Details of Drug

Details of Drug

 Drug General Information (ID: D0683)
  Drug Name
Fluticasone
  Drug Type Small molecule
  Drug Synonymous
Fluticaps; Fluticaps (TN); Fluticasone (INN); S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate
    Click to Show/Hide
  Disease Class CA08: Vasomotor/allergic rhinitis
  Therapeutic Class Antiinflammatory Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C22H27F3O4S
  InChI 1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1
  InChIKey MGNNYOODZCAHBA-GQKYHHCASA-N
  Canonical SMILES CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)SCF)O)C)O)F)C)F
  External Link
Pubchem ID 5311101
CAS Number 90566-53-3
CHEBI ID 5134
TTD ID D0LC6K

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM009  Altered absorption (Unspecific)
BM010  Transporter inhibition
BM011  Transporter induction
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM043  Additive immunosuppressive effects
BM065  Increased risk of hypokalemia
BM067  Increased risk of hyponatremia
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Fluticasone
      Affected gastrointestinal absorption
   Altered absorption (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0814
 
Insulin human (inhalation, rapid acting)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[62], [63], [64]
      Affected cellular transport
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  50
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0080
 
Amprenavir
 
C25H35N3O6S
 
65016 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0116
 
Atazanavir
 
C38H52N6O7
 
148192 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0192
 
Boceprevir
 
C27H45N5O5
 
10324367 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0349
 
Clarithromycin
 
C38H69NO13
 
84029 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0375
 
Cobicistat
 
C40H53N7O5S2
 
25151504 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0386
 
Conivaptan
 
C32H26N4O2
 
151171 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0439
 
Delavirdine
 
C22H28N6O3S
 
5625 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0692
 
Fosamprenavir
 
C25H36N3O9PS
 
131536 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0799
 
Indinavir
 
C36H47N5O4
 
5362440 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0867
 
Itraconazole
 
C35H38Cl2N8O4
 
55283 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0946
 
Lonafarnib
 
C27H31Br2ClN4O2
 
148195 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D1119
 
Nelfinavir
 
C32H45N3O4S
 
64143 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D1315
 
Posaconazole
 
C37H42F2N8O4
 
468595 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D1415
 
Ritonavir
 
C37H48N6O5S2
 
392622 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [20], [22], [23], [25], [26], [27], [29], [30], [32], [33], [34], [36], [38], [39], [40]
D1444
 
Saquinavir
 
C38H50N6O5
 
441243 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D1541
 
Telaprevir
 
C36H53N7O6
 
3010818 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D1544
 
Telithromycin
 
C43H65N5O10
 
3002190 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D1653
 
Troleandomycin
 
C41H67NO15
 
202225 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D1706
 
Voriconazole
 
C16H14F3N5O
 
71616 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[48]
D0100
 
Aprepitant
 
C23H21F7N4O3
 
135413536 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D0313
 
Chloramphenicol
 
C11H12Cl2N2O5
 
5959 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D0341
 
Ciprofloxacin
 
C17H18FN3O3
 
2764 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D0413
 
Dalfopristin
 
C34H50N4O9S
 
6323289 
Moderate    Inter Info   
[47], [51], [53]
D0426
 
Darunavir
 
C27H37N3O7S
 
213039 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D0497
 
Diltiazem
 
C22H26N2O4S
 
39186 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D0543
 
Duvelisib
 
C22H17ClN6O
 
50905713 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D0667
 
Fluconazole
 
C13H12F2N6O
 
3365 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D0171
 
Berotralstat
 
C30H26F4N6O
 
137528262 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D0696
 
Fosnetupitant
 
C31H35F6N4O5P
 
71544786 
Moderate    Inter Info   
[47], [51], [53]
D0896
 
Larotrectinib
 
C21H22F2N6O2
 
46188928 
Moderate    Inter Info   
[47], [41], [58]
D1709
 
Voxelotor
 
C19H19N3O3
 
71602803 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D0693
 
Fosaprepitant
 
C23H22F7N4O6P
 
135413538 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D0699
 
Fostamatinib
 
C23H26FN6O9P
 
11671467 
Moderate    Inter Info   
[60]
D0793
 
Imatinib
 
C29H31N7O
 
5291 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D0894
 
Lapatinib
 
C29H26ClFN4O4S
 
208908 
Moderate    Inter Info   
[65]
D0899
 
Lefamulin
 
C28H45NO5S
 
25185057 
Moderate    Inter Info   
[66]
D0906
 
Letermovir
 
C29H28F4N4O4
 
45138674 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D1127
 
Netupitant
 
C30H32F6N4O
 
6451149 
Moderate    Inter Info   
[47], [51], [53]
D1398
 
Ribociclib
 
C23H30N8O
 
44631912 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D1505
 
Stiripentol
 
C14H18O3
 
5311454 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D1690
 
Verapamil
 
C27H38N2O4
 
2520 
Moderate    Inter Info   
[47], [41], [50], [51], [52], [53], [54]
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Minor    Inter Info   
[75], [41], [25], [26], [28]
   CYP450 enzyme induction Drug Num:  9
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Moderate    Inter Info   
[41], [49]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Moderate    Inter Info   
[55], [47], [41], [56]
D0545
 
