Details of Drug

Details of Drug

 Drug General Information (ID: D0658)
  Drug Name
Fidaxomicin
  Drug Type Small molecule
  Drug Synonymous
Dificid (TN)
    Click to Show/Hide
  Disease Class 1A04: Clostridium difficile enterocolitis
  Therapeutic Class Macrolides
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C52H74Cl2O18
  InChI 1S/C52H74Cl2O18/c1-13-30-22-26(6)33(56)18-16-15-17-31(23-66-51-45(65-12)42(61)44(29(9)67-51)69-49(64)35-32(14-2)36(53)39(58)37(54)38(35)57)48(63)68-34(28(8)55)20-19-25(5)21-27(7)43(30)70-50-41(60)40(59)46(52(10,11)72-50)71-47(62)24(3)4/h15-17,19,21-22,24,28-30,33-34,40-46,50-51,55-61H,13-14,18,20,23H2,1-12H3/b16-15+,25-19+,26-22+,27-21+,31-17+/t28-,29-,30+,33+,34+,40-,41+,42+,43+,44-,45+,46+,50-,51-/m1/s1
  InChIKey ZVGNESXIJDCBKN-UUEYKCAUSA-N
  Canonical SMILES CCC1C=C(C(CC=CC=C(C(=O)OC(CC=C(C=C(C1OC2C(C(C(C(O2)(C)C)OC(=O)C(C)C)O)O)C)C)C(C)O)COC3C(C(C(C(O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)C
  External Link
Pubchem ID 10034073
CAS Number 873857-62-6
TTD ID D06LNW
VARIDT ID DR00545

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
AM007  Pharmacodynamic antagonistic effects
BM010  Transporter inhibition
BM011  Transporter induction
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM100  Antagonize the effect of vaccine/toxoid
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Fidaxomicin
      Affected cellular transport
   Transporter inhibition Drug Num:  68
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0171
 
Berotralstat
 
C30H26F4N6O
 
137528262 
Major    Inter Info   
[1], [2], [3], [4]
D1388
 
Relugolix
 
C29H27F2N7O5S
 
10348973 
Major    Inter Info   
[1], [2], [3], [4]
D1688
 
Venetoclax
 
C45H50ClN7O7S
 
49846579 
Major    Inter Info   
[1], [2], [3], [4]
D0044
 
Alpelisib
 
C19H22F3N5O2S
 
56649450 
Moderate    Inter Info   
[3], [8], [9]
D0182
 
Binimetinib
 
C17H15BrF2N4O3
 
10288191 
Moderate    Inter Info   
[1], [3], [11]
D0569
 
Encorafenib
 
C22H27ClFN7O4S
 
50922675 
Moderate    Inter Info   
[3], [12]
D0590
 
Erdafitinib
 
C25H30N6O2
 
67462786 
Moderate    Inter Info   
[15]
D0699
 
Fostamatinib
 
C23H26FN6O9P
 
11671467 
Moderate    Inter Info   
[16]
D0785
 
Ibrutinib
 
C25H24N6O2
 
24821094 
Moderate    Inter Info   
[3], [18]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Moderate    Inter Info   
[19]
D0963
 
Lusutrombopag
 
C29H32Cl2N2O5S
 
49843517 
Moderate    Inter Info   
[20]
D1409
 
Ripretinib
 
C24H21BrFN5O2
 
71584930 
Moderate    Inter Info   
[1], [24]
D1532
 
Talazoparib
 
C19H14F2N6O
 
135565082 
Moderate    Inter Info   
[1], [2], [3], [4]
D0115
 
Astemizole
 
C28H31FN4O
 
2247 
Minor    Inter Info   
[1], [3], [4]
D0170
 
Bepridil
 
C24H34N2O
 
2351 
Minor    Inter Info   
[4]
D0192
 
Boceprevir
 
C27H45N5O5
 
10324367 
Minor    Inter Info   
[1], [3], [4]
D0349
 
Clarithromycin
 
C38H69NO13
 
84029 
Minor    Inter Info   
[4]
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Minor    Inter Info   
[4]
D0497
 
Diltiazem
 
C22H26N2O4S
 
39186 
Minor    Inter Info   
[4]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Minor    Inter Info   
[4]
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Minor    Inter Info   
[4]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Minor    Inter Info   
[1], [3], [4]
D0230
 
Cabozantinib
 
C28H24FN3O5
 
25102847 
Minor    Inter Info   
[1], [3], [4]
D0251
 
Capmatinib
 
C23H17FN6O
 
25145656 
Minor    Inter Info   
[4]
D0408
 
Daclatasvir
 
C40H50N8O6
 
25154714 
Minor    Inter Info   
[1], [3], [4]
D0555
 
Elagolix
 
C32H30F5N3O5
 
11250647 
Minor    Inter Info   
[1], [3], [4]
D0559
 
Eliglustat
 
C23H36N2O4
 
23652731 
Minor    Inter Info   
[1], [2], [3], [4]
D0725
 
Glasdegib
 
C21H22N6O
 
25166913 
Minor    Inter Info   
[4]
D0726
 
Glecaprevir
 
C38H46F4N6O9S
 
66828839 
Minor    Inter Info   
[1], [3], [4]
D0866
 
Istradefylline
 
C20H24N4O4
 
5311037 
Minor    Inter Info   
[1], [3], [4]
D0898
 
Ledipasvir
 
C49H54F2N8O6
 
67505836 
Minor    Inter Info   
[1], [3], [4]
D1124
 
Neratinib
 
C30H29ClN6O3
 
9915743 
Minor    Inter Info   
[1], [3], [4]
D1258
 
Pexidartinib
 
C20H15ClF3N5
 
25151352 
Minor    Inter Info   
[1], [3], [4]
D1313
 
Ponatinib
 
C29H27F3N6O
 
24826799 
Minor    Inter Info   
[1], [3], [4]
D1423
 
Rolapitant
 
C25H26F6N2O2
 
10311306 
Minor    Inter Info   
[1], [3], [4]
D1445
 
Sarecycline
 
C24H29N3O8
 
54681908 
Minor    Inter Info   
[1], [3], [4]
D1524
 
Suvorexant
 
C23H23ClN6O2
 
24965990 
Minor    Inter Info   
[1], [3], [4]
D1653
 
Troleandomycin
 
C41H67NO15
 
202225 
Minor    Inter Info   
[1], [3], [4]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Minor    Inter Info   
[4]
D1686
 
