Details of Drug

Details of Drug

 Drug General Information (ID: D0673)
  Drug Name
Flunisolide (nasal)
  Drug Type Small molecule
  Drug Synonymous
Aerobid; Aerospan; Bronalide; Flunisolida; Flunisolidum; Lunis; Nasalide; Nasarel; Nisolid; Rhinalar; Rhinolar; Soluzione; Synaclyn; Syntaris; Aerobid M; Aerospan HFA; Flunisolide HFA; Flunisolide [INN]; Flunisolide [anhydrous]; Flunisolide anhydrous; F0437; RS 3999; AeroBid (TN); Flunisolida [INN-Spanish]; Flunisolide (anhydrous); Flunisolidum [INN-Latin]; Nasalide (TN); Nasarel (TN); RS-3999; AeroBid, Nasalide, Nasarel,Flunisolide; Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone; Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-,cyclic 16,17-acetal with acetone; 6 alpha-fluoro-11 beta,16 alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16, 17-acetal with acetone; 6 alpha-fluorodihydroxy-16 alpha,17 alpha-isopropylidenedioxy-1,4-pregnadiene-3,20-dione; 6-Fluoro-11,21-dihydroxy-16,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione; 6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16, 17-acetal with acetone; 6alpha-fluoro-11beta,21-dihydroxy-16alpha,17alpha-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
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  Disease Class CA08: Vasomotor/allergic rhinitis
  Therapeutic Class Antiasthmatic Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C24H31FO6
  InChI 1S/C24H31FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h5-7,13-14,16-17,19-20,26,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1
  InChIKey XSFJVAJPIHIPKU-XWCQMRHXSA-N
  Canonical SMILES CC1(OC2CC3C4CC(C5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C)F)C
  External Link
Pubchem ID 82153
CAS Number 542449
CHEBI ID 5106
TTD ID D0FM2P
INTEDE ID DR0710

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
BM017  CYP450 enzyme inhibition
  Relation Graph
 Full list of drugs interacting with Flunisolide (nasal)
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  29
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0080
 
Amprenavir
 
C25H35N3O6S
 
65016 
Moderate    Inter Info   
[1], [2], [3]
D0116
 
Atazanavir
 
C38H52N6O7
 
148192 
Moderate    Inter Info   
[1], [2], [3]
D0192
 
Boceprevir
 
C27H45N5O5
 
10324367 
Moderate    Inter Info   
[1], [2], [3]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Moderate    Inter Info   
[1], [2], [3]
D0349
 
Clarithromycin
 
C38H69NO13
 
84029 
Moderate    Inter Info   
[1], [2], [3]
D0375
 
Cobicistat
 
C40H53N7O5S2
 
25151504 
Moderate    Inter Info   
[1], [2], [3]
D0386
 
Conivaptan
 
C32H26N4O2
 
151171 
Moderate    Inter Info   
[1], [2], [3]
D0426
 
Darunavir
 
C27H37N3O7S
 
213039 
Moderate    Inter Info   
[1], [2], [3]
D0439
 
Delavirdine
 
C22H28N6O3S
 
5625 
Moderate    Inter Info   
[1], [2], [3]
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Moderate    Inter Info   
[1], [2], [3]
D0638
 
Fedratinib
 
C27H36N6O3S
 
16722836 
Moderate    Inter Info   
[1], [2], [3]
D0692
 
Fosamprenavir
 
C25H36N3O9PS
 
131536 
Moderate    Inter Info   
[1], [2], [3]
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Moderate    Inter Info   
[1], [2], [3]
D0799
 
Indinavir
 
C36H47N5O4
 
5362440 
Moderate    Inter Info   
[1], [2], [3]
D0867
 
Itraconazole
 
C35H38Cl2N8O4
 
55283 
Moderate    Inter Info   
[1], [2], [3]
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Moderate    Inter Info   
[1], [2], [3]
D0946
 
Lonafarnib
 
C27H31Br2ClN4O2
 
148195 
Moderate    Inter Info   
[1], [2], [3]
D1057
 
Miconazole
 
C18H14Cl4N2O
 
4189 
Moderate    Inter Info   
[1], [2], [3]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Moderate    Inter Info   
[1], [2], [3]
D1119
 
Nelfinavir
 
C32H45N3O4S
 
64143 
Moderate    Inter Info   
[1], [2], [3]
D1315
 
Posaconazole
 
C37H42F2N8O4
 
468595 
Moderate    Inter Info   
[1], [2], [3]
D1415
 
Ritonavir
 
C37H48N6O5S2
 
392622 
Moderate    Inter Info   
[1], [2], [3]
D1444
 
Saquinavir
 
C38H50N6O5
 
441243 
Moderate    Inter Info   
[1], [2], [3]
D1541
 
Telaprevir
 
C36H53N7O6
 
3010818 
Moderate    Inter Info   
[1], [2], [3]
D1544
 
Telithromycin
 
C43H65N5O10
 
3002190 
Moderate    Inter Info   
[1], [2], [3]
D1653
 
Troleandomycin
 
C41H67NO15
 
202225 
Moderate    Inter Info   
[1], [2], [3]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Moderate    Inter Info   
[1], [2], [3]
D1706
 
Voriconazole
 
C16H14F3N5O
 
71616 
Moderate    Inter Info   
[1], [2], [3]
D1709
 
Voxelotor
 
C19H19N3O3
 
71602803 
Moderate    Inter Info   
[1], [2], [3]
References
1 Edsbacker S, Andersson T "Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease." Clin Pharmacokinet 43 (2004): 803-21. [PMID: 15355126]
2 Finkenbine RD, Frye MD "Case of psychosis due to prednisone-clarithromycin interaction." Gen Hosp Psychiat 20 (1998): 325-6. [PMID: 9788033]
3 Soldatos G, Sztal-Mazer S, Woolley I, Stockigt J "Exogenous glucocorticoid excess as a result of ritonavir-fluticasone interaction." Intern Med J 35 (2005): 67-8. [PMID: 15667475]