Echinacea
 
NA
 
NA
Moderate    Inter Info   
[47], [57]
D1493
 
Somapacitan
 
C54H95N13O20S2
 
129894493 
Moderate    Inter Info   
[47], [41], [59]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Moderate    Inter Info   
[67]
D1128
 
Nevirapine
 
C15H14N4O
 
4463 
Moderate    Inter Info   
[47], [41], [68], [69]
D1258
 
Pexidartinib
 
C20H15ClF3N5
 
25151352 
Moderate    Inter Info   
[71]
D1494
 
Somatotropin
 
NA
 
NA
Moderate    Inter Info   
[47], [41], [59]
D1495
 
Somatrem
 
C43H72N14O14
 
5487805 
Moderate    Inter Info   
[47], [41], [72], [59]
      Pharmacodynamic additive effects
   Additive immunosuppressive effects Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0348
 
Cladribine
 
C10H12ClN5O3
 
20279 
Major    Inter Info   
[41], [42]
D0501
 
Dinutuximab
 
NA
 
NA
Major    Inter Info   
[41]
D0203
 
Brexucabtagene autoleucel
 
NA
 
NA
Major    Inter Info   
[41]
D1174
 
Omacetaxine mepesuccinate
 
C29H39NO9
 
285033 
Moderate    Inter Info   
[70]
   Increased risk of hypokalemia Drug Num:  14
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0103
 
Arformoterol
 
C19H24N2O4
 
3083544 
Minor    Inter Info   
[73], [47], [41], [74]
D0691
 
Formoterol
 
C19H24N2O4
 
3410 
Minor    Inter Info   
[73], [47], [41], [74]
D0797
 
Indacaterol
 
C24H28N2O3
 
6918554 
Minor    Inter Info   
[73], [47], [41], [74]
D0854
 
Isoetharine
 
C13H21NO3
 
3762 
Minor    Inter Info   
[73], [47], [41], [74]
D0859
 
Isoprenaline
 
C11H17NO3
 
3779 
Minor    Inter Info   
[47], [41], [74]
D0924
 
Levosalbutamol
 
C13H21NO3
 
123600 
Minor    Inter Info   
[47], [41], [74]
D1185
 
Orciprenaline
 
C11H17NO3
 
4086 
Minor    Inter Info   
[47], [41], [74]
D1298
 
Pirbuterol
 
C12H20N2O3
 
4845 
Minor    Inter Info   
[73], [47], [41], [74]
D1374
 
Racepinephrine
 
C9H13NO3
 
838 
Minor    Inter Info   
[73], [47], [41], [74]
D1414
 
Ritodrine
 
C17H21NO3
 
33572 
Minor    Inter Info   
[73], [47], [41], [74]
D1438
 
Salbutamol
 
C13H21NO3
 
2083 
Minor    Inter Info   
[47], [41], [74]
D1440
 
Salmeterol
 
C25H37NO4
 
5152 
Minor    Inter Info   
[73], [47], [41], [74]
D1554
 
Terbutaline
 
C12H19NO3
 
5403 
Minor    Inter Info   
[73], [47], [41], [74]
D1695
 
Vilanterol
 
C24H33Cl2NO5
 
10184665 
Minor    Inter Info   
[47], [41], [74]
   Increased risk of hyponatremia Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0449
 
Desmopressin
 
C46H64N14O12S2
 
5311065 
Major    Inter Info   
[43], [41], [44], [45], [46], [47]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1817
 
Indium In-111 oxyquinoline
 
C27H18InN3O3
 
16685037 
Moderate    Inter Info   
[61]
References
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2 Bhumbra NA, Sahloff EG, Oehrtman SJ, Horner JM "Exogenous Cushing syndrome with inhaled fluticasone in a child receiving lopinavir/ritonavir." Ann Pharmacother 41 (2007): 1306-9. [PMID: 17535841]
3 Boorsma M, Andersson N, Larsson P, Ullman A "Assessment of the relative systemic potency of inihaled fluticasone and budesonide." Eur Respir J 9 (1996): 1427-32. [PMID: 8836654]
4 Brus R "Effects of high-dose inhaled corticosteroids on plasma cortisol consentrations in healthy adults." Arch Intern Med 159 (1999): 1903-8. [PMID: 10493320]
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50 Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
51 Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
52 Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
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66 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
67 Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
68 Product Information. Viramune (nevirapine). Boehringer-Ingelheim, Ridgefield, CT.
69 Product Information. Viramune XR (nevirapine). Boehringer Ingelheim, Ridgefield, CT.
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71 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
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