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
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