Details of Drug

Details of Drug

 Drug General Information (ID: D0778)
  Drug Name
Hydroxyamphetamine (ophthalmic)
  Drug Type Small molecule
  Drug Synonymous
4-(2-Aminopropyl)phenol; hydroxyamphetamine; Paredrine; 103-86-6; 4-Hydroxyamphetamine; Norpholedrine; Oxamphetamine; Norveritol; Pulsoton; p-HYDROXYAMPHETAMINE; Hydroxyamfetamine; Oksamfetamin; Oxamfetamin; Oxamphetaminium; Paredrinex; Nov-Pholedrin; Paradrine; Pedrolon; p-(2-Aminopropyl)phenol; Phenol, 4-(2-aminopropyl)-; Phenol,4-(2-aminopropyl)-; Hydroxyamphetamide; Phenol, p-(2-aminopropyl)-; 1-p-Hydroxyphenyl-2-propylamine; 2-Amino-1-(p-hydroxyphenyl)propane; .alpha.-Methyltyramine; DL-p-Hydroxyamphetamine; alpha-Methyltyramine; NSC 170995; dl-4-hydroxyamphetamine; 1518-86-1; DL-p-(2-Aminopropyl)phenol; 4-Hydroxy-.alpha.-methylphenethylamine; NSC-170995; p-Hydroxy-.alpha.-methylphenethylamine; p-Hydroxy-alpha-methylphenethylamine; 4-Hydroxy-alpha-methylphenethylamine; UNII-FQR280JW2N; EINECS 203-152-8; BRN 2413849; Hydroxyamfetamine [INN:BAN]; FQR280JW2N; Predrolon (Salt/Mix); Spectrum_001243; Spectrum3_001037; Spectrum4_001174; Spectrum5_001674; (RS)-4-hydroxyamphetamine; Hydroxyamphetamine,(+/-); Racemic p-hydroxyamphetamine; WLN: Z3R DQ; CHEMBL1546; 4-(2-amino-propyl)-phenol; BSPBio_002853; KBioGR_001807; KBioSS_001723; 3-13-00-01709 (Beilstein Handbook Reference); SCHEMBL125440; DTXSID3023134; BDBM81459; KBio2_001723; KBio2_004291; KBio2_006859; KBio3_002073; CHEBI:103855; HY-B1098; NSC_3651; 1-(4-Hydroxyphenyl)propane-2-amine; NSC170995; PDSP1_001107; PDSP2_001091; AKOS000155358; AKOS017269170; CS-4687; DB09352; MCULE-6999513658; Phenol, 4-(2-aminopropyl)- (9CI); NCGC00178433-01; NCGC00178433-02; BS-13447; CAS_103-86-6; Phenol, p-(2-aminopropyl)-, (.+/-.)-; EN300-53926; Phenol, 4-(2-aminopropyl)-, (.+/-.)-; AB01563354_01; Q5955531; BRD-A80871782-004-01-0; Z57102382
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  Therapeutic Class Mydriatics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C9H13NO
  InChI InChI=1S/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3
  InChIKey GIKNHHRFLCDOEU-UHFFFAOYSA-N
  Canonical SMILES CC(CC1=CC=C(C=C1)O)N
  External Link
Pubchem ID 3651
INTEDE ID DR1770

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
BM017  CYP450 enzyme inhibition
BM041  Additive hypertensive effects
BM078  Increased risk of rapid heart rate
  Relation Graph
 Full list of drugs interacting with Hydroxyamphetamine (ophthalmic)
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0298
 
Celecoxib
 
C17H14F3N3O2S
 
2662 
Moderate    Inter Info   
[4]
D0338
 
Cinacalcet
 
C22H22F3N
 
156419 
Moderate    Inter Info   
[5], [6], [7]
D0732
 
Glycerol phenylbutyrate
 
C33H38O6
 
10482134 
Moderate    Inter Info   
[12], [13]
D0171
 
Berotralstat
 
C30H26F4N6O
 
137528262 
Moderate    Inter Info   
[14]
D0638
 
Fedratinib
 
C27H36N6O3S
 
16722836 
Moderate    Inter Info   
[15], [16], [17]
      Pharmacodynamic additive effects
   Additive hypertensive effects Drug Num:  25
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0103
 
