Details of Drug | MecDDI

Drug General Information (ID: D0754)
Drug Name		Heparin (flush)
Drug Type		Small molecule
Drug Synonymous		Arteven; Bemiparin; Certoparin; Clivarine; Dalteparin; Eparina; Fluxum; Fraxiparin; Heparina; Heparinate; Heparine; Heparinum; Hepathrom; Innohep; Liquaemin; Liquemin; Logiparin; Multiparin; Nadroparin; Nadroparine; Novoheparin; Pabyrin; Parnaparin; Parvoparin; Pularin; Sandoparin; Subeparin; Sublingula; Thromboliquine; Tinzaparin; Triofiban; Vetren; Allocinnamic acid; Ardeparin sodium; Bemiparin sodium; Enoxaparin sodium; Eparina [DCIT]; Fragmin A; Fragmin B; Fragmin IV; Hep Flush Kit in plastic container; Heparin Lock Flush in plastic container; Heparin Lock Flush preservative free; Heparin Lock Flush preservative free in plastic container; Heparin natrium; Heparin sulfate; Heparinic acid; Heparinum natricum; Isocinnamic acid; Minolteparin sodium; Parnaparin sodium; Reviparin sodium; Sodium acid heparin; Sodium heparinate; Tinzaparin sodium; Vitrum AB; CY 216; Cy 222; FR 860; H 2149; Heparin CY 216; KB 101; Kabi 2165; LHN 1; Lioton 1000; OP 386; OP 622; Ro 11; WY 90493RD; ALFA 87-120; ALFA 87-163; ALFA 87-198; ALFA 87-81; ALFA 88-247; Alpha-Heparin; Cis-Cinnamic acid; Depo-Heparin; Hed-heparin; Hep-Lock; Heparin, sodium salt; Heparina [INN-Spanish]; Heparine [INN-French]; Heparinum [INN-Latin]; Hepflush-10; Inno-Hep; Normiflo (TN); Hep-Lock U/P; Cis-.beta.-Carboxystyrene Click to Show/Hide
Disease Class		BA43: Coronary thrombosis; DB61-GB90: Thrombosis; BD71: Deep vein thrombosis; BD72: Venous thromboembolism
Therapeutic Class		Anticoagulants
Structure
Structure		3D Structure				2D Structure
Formula		C26H42N2O37S5
InChI		1S/C26H42N2O37S5/c1-4(30)27-7-9(31)13(6(56-23(7)39)3-55-67(43,44)45)58-26-19(65-70(52,53)54)12(34)16(20(62-26)22(37)38)60-24-8(28-66(40,41)42)15(63-68(46,47)48)14(5(2-29)57-24)59-25-18(64-69(49,50)51)11(33)10(32)17(61-25)21(35)36/h5-20,23-26,28-29,31-34,39H,2-3H2,1H3,(H,27,30)(H,35,36)(H,37,38)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)
InChIKey		HTTJABKRGRZYRN-UHFFFAOYSA-N
Canonical SMILES		CC(=O)NC1C(C(C(OC1O)COS(=O)(=O)O)OC2C(C(C(C(O2)C(=O)O)OC3C(C(C(C(O3)CO)OC4C(C(C(C(O4)C(=O)O)O)O)OS(=O)(=O)O)OS(=O)(=O)O)NS(=O)(=O)O)O)OS(=O)(=O)O)O
External Link
		Pubchem ID		772
		CAS Number		9005-49-6
		TTD ID		D01ZJK
		INTEDE ID		DR0806

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM050 Increased risk of bleeding
Relation Graph

Full list of drugs interacting with Heparin (flush)
Pharmacodynamic additive effects
					Increased risk of bleeding																																																																Drug Num: 7
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D0104															Argatroban															C23H36N6O5S															92722															Major															Inter Info													[1], [2]
D1623															Trastuzumab emtansine															NA															NA															Major															Inter Info													[3], [4], [5]
D0904															Lepirudin															C287H440N80O111S6															118856773															Major															Inter Info													[1], [2]
D0114															Asparaginase Escherichia coli															NA															NA															Moderate															Inter Info													[6], [4], [7]
D0113															Asparaginase Erwinia chrysanthemi															NA															NA															Moderate															Inter Info													[6], [4], [7]
D0232															Calaspargase pegol															NA															NA															Moderate															Inter Info													[6], [4], [7]
D1234															Pegaspargase															C14H19NO															436058															Moderate															Inter Info													[6], [4], [7]

References
1	Product Information. Acova (argatroban) SmithKline Beecham, Philadelphia, PA.
2	Product Information. Refludan (lepirudin). Hoechst Marion-Roussel Inc, Kansas City, MO.
3	Cerner Multum, Inc. "Australian Product Information.".
4	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5	Product Information. Kadcyla (ado-trastuzumab). Genentech, South San Francisco, CA.
6	Caruso V, Iacoviello L, Di Castelnuovo A, et.al "Thrombotic complications in childhood acute lymphoblastic leukemia: a meta-analysis of 17 prospective studies comprising 1752 pediatric patients." Blood 108 (2006): 2216-22. [PMID: 16804111]
7	Duarte X, Esteves S, Neto AM, Pereira F "Incidence and risk factors for central nervous system thrombosis in paediatric acute lymphoblastic leukaemia during intensive asparaginase treatment: a single-centre study." Br J Haematol 174 (2016): 280-91. [PMID: 27018199]