Velpatasvir
 
C49H54N8O8
 
67683363 
Minor    Inter Info   
[1], [3], [4]
D0665
 
Flibanserin
 
C20H21F3N4O
 
6918248 
Minor    Inter Info   
[1], [3], [4]
D0852
 
Isavuconazonium
 
C35H35F2N8O5S+
 
6918606 
Minor    Inter Info   
[1], [3], [4]
D0867
 
Itraconazole
 
C35H38Cl2N8O4
 
55283 
Minor    Inter Info   
[1], [3], [4]
D0869
 
Ivacaftor
 
C24H28N2O3
 
16220172 
Minor    Inter Info   
[1], [3], [4]
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Minor    Inter Info   
[4]
D0894
 
Lapatinib
 
C29H26ClFN4O4S
 
208908 
Minor    Inter Info   
[1], [2], [3], [4]
D0944
 
Lomitapide
 
C39H37F6N3O2
 
9853053 
Minor    Inter Info   
[1], [3], [4]
D1062
 
Midostaurin
 
C35H30N4O4
 
9829523 
Minor    Inter Info   
[1], [3], [4]
D1119
 
Nelfinavir
 
C32H45N3O4S
 
64143 
Minor    Inter Info   
[4]
D1134
 
Nifedipine
 
C17H18N2O6
 
4485 
Minor    Inter Info   
[1], [3], [4]
D1136
 
Nilotinib
 
C28H22F3N7O
 
644241 
Minor    Inter Info   
[1], [2], [3], [4]
D1348
 
Progesterone
 
C21H30O2
 
5994 
Minor    Inter Info   
[1], [3], [4]
D1353
 
Propafenone
 
C21H27NO3
 
4932 
Minor    Inter Info   
[4]
D1371
 
Quinidine
 
C20H24N2O2
 
441074 
Minor    Inter Info   
[4]
D1372
 
Quinine
 
C20H24N2O2
 
3034034 
Minor    Inter Info   
[4]
D1383
 
Ranolazine
 
C24H33N3O4
 
56959 
Minor    Inter Info   
[1], [3], [4]
D1415
 
Ritonavir
 
C37H48N6O5S2
 
392622 
Minor    Inter Info   
[4]
D1444
 
Saquinavir
 
C38H50N6O5
 
441243 
Minor    Inter Info   
[4]
D1497
 
Sorafenib
 
C21H16ClF3N4O3
 
216239 
Minor    Inter Info   
[1], [3], [4]
D1501
 
Spironolactone
 
C24H32O4S
 
5833 
Minor    Inter Info   
[4]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Minor    Inter Info   
[4]
D1533
 
Tamoxifen
 
C26H29NO
 
2733526 
Minor    Inter Info   
[1], [3], [4]
D1541
 
Telaprevir
 
C36H53N7O6
 
3010818 
Minor    Inter Info   
[1], [3], [4]
D1544
 
Telithromycin
 
C43H65N5O10
 
3002190 
Minor    Inter Info   
[4]
D1579
 
Ticagrelor
 
C23H28F2N6O4S
 
9871419 
Minor    Inter Info   
[1], [2], [3], [4]
D1608
 
Tolvaptan
 
C26H25ClN2O3
 
216237 
Minor    Inter Info   
[1], [3], [4]
D1664
 
Ulipristal
 
C28H35NO3
 
13559281 
Minor    Inter Info   
[1], [3], [4]
D1690
 
Verapamil
 
C27H38N2O4
 
2520 
Minor    Inter Info   
[4]
   Transporter induction Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Moderate    Inter Info   
[13], [1], [3], [14]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0720
 
Gilteritinib
 
C29H44N8O3
 
49803313 
Moderate    Inter Info   
[3], [17]
D0896
 
Larotrectinib
 
C21H22F2N6O2
 
46188928 
Moderate    Inter Info   
[1], [2], [3], [4]
   CYP450 enzyme induction Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Moderate    Inter Info   
[3], [10]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Major    Inter Info   
[3], [5], [6]
D1693
 
Vibrio cholerae CVD 103-HgR strain live antigen (live)
 
NA
 
NA
Major    Inter Info   
[7]
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Moderate    Inter Info   
[21], [22], [23]
References
1 Cerner Multum, Inc. "Australian Product Information.".
2 Cerner Multum, Inc. "Canadian Product Information.".
3 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4 Product Information. Dificid (fidaxomicin). Optimer Pharmaceuticals, San Diego, CA.
5 UK government "Typhoid.".
6 American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
7 Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
8 Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
9 Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
10 Product Information. Erleada (apalutamide). Janssen Biotech, Inc., Horsham, PA, PA.
11 Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
12 Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
13 Benoist G, van Oort I, et al "Drug-drug interaction potential in men treated with enzalutamide: Mind the gap." Br J Clin Pharmacol 0 (2017): epub. [PMID: 28881501]
14 Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
15 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
16 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
17 Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
18 Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
19 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
20 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
21 Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
22 MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
23 Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
24 Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.