Arformoterol
 
C19H24N2O4
 
3083544 
Moderate    Inter Info   
[1], [2], [3]
D0451
 
Desvenlafaxine
 
C16H25NO2
 
125017 
Moderate    Inter Info   
[8], [9], [10]
D0538
 
Droxidopa
 
C9H11NO5
 
92974 
Moderate    Inter Info   
[11]
D0539
 
Duloxetine
 
C18H19NOS
 
60835 
Moderate    Inter Info   
[8], [9], [10]
D0691
 
Formoterol
 
C19H24N2O4
 
3410 
Moderate    Inter Info   
[1], [2], [3]
D0924
 
Levosalbutamol
 
C13H21NO3
 
123600 
Moderate    Inter Info   
[1], [2], [3]
D1374
 
Racepinephrine
 
C9H13NO3
 
838 
Moderate    Inter Info   
[1], [2], [3]
D1492
 
Solriamfetol
 
C10H14N2O2
 
10130337 
Moderate    Inter Info   
[18]
D0797
 
Indacaterol
 
C24H28N2O3
 
6918554 
Moderate    Inter Info   
[1], [2], [3]
D0854
 
Isoetharine
 
C13H21NO3
 
3762 
Moderate    Inter Info   
[1], [2], [3]
D0859
 
Isoprenaline
 
C11H17NO3
 
3779 
Moderate    Inter Info   
[1], [2], [3]
D0879
 
Ketamine
 
C13H16ClNO
 
3821 
Moderate    Inter Info   
[5], [12], [19]
D0920
 
Levomilnacipran
 
C15H22N2O
 
6917779 
Moderate    Inter Info   
[8], [9], [10]
D1066
 
Milnacipran
 
C15H22N2O
 
65833 
Moderate    Inter Info   
[8], [9], [10]
D1171
 
Olodaterol
 
C21H26N2O5
 
11504295 
Moderate    Inter Info   
[1], [2], [3]
D1185
 
Orciprenaline
 
C11H17NO3
 
4086 
Moderate    Inter Info   
[1], [2], [3]
D1298
 
Pirbuterol
 
C12H20N2O3
 
4845 
Moderate    Inter Info   
[1], [2], [3]
D1414
 
Ritodrine
 
C17H21NO3
 
33572 
Moderate    Inter Info   
[1], [2], [3]
D1438
 
Salbutamol
 
C13H21NO3
 
2083 
Moderate    Inter Info   
[1], [2], [3]
D1440
 
Salmeterol
 
C25H37NO4
 
5152 
Moderate    Inter Info   
[1], [2], [3]
D1464
 
Sibutramine
 
C17H26ClN
 
5210 
Moderate    Inter Info   
[20], [21], [22]
D1535
 
Tapentadol
 
C14H23NO
 
9838022 
Moderate    Inter Info   
[8], [9], [10]
D1554
 
Terbutaline
 
C12H19NO3
 
5403 
Moderate    Inter Info   
[1], [2], [3]
D1689
 
Venlafaxine
 
C17H27NO2
 
5656 
Moderate    Inter Info   
[8], [9], [10]
D1695
 
Vilanterol
 
C24H33Cl2NO5
 
10184665 
Moderate    Inter Info   
[1], [2], [3]
References
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2 Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
3 Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
4 Product Information. Celebrex (celecoxib). Searle, Chicago, IL.
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6 Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online.".
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8 Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
9 Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
10 Product Information. Nucynta (tapentadol). PriCara Pharmaceuticals, Raritan, NJ.
11 Product Information. Northera (droxidopa). Chelsea Therapeutics Inc, Charlotte, NC.
12 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
13 Product Information. Ravicti (glycerol phenylbutyrate). Hyperion Therapeutics Inc, South San Francisco, CA.
14 Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
15 Bailey DG, Arnold JMO, Spence JD "Grapefruit juice and drugs - how significant is the interaction." Clin Pharmacokinet 26 (1994): 91-8. [PMID: 8162660]
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17 Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
18 Product Information. Sunosi (solriamfetol). Jazz Pharmaceuticals, Palo Alto, CA.
19 Product Information. Ketalar (ketamine). JHP Pharmaceuticals, Saddle River, NJ.
20 Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
21 Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
22 Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.