Details of Drug

Details of Drug

 Drug General Information (ID: D0721)
  Drug Name
Ginger
  Drug Type Natural product
  Drug Synonymous
Absinthin; 1362-42-1; Absinthiin; Absynthin; (+)-absinthin; UNII-OE5992O64P; OE5992O64P; (1R,2R,5S,8S,9S,12S,13R,14S,15S,16R,17S,20S,21S,24S)-12,17-dihydroxy-3,8,12,17,21,25-hexamethyl-6,23-dioxaheptacyclo[13.9.2.0(1,16).0(2,14).0(4,13).0(5,9).0(20,24)]hexacosa-3,25-diene-7,22-dione; Ginger; Ginger Root Powder; C30H40O6; NSC 407315; SCHEMBL873059; CHEBI:2366; CHEMBL4647301; HY-N0742; ZINC8214476; s3288; AC-35046; CS-0009774; Y0021; C09286; Q332313
    Click to Show/Hide
  Therapeutic Class Herbal Products
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C30H40O6
  InChI InChI=1S/C30H40O6/c1-12-11-18-20-21(30(12)24(18)29(6,34)10-8-17-14(3)27(32)36-25(17)30)15(4)19-22(20)28(5,33)9-7-16-13(2)26(31)35-23(16)19/h11,13-14,16-18,20-25,33-34H,7-10H2,1-6H3/t13-,14-,16-,17-,18+,20-,21-,22-,23-,24-,25-,28-,29-,30+/m0/s1
  InChIKey PZHWYURJZAPXAN-ILOFNVQHSA-N
  Canonical SMILES C[C@H]1[C@@H]2CC[C@]([C@@H]3[C@H]4[C@H]5C=C([C@@]6([C@H]4C(=C3[C@H]2OC1=O)C)[C@@H]5[C@@](CC[C@@H]7[C@@H]6OC(=O)[C@H]7C)(C)O)C)(C)O
  External Link
Pubchem ID 442138

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM010  Transporter inhibition
BM017  CYP450 enzyme inhibition
BM050  Increased risk of bleeding
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Ginger
      Affected cellular transport
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  11
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Moderate    Inter Info   
[7], [8]
D0629
 
Everolimus
 
C53H83NO14
 
6442177 
Moderate    Inter Info   
[9], [10]
D0008
 
Acalabrutinib
 
C26H23N7O2
 
71226662 
Moderate    Inter Info   
[11], [10]
D0129
 
Avapritinib
 
C26H27FN10
 
118023034 
Moderate    Inter Info   
[12], [13]
D0962
 
Lurbinectedin
 
C41H44N4O10S
 
57327016 
Moderate    Inter Info   
[14]
D1189
 
Osilodrostat
 
C13H10FN3
 
44139752 
Moderate    Inter Info   
[12], [15]
D1324
 
Pralsetinib
 
C27H32FN9O2
 
129073603 
Moderate    Inter Info   
[16]
D1409
 
Ripretinib
 
C24H21BrFN5O2
 
71584930 
Moderate    Inter Info   
[17], [18]
D1459
 
Selpercatinib
 
C29H31N7O3
 
134436906 
Moderate    Inter Info   
[12], [19]
D1143
 
Nitisinone
 
C14H10F3NO5
 
115355 
Moderate    Inter Info   
[20], [17], [12]
D1404
 
Rilpivirine
 
C22H18N6
 
6451164 
Moderate    Inter Info   
[17], [21], [12], [22]
      Pharmacodynamic additive effects
   Increased risk of bleeding Drug Num:  38
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0005
 
Abciximab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0017
 
Acetylsalicylic acid
 
C9H8O4
 
2244 
Moderate    Inter Info   
[6], [3], [5]
D0047
 
Alteplase
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0087
 
Anisindione
 
C16H12O3
 
2197 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0088
 
Anistreplase
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0096
 
Apixaban
 
C25H25N5O4
 
10182969 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0102
 
Ardeparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0104
 
Argatroban
 
C23H36N6O5S
 
92722 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0189
 
Bivalirudin
 
C98H138N24O33
 
16129704 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0247
 
Cangrelor
 
C17H25Cl2F3N5O12P3S2
 
9854012 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0250
 
Caplacizumab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0364
 
Clopidogrel
 
C16H16ClNO2S
 
60606 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0414
 
Dalteparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0415
 
Danaparoid
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0435
 
Defibrotide
 
C20H21N4O6P
 
135565962 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Moderate    Inter Info   
[6], [3], [5]
D0506
 
Dipyridamole
 
C24H40N8O4
 
3108 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0551
 
Edoxaban
 
C24H30ClN7O4S
 
10280735 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0574
 
Enoxaparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0588
 
Eptifibatide
 
C35H49N11O9S2
 
448812 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0690
 
Fondaparinux
 
C31H53N3O49S8
 
5282448 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0092
 
Antithrombin Alfa
 
NA
 
NA
Moderate    Inter Info   
[6], [3], [5]
D0093
 
Antithrombin III human
 
NA
 
NA
Moderate    Inter Info   
[6], [3], [5]
D0176
 
Betrixaban
 
C23H22ClN5O3
 
10275777 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0753
 
Heparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D0904
 
Lepirudin
 
C287H440N80O111S6
 
118856773 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D1328
 
Prasugrel
 
C20H20FNO3S
 
6918456 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D1395
 
Reteplase
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D1417
 
Rivaroxaban
 
C19H18ClN3O5S
 
9875401 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D1506
 
Streptokinase
 
C11H19NO2
 
9815560 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D1518
 
Sulfinpyrazone
 
C23H20N2O3S
 
5342 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D1550
 
Tenecteplase
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D1579
 
Ticagrelor
 
C23H28F2N6O4S
 
9871419 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D1588
 
Tinzaparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D1593
 
Tirofiban
 
C22H36N2O5S
 
60947 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D1669
 
Urokinase
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D1705
 
Vorapaxar
 
C29H33FN2O4
 
10077130 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Moderate    Inter Info   
[1], [2], [3], [4], [5]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1691
 
Verteporfin
 
C82H84N8O16
 
11980904 
Moderate    Inter Info   
[23], [24]
References
1 Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7 quiz 1228-30. [PMID: 10902065]
2 Jiang X, Williams KM, Liauw WS, et al. "Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects." Br J Clin Pharmacol 59 (2005): 425-32. [PMID: 15801937]
3 Kruth P, Brosi E, Fux R, Morike K, Gleiter CH "Ginger-associated overanticoagulation by phenprocoumon." Ann Pharmacother 38 (2004): 257-60. [PMID: 14742762]
4 Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
5 Vaes LP, Chyka PA "Interactions of warfarin with garlic, ginger, or ginseng: nature of evidence." Ann Pharmacother 34 (2000): 1478-82. [PMID: 11144706]
6 Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7 quiz 1228-30. [PMID: 10902065]
7 Kimura Y, Ito H, Hatano T "Effects of mace and nutmeg on human cytochrome P450 3A4 and 2C9 activity." Biol Pharm Bull 33 (2010): 1977-82. [PMID: 21139236]
8 Revol B, Gautier-Veyret E, Arrive C, et al. Pharmacokinetic herb-drug interaction between ginger and crizotinib.?Br J Clin Pharmacol. 2020;86(9):1892-1893. [PMID: 30701569]
9 Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
10 Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
11 Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
12 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
13 Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
14 Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
15 Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
16 Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
17 Cerner Multum, Inc. "Australian Product Information.".
18 Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
19 Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
20 Canadian Pharmacists Association.
21 Cerner Multum, Inc. "Canadian Product Information.".
22 Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
23 Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
24 Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.