Details of Drug

Drug General Information (ID: D0735)
Drug Name		Goldenseal
Drug Type		Natural product
Drug Synonymous		84603-60-1; EINECS 283-261-5; Extract of golden seal; Golden seal, Hydrastis canadensis, ext.; Goldenseal; Goldenseal powder; Guna-lympho; Hydrastis; Hydrastis canadensis extract; Opsonat Click to Show/Hide
Therapeutic Class		Herbal Products

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM019 UGT inhibition
Relation Graph

Full list of drugs interacting with Goldenseal
Affected cellular transport
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 97
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[1], [2]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[3]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[1], [4], [5], [6], [7], [8], [9], [10], [11]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[12], [7], [13]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[14], [15]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [15], [28], [29], [30], [31]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[32]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[33], [15], [34]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [5], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [15], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[18], [96]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[18], [97]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[18], [98]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[1], [18], [99]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[100], [1], [18], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[100], [1], [18]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[114]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[18], [115]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[116]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[37], [39], [94]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[117]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[127]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[141], [15]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[142], [143], [144], [145], [146], [5], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[166], [1], [18], [167], [168], [169], [170], [171], [172]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[173]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[174], [175]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[176]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[177]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[178]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[179]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[180]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[148], [150], [161]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[142], [143], [144], [145], [146], [5], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[181]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[182], [15]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[183]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[184]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[18], [185]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[186]
D0739		Grazoprevir	C38H50N6O9S	44603531	Moderate		Inter Info	[187], [188]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[18], [189]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[190], [15]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[191], [1], [18], [192], [193], [194], [195]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[1], [18], [192]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[18], [196]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[197], [198]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[1], [18], [199]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[200]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[201], [15]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[202]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [5], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [15], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[203]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[1], [18], [204], [15]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[205]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[206]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[148], [150], [161]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[148], [150], [161]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[207], [208]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[191], [1], [18]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[209]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[187], [210]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[211]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[1], [18], [212]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[18], [213]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[214], [215]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[187], [216]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[217]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[218]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[219]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[1], [220], [18], [221]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[1], [222]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[187], [223]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[224]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [5], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [15], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[225]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[18], [19], [226]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[1], [227]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[187], [228]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[229], [230], [231]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[18], [232], [233]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[234]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[235], [15]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[1], [18], [236]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[1], [18], [237]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[238]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[1], [239], [240]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[241], [242]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[243]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[244], [134], [245], [246]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[247]
D0599		Escitalopram	C20H21FN2O	146570	Minor		Inter Info	[241], [242]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[1], [239], [240]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[248]
D1607		Tolterodine	C22H31NO	443879	Minor		Inter Info	[249], [250], [134]
D1664		Ulipristal	C28H35NO3	13559281	Minor		Inter Info	[18], [251]

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99	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
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159	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
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173	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
174	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
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176	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
177	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
178	Product Information. Relpax (eletriptan). Pfizer U.S. Pharmaceuticals, New York, NY.
179	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
180	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
181	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
182	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
183	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
184	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
185	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
186	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
187	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
188	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
189	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
190	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
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195	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
196	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
197	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
198	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
199	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
200	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
201	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
202	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
203	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
204	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
205	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
206	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
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208	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
209	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
210	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
211	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
212	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
213	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
214	Hamberg P, Woo MM, Chen LC, et al. "Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor." Cancer Chemother Pharmacol 68 (2011): 805-13. [PMID: 21706316]
215	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
216	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
217	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
218	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
219	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
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221	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
222	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
223	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
224	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
225	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
226	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
227	Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
228	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
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234	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
235	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
236	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
237	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
238	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
239	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
240	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
241	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
242	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
243	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
244	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
245	Rojas-Fernandez C, Fisher C "Drug interactions and donepezil." J Am Geriat Soc 40 (2000): 597-8. [PMID: 10811561]
246	Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses." Br J Clin Pharmacol 46 (1998): 30-4. [PMID: 9839763]
247	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
248	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
249	Brynne N, Svanstrom C, AbergWistedt A, Hallen B, Bertilsson L "Fluoxetine inhibits the metabolism of tolterodin-pharmacokinetic implications and proposed clinical relevance." Br J Clin Pharmacol 48 (1999): 553-63. [PMID: 10583026]
250	Product Information. Detrol (tolterodine). Pharmacia and Upjohn, Kalamazoo, MI.
251	Product Information. ella (ulipristal). Afaxys Inc., Charleston, SC.

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