Details of Drug

Drug General Information (ID: D0746)
Drug Name	Guanidine
Drug Type	Small molecule
Drug Synonymous	guanidine; Iminourea; Aminomethanamidine; Carbamidine; 113-00-8; Carbamamidine; Guanidin; Imidourea; Aminoformamidine; UNII-JU58VJ6Y3B; CHEBI:42820; JU58VJ6Y3B; H2N-C(=NH)-NH2; Guanidine, Hydrochloride; Gu; GAI; Guanidine, free base; EINECS 204-021-8; BRN 0506044; HSDB 7603; CHEMBL821; Epitope ID:140101; NCIOpen2_007946; 4-03-00-00148 (Beilstein Handbook Reference); (NH2)2C=NH; GTPL4783; DTXSID0023117; BCP26146; ZINC8101126; BDBM50420178; STL223269; AKOS009031425; DB00536; MCULE-1152750770; SBI-0207070.P001; FT-0626820; C17349; AB00053583_04; 113G008; Q183309; A9B89FF5-2922-47CC-82CE-AC4157B624AE; Ribavirin Impurity T; Iminourea;Diaminomethanimine;Guanidinebase;Carbamidine; 90332-86-8; GZ6 Click to Show/Hide
Therapeutic Class	Cholinergic Muscle Stimulants
Structure
Structure	3D Structure		2D Structure
Formula	CH5N3
InChI	InChI=1S/CH5N3/c2-1(3)4/h(H5,2,3,4)
InChIKey	ZRALSGWEFCBTJO-UHFFFAOYSA-N
Canonical SMILES	C(=N)(N)N
External Link
	Pubchem ID	3520
	VARIDT ID	DR01303

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM037 Additive cholinergic effects BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM091 Antagonize the effect of cholinergic agents
Relation Graph

Full list of drugs interacting with Guanidine
Pharmacodynamic additive effects
	Additive cholinergic effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[10], [11]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[12], [13], [14]
D1285		Physostigmine	C15H21N3O2	5983	Moderate		Inter Info	[12], [13], [14]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[12], [13], [14]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[12], [13], [14]
	Additive immunosuppressive effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[1], [2]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[8]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[17]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[18]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[19]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[20]
	Additive myelosuppressive effects					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1], [3], [4]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[5], [6], [7]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[5], [1], [15], [16]
Pharmacodynamic antagonistic effects
	Antagonize the effect of cholinergic agents					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[9]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[9]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[9]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[9]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[9]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[9]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[9]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[9]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[9]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[9]
D0759		Homatropine	C16H21NO3	5282593	Moderate		Inter Info	[9]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[9]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[9]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[9]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[9]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[9]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[9]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[9]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[9]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[9]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[9]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[9]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[9]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[9]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
3	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
4	Canadian Pharmacists Association "e-CPS."
5	Cerner Multum, Inc. "Australian Product Information.".
6	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
7	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
8	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
9	Product Information. Mestinon (pyridostigmine). ICN Pharmaceuticals Inc, Cost Mesa, CA.
10	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
11	Product Information. Firdapse (amifampridine). Catalyst Pharmaceuticals, Inc., Coral Gables, FL.
12	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
13	Product Information. Cognex (tacrine). Parke-Davis, Morris Plains, NJ.
14	Product Information. Reminyl (galantamine) Janssen Pharmaceuticals, Titusville, NJ.
15	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
16	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
17	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
18	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
19	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
20	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